SK982003A3 - Enhancement of antibody-cytokine fusion protein mediated immune responses by combined treatment with immunocytokine uptake enhancing agents - Google Patents
Enhancement of antibody-cytokine fusion protein mediated immune responses by combined treatment with immunocytokine uptake enhancing agents Download PDFInfo
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- SK982003A3 SK982003A3 SK98-2003A SK982003A SK982003A3 SK 982003 A3 SK982003 A3 SK 982003A3 SK 982003 A SK982003 A SK 982003A SK 982003 A3 SK982003 A3 SK 982003A3
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
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| US21503800P | 2000-06-29 | 2000-06-29 | |
| PCT/US2001/020958 WO2002002143A2 (fr) | 2000-06-29 | 2001-06-29 | Renforcement des reponses immunitaires dont la mediation est assuree par une proteine de fusion anticorp-cytokine via le traitement combine a base d'agents ameliorant la fixation des immunocytokines |
Publications (1)
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| SK982003A3 true SK982003A3 (en) | 2004-05-04 |
Family
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Family Applications (1)
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| SK98-2003A SK982003A3 (en) | 2000-06-29 | 2001-06-29 | Enhancement of antibody-cytokine fusion protein mediated immune responses by combined treatment with immunocytokine uptake enhancing agents |
Country Status (22)
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| US (2) | US7517526B2 (fr) |
| EP (1) | EP1294401B1 (fr) |
| JP (1) | JP5390055B2 (fr) |
| KR (1) | KR20030064275A (fr) |
| CN (1) | CN1270775C (fr) |
| AT (1) | ATE368475T1 (fr) |
| AU (2) | AU2001271729B2 (fr) |
| BR (1) | BR0112111A (fr) |
| CA (1) | CA2412845C (fr) |
| CZ (1) | CZ2003214A3 (fr) |
| DE (1) | DE60129695T2 (fr) |
| DK (1) | DK1294401T3 (fr) |
| ES (1) | ES2288967T3 (fr) |
| HU (1) | HUP0300868A3 (fr) |
| MX (1) | MXPA02012734A (fr) |
| NO (1) | NO20026245L (fr) |
| PL (1) | PL358582A1 (fr) |
| PT (1) | PT1294401E (fr) |
| RU (1) | RU2272644C2 (fr) |
| SK (1) | SK982003A3 (fr) |
| WO (1) | WO2002002143A2 (fr) |
| ZA (1) | ZA200300759B (fr) |
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| ES2221717T3 (es) | 1997-12-08 | 2005-01-01 | Emd Lexigen Research Center Corp. | Proteinas de fusion heterodimeras utiles para inmunoterapia dirigida e inmunoestimulacion general. |
| US20030105294A1 (en) * | 1998-02-25 | 2003-06-05 | Stephen Gillies | Enhancing the circulating half life of antibody-based fusion proteins |
| JP2002511432A (ja) * | 1998-04-15 | 2002-04-16 | レキシジェン ファーマシューティカルズ コーポレイション | 新脈管形成インヒビターの同時投与による抗体−サイトカイン融合タンパク質媒介性免疫応答の増強 |
| CA2372400C (fr) * | 1999-05-19 | 2010-04-27 | Lexigen Pharmaceuticals Corp. | Expression et exportation de proteines interferon alpha en tant que proteines de fusion |
| SK782002A3 (en) | 1999-07-21 | 2003-08-05 | Lexigen Pharm Corp | FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
| US7067110B1 (en) | 1999-07-21 | 2006-06-27 | Emd Lexigen Research Center Corp. | Fc fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
| KR100827757B1 (ko) * | 1999-08-09 | 2008-05-07 | 메르크 파텐트 게엠베하 | 복수의 시토킨-항체 복합체 |
| US20050202538A1 (en) * | 1999-11-12 | 2005-09-15 | Merck Patent Gmbh | Fc-erythropoietin fusion protein with improved pharmacokinetics |
| ATE336514T1 (de) | 2000-02-11 | 2006-09-15 | Merck Patent Gmbh | Steigerung der zirkulierenden halbwertzeit von auf antikörpern basierenden fusionsproteinen |
