SK99997A3 - Improved synthesis of cyclopropylacetylene - Google Patents
Improved synthesis of cyclopropylacetylene Download PDFInfo
- Publication number
- SK99997A3 SK99997A3 SK999-97A SK99997A SK99997A3 SK 99997 A3 SK99997 A3 SK 99997A3 SK 99997 A SK99997 A SK 99997A SK 99997 A3 SK99997 A3 SK 99997A3
- Authority
- SK
- Slovakia
- Prior art keywords
- temperature
- reaction mixture
- butyllithium
- cyclopropylacetylene
- sodium
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C13/00—Cyclic hydrocarbons containing rings other than, or in addition to, six-membered aromatic rings
- C07C13/02—Monocyclic hydrocarbons or acyclic hydrocarbon derivatives thereof
- C07C13/04—Monocyclic hydrocarbons or acyclic hydrocarbon derivatives thereof with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C1/00—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon
- C07C1/26—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon starting from organic compounds containing only halogen atoms as hetero-atoms
- C07C1/30—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon starting from organic compounds containing only halogen atoms as hetero-atoms by splitting-off the elements of hydrogen halide from a single molecule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
- C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D265/18—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/376,611 US5663467A (en) | 1995-01-23 | 1995-01-23 | Synthesis of cyclopropylacetylene |
| PCT/US1996/000628 WO1996022955A1 (en) | 1995-01-23 | 1996-01-19 | Improved synthesis of cyclopropylacetylene |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK99997A3 true SK99997A3 (en) | 1998-05-06 |
Family
ID=23485719
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK999-97A SK99997A3 (en) | 1995-01-23 | 1996-01-19 | Improved synthesis of cyclopropylacetylene |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US5663467A (de) |
| EP (1) | EP0805790B1 (de) |
| JP (1) | JP3107829B2 (de) |
| KR (1) | KR19980701577A (de) |
| CN (1) | CN1056824C (de) |
| AR (1) | AR000771A1 (de) |
| AT (1) | ATE186903T1 (de) |
| AU (1) | AU692674B2 (de) |
| BR (1) | BR9606782A (de) |
| CA (1) | CA2210577A1 (de) |
| CZ (1) | CZ234997A3 (de) |
| DE (1) | DE69605282T2 (de) |
| DK (1) | DK0805790T3 (de) |
| EA (1) | EA000074B1 (de) |
| ES (1) | ES2140062T3 (de) |
| FI (1) | FI973086A0 (de) |
| GR (1) | GR3032200T3 (de) |
| HR (1) | HRP960029B1 (de) |
| HU (1) | HUP9800849A3 (de) |
| NZ (1) | NZ301206A (de) |
| SK (1) | SK99997A3 (de) |
| WO (1) | WO1996022955A1 (de) |
| YU (1) | YU3696A (de) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU3736197A (en) * | 1996-07-26 | 1998-02-20 | Du Pont Pharmaceuticals Company | A practical synthesis of benzoxazinones useful as hiv reverse transcripta se inhibitors |
| ZA9711256B (en) | 1996-12-16 | 1999-06-15 | Du Pont Merck Pharma | Asymmetric synthesis of benzoxazinones |
| WO1998027034A1 (en) * | 1996-12-16 | 1998-06-25 | Du Pont Pharmaceuticals Company | An improved synthesis of cyclopropylacetylene |
| US5955627A (en) * | 1996-12-16 | 1999-09-21 | Kuraray Co., Ltd. | Process for the preparation of cyclopropylacetylene derivatives |
| US5932726A (en) * | 1996-12-16 | 1999-08-03 | Dupont Pharmaceuticals Company | Asymmetric synthesis of benzoxazinones |
