WO1998016246A1 - Immunotherapie amelioree par cytokine pour tumeurs cerebrales - Google Patents

Immunotherapie amelioree par cytokine pour tumeurs cerebrales Download PDF

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Publication number
WO1998016246A1
WO1998016246A1 PCT/US1997/018455 US9718455W WO9816246A1 WO 1998016246 A1 WO1998016246 A1 WO 1998016246A1 US 9718455 W US9718455 W US 9718455W WO 9816246 A1 WO9816246 A1 WO 9816246A1
Authority
WO
WIPO (PCT)
Prior art keywords
cytokine
cells
mmor
tumor
csf
Prior art date
Application number
PCT/US1997/018455
Other languages
English (en)
Other versions
WO1998016246A9 (fr
Inventor
Henry Brem
Drew M. Pardoll
Reid C. Thompson
Elizabeth M. Jaffee
Kam W. Leong
Matthew G. Ewend
Original Assignee
Johns Hopkins University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johns Hopkins University filed Critical Johns Hopkins University
Priority to EP97910921A priority Critical patent/EP0930892A1/fr
Priority to CA002267977A priority patent/CA2267977A1/fr
Priority to JP10518504A priority patent/JP2001502331A/ja
Priority to AU48182/97A priority patent/AU4818297A/en
Publication of WO1998016246A1 publication Critical patent/WO1998016246A1/fr
Publication of WO1998016246A9 publication Critical patent/WO1998016246A9/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0085—Brain, e.g. brain implants; Spinal cord
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Definitions

  • cytokines including IL-3 and IL-7 can be secreted from cells by applying the methods used for the cytokines described above or by the general procedures for genetically modifying nonimmunogenic murine fibrosarcoma described in Karp, S. E. , et al., /. Immunol. , 150:896-908 (1993) and Jaffee, E. et al., J. Immunotherapy, in press (1995).
  • the publications cited above describe methods of genetically engineering cells to secrete cytokines.
  • cancer vaccines expressing two or more cytokines from engineered vectors containing genes encoding two different cytokines or by sequential recombinant retrovirus-mediated genetic transductions can be prepared.
  • Example 4 Intracranial delivery of microencapsulated interleukin-2 produces long term memory and protects against re- challenges

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne une thérapie permettant de traiter des patients atteints de cancer en combinant l'administration par voie générale d'une cytokine et d'un véhicule pharmaceutiquement acceptable avec l'administration locale d'une cytokine et d'un véhicule pharmaceutiquement acceptable. Dans le mode de réalisation préféré, les tumeurs cérébrales sont traitées au moyen d'une cytokine telle que le GM-CSF administré par voie générale, de préférence en combinaison avec un antigène tumoral tel que des cellules tumorales incapables de se répliquer, et d'une cytokine telle que l'IL-2 ou l'IL-4 administrée localement, de préférence dans un véhicule assurant sa libération lente tel que des cellules transduites, et de préférence des cellules tumorales incapables de se répliquer, ou incorporée dans des véhicules microparticulaires tels que des microsphères polymères.
PCT/US1997/018455 1996-10-16 1997-10-15 Immunotherapie amelioree par cytokine pour tumeurs cerebrales WO1998016246A1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP97910921A EP0930892A1 (fr) 1996-10-16 1997-10-15 Immunotherapie amelioree par cytokine pour tumeurs cerebrales
CA002267977A CA2267977A1 (fr) 1996-10-16 1997-10-15 Immunotherapie amelioree par cytokine pour tumeurs cerebrales
JP10518504A JP2001502331A (ja) 1996-10-16 1997-10-15 脳腫瘍に対するサイトカインで増強した免疫療法
AU48182/97A AU4818297A (en) 1996-10-16 1997-10-15 Cytokine enhanced immunotherapy for brain tumors

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73159796A 1996-10-16 1996-10-16
US08/731,597 1996-10-16

Publications (2)

Publication Number Publication Date
WO1998016246A1 true WO1998016246A1 (fr) 1998-04-23
WO1998016246A9 WO1998016246A9 (fr) 1998-08-13

Family

ID=24940192

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/018455 WO1998016246A1 (fr) 1996-10-16 1997-10-15 Immunotherapie amelioree par cytokine pour tumeurs cerebrales

Country Status (5)