| RU2272644C2 (ru) * | 2000-06-29 | 2006-03-27 | Мерк Патент Гмбх | Усиление иммунной реакции, медиатором которой является слитый протеин антитело-цитокин, при помощи комбинированного лечения агентами, увеличивающими поглощение иммуноцитокина |
| EP1366067B1 (fr) * | 2001-03-07 | 2012-09-26 | Merck Patent GmbH | Technique d'expression pour des proteines contenant un fragment d'anticorps isotype chimerique |
| WO2002079415A2 (fr) * | 2001-03-30 | 2002-10-10 | Lexigen Pharmaceuticals Corp. | Reduction de l'immunogenicite de proteines de fusion |
| AU2002308562B2 (en) * | 2001-05-03 | 2008-01-24 | Merck Patent Gmbh | Recombinant tumor specific antibody and use thereof |
| US20030190705A1 (en) | 2001-10-29 | 2003-10-09 | Sunol Molecular Corporation | Method of humanizing immune system molecules |
| EP1454138B1 (fr) * | 2001-12-04 | 2012-01-18 | Merck Patent GmbH | Immunocytokines a selectivite modulee |
| PL211180B1 (pl) * | 2002-12-17 | 2012-04-30 | Merck Patent Gmbh | Białko fuzyjne typu przeciwciało-IL2, wektor zawierający sekwencję kwasów nukleinowych kodujących takie białko, kompozycja farmaceutyczna zawierająca takie białko fuzyjne oraz jego zastosowania do wytwarzania leków |
| US20050069521A1 (en) * | 2003-08-28 | 2005-03-31 | Emd Lexigen Research Center Corp. | Enhancing the circulating half-life of interleukin-2 proteins |
| DE602004013372T2 (de) * | 2003-12-30 | 2009-07-02 | Merck Patent Gmbh | Il-7-fusionsproteine mit antikörperportionen, deren herstellung und deren verwendung |
| JP2008504008A (ja) * | 2003-12-31 | 2008-02-14 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | 改良された薬物動態を有するＦｃ−エリスロポエチン融合タンパク質 |
| EP1702069A2 (fr) | 2004-01-05 | 2006-09-20 | EMD Lexigen Research Center Corp. | Interleukine-12 ciblee sur la fibronectine oncofoetale |
| DE602005016773D1 (de) * | 2004-01-22 | 2009-11-05 | Merck Patent Gmbh | Antikrebs-antikörper mit reduzierter komplementfixierung |
| US7670595B2 (en) * | 2004-06-28 | 2010-03-02 | Merck Patent Gmbh | Fc-interferon-beta fusion proteins |
| KR20070085886A (ko) * | 2004-12-09 | 2007-08-27 | 메르크 파텐트 게엠베하 | 감소된 면역원성의 ｉｌ-7 변이체 |
| US20070104689A1 (en) * | 2005-09-27 | 2007-05-10 | Merck Patent Gmbh | Compositions and methods for treating tumors presenting survivin antigens |
| WO2007045465A1 (fr) | 2005-10-21 | 2007-04-26 | F. Hoffmann-La Roche Ag | Procede d'expression par recombinaison d'un polypeptide |
| JP2009519024A (ja) * | 2005-12-15 | 2009-05-14 | マイクロメット アクツィエン ゲゼルシャフト | ドメイン移植抗体 |
| WO2007076933A1 (fr) * | 2005-12-30 | 2007-07-12 | Merck Patent Gmbh | Variants de polypeptides p40 de l'interleukine 12 ayant une stabilité améliorée |
| EP2270050B1 (fr) | 2005-12-30 | 2013-06-05 | Merck Patent GmbH | Anticorps anti-CD19 avec une immunogénicité réduite |
| TW200817438A (en) * | 2006-08-17 | 2008-04-16 | Hoffmann La Roche | A conjugate of an antibody against CCR5 and an antifusogenic peptide |
| WO2008124086A2 (fr) * | 2007-04-05 | 2008-10-16 | President And Fellows Of Harvard College | Activateurs chimériques, thérapies protéiniques à conception quantitative et leurs utilisations |
| WO2009001219A2 (fr) * | 2007-06-28 | 2008-12-31 | Philogen S.P.A | Immunocytokines pour le traitement du cancer en combinaison avec des agents chimiothérapeutiques |
| AR067584A1 (es) | 2007-07-20 | 2009-10-14 | Hoffmann La Roche | Un conjugado de un anticuerpo contra la cd4 y peptidos antifusogenicos |
| EP2044949A1 (fr) * | 2007-10-05 | 2009-04-08 | Immutep | Utilisation de lag-3 recombinant ou ses dérivatifs pour déclencher la réponse immune des monocytes |
| JP2012506394A (ja) * | 2008-10-21 | 2012-03-15 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | 放射線および免疫サイトカインによる癌治療 |
