SMT201600072B - Sale sodico di 6-fluoro-3-idrossi-2-pirazina carbossammide - Google Patents
Sale sodico di 6-fluoro-3-idrossi-2-pirazina carbossammideInfo
- Publication number
- SMT201600072B SMT201600072B SM201600072T SM201600072T SMT201600072B SM T201600072 B SMT201600072 B SM T201600072B SM 201600072 T SM201600072 T SM 201600072T SM 201600072 T SM201600072 T SM 201600072T SM T201600072 B SMT201600072 B SM T201600072B
- Authority
- SM
- San Marino
- Prior art keywords
- carbossamide
- pirazine
- fluoro
- hydroxy
- sodium salt
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2010221682 | 2010-09-30 | ||
PCT/JP2011/072333 WO2012043700A1 (ja) | 2010-09-30 | 2011-09-29 | 6-フルオロ-3-ヒドロキシ-2-ピラジンカルボキサミドのナトリウム塩 |
Publications (1)
Publication Number | Publication Date |
---|---|
SMT201600072B true SMT201600072B (it) | 2016-04-29 |
Family
ID=45893139
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SM201600072T SMT201600072B (it) | 2010-09-30 | 2016-03-14 | Sale sodico di 6-fluoro-3-idrossi-2-pirazina carbossammide |
Country Status (20)
Country | Link |
---|---|
US (3) | US20130274472A1 (xx) |
EP (1) | EP2623498B1 (xx) |
JP (1) | JPWO2012043700A1 (xx) |
CN (1) | CN103209966B (xx) |
CY (1) | CY1117041T1 (xx) |
DK (1) | DK2623498T3 (xx) |
ES (1) | ES2554630T3 (xx) |
HK (1) | HK1183015A1 (xx) |
HR (1) | HRP20151263T1 (xx) |
HU (1) | HUE026872T2 (xx) |
MY (1) | MY161429A (xx) |
PH (1) | PH12015501649A1 (xx) |
PL (1) | PL2623498T3 (xx) |
PT (1) | PT2623498E (xx) |
RS (1) | RS54408B1 (xx) |
SG (1) | SG189161A1 (xx) |
SI (1) | SI2623498T1 (xx) |
SM (1) | SMT201600072B (xx) |
TW (1) | TWI552998B (xx) |
WO (1) | WO2012043700A1 (xx) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8778398B2 (en) | 2008-11-04 | 2014-07-15 | Jazz Pharmaceuticals, Inc. | Immediate release formulations and dosage forms of gamma-hydroxybutyrate |
CA2794171C (en) | 2010-03-24 | 2018-07-03 | Jazz Pharmaceuticals, Inc. | Controlled release dosage forms for high dose, water soluble and hygroscopic drug substances |
SI2623497T1 (sl) * | 2010-09-30 | 2016-04-29 | Toyama Chemical Co., Ltd. | Megluminska sol 6-fluoro-3-hidroksi-2-pirazinkarboksamida |
MX360889B (es) * | 2012-12-22 | 2018-11-20 | Kbp Biosciences Co Ltd | Forma cristalina de un compuesto usado como un antagonista del receptor mineralocorticoide y metodo de preparacion de la misma. |
US10765753B2 (en) * | 2014-12-30 | 2020-09-08 | Samyang Biopharmaceuticals Corporation | Polymer nanoparticle freeze-dried product, and preparation method therefor |
US10398662B1 (en) | 2015-02-18 | 2019-09-03 | Jazz Pharma Ireland Limited | GHB formulation and method for its manufacture |
WO2018003946A1 (ja) * | 2016-06-30 | 2018-01-04 | 富山化学工業株式会社 | 凍結乾燥製剤の製造方法 |
UY37341A (es) | 2016-07-22 | 2017-11-30 | Flamel Ireland Ltd | Formulaciones de gamma-hidroxibutirato de liberación modificada con farmacocinética mejorada |
