SMT201600184B - Sale di meglumina di 6-fluoro-3-idrossi-2-pirazincarbossammide - Google Patents
Sale di meglumina di 6-fluoro-3-idrossi-2-pirazincarbossammideInfo
- Publication number
- SMT201600184B SMT201600184B SM201600184T SM201600184T SMT201600184B SM T201600184 B SMT201600184 B SM T201600184B SM 201600184 T SM201600184 T SM 201600184T SM 201600184 T SM201600184 T SM 201600184T SM T201600184 B SMT201600184 B SM T201600184B
- Authority
- SM
- San Marino
- Prior art keywords
- pirazincarbosside
- fluoro
- hydroxy
- meglumin salt
- meglumin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
- C07C215/06—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
- C07C215/10—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic with one amino group and at least two hydroxy groups bound to the carbon skeleton
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010221620 | 2010-09-30 | ||
| PCT/JP2011/072329 WO2012043696A1 (ja) | 2010-09-30 | 2011-09-29 | ６－フルオロ－３－ヒドロキシ－２－ピラジンカルボキサミドのメグルミン塩 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SMT201600184B true SMT201600184B (it) | 2016-08-31 |
Family
ID=45893135
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SM201600184T SMT201600184B (it) | 2010-09-30 | 2016-06-16 | Sale di meglumina di 6-fluoro-3-idrossi-2-pirazincarbossammide |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US20130217708A1 (it) |
| EP (1) | EP2623497B1 (it) |
| JP (1) | JP5936546B2 (it) |
| CN (1) | CN103209967B (it) |
| CY (1) | CY1117218T1 (it) |
| DK (1) | DK2623497T3 (it) |
| ES (1) | ES2561878T3 (it) |
| HK (1) | HK1183014A1 (it) |
| HR (1) | HRP20160218T1 (it) |
| HU (1) | HUE026794T2 (it) |
| MY (1) | MY161757A (it) |
| PH (1) | PH12015501328A1 (it) |
| PL (1) | PL2623497T3 (it) |
| RS (1) | RS54642B1 (it) |
| SG (1) | SG188662A1 (it) |
| SI (1) | SI2623497T1 (it) |
| SM (1) | SMT201600184B (it) |
| TW (1) | TWI507397B (it) |
| WO (1) | WO2012043696A1 (it) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8778398B2 (en) | 2008-11-04 | 2014-07-15 | Jazz Pharmaceuticals, Inc. | Immediate release formulations and dosage forms of gamma-hydroxybutyrate |
| AU2011232408B2 (en) | 2010-03-24 | 2015-07-30 | Jazz Pharmaceuticals, Inc. | Controlled release dosage forms for high dose, water soluble and hygroscopic drug substances |
| ES2554630T3 (es) | 2010-09-30 | 2015-12-22 | Toyama Chemical Co., Ltd. | Sal sódica de 6-fluoro-3-hidroxi-2-pirazinocarboxamida |
| TWI788044B (zh) | 2013-03-15 | 2022-12-21 | 美商百歐維拉提夫治療公司 | 因子ｉｘ多肽調配物 |
| AU2015236340B2 (en) | 2014-03-24 | 2020-02-06 | Bioverativ Therapeutics Inc. | Lyophilized factor IX formulations |
| CN104610153B (zh) * | 2015-01-19 | 2017-02-22 | 沈阳中海生物技术开发有限公司 | 奥扎格雷葡甲胺盐及其组合物、制备方法和用途 |
| US10398662B1 (en) | 2015-02-18 | 2019-09-03 | Jazz Pharma Ireland Limited | GHB formulation and method for its manufacture |
| WO2018003946A1 (ja) * | 2016-06-30 | 2018-01-04 | 富山化学工業株式会社 | 凍結乾燥製剤の製造方法 |