| EA201171259A1 (ru) | 2009-04-22 | 2012-05-30 | Мерк Патент Гмбх | Антительные гибридные белки с модифицированными сайтами связывания fcrn |
| KR20120053042A (ko) * | 2009-08-17 | 2012-05-24 | 로슈 글리카트 아게 | 표적화된 면역접합체 |
| US20120244145A1 (en) * | 2009-11-16 | 2012-09-27 | Duke University | Enhanced immunological responses |
| EP3626739A1 (fr) | 2011-06-24 | 2020-03-25 | Stephen D. Gillies | Protéines de fusion d'immunoglobuline à chaîne légère et leurs procédés d'utilisation |
| GB201403775D0 (en) | 2014-03-04 | 2014-04-16 | Kymab Ltd | Antibodies, uses & methods |
| GB201419184D0 (en) | 2014-10-28 | 2014-12-10 | Adc Biotechnology Ltd | Method of synthesising biomolecule-effector/reporter-conjugates using affinity resins |
| US9567399B1 (en) | 2016-06-20 | 2017-02-14 | Kymab Limited | Antibodies and immunocytokines |
| EP3534947A1 (fr) | 2016-11-03 | 2019-09-11 | Kymab Limited | Anticorps, combinaisons comprenant des anticorps, biomarqueurs, utilisations et procédés |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| EP3675892A4 (fr) | 2017-07-03 | 2021-10-06 | Torque Therapeutics, Inc. | Molécules de fusion immunostimulatrices et leurs utilisations |
| JP2021506291A (ja) | 2017-12-19 | 2021-02-22 | ゼンコア インコーポレイテッド | 改変されたｉｌ−２ ｆｃ融合タンパク質 |
| SG11202103192RA (en) | 2018-10-03 | 2021-04-29 | Xencor Inc | Il-12 heterodimeric fc-fusion proteins |
| CN113811549A (zh) | 2019-02-21 | 2021-12-17 | Xencor股份有限公司 | 非靶向和靶向性il-10 fc融合蛋白 |
| EP3969119A1 (fr) | 2019-05-17 | 2022-03-23 | Xencor, Inc. | Protéines de fusion il-7-fc |
| CA3157024A1 (fr) | 2019-10-03 | 2021-04-08 | Xencor, Inc. | Proteines de fusion fc heterodimeres d'il-12 ciblees |
| CA3162406A1 (fr) | 2020-01-10 | 2021-07-15 | Vijaya Raghavan PATTABIRAMAN | Polypeptides il-2 modifies et leurs utilisations |
| EP4133085A1 (fr) | 2020-04-10 | 2023-02-15 | CytomX Therapeutics, Inc. | Constructions de cytokine activables et compositions et procédés associés |
| EP4308594A2 (fr) | 2021-03-16 | 2024-01-24 | CytomX Therapeutics, Inc. | Constructions de cytokines activables masquées et méthodes et compositions associées |
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| AU2022306145A1 (en) * | 2021-07-09 | 2024-02-01 | Bright Peak Therapeutics Ag | Antibody conjugates and manufacture thereof |
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Also Published As
| Publication number | Publication date |
|---|---|
| HUP0300868A3 (en) | 2005-11-28 |
| CZ2003214A3 (cs) | 2003-08-13 |
| WO2002002143A2 (fr) | 2002-01-10 |
| PT1294401E (pt) | 2007-11-09 |
| EP1294401B1 (fr) | 2007-08-01 |
| DE60129695D1 (de) | 2007-09-13 |
| MXPA02012734A (es) | 2003-04-25 |
| CN1529619A (zh) | 2004-09-15 |
| HUP0300868A2 (hu) | 2003-07-28 |
| DK1294401T3 (da) | 2007-10-08 |
| ZA200300759B (en) | 2004-04-28 |
| NO20026245L (no) | 2003-02-26 |
| EP1294401A2 (fr) | 2003-03-26 |
| CN1270775C (zh) | 2006-08-23 |
| JP5390055B2 (ja) | 2014-01-15 |
| AU7172901A (en) | 2002-01-14 |
| RU2272644C2 (ru) | 2006-03-27 |
| BR0112111A (pt) | 2003-05-06 |
| US20100297060A1 (en) | 2010-11-25 |
| DE60129695T2 (de) | 2008-06-05 |
| ATE368475T1 (de) | 2007-08-15 |
| JP2004501981A (ja) | 2004-01-22 |
| PL358582A1 (en) | 2004-08-09 |
| NO20026245D0 (no) | 2002-12-27 |
| US7517526B2 (en) | 2009-04-14 |
| KR20030064275A (ko) | 2003-07-31 |
| CA2412845C (fr) | 2014-07-22 |
| AU2001271729B2 (en) | 2007-01-04 |
| WO2002002143A3 (fr) | 2002-07-18 |
| ES2288967T3 (es) | 2008-02-01 |
| US20030049227A1 (en) | 2003-03-13 |
| CA2412845A1 (fr) | 2002-01-10 |
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