US11986451B1 (en) | 2016-07-22 | 2024-05-21 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
US11602513B1 (en) | 2016-07-22 | 2023-03-14 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
US11504347B1 (en) | 2016-07-22 | 2022-11-22 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
US11602512B1 (en) | 2016-07-22 | 2023-03-14 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
US20180263936A1 (en) | 2017-03-17 | 2018-09-20 | Jazz Pharmaceuticals Ireland Limited | Gamma-hydroxybutyrate compositions and their use for the treatment of disorders |
EP3733182A4 (en) * | 2017-12-28 | 2021-09-01 | FUJIFILM Toyama Chemical Co., Ltd. | PROCESS FOR PREPARING A FREEZE-DRIED FORMULATION |
MX2021005691A (es) | 2018-11-19 | 2021-07-07 | Jazz Pharmaceuticals Ireland Ltd | Formulaciones de farmacos resistentes al alcohol. |
CN113473980A (zh) | 2019-03-01 | 2021-10-01 | 弗拉梅尔爱尔兰有限公司 | 在进食状态下具有改善的药代动力学的γ-羟基丁酸酯组合物 |
CN111249229B (zh) * | 2020-03-10 | 2023-05-02 | 北京阜康仁生物制药科技有限公司 | 一种稳定的法匹拉韦注射液及其制备方法 |
TR202017792A2 (tr) * | 2020-11-06 | 2021-01-21 | Aroma Ilac Sanayi Ltd Sti | 6-floro-3-hidroksi-2-pirazinkarboksamid etken maddesi veya sodyum tuzunu içeren liyofilizasyon tekniğiyle üretilen yeni bir farmasötik kompozisyon |
CN112546234B (zh) * | 2020-12-11 | 2021-10-15 | 山东大学 | 一种法匹拉韦药用结合物及在制备抗病毒药物制剂中的应用 |
CN112574130B (zh) * | 2020-12-11 | 2021-10-15 | 山东大学 | 一种法匹拉韦药物共晶及其制备方法和应用 |
WO2022131112A1 (ja) | 2020-12-18 | 2022-06-23 | 富士フイルム富山化学株式会社 | 医薬組成物 |
CN116761591A (zh) | 2020-12-18 | 2023-09-15 | 富士胶片富山化学株式会社 | 药物组合物 |
WO2023033683A1 (ru) * | 2021-09-06 | 2023-03-09 | Общество С Ограниченной Ответственностью "Промомед Рус" | Противовирусная фармацевтическая композиция, содержащая фавипиравир и аминокислоту |
US11583510B1 (en) | 2022-02-07 | 2023-02-21 | Flamel Ireland Limited | Methods of administering gamma hydroxybutyrate formulations after a high-fat meal |
US11779557B1 (en) | 2022-02-07 | 2023-10-10 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ID25469A (id) | 1998-01-07 | 2000-10-05 | Meiji Seika Kaisha | Komposisi sefalosporin amorf yang stabil secara kristalografi dan proses pembuatannya |
WO2000010569A1 (fr) * | 1998-08-20 | 2000-03-02 | Toyama Chemical Co., Ltd. | Derives heterocycliques azotes de carboxamide ou certains de leurs sels et antiviraux les contenant les deux |
BRPI0108374B8 (pt) | 2000-02-16 | 2021-05-25 | Fujifilm Toyama Chemical Co Ltd | derivado de pirazina ou um sal deste e composição farmacêutica |
PL2123276T3 (pl) * | 2007-02-16 | 2013-04-30 | Toyama Chemical Co Ltd | Kompozycja farmaceutyczna zawierająca pochodną pirazyny oraz sposób stosowania pochodnej pirazyny w kombinacji |
JP5174365B2 (ja) * | 2007-03-23 | 2013-04-03 | 第一三共株式会社 | キノロン含有凍結乾燥製剤の製造方法 |
JP2008231064A (ja) | 2007-03-23 | 2008-10-02 | Nippon Shokubai Co Ltd | カルバゾイルアルキル(メタ)アクリレートの製造方法 |
