PT2623498E - Sal de sódio de 6-fluoro-3-hidroxi-2-pirazino-carboxamida - Google Patents
Sal de sódio de 6-fluoro-3-hidroxi-2-pirazino-carboxamida Download PDFInfo
- Publication number
- PT2623498E PT2623498E PT118292531T PT11829253T PT2623498E PT 2623498 E PT2623498 E PT 2623498E PT 118292531 T PT118292531 T PT 118292531T PT 11829253 T PT11829253 T PT 11829253T PT 2623498 E PT2623498 E PT 2623498E
- Authority
- PT
- Portugal
- Prior art keywords
- fluoro
- hydroxy
- sodium salt
- pyrazine carboxamide
- pyrazine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010221682 | 2010-09-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2623498E true PT2623498E (pt) | 2016-02-02 |
Family
ID=45893139
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT118292531T PT2623498E (pt) | 2010-09-30 | 2011-09-29 | Sal de sódio de 6-fluoro-3-hidroxi-2-pirazino-carboxamida |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US20130274472A1 (pt) |
| EP (1) | EP2623498B1 (pt) |
| JP (1) | JPWO2012043700A1 (pt) |
| CN (1) | CN103209966B (pt) |
| CY (1) | CY1117041T1 (pt) |
| DK (1) | DK2623498T3 (pt) |
| ES (1) | ES2554630T3 (pt) |
| HK (1) | HK1183015A1 (pt) |
| HR (1) | HRP20151263T1 (pt) |
| HU (1) | HUE026872T2 (pt) |
| MY (1) | MY161429A (pt) |
| PH (1) | PH12015501649A1 (pt) |
| PL (1) | PL2623498T3 (pt) |
| PT (1) | PT2623498E (pt) |
| RS (1) | RS54408B1 (pt) |
| SG (1) | SG189161A1 (pt) |
| SI (1) | SI2623498T1 (pt) |
| SM (1) | SMT201600072B (pt) |
| TW (1) | TWI552998B (pt) |
| WO (1) | WO2012043700A1 (pt) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8778398B2 (en) | 2008-11-04 | 2014-07-15 | Jazz Pharmaceuticals, Inc. | Immediate release formulations and dosage forms of gamma-hydroxybutyrate |
| MX2020011961A (es) | 2010-03-24 | 2022-04-19 | Jazz Pharmaceuticals Inc | Formas de dosis de liberacion controlada para substancias de farmaco de alta dosis, solubles en agua e higroscopicas. |
| EP2623497B1 (en) * | 2010-09-30 | 2016-01-20 | Toyama Chemical Co., Ltd. | Meglumine salt of 6-fluoro-3-hydroxy-2-pyrazine carboxamide |
| BR112015014839B1 (pt) * | 2012-12-22 | 2022-09-06 | Kbp Biosciences Co., Ltd | Forma cristalina do composto utilizado como antagonista do receptor de mineralocorticoide, seus usos, seu processo de preparação e composição farmacêutica |
| JP6487051B2 (ja) * | 2014-12-30 | 2019-03-20 | サムヤン バイオファーマシューティカルズ コーポレイションＳａｍｙａｎｇ Ｂｉｏｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｃｏｒｐｏｒａｔｉｏｎ | ポリマーナノ粒子の凍結乾燥物、及びその製造方法 |
| US10398662B1 (en) | 2015-02-18 | 2019-09-03 | Jazz Pharma Ireland Limited | GHB formulation and method for its manufacture |
| WO2018003946A1 (ja) * | 2016-06-30 | 2018-01-04 | 富山化学工業株式会社 | 凍結乾燥製剤の製造方法 |
| US11986451B1 (en) | 2016-07-22 | 2024-05-21 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11602512B1 (en) | 2016-07-22 | 2023-03-14 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| UY37341A (es) | 2016-07-22 | 2017-11-30 | Flamel Ireland Ltd | Formulaciones de gamma-hidroxibutirato de liberación modificada con farmacocinética mejorada |