Country Link
EP (1) EP0930892A1 (fr)
JP (1) JP2001502331A (fr)
AU (1) AU4818297A (fr)
CA (1) CA2267977A1 (fr)
WO (1) WO1998016246A1 (fr)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1076564A1 (fr) * 1998-04-02 2001-02-21 The Regents of the University of California Procedes servant a augmenter le developpement de cellules presentant des antigenes et les reactions immunes antitumorales chez un patient humain
US6193970B1 (en) * 1993-12-14 2001-02-27 The Johns Hopkins University School Of Medicine Controlled release of pharmaceutically active substances for immunotherapy
WO2001047546A2 (fr) * 1999-12-28 2001-07-05 Brown University Research Foundation Methodes pour l'immunotherapie antitumorale utilisant des cytokines et produits correspondants
US6277368B1 (en) 1996-07-25 2001-08-21 The Regents Of The University Of California Cancer immunotherapy using autologous tumor cells combined with cells expressing a membrane cytokine
WO2003080111A2 (fr) * 2002-03-25 2003-10-02 Technologies Biolactis Inc. Agents chimiotherapeutiqes utilises en tant qu'adjuvants vaccinaux contre le cancer et procedes therapeutiques correspondants
JP2004501981A (ja) * 2000-06-29 2004-01-22 メルク　パテント　ゲゼルシャフト　ミット　ベシュレンクテル　ハフトング 免疫サイトカインの取り込み増強剤との併用治療による抗体−サイトカイン融合タンパク質媒介免疫応答の増強
US6911204B2 (en) 2000-08-11 2005-06-28 Favrille, Inc. Method and composition for altering a B cell mediated pathology
WO2006008582A1 (fr) * 2004-06-30 2006-01-26 Sygnis Bioscience Gmbh / Co. Kg Traitement de troubles neurologiques avec des facteurs de croissance hematopoietiques
US9814682B2 (en) 2002-06-17 2017-11-14 Maxivax Sa Vaccination with immuno-isolated cells producing an immunomodulator
US9861689B2 (en) 2015-09-25 2018-01-09 Maxivax Sa Vaccination with immuno-isolated cells producing an immunomodulator

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3806888B1 (fr) 2018-06-12 2024-01-31 Obsidian Therapeutics, Inc. Constructions régulatrices dérivées de pde5 et procédés d'utilisation en immunothérapie
US20220056092A1 (en) 2018-12-11 2022-02-24 Obsidian Therapeutics, Inc. Membrane bound il12 compositions and methods for tunable regulation
KR20210149251A (ko) 2019-03-08 2021-12-08 옵시디안 테라퓨틱스, 인크. 조율가능한 조절을 위한 인간 탄산 무수화효소 2 조성물 및 방법
BR112021025022A2 (pt) 2019-06-12 2022-02-22 Obsidian Therapeutics Inc Composições de ca2 e métodos para regulação ajustáveis
US20220267398A1 (en) 2019-06-12 2022-08-25 Obsidian Therapeutics, Inc. Ca2 compositions and methods for tunable regulation
WO2021040736A1 (fr) 2019-08-30 2021-03-04 Obsidian Therapeutics, Inc. Compositions à base de car cd19 tandem et méthodes d'immunothérapie
CN114651003A (zh) 2019-09-10 2022-06-21 黑曜石疗法公司 用于可调调节的ca2-il15融合蛋白

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
BELLDEGRUN ET AL: "HUMAN RENAL CARCINOMA LINE TRANSFECTED WITH INTERLEUKIN-2 AND/OR INTERFERON ALPHA GENE(S): IMPLICATIONS FOR LIVE CANCER VACCINES", JOURNAL OF THE NATIONAL CANCER INSTITUTE, vol. 85, 1993, pages 207 - 216, XP002057839 *
DRANOFF ET AL: "VACCINATION WITH IRRADIATED TUMOR CELLS ENGINEERED TO SECRETE MURINE GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR STIMULATES POTENT, SPECIFIC, AND LONG-LASTING ANTI-TUMOR IMMUNITY", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES,USA, vol. 90, 1993, pages 3539 - 3543, XP002057840 *
GOLUMBEK ET AL: "CONTROLLED RELEASE, BIODEGRADABLE CYTOKINE DEPOTS: A NEW APPROACH IN CANCER VACCINE DESIGN", CANCER RESEARCH, vol. 53, 1993, pages 5841 - 5844, XP002057841 *
HOLLINGSWORTH ET AL: "THE EFFECT OF COMBINED EXPRESSSION OF INTERLEUKIN 2 AND INTERLEUKIN 4 ON THE TUMORIGENICITY AND TREATMENT OF B16F10 MELANOMA", BRITISH JOURNAL OF CANCER, vol. 74, July 1996 (1996-07-01), pages 6 - 15, XP002057838 *
PAPPO ET AL: "ADMINISTRATION OF SYSTEMIC OR LOCAL INTERLEUKIN-2 ENHANCES THE ANTI-TUMOR EFFECTS OF INTERLEUKIN-12 GENE THERAPY", JOURNAL OF SURGICAL RESEARCH, vol. 58, 1995, pages 218 - 226, XP002057836 *
PIPPIN ET AL: "LOCAL IL-4 DELIVERY ENHANCES IMMUNE REACTIVITY TO MURINE TUMORS: GENE THERAPY IN COMBINATION WITH IL2", CANCER GENE THERAPY, vol. 1, no. 1, 1994, pages 35 - 42, XP002057835 *
THOMPSON ET AL: "SYSTEMIC AND LOCAL PARACRINE CYTOKINE THERAPIES USING TRANSDUCED TUMOR CELLS ARE SYNERGISTIC IN TREATING INTRACRANIAL TUMORS", JOURNAL OF IMMUNOTHERAPY, vol. 19, no. 6, November 1996 (1996-11-01), pages 405 - 413, XP002057842 *
VAGLIANI ET AL: "INTERLEUKIN 12 POTENTIATES THE CURATIVE EFFECT OF A VACCINE BASED ON INTERLEUKIN 2-TRANSDUCED TUMOR CELLS", CANCER RESEARCH, vol. 56, 1 February 1996 (1996-02-01), pages 467 - 470, XP002057837 *