CN104672153B (zh) | 2007-09-27 | 2019-04-23 | 富士胶片富山化学株式会社 | 6-氟-3-羟基-2-氰基吡嗪的有机胺盐及其制备方法 |
SG174291A1 (en) | 2009-03-13 | 2011-10-28 | Toyama Chemical Co Ltd | Tablet and granulated powder containing 6-fluoro-3-hydroxy-2-pyrazinecarboxamide |
SI2623497T1 (sl) | 2010-09-30 | 2016-04-29 | Toyama Chemical Co., Ltd. | Megluminska sol 6-fluoro-3-hidroksi-2-pirazinkarboksamida |
-
2011
- 2011-09-29 SG SG2013023437A patent/SG189161A1/en unknown
- 2011-09-29 CN CN201180055060.8A patent/CN103209966B/zh active Active
- 2011-09-29 PT PT118292531T patent/PT2623498E/pt unknown
- 2011-09-29 US US13/876,998 patent/US20130274472A1/en not_active Abandoned
- 2011-09-29 SI SI201130722T patent/SI2623498T1/sl unknown
- 2011-09-29 JP JP2012536536A patent/JPWO2012043700A1/ja active Pending
- 2011-09-29 TW TW100135298A patent/TWI552998B/zh active
- 2011-09-29 DK DK11829253.1T patent/DK2623498T3/en active
- 2011-09-29 WO PCT/JP2011/072333 patent/WO2012043700A1/ja active Application Filing
- 2011-09-29 HU HUE11829253A patent/HUE026872T2/en unknown
- 2011-09-29 RS RS20150767A patent/RS54408B1/en unknown
- 2011-09-29 EP EP11829253.1A patent/EP2623498B1/en active Active
- 2011-09-29 ES ES11829253.1T patent/ES2554630T3/es active Active
- 2011-09-29 MY MYPI2013001093A patent/MY161429A/en unknown
- 2011-09-29 PL PL11829253T patent/PL2623498T3/pl unknown
-
2013
- 2013-09-02 HK HK13110207.3A patent/HK1183015A1/xx unknown
-
2014
- 2014-10-16 US US14/515,673 patent/US9096547B2/en active Active
-
2015
- 2015-06-08 US US14/733,199 patent/US20150266831A1/en not_active Abandoned
- 2015-07-24 PH PH12015501649A patent/PH12015501649A1/en unknown
- 2015-11-24 HR HRP20151263TT patent/HRP20151263T1/hr unknown
- 2015-12-09 CY CY20151101124T patent/CY1117041T1/el unknown
-
2016
- 2016-03-14 SM SM201600072T patent/SMT201600072B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
HRP20151263T1 (hr) | 2015-12-18 |
CN103209966A (zh) | 2013-07-17 |
TWI552998B (zh) | 2016-10-11 |
US20150038713A1 (en) | 2015-02-05 |
US9096547B2 (en) | 2015-08-04 |
HUE026872T2 (en) | 2016-07-28 |
EP2623498A1 (en) | 2013-08-07 |
PL2623498T3 (pl) | 2016-05-31 |
EP2623498B1 (en) | 2015-11-18 |
US20130274472A1 (en) | 2013-10-17 |
CY1117041T1 (el) | 2017-04-05 |
JPWO2012043700A1 (ja) | 2014-02-24 |
TW201219375A (en) | 2012-05-16 |
EP2623498A4 (en) | 2014-03-26 |
PH12015501649B1 (en) | 2015-10-05 |
MY161429A (en) | 2017-04-14 |
SI2623498T1 (sl) | 2016-03-31 |
ES2554630T3 (es) | 2015-12-22 |
SG189161A1 (en) | 2013-05-31 |
PT2623498E (pt) | 2016-02-02 |
US20150266831A1 (en) | 2015-09-24 |
WO2012043700A1 (ja) | 2012-04-05 |
HK1183015A1 (en) | 2013-12-13 |
DK2623498T3 (en) | 2016-02-22 |
CN103209966B (zh) | 2015-06-10 |
RS54408B1 (en) | 2016-04-28 |
PH12015501649A1 (en) | 2015-10-05 |
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