| CA2279198C (en) * | 1997-02-05 | 2009-04-14 | Merck & Co., Inc. | Process for the crystallization of a reverse transcriptase inhibitor using an anti-solvent |
| US5965729A (en) * | 1997-02-05 | 1999-10-12 | Merck & Co., Inc. | Process for the crystallization of a reverse transcriptase inhibitor using an anti-solvent |
| EP0973708A1 (de) | 1997-03-07 | 2000-01-26 | Basf Aktiengesellschaft | Verbessertes verfahren zur herstellung von cyclopropylacetylen |
| BR9808486A (pt) * | 1997-04-07 | 2000-05-23 | Du Pont Pharm Co | Processo para a preparação de um composto |
| AR011731A1 (es) * | 1997-05-16 | 2000-08-30 | Merck & Co Inc | Un proceso de reaccion de adicion enantioselectiva eficiente utilizando un reactivo de organozinc. |
| SK1022000A3 (en) * | 1997-07-31 | 2000-09-12 | Du Pont Pharm Co | A process for the preparation of cyclopropylacetylene |
| EP1001919A4 (de) * | 1997-08-06 | 2000-10-11 | Merck & Co Inc | Effiziente synthese von cyclopropylacetylen |
| US6072094A (en) * | 1997-08-06 | 2000-06-06 | Merck & Co., Inc. | Efficient synthesis of cyclopropylacetylene |
| EP0922686B1 (de) * | 1997-12-10 | 2002-02-06 | Lonza A.G. | Verfahren zur Herstellung von Ethinylcyclopropan |
| KR100350752B1 (ko) * | 1998-02-06 | 2002-08-28 | 가부시키가이샤 구라레 | 시클로프로필아세틸렌 유도체의 제조방법 |
| US5952537A (en) * | 1998-03-13 | 1999-09-14 | Wiley Organics, Inc. | Preparation of cycloalkylacetylene compounds using dialkylaminomagnesium halide or bis(dialkylamino)magnesium |
| UA72207C2 (uk) | 1998-04-07 | 2005-02-15 | Брістол- Майєрс Сквібб Фарма Компані | Фармацевтична композиція ефавіренцу з добавкою дезінтегруючих агентів у вигляді швидкорозчинних капсул або таблеток та спосіб її виготовлення |
| US20010014352A1 (en) | 1998-05-27 | 2001-08-16 | Udit Batra | Compressed tablet formulation |
| US6235957B1 (en) | 1998-06-29 | 2001-05-22 | Dupont Pharmaceuticals Company | Process for the preparation of cyclopropylacetylene |
| US6288297B1 (en) | 1998-10-01 | 2001-09-11 | Dupont Pharmaceuticals Company | Process for the preparation of cyclopropylacetylene |
| WO2000018706A1 (en) | 1998-10-01 | 2000-04-06 | Du Pont Pharmaceuticals Company | Process for the preparation of cyclopropylacetylene |
| GB2355988A (en) | 1999-10-28 | 2001-05-09 | Merck & Co Inc | Synthesis of cyclopropylacetylene in a one-pot process using a diazo-keto-phos phonate |
| GB2355724A (en) * | 1999-10-28 | 2001-05-02 | Merck & Co Inc | Synthesis of cyclopropylacetylene from propiolic acid (2-propynoic acid) |
| US8080655B2 (en) * | 2009-07-20 | 2011-12-20 | Apotex Pharmachem Inc. | Methods of making efavirenz and intermediates thereof |
| EP2471783A1 (de) | 2010-12-23 | 2012-07-04 | Esteve Química, S.A. | Neuartige polymorphe Form von Efavirenz |
| CN103254087B (zh) * | 2013-06-07 | 2015-03-18 | 郑州大学 | 依非韦伦中间体的制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU578293A1 (ru) * | 1972-02-04 | 1977-10-30 | Институт Органической Химии Имени Н.Д.Зелинского Ан Ссср | Способ получени циклопропилацетилена |
| SU555079A1 (ru) * | 1976-01-30 | 1977-04-25 | Институт органической химии им.Н.Д.Зелинского АН СССР | Способ получени циклопропилацетилена |
| SU572445A1 (ru) * | 1976-04-05 | 1977-09-15 | Институт Органической Химии Имени Н.Д. Зелинского Ан Ссср | Способ получени циклопропилацетилена |
-
1995
- 1995-01-23 US US08/376,611 patent/US5663467A/en not_active Expired - Fee Related
-
1996
