MX360889B - Forma cristalina de un compuesto usado como un antagonista del receptor mineralocorticoide y metodo de preparacion de la misma. - Google Patents
Forma cristalina de un compuesto usado como un antagonista del receptor mineralocorticoide y metodo de preparacion de la misma.Info
- Publication number
- MX360889B MX360889B MX2015008193A MX2015008193A MX360889B MX 360889 B MX360889 B MX 360889B MX 2015008193 A MX2015008193 A MX 2015008193A MX 2015008193 A MX2015008193 A MX 2015008193A MX 360889 B MX360889 B MX 360889B
- Authority
- MX
- Mexico
- Prior art keywords
- crystal form
- preparation
- receptor antagonist
- compound used
- method therefor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/40—Mineralocorticosteroids, e.g. aldosterone; Drugs increasing or potentiating the activity of mineralocorticosteroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/50—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/58—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems with hetero atoms directly attached to the ring nitrogen atom
- C07D215/60—N-oxides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La presente invención pertenece al campo técnico de las medicinas, y se refiere a una forma cristalina de un compuesto usado como antagonista del receptor mineralocorticoide y a un método de preparación del mismo, y en particular, a un método para preparar un compuesto 2- cloro-4-{(3S,3aR)]-3-ciclopentil-7-( 4-hidroxipiperidina-1-carbonil)-3,3a,4,5-tetrahidro-2H- pirazolo[3,4-fjquinolina-2-il]benzonitrilo de la fórmula (I), una forma cristalina del mismo, un método de preparación de la forma cristalina, y el uso de la forma cristalina en la preparación de fármacos para el tratamiento y/o la prevención de una lesión renal o enfermedades cardiovasculares. (ver Fórmula).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210563636 | 2012-12-22 | ||
| PCT/CN2013/090252 WO2014094664A1 (zh) | 2012-12-22 | 2013-12-23 | 作为盐皮质激素受体拮抗剂的化合物的晶型及其制备方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2015008193A MX2015008193A (es) | 2016-02-05 |
| MX360889B true MX360889B (es) | 2018-11-20 |
Family
ID=50977609
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2015008193A MX360889B (es) | 2012-12-22 | 2013-12-23 | Forma cristalina de un compuesto usado como un antagonista del receptor mineralocorticoide y metodo de preparacion de la misma. |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US9809589B2 (es) |
| EP (2) | EP3954688A1 (es) |
| JP (6) | JP2016503041A (es) |
| KR (1) | KR101737883B1 (es) |
| CN (1) | CN105026391B (es) |
| AU (1) | AU2013362400B2 (es) |
| BR (1) | BR112015014839B1 (es) |
| CA (1) | CA2895968C (es) |
| ES (1) | ES2897496T3 (es) |
| HK (2) | HK1212676A1 (es) |
| IL (1) | IL239581B (es) |
| MX (1) | MX360889B (es) |
| NZ (1) | NZ709361A (es) |
| RU (1) | RU2622105C2 (es) |
| SG (1) | SG11201504928XA (es) |
| WO (1) | WO2014094664A1 (es) |
| ZA (1) | ZA201504485B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3954688A1 (en) * | 2012-12-22 | 2022-02-16 | Kbp Biosciences Pte. Ltd. | Crystal forms of compound used as mineralocorticoid receptor antagonist and methods for their preparation |
| MY195054A (en) * | 2016-09-24 | 2023-01-05 | Kbp Biosciences Co Ltd | Pharmaceutical Composition Comprising Mineralocorticoid Receptor Antagonist and use Thereof |
| BR112021017276A2 (pt) * | 2019-03-01 | 2021-11-09 | Kbp Biosciences Co Ltd | Método para preparar composto tricíclico e intermediário do mesmo |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5245716B1 (es) * | 1970-07-10 | 1977-11-17 | ||