| US11602513B1 (en) | 2016-07-22 | 2023-03-14 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11504347B1 (en) | 2016-07-22 | 2022-11-22 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US20180263936A1 (en) | 2017-03-17 | 2018-09-20 | Jazz Pharmaceuticals Ireland Limited | Gamma-hydroxybutyrate compositions and their use for the treatment of disorders |
| CN111556752A (zh) * | 2017-12-28 | 2020-08-18 | 富士胶片富山化学株式会社 | 冻干制剂的制造方法 |
| MX2021005691A (es) | 2018-11-19 | 2021-07-07 | Jazz Pharmaceuticals Ireland Ltd | Formulaciones de farmacos resistentes al alcohol. |
| CN113473980A (zh) | 2019-03-01 | 2021-10-01 | 弗拉梅尔爱尔兰有限公司 | 在进食状态下具有改善的药代动力学的γ-羟基丁酸酯组合物 |
| CN111249229B (zh) * | 2020-03-10 | 2023-05-02 | 北京阜康仁生物制药科技有限公司 | 一种稳定的法匹拉韦注射液及其制备方法 |
| TR202017792A2 (tr) * | 2020-11-06 | 2021-01-21 | Aroma Ilac Sanayi Ltd Sti | 6-floro-3-hidroksi-2-pirazinkarboksamid etken maddesi veya sodyum tuzunu içeren liyofilizasyon tekniğiyle üretilen yeni bir farmasötik kompozisyon |
| CN112574130B (zh) * | 2020-12-11 | 2021-10-15 | 山东大学 | 一种法匹拉韦药物共晶及其制备方法和应用 |
| CN113750105A (zh) * | 2020-12-11 | 2021-12-07 | 山东大学 | 一种法匹拉韦药用结合物及在制备抗病毒药物制剂中的应用 |
| US20240041866A1 (en) | 2020-12-18 | 2024-02-08 | Fujifilm Toyama Chemical Co., Ltd. | Pharmaceutical composition |
| EP4265252A1 (en) | 2020-12-18 | 2023-10-25 | FUJIFILM Toyama Chemical Co., Ltd. | Pharmaceutical composition |
| WO2023033683A1 (ru) * | 2021-09-06 | 2023-03-09 | Общество С Ограниченной Ответственностью "Промомед Рус" | Противовирусная фармацевтическая композиция, содержащая фавипиравир и аминокислоту |
| US11779557B1 (en) | 2022-02-07 | 2023-10-10 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11583510B1 (en) | 2022-02-07 | 2023-02-21 | Flamel Ireland Limited | Methods of administering gamma hydroxybutyrate formulations after a high-fat meal |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU736555B2 (en) | 1998-01-07 | 2001-08-02 | Meiji Seika Pharma Co., Ltd. | A composition comprising a crystallographically stable, amphorous cephalosporin and processes for the preparation thereof |
| CZ301763B6 (cs) | 1998-08-20 | 2010-06-16 | Toyama Chemical Co., Ltd. | Protivirový prostredek a derivát dusíkatého heterocyklického karboxamidu |
| ATE294185T1 (de) | 2000-02-16 | 2005-05-15 | Toyama Chemical Co Ltd | Neue pyrazin-derivate oder salze davon, pharmazeutische zusammensetzungen, die die derivate oder deren salze enthalten und intermediäre zur herstellung der derivate |
| CN101610772B (zh) | 2007-02-16 | 2013-01-16 | 富山化学工业株式会社 | 包含吡嗪衍生物的药物组合物和使用吡嗪衍生物的联合用药的方法 |
| JP2008231064A (ja) | 2007-03-23 | 2008-10-02 | Nippon Shokubai Co Ltd | カルバゾイルアルキル（メタ）アクリレートの製造方法 |
| JP5174365B2 (ja) * | 2007-03-23 | 2013-04-03 | 第一三共株式会社 | キノロン含有凍結乾燥製剤の製造方法 |