| US11602512B1 (en) | 2016-07-22 | 2023-03-14 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| UY37341A (es) | 2016-07-22 | 2017-11-30 | Flamel Ireland Ltd | Formulaciones de gamma-hidroxibutirato de liberación modificada con farmacocinética mejorada |
| US11986451B1 (en) | 2016-07-22 | 2024-05-21 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11602513B1 (en) | 2016-07-22 | 2023-03-14 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11504347B1 (en) | 2016-07-22 | 2022-11-22 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US20180263936A1 (en) | 2017-03-17 | 2018-09-20 | Jazz Pharmaceuticals Ireland Limited | Gamma-hydroxybutyrate compositions and their use for the treatment of disorders |
| US11679083B2 (en) | 2017-12-28 | 2023-06-20 | Fujifilm Toyama Chemical Co., Ltd. | Method for producing freeze-dried formulation |
| CA3115122A1 (en) | 2018-11-19 | 2020-05-28 | Jazz Pharmaceuticals Ireland Limited | Alcohol-resistant drug formulations |
| JP2022522270A (ja) | 2019-03-01 | 2022-04-15 | フラメル アイルランド リミテッド | 食事摂取状態における改善された薬物動態を有するガンマ－ヒドロキシ酪酸塩組成物 |
| CN111214446B (zh) * | 2020-03-07 | 2022-02-25 | 瑞阳制药股份有限公司 | 一种供注射用法匹拉韦l-精氨酸盐冻干制剂 |
| CN113750105A (zh) * | 2020-12-11 | 2021-12-07 | 山东大学 | 一种法匹拉韦药用结合物及在制备抗病毒药物制剂中的应用 |
| WO2022131117A1 (ja) | 2020-12-18 | 2022-06-23 | 富士フイルム富山化学株式会社 | 医薬組成物 |
| WO2022131112A1 (ja) | 2020-12-18 | 2022-06-23 | 富士フイルム富山化学株式会社 | 医薬組成物 |
| US11583510B1 (en) | 2022-02-07 | 2023-02-21 | Flamel Ireland Limited | Methods of administering gamma hydroxybutyrate formulations after a high-fat meal |
| US11779557B1 (en) | 2022-02-07 | 2023-10-10 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4590269A (en) * | 1984-03-29 | 1986-05-20 | Syntex (U.S.A.) Inc. | Process for preparing the cyclic phosphate ester of substituted 9-(1,3-dihydroxy-2-propoxymethyl)purines |
| IT1207994B (it) | 1986-01-03 | 1989-06-01 | Therapicon Srl | Sali idrosulubili di composti adattivita' antiinfiammatoria ed analgesica, loro preparazione ed utilizzo in composizioni farmaceutiche. |
| JP3845876B2 (ja) * | 1995-04-20 | 2006-11-15 | アステラス製薬株式会社 | ピラジン誘導体又はその塩を含有する安定な注射用組成物及びその製造方法 |
| PL194097B1 (pl) | 1998-01-07 | 2007-04-30 | Meiji Seika Kaisha | Kompozycja zawierająca krystalograficznie trwałą amorficzną cefalosporynę i sposób jej wytwarzania |
| DE69937405T2 (de) * | 1998-08-20 | 2008-02-14 | Toyama Chemical Co. Ltd. | Stickstoffheterocyclische Carboxamidverbindungen oder deren Salze als antivirale Mittel |
| JP4379767B2 (ja) | 2000-02-16 | 2009-12-09 | 富山化学工業株式会社 | 新規なピラジン誘導体またはその塩、それらを含有する医薬組成物並びにそれらの製造中間体 |
| DE10161077A1 (de) * | 2001-12-12 | 2003-06-18 | Boehringer Ingelheim Vetmed | Hochkonzentrierte stabile Meloxicamlösungen zur nadellosen Injektion |
| DK1868581T3 (da) * | 2005-04-11 | 2012-07-09 | Abbott Lab | Farmaceutiske sammensætninger med forbedrede opløsningsprofiler til dårligt opløselige lægemidler |
