HRP960029B1 - Improved synthesis of cyclopropylacetylene - Google Patents

Improved synthesis of cyclopropylacetylene

Info

Publication number
HRP960029B1
HRP960029B1 HR960029A HRP960029A HRP960029B1 HR P960029 B1 HRP960029 B1 HR P960029B1 HR 960029 A HR960029 A HR 960029A HR P960029 A HRP960029 A HR P960029A HR P960029 B1 HRP960029 B1 HR P960029B1
Authority
HR
Croatia
Prior art keywords
cyclopropylacetylene
improved synthesis
synthesis
improved
Prior art date
Application number
HR960029A
Other languages
English (en)
Inventor
S Thompson Andrew
G Corley Edward
Huntington Martha
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of HRP960029A2 publication Critical patent/HRP960029A2/hr
Publication of HRP960029B1 publication Critical patent/HRP960029B1/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C13/00Cyclic hydrocarbons containing rings other than, or in addition to, six-membered aromatic rings
    • C07C13/02Monocyclic hydrocarbons or acyclic hydrocarbon derivatives thereof
    • C07C13/04Monocyclic hydrocarbons or acyclic hydrocarbon derivatives thereof with a three-membered ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C1/00Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon
    • C07C1/26Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon starting from organic compounds containing only halogen atoms as hetero-atoms
    • C07C1/30Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon starting from organic compounds containing only halogen atoms as hetero-atoms by splitting-off the elements of hydrogen halide from a single molecule
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D265/00Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/041,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/121,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/141,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/181,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 2
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/02Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HR960029A 1995-01-23 1996-01-22 Improved synthesis of cyclopropylacetylene HRP960029B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/376,611 US5663467A (en) 1995-01-23 1995-01-23 Synthesis of cyclopropylacetylene

Publications (2)

Publication Number Publication Date
HRP960029A2 HRP960029A2 (en) 1997-08-31
HRP960029B1 true HRP960029B1 (en) 2000-12-31

Family

ID=23485719

Family Applications (1)

Application Number Title Priority Date Filing Date
HR960029A HRP960029B1 (en) 1995-01-23 1996-01-22 Improved synthesis of cyclopropylacetylene

Country Status (23)

Country Link
US (1) US5663467A (de)
EP (1) EP0805790B1 (de)
JP (1) JP3107829B2 (de)
KR (1) KR19980701577A (de)
CN (1) CN1056824C (de)
AR (1) AR000771A1 (de)
AT (1) ATE186903T1 (de)
AU (1) AU692674B2 (de)
BR (1) BR9606782A (de)
CA (1) CA2210577A1 (de)
CZ (1) CZ234997A3 (de)
DE (1) DE69605282T2 (de)
DK (1) DK0805790T3 (de)
EA (1) EA000074B1 (de)
ES (1) ES2140062T3 (de)
FI (1) FI973086A (de)
GR (1) GR3032200T3 (de)
HR (1) HRP960029B1 (de)
HU (1) HUP9800849A3 (de)
NZ (1) NZ301206A (de)
SK (1) SK99997A3 (de)
WO (1) WO1996022955A1 (de)
YU (1) YU3696A (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3736197A (en) * 1996-07-26 1998-02-20 Du Pont Pharmaceuticals Company A practical synthesis of benzoxazinones useful as hiv reverse transcripta se inhibitors
US5955627A (en) * 1996-12-16 1999-09-21 Kuraray Co., Ltd. Process for the preparation of cyclopropylacetylene derivatives
US5932726A (en) * 1996-12-16 1999-08-03 Dupont Pharmaceuticals Company Asymmetric synthesis of benzoxazinones
US6028237A (en) * 1996-12-16 2000-02-22 Dupont Pharmaceuticals Company Synthesis of cyclopropylacetylene
ZA9711256B (en) 1996-12-16 1999-06-15 Du Pont Merck Pharma Asymmetric synthesis of benzoxazinones
US5965729A (en) 1997-02-05 1999-10-12 Merck & Co., Inc. Process for the crystallization of a reverse transcriptase inhibitor using an anti-solvent
CN1073991C (zh) * 1997-02-05 2001-10-31 麦克公司 使用抗溶剂的逆转录酶抑制剂结晶工艺
CA2283118A1 (en) 1997-03-07 1998-09-17 Basf Aktiengesellschaft Improved process for preparing cyclopropylacetylene
EA199900911A1 (ru) * 1997-04-07 2000-04-24 Дюпон Фармасьютикалз Компани Асимметрический синтез бензоксазинонов через новые промежуточные соединения
US6015926A (en) * 1997-05-16 2000-01-18 Merck & Co., Inc. Efficient enantioselective addition reaction using an organozinc reagent
EP1000001A1 (de) * 1997-07-31 2000-05-17 Dupont Pharmaceuticals Company Verfahren zur herstellung von cyclopropylacetylen
CA2298835A1 (en) * 1997-08-06 1999-02-18 Merck & Co., Inc. Efficient synthesis of cyclopropylacetylene
US6072094A (en) * 1997-08-06 2000-06-06 Merck & Co., Inc. Efficient synthesis of cyclopropylacetylene
PT922686E (pt) * 1997-12-10 2002-07-31 Lonza Ag Processo para a producao de etinilciclopropano
KR100350752B1 (ko) * 1998-02-06 2002-08-28 가부시키가이샤 구라레 시클로프로필아세틸렌 유도체의 제조방법
US5952537A (en) 1998-03-13 1999-09-14 Wiley Organics, Inc. Preparation of cycloalkylacetylene compounds using dialkylaminomagnesium halide or bis(dialkylamino)magnesium
UA72207C2 (uk) * 1998-04-07 2005-02-15 Брістол- Майєрс Сквібб Фарма Компані Фармацевтична композиція ефавіренцу з добавкою дезінтегруючих агентів у вигляді швидкорозчинних капсул або таблеток та спосіб її виготовлення
US20010014352A1 (en) 1998-05-27 2001-08-16 Udit Batra Compressed tablet formulation
US6235957B1 (en) 1998-06-29 2001-05-22 Dupont Pharmaceuticals Company Process for the preparation of cyclopropylacetylene
US6288297B1 (en) 1998-10-01 2001-09-11 Dupont Pharmaceuticals Company Process for the preparation of cyclopropylacetylene
AU6281199A (en) 1998-10-01 2000-04-17 Du Pont Pharmaceuticals Company Process for the preparation of cyclopropylacetylene
GB2355988A (en) 1999-10-28 2001-05-09 Merck & Co Inc Synthesis of cyclopropylacetylene in a one-pot process using a diazo-keto-phos phonate
GB2355724A (en) * 1999-10-28 2001-05-02 Merck & Co Inc Synthesis of cyclopropylacetylene from propiolic acid (2-propynoic acid)
US8080655B2 (en) * 2009-07-20 2011-12-20 Apotex Pharmachem Inc. Methods of making efavirenz and intermediates thereof
EP2471783A1 (de) 2010-12-23 2012-07-04 Esteve Química, S.A. Neuartige polymorphe Form von Efavirenz
CN103254087B (zh) * 2013-06-07 2015-03-18 郑州大学 依非韦伦中间体的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU578293A1 (ru) * 1972-02-04 1977-10-30 Институт Органической Химии Имени Н.Д.Зелинского Ан Ссср Способ получени циклопропилацетилена
SU555079A1 (ru) * 1976-01-30 1977-04-25 Институт органической химии им.Н.Д.Зелинского АН СССР Способ получени циклопропилацетилена
SU572445A1 (ru) * 1976-04-05 1977-09-15 Институт Органической Химии Имени Н.Д. Зелинского Ан Ссср Способ получени циклопропилацетилена