| RU2470924C2 (ru) * | 2007-09-27 | 2012-12-27 | Тояма Кемикал Ко., Лтд. | Органическая аминовая соль 6-фтор-3-гидрокси-2-пиразинкарбонитрила и способ ее получения |
| CN102348458B (zh) | 2009-03-13 | 2013-11-06 | 富山化学工业株式会社 | 含有6-氟-3-羟基-2-吡嗪甲酰胺的片剂和粒状粉剂 |
| EP2623497B1 (en) | 2010-09-30 | 2016-01-20 | Toyama Chemical Co., Ltd. | Meglumine salt of 6-fluoro-3-hydroxy-2-pyrazine carboxamide |
-
2011
- 2011-09-29 JP JP2012536536A patent/JPWO2012043700A1/ja active Pending
- 2011-09-29 CN CN201180055060.8A patent/CN103209966B/zh active Active
- 2011-09-29 ES ES11829253.1T patent/ES2554630T3/es active Active
- 2011-09-29 PT PT118292531T patent/PT2623498E/pt unknown
- 2011-09-29 SI SI201130722T patent/SI2623498T1/sl unknown
- 2011-09-29 RS RS20150767A patent/RS54408B1/en unknown
- 2011-09-29 HU HUE11829253A patent/HUE026872T2/en unknown
- 2011-09-29 EP EP11829253.1A patent/EP2623498B1/en active Active
- 2011-09-29 SG SG2013023437A patent/SG189161A1/en unknown
- 2011-09-29 TW TW100135298A patent/TWI552998B/zh active
- 2011-09-29 PL PL11829253T patent/PL2623498T3/pl unknown
- 2011-09-29 WO PCT/JP2011/072333 patent/WO2012043700A1/ja active Application Filing
- 2011-09-29 MY MYPI2013001093A patent/MY161429A/en unknown
- 2011-09-29 US US13/876,998 patent/US20130274472A1/en not_active Abandoned
- 2011-09-29 DK DK11829253.1T patent/DK2623498T3/en active
-
2013
- 2013-09-02 HK HK13110207.3A patent/HK1183015A1/xx unknown
-
2014
- 2014-10-16 US US14/515,673 patent/US9096547B2/en active Active
-
2015
- 2015-06-08 US US14/733,199 patent/US20150266831A1/en not_active Abandoned
- 2015-07-24 PH PH12015501649A patent/PH12015501649A1/en unknown
- 2015-11-24 HR HRP20151263TT patent/HRP20151263T1/hr unknown
- 2015-12-09 CY CY20151101124T patent/CY1117041T1/el unknown
-
2016
- 2016-03-14 SM SM201600072T patent/SMT201600072B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PH12015501649B1 (en) | 2015-10-05 |
| PL2623498T3 (pl) | 2016-05-31 |
| JPWO2012043700A1 (ja) | 2014-02-24 |
| US20130274472A1 (en) | 2013-10-17 |
| EP2623498A4 (en) | 2014-03-26 |
| HK1183015A1 (en) | 2013-12-13 |
| HUE026872T2 (en) | 2016-07-28 |
| CY1117041T1 (el) | 2017-04-05 |
| TW201219375A (en) | 2012-05-16 |
| TWI552998B (zh) | 2016-10-11 |
| DK2623498T3 (en) | 2016-02-22 |
| US20150038713A1 (en) | 2015-02-05 |
| SI2623498T1 (sl) | 2016-03-31 |
| CN103209966B (zh) | 2015-06-10 |
| MY161429A (en) | 2017-04-14 |
| SG189161A1 (en) | 2013-05-31 |
| SMT201600072B (it) | 2016-04-29 |
| WO2012043700A1 (ja) | 2012-04-05 |
| US20150266831A1 (en) | 2015-09-24 |
| EP2623498A1 (en) | 2013-08-07 |
| CN103209966A (zh) | 2013-07-17 |
| PH12015501649A1 (en) | 2015-10-05 |
| HRP20151263T1 (hr) | 2015-12-18 |
| RS54408B1 (en) | 2016-04-28 |
| US9096547B2 (en) | 2015-08-04 |
| ES2554630T3 (es) | 2015-12-22 |
| EP2623498B1 (en) | 2015-11-18 |
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