| ZA200905536B (en) | 2007-02-16 | 2010-10-27 | Toyama Chemical Co Ltd | Pharmaceutical composition comprising pyrazine derivative, and method of using pyrazine derivative in combination |
| JP5174365B2 (ja) * | 2007-03-23 | 2013-04-03 | 第一三共株式会社 | キノロン含有凍結乾燥製剤の製造方法 |
| KR101574567B1 (ko) | 2007-09-27 | 2015-12-07 | 토야마 케미칼 컴퍼니 리미티드 | 6-플루오로-3-히드록시-2-피라진카보니트릴의 유기아민염 및 그 제조법 |
| JP5583659B2 (ja) | 2009-03-13 | 2014-09-03 | 富山化学工業株式会社 | ６−フルオロ−３−ヒドロキシ−２−ピラジンカルボキサミド含有錠剤および造粒末 |
| ES2554630T3 (es) | 2010-09-30 | 2015-12-22 | Toyama Chemical Co., Ltd. | Sal sódica de 6-fluoro-3-hidroxi-2-pirazinocarboxamida |
-
2011
- 2011-09-29 ES ES11829249.9T patent/ES2561878T3/es active Active
- 2011-09-29 HU HUE11829249A patent/HUE026794T2/en unknown
- 2011-09-29 EP EP11829249.9A patent/EP2623497B1/en active Active
- 2011-09-29 SI SI201130754T patent/SI2623497T1/sl unknown
- 2011-09-29 SG SG2013023353A patent/SG188662A1/en unknown
- 2011-09-29 PL PL11829249T patent/PL2623497T3/pl unknown
- 2011-09-29 RS RS20160178A patent/RS54642B1/en unknown
- 2011-09-29 TW TW100135204A patent/TWI507397B/zh active
- 2011-09-29 US US13/877,037 patent/US20130217708A1/en not_active Abandoned
- 2011-09-29 WO PCT/JP2011/072329 patent/WO2012043696A1/ja active Application Filing
- 2011-09-29 MY MYPI2013001091A patent/MY161757A/en unknown
- 2011-09-29 DK DK11829249.9T patent/DK2623497T3/en active
- 2011-09-29 JP JP2012536534A patent/JP5936546B2/ja active Active
- 2011-09-29 CN CN201180055096.6A patent/CN103209967B/zh active Active
-
2013
- 2013-09-02 HK HK13110206.4A patent/HK1183014A1/xx unknown
-
2014
- 2014-10-07 US US14/508,185 patent/US9090571B2/en active Active
-
2015
- 2015-06-09 US US14/734,263 patent/US20150266832A1/en not_active Abandoned
- 2015-06-15 PH PH12015501328A patent/PH12015501328A1/en unknown
-
2016
- 2016-02-23 CY CY20161100148T patent/CY1117218T1/el unknown
- 2016-03-01 HR HRP20160218T patent/HRP20160218T1/hr unknown
- 2016-06-16 SM SM201600184T patent/SMT201600184B/it unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PH12015501328B1 (en) | 2015-09-21 |
| DK2623497T3 (en) | 2016-03-21 |
| EP2623497B1 (en) | 2016-01-20 |
| CY1117218T1 (el) | 2017-04-05 |
| CN103209967B (zh) | 2015-04-08 |
| MY161757A (en) | 2017-05-15 |
| PL2623497T3 (pl) | 2016-07-29 |
| PH12015501328A1 (en) | 2015-09-21 |
| WO2012043696A1 (ja) | 2012-04-05 |
| US20130217708A1 (en) | 2013-08-22 |
| EP2623497A1 (en) | 2013-08-07 |
| US20150266832A1 (en) | 2015-09-24 |
| TWI507397B (zh) | 2015-11-11 |
| EP2623497A4 (en) | 2014-03-26 |
| SI2623497T1 (sl) | 2016-04-29 |
| TW201217343A (en) | 2012-05-01 |
| SG188662A1 (en) | 2013-05-31 |
| JPWO2012043696A1 (ja) | 2014-02-24 |
| HK1183014A1 (en) | 2013-12-13 |
| US20150031885A1 (en) | 2015-01-29 |
| RS54642B1 (en) | 2016-08-31 |
| HUE026794T2 (en) | 2016-07-28 |
| ES2561878T3 (es) | 2016-03-01 |
| CN103209967A (zh) | 2013-07-17 |
| JP5936546B2 (ja) | 2016-06-22 |
| HRP20160218T1 (hr) | 2016-03-25 |
| US9090571B2 (en) | 2015-07-28 |
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