CA2267977A1 - Immunotherapie amelioree par cytokine pour tumeurs cerebrales - Google Patents
Immunotherapie amelioree par cytokine pour tumeurs cerebrales Download PDFInfo
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- CA2267977A1 CA2267977A1 CA002267977A CA2267977A CA2267977A1 CA 2267977 A1 CA2267977 A1 CA 2267977A1 CA 002267977 A CA002267977 A CA 002267977A CA 2267977 A CA2267977 A CA 2267977A CA 2267977 A1 CA2267977 A1 CA 2267977A1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0085—Brain, e.g. brain implants; Spinal cord
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychology (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
La présente invention concerne une thérapie permettant de traiter des patients atteints de cancer en combinant l'administration par voie générale d'une cytokine et d'un véhicule pharmaceutiquement acceptable avec l'administration locale d'une cytokine et d'un véhicule pharmaceutiquement acceptable. Dans le mode de réalisation préféré, les tumeurs cérébrales sont traitées au moyen d'une cytokine telle que le GM-CSF administré par voie générale, de préférence en combinaison avec un antigène tumoral tel que des cellules tumorales incapables de se répliquer, et d'une cytokine telle que l'IL-2 ou l'IL-4 administrée localement, de préférence dans un véhicule assurant sa libération lente tel que des cellules transduites, et de préférence des cellules tumorales incapables de se répliquer, ou incorporée dans des véhicules microparticulaires tels que des microsphères polymères.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73159796A | 1996-10-16 | 1996-10-16 | |
| US08/731597 | 1996-10-16 | ||
| PCT/US1997/018455 WO1998016246A1 (fr) | 1996-10-16 | 1997-10-15 | Immunotherapie amelioree par cytokine pour tumeurs cerebrales |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2267977A1 true CA2267977A1 (fr) | 1998-04-23 |
Family
ID=24940192
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002267977A Abandoned CA2267977A1 (fr) | 1996-10-16 | 1997-10-15 | Immunotherapie amelioree par cytokine pour tumeurs cerebrales |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0930892A1 (fr) |
| JP (1) | JP2001502331A (fr) |
| AU (1) | AU4818297A (fr) |
| CA (1) | CA2267977A1 (fr) |
| WO (1) | WO1998016246A1 (fr) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH09506866A (ja) * | 1993-12-14 | 1997-07-08 | ジョーンズ ホプキンス ユニバーシティー スクール オブ メディシン | 医薬として活性のある物質の免疫療法のための放出制御 |
| US6277368B1 (en) | 1996-07-25 | 2001-08-21 | The Regents Of The University Of California | Cancer immunotherapy using autologous tumor cells combined with cells expressing a membrane cytokine |
| DE69939821D1 (de) * | 1998-04-02 | 2008-12-11 | Univ California | Zusammensetzungen zur erhöhung der zahl antigen präsentierender zellen und der antitumoralen antwort in menschlichen patienten |
| AU2457701A (en) * | 1999-12-28 | 2001-07-09 | Brown University Research Foundation | Methods and products for tumor immunotherapy using cytokines |
| RU2272644C2 (ru) * | 2000-06-29 | 2006-03-27 | Мерк Патент Гмбх | Усиление иммунной реакции, медиатором которой является слитый протеин антитело-цитокин, при помощи комбинированного лечения агентами, увеличивающими поглощение иммуноцитокина |
| US6911204B2 (en) | 2000-08-11 | 2005-06-28 | Favrille, Inc. | Method and composition for altering a B cell mediated pathology |
| CA2479528A1 (fr) * | 2002-03-25 | 2003-10-02 | Technologies Biolactis Inc. | Agents chimiotherapeutiqes utilises en tant qu'adjuvants vaccinaux contre le cancer et procedes therapeutiques correspondants |
| EP1374893A1 (fr) | 2002-06-17 | 2004-01-02 | NovImmune S.A. | Vaccination au moyen de cellules immuno-isolées produisant un immunomodulateur |
| US7695723B2 (en) * | 2002-12-31 | 2010-04-13 | Sygnis Bioscience Gmbh & Co. Kg | Methods of treating neurological conditions with hematopoietic growth factors |
| WO2017064571A1 (fr) | 2015-09-25 | 2017-04-20 | Maxivax Sa | Vaccination avec des cellules immuno-isolées produisant un immunomodulateur |
| US20220403001A1 (en) | 2018-06-12 | 2022-12-22 | Obsidian Therapeutics, Inc. | Pde5 derived regulatory constructs and methods of use in immunotherapy |
| WO2020123716A1 (fr) | 2018-12-11 | 2020-06-18 | Obsidian Therapeutics, Inc. | Il12 liée à la membrane, compositions et procédés de régulation accordable |
| EP3935159A1 (fr) | 2019-03-08 | 2022-01-12 | Obsidian Therapeutics, Inc. | Compositions d'anhydrase carbonique humaine 2 et procédés de régulation accordable |
| US20220267398A1 (en) | 2019-06-12 | 2022-08-25 | Obsidian Therapeutics, Inc. | Ca2 compositions and methods for tunable regulation |
| US20220259284A1 (en) | 2019-06-12 | 2022-08-18 | Obsidian Therapeutics, Inc. | Ca2 compositions and methods for tunable regulation |
| WO2021040736A1 (fr) | 2019-08-30 | 2021-03-04 | Obsidian Therapeutics, Inc. | Compositions à base de car cd19 tandem et méthodes d'immunothérapie |
| US20220332780A1 (en) | 2019-09-10 | 2022-10-20 | Obsidian Therapeutics, Inc. | Ca2-il15 fusion proteins for tunable regulation |
-
1997
- 1997-10-15 WO PCT/US1997/018455 patent/WO1998016246A1/fr not_active Application Discontinuation
- 1997-10-15 EP EP97910921A patent/EP0930892A1/fr not_active Ceased
- 1997-10-15 AU AU48182/97A patent/AU4818297A/en not_active Abandoned
- 1997-10-15 CA CA002267977A patent/CA2267977A1/fr not_active Abandoned
- 1997-10-15 JP JP10518504A patent/JP2001502331A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU4818297A (en) | 1998-05-11 |
| JP2001502331A (ja) | 2001-02-20 |
| EP0930892A1 (fr) | 1999-07-28 |
| WO1998016246A1 (fr) | 1998-04-23 |
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