Also Published As

Publication number Publication date
KR19980701577A (ko) 1998-05-15
SK99997A3 (en) 1998-05-06
FI973086A0 (fi) 1997-07-22
GR3032200T3 (en) 2000-04-27
CN1169137A (zh) 1997-12-31
BR9606782A (pt) 1997-12-30
WO1996022955A1 (en) 1996-08-01
DK0805790T3 (da) 2000-05-01
AU4657496A (en) 1996-08-14
US5663467A (en) 1997-09-02
DE69605282T2 (de) 2000-07-13
CA2210577A1 (en) 1996-08-01
DE69605282D1 (en) 1999-12-30
FI973086A (fi) 1997-07-22
JPH10512880A (ja) 1998-12-08
NZ301206A (en) 1998-11-25
EA000074B1 (ru) 1998-06-25
CZ234997A3 (cs) 1998-02-18
MX9705562A (es) 1997-10-31
YU3696A (sh) 1998-11-05
AR000771A1 (es) 1997-08-06
ATE186903T1 (de) 1999-12-15
EP0805790B1 (de) 1999-11-24
CN1056824C (zh) 2000-09-27
EP0805790A1 (de) 1997-11-12
JP3107829B2 (ja) 2000-11-13
EA199700139A1 (ru) 1997-12-30
AU692674B2 (en) 1998-06-11
ES2140062T3 (es) 2000-02-16
HUP9800849A2 (hu) 1999-01-28
HRP960029A2 (en) 1997-08-31
HUP9800849A3 (en) 2001-01-29

Similar Documents

Publication Publication Date Title
GR3032200T3 (en) Improved synthesis of cyclopropylacetylene
AU2657095A (en) Synthesis of oligonucleotides
IL143517A0 (en) Novel synthesis
GB9526560D0 (en) Use of 2-Amino-Heterocycles
GB9512290D0 (en) Uses of polyhexanide
AU5381696A (en) Synthesis of bis-indolylmaleimides
AU5521498A (en) An improved synthesis of cyclopropylacetylene
IL116924A0 (en) Preparation of n-aryl- and n-hetarylhydroxylamines
IL126272A0 (en) Synthesis of indolylmaleimides
IL128376A0 (en) Synthesis of bisindolylmalimides
ZA96725B (en) Use of phenyclyclohexylcarboxamides
EP0827506A4 (de) Synthese von glycopolymeren
AU3948395A (en) Synthesis of 6-azaandrostenones
GB2301636B (en) Manufacture of gaskets
EP0781750A3 (de) Asymmetrische Synthese von alpha-cycloalkylalkyl substituierten Methanaminen
AU7267298A (en) Synthesis of discodermolide and analogs
IL118238A0 (en) Synthesis of benzoquinolinones
IL117786A (en) Preparation of alpha-bisoximes
HU9602277D0 (en) Synthesis of silyl cyanohydrins
EP0923519A4 (de) Herstellung von haloalkynolen
EP1001919A4 (de) Effiziente synthese von cyclopropylacetylen
IL122213A0 (en) Synthesis of deoxypyridinoline
ZA963356B (en) Novel uses of heptafluoropropane
GB9505135D0 (en) Synthesis of pheromone
GB9512361D0 (en) Manufacture of gaskets

Legal Events

Date Code Title Description
A1OB Publication of a patent application
AIPI Request for the grant of a patent on the basis of a substantive examination of a patent application
B1PR Patent granted
ODRP Renewal fee for the maintenance of a patent

Payment date: 20010122

Year of fee payment: 6

PBON Lapse due to non-payment of renewal fee

Effective date: 20020123