| CN85101404A (zh) * | 1985-05-16 | 1987-01-17 | 帝人株式会社 | 头孢菌素衍生物的生产过程 |
| JPH04235188A (ja) * | 1990-06-19 | 1992-08-24 | Takeda Chem Ind Ltd | ペネム化合物の結晶、その製造方法および抗菌剤 |
| DE4235133A1 (de) * | 1992-10-19 | 1994-04-21 | Bayer Ag | Kristallines (R)-(-)-2-Cycloheptyl-N-methylsulfonyl-[4-(2-chinolinyl-methoxy)-phenyl]-acetamid |
| JP3623531B2 (ja) * | 1993-06-07 | 2005-02-23 | ビーエーエスエフ アクチェンゲゼルシャフト | 結晶質ｌ−アスコルビン酸−２−燐酸エステルマグネシウム塩の製造法 |
| DE69719698T2 (de) * | 1996-06-28 | 2003-10-23 | Koninklijke Philips Electronics N.V., Eindhoven | Verfahren und vorrichtung zur übertragung von teletextseiten |
| AU711539B2 (en) | 1996-09-05 | 1999-10-14 | Astra Pharmaceuticals Limited | Novel aryl-pyridazines |
| EP1813616B1 (en) | 2002-11-22 | 2013-03-27 | Active Biotech AB | Pyrazoloquinolines with immunomodulating activity |
| CA2596735C (en) * | 2005-03-21 | 2013-01-08 | Hitoshi Harada | Crystal of 5-[2-amino-4-(2-furyl)pyrimidin-5-yl]-1- methylpyridin-2(1h)-one and processes for producing the same |
| DE102007054497B3 (de) * | 2007-11-13 | 2009-07-23 | Sanofi-Aventis Deutschland Gmbh | Neue kristalline Diphenylazetidinonhydrate und Verfahren zu deren Herstellung |
| CN102372710A (zh) * | 2010-08-18 | 2012-03-14 | 山东轩竹医药科技有限公司 | 作为盐皮质激素受体拮抗剂的并环类化合物 |
| WO2012043700A1 (ja) * | 2010-09-30 | 2012-04-05 | 富山化学工業株式会社 | ６－フルオロ－３－ヒドロキシ－２－ピラジンカルボキサミドのナトリウム塩 |
| EP3954688A1 (en) * | 2012-12-22 | 2022-02-16 | Kbp Biosciences Pte. Ltd. | Crystal forms of compound used as mineralocorticoid receptor antagonist and methods for their preparation |
-
2013
- 2013-12-23 EP EP21194531.6A patent/EP3954688A1/en active Pending
- 2013-12-23 US US14/653,933 patent/US9809589B2/en active Active
- 2013-12-23 CA CA2895968A patent/CA2895968C/en active Active
- 2013-12-23 BR BR112015014839-5A patent/BR112015014839B1/pt active IP Right Grant
- 2013-12-23 EP EP13864994.2A patent/EP2937348B1/en active Active
- 2013-12-23 ES ES13864994T patent/ES2897496T3/es active Active
- 2013-12-23 MX MX2015008193A patent/MX360889B/es active IP Right Grant
- 2013-12-23 AU AU2013362400A patent/AU2013362400B2/en active Active
- 2013-12-23 RU RU2015130222A patent/RU2622105C2/ru active
- 2013-12-23 SG SG11201504928XA patent/SG11201504928XA/en unknown
- 2013-12-23 NZ NZ709361A patent/NZ709361A/en unknown
- 2013-12-23 JP JP2015548180A patent/JP2016503041A/ja active Pending
- 2013-12-23 CN CN201380066871.7A patent/CN105026391B/zh active Active
- 2013-12-23 WO PCT/CN2013/090252 patent/WO2014094664A1/zh active Application Filing
- 2013-12-23 KR KR1020157019924A patent/KR101737883B1/ko active IP Right Grant
-
2015
- 2015-06-22 IL IL239581A patent/IL239581B/en active IP Right Grant
- 2015-06-22 ZA ZA2015/04485A patent/ZA201504485B/en unknown
-
2016
- 2016-01-15 HK HK16100440.8A patent/HK1212676A1/zh unknown
- 2016-05-03 HK HK16105012.5A patent/HK1217019A1/zh unknown
-
2017
- 2017-07-04 JP JP2017131078A patent/JP2017165787A/ja active Pending
-
2019
- 2019-02-05 JP JP2019018876A patent/JP2019065057A/ja active Pending
-
2020
- 2020-04-16 JP JP2020073415A patent/JP6986197B6/ja active Active
-
2021
- 2021-11-02 JP JP2021179425A patent/JP2022009922A/ja active Pending
-
2023
- 2023-11-17 JP JP2023195879A patent/JP2024009114A/ja active Pending
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Legal Events
| Date | Code | Title | Description |
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| FG | Grant or registration |