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6193970B1 (en) * 1993-12-14 2001-02-27 The Johns Hopkins University School Of Medicine Controlled release of pharmaceutically active substances for immunotherapy
US7264820B2 (en) 1996-07-25 2007-09-04 The Regents Of The University Of California Cancer immunotherapy using autologous tumor cells combined with cells expressing a membrane cytokline
US7364726B2 (en) 1996-07-25 2008-04-29 The Regents Of The University Of California Pharmaceutical composition for cancer treatment containing cells that express a membrane cytokine
US6277368B1 (en) 1996-07-25 2001-08-21 The Regents Of The University Of California Cancer immunotherapy using autologous tumor cells combined with cells expressing a membrane cytokine
EP1076564A4 (fr) * 1998-04-02 2005-02-23 Univ California Procedes servant a augmenter le developpement de cellules presentant des antigenes et les reactions immunes antitumorales chez un patient humain
EP1076564A1 (fr) * 1998-04-02 2001-02-21 The Regents of the University of California Procedes servant a augmenter le developpement de cellules presentant des antigenes et les reactions immunes antitumorales chez un patient humain
WO2001047546A3 (fr) * 1999-12-28 2001-12-06 Univ Brown Res Found Methodes pour l'immunotherapie antitumorale utilisant des cytokines et produits correspondants
WO2001047546A2 (fr) * 1999-12-28 2001-07-05 Brown University Research Foundation Methodes pour l'immunotherapie antitumorale utilisant des cytokines et produits correspondants
JP2004501981A (ja) * 2000-06-29 2004-01-22 メルク　パテント　ゲゼルシャフト　ミット　ベシュレンクテル　ハフトング 免疫サイトカインの取り込み増強剤との併用治療による抗体−サイトカイン融合タンパク質媒介免疫応答の増強
US6911204B2 (en) 2000-08-11 2005-06-28 Favrille, Inc. Method and composition for altering a B cell mediated pathology
US8114404B2 (en) 2000-08-11 2012-02-14 Mmrglobal, Inc. Method and composition for altering a B cell mediated pathology
US8133486B2 (en) 2000-08-11 2012-03-13 Mmrglobal, Inc. Method and composition for altering a B cell mediated pathology
US8637638B2 (en) 2000-08-11 2014-01-28 Mmrglobal, Inc. Method and composition for altering a B cell mediated pathology
WO2003080111A3 (fr) * 2002-03-25 2003-11-13 Technologies Biolactis Inc Agents chimiotherapeutiqes utilises en tant qu'adjuvants vaccinaux contre le cancer et procedes therapeutiques correspondants
WO2003080111A2 (fr) * 2002-03-25 2003-10-02 Technologies Biolactis Inc. Agents chimiotherapeutiqes utilises en tant qu'adjuvants vaccinaux contre le cancer et procedes therapeutiques correspondants
US9814682B2 (en) 2002-06-17 2017-11-14 Maxivax Sa Vaccination with immuno-isolated cells producing an immunomodulator
WO2006008582A1 (fr) * 2004-06-30 2006-01-26 Sygnis Bioscience Gmbh / Co. Kg Traitement de troubles neurologiques avec des facteurs de croissance hematopoietiques
US9861689B2 (en) 2015-09-25 2018-01-09 Maxivax Sa Vaccination with immuno-isolated cells producing an immunomodulator
US11013790B2 (en) 2015-09-25 2021-05-25 Maxivax Sa Vaccination with immuno-isolated cells producing an immunomodulator

Also Published As

Publication number Publication date
JP2001502331A (ja) 2001-02-20
AU4818297A (en) 1998-05-11
CA2267977A1 (fr) 1998-04-23
EP0930892A1 (fr) 1999-07-28

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