- 1996-01-19 BR BR9606782A patent/BR9606782A/pt not_active Application Discontinuation
- 1996-01-19 WO PCT/US1996/000628 patent/WO1996022955A1/en active IP Right Grant
- 1996-01-19 DK DK96902153T patent/DK0805790T3/da active
- 1996-01-19 EA EA199700139A patent/EA000074B1/ru not_active IP Right Cessation
- 1996-01-19 DE DE69605282T patent/DE69605282T2/de not_active Expired - Fee Related
- 1996-01-19 JP JP08522919A patent/JP3107829B2/ja not_active Expired - Fee Related
- 1996-01-19 NZ NZ301206A patent/NZ301206A/en unknown
- 1996-01-19 EP EP96902153A patent/EP0805790B1/de not_active Expired - Lifetime
- 1996-01-19 ES ES96902153T patent/ES2140062T3/es not_active Expired - Lifetime
- 1996-01-19 AU AU46574/96A patent/AU692674B2/en not_active Ceased
- 1996-01-19 CN CN96191577A patent/CN1056824C/zh not_active Expired - Fee Related
- 1996-01-19 CA CA002210577A patent/CA2210577A1/en not_active Abandoned
- 1996-01-19 SK SK999-97A patent/SK99997A3/sk unknown
- 1996-01-19 CZ CZ972349A patent/CZ234997A3/cs unknown
- 1996-01-19 KR KR1019970704969A patent/KR19980701577A/ko active IP Right Grant
- 1996-01-19 HU HU9800849A patent/HUP9800849A3/hu unknown
- 1996-01-19 AT AT96902153T patent/ATE186903T1/de not_active IP Right Cessation
- 1996-01-22 AR ARP960101100A patent/AR000771A1/es unknown
- 1996-01-22 HR HR960029A patent/HRP960029B1/xx not_active IP Right Cessation
- 1996-01-22 YU YU3696A patent/YU3696A/sh unknown
-
1997
- 1997-07-22 FI FI973086A patent/FI973086A0/fi unknown
-
1999
- 1999-12-21 GR GR990403286T patent/GR3032200T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUP9800849A2 (hu) | 1999-01-28 |
| FI973086A (fi) | 1997-07-22 |
| CZ234997A3 (cs) | 1998-02-18 |
| EA199700139A1 (ru) | 1997-12-30 |
| WO1996022955A1 (en) | 1996-08-01 |
| GR3032200T3 (en) | 2000-04-27 |
| CA2210577A1 (en) | 1996-08-01 |
| YU3696A (sh) | 1998-11-05 |
| JPH10512880A (ja) | 1998-12-08 |
| ES2140062T3 (es) | 2000-02-16 |
| CN1169137A (zh) | 1997-12-31 |
| MX9705562A (es) | 1997-10-31 |
| DK0805790T3 (da) | 2000-05-01 |
| AU4657496A (en) | 1996-08-14 |
| NZ301206A (en) | 1998-11-25 |
| CN1056824C (zh) | 2000-09-27 |
| FI973086A0 (fi) | 1997-07-22 |
| JP3107829B2 (ja) | 2000-11-13 |
| DE69605282T2 (de) | 2000-07-13 |
| ATE186903T1 (de) | 1999-12-15 |
| KR19980701577A (ko) | 1998-05-15 |
| HUP9800849A3 (en) | 2001-01-29 |
| EA000074B1 (ru) | 1998-06-25 |
| HRP960029A2 (en) | 1997-08-31 |
| BR9606782A (pt) | 1997-12-30 |
| AR000771A1 (es) | 1997-08-06 |
| AU692674B2 (en) | 1998-06-11 |
| EP0805790A1 (de) | 1997-11-12 |
| DE69605282D1 (en) | 1999-12-30 |
| US5663467A (en) | 1997-09-02 |
| EP0805790B1 (de) | 1999-11-24 |
| HRP960029B1 (en) | 2000-12-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SK99997A3 (en) | Improved synthesis of cyclopropylacetylene | |
| US5698741A (en) | Asymmetric synthesis of (-)6-chloro-4-cyclopropyl-ethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one | |
| EP0582455B1 (de) | Benzoxazinone als Inhibitoren von reverser Trans-Kriptase von HIV | |
| SK280000B6 (sk) | Enantiomérne 4-amino-2-cyklopentén-1-metanoly | |
| CZ247092A3 (cs) | Cyklopentenové deriváty | |
| WO2009061374A2 (en) | Deuterated fingolimod | |
| JP4225585B2 (ja) | オキサゾロキノリノン誘導体ならびにその製造法および医薬への応用 | |
| JPH0649076A (ja) | 置換フエニルキナゾリン誘導体 | |
| US4080450A (en) | 2-Carbamoyl-1,2,4,5-tetrahydro-3H-2-benzazepin-3-ones | |
| JPS6157559A (ja) | ベンズアゼピン誘導体 |