SK85997A3 - Method, compositions and kits for increasing the oral bioavailability of pharmaceutical agents - Google Patents
Method, compositions and kits for increasing the oral bioavailability of pharmaceutical agents Download PDFInfo
- Publication number
- SK85997A3 SK85997A3 SK859-97A SK85997A SK85997A3 SK 85997 A3 SK85997 A3 SK 85997A3 SK 85997 A SK85997 A SK 85997A SK 85997 A3 SK85997 A3 SK 85997A3
- Authority
- SK
- Slovakia
- Prior art keywords
- paclitaxel
- cyclosporin
- agent
- oral
- group
- Prior art date
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- 230000001965 increasing effect Effects 0.000 title claims abstract description 30
- 238000000034 method Methods 0.000 title abstract description 43
- 239000000203 mixture Substances 0.000 title description 19
- 239000008177 pharmaceutical agent Substances 0.000 title description 3
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- 239000003795 chemical substances by application Substances 0.000 claims abstract description 176
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- ZNVBEWJRWHNZMK-SYOLRUPNSA-N (3s,6s,9s,12r,15s,18s,21s,24s,30s,33s)-33-[(e,1r,2r)-1-hydroxy-2-methylhex-4-enyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21,30-tri(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17,20,2 Chemical compound C\C=C\C[C@@H](C)[C@@H](O)[C@@H]1N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C(=O)[C@H](C(C)C)NC1=O ZNVBEWJRWHNZMK-SYOLRUPNSA-N 0.000 claims abstract description 12
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- DNXIKVLOVZVMQF-UHFFFAOYSA-N (3beta,16beta,17alpha,18beta,20alpha)-17-hydroxy-11-methoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]-yohimban-16-carboxylic acid, methyl ester Natural products C1C2CN3CCC(C4=CC=C(OC)C=C4N4)=C4C3CC2C(C(=O)OC)C(O)C1OC(=O)C1=CC(OC)=C(OC)C(OC)=C1 DNXIKVLOVZVMQF-UHFFFAOYSA-N 0.000 claims description 8
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US707195P | 1995-10-26 | 1995-10-26 | |
| US08/608,776 US5968972A (en) | 1995-10-26 | 1996-02-29 | Method for increasing the oral bioactivity of pharmaceutical agents |
| US08/733,142 US6245805B1 (en) | 1995-10-26 | 1996-10-16 | Method, compositions and kits for increasing the oral bioavailability of pharmaceutical agents |
| PCT/IB1996/001485 WO1997015269A2 (en) | 1995-10-26 | 1996-10-24 | Method, compositions and kits for increasing the oral bioavailability of pharmaceutical agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK85997A3 true SK85997A3 (en) | 1998-06-03 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK859-97A SK85997A3 (en) | 1995-10-26 | 1996-10-24 | Method, compositions and kits for increasing the oral bioavailability of pharmaceutical agents |
Country Status (22)
| Country | Link |
|---|---|
| US (6) | US6245805B1 (de) |
| EP (1) | EP0794794B1 (de) |
| JP (1) | JP3361102B2 (de) |
| CN (2) | CN1119146C (de) |
| AT (1) | ATE311903T1 (de) |
| AU (1) | AU698142B2 (de) |
| BR (1) | BR9607066A (de) |
| CA (1) | CA2205534A1 (de) |
| CZ (1) | CZ202897A3 (de) |
| DE (2) | DE794794T1 (de) |
| DK (1) | DK0794794T3 (de) |
| ES (1) | ES2109899T3 (de) |
| HK (1) | HK1001960A1 (de) |
| HU (1) | HUP9900457A3 (de) |
| IL (1) | IL121160A0 (de) |
| MX (1) | MX9704629A (de) |
| NO (1) | NO321091B1 (de) |
| NZ (1) | NZ324801A (de) |
| PL (2) | PL192544B1 (de) |
| RU (1) | RU2217135C2 (de) |
| SK (1) | SK85997A3 (de) |
| WO (1) | WO1997015269A2 (de) |
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| US5439686A (en) * | 1993-02-22 | 1995-08-08 | Vivorx Pharmaceuticals, Inc. | Methods for in vivo delivery of substantially water insoluble pharmacologically active agents and compositions useful therefor |
| US6395770B1 (en) * | 1995-10-26 | 2002-05-28 | Baker Norton Pharmaceuticals, Inc. | Method and compositions for administering taxanes orally to human patients |
| US6245805B1 (en) * | 1995-10-26 | 2001-06-12 | Baker Norton Pharmaceuticals, Inc. | Method, compositions and kits for increasing the oral bioavailability of pharmaceutical agents |
| US6964946B1 (en) * | 1995-10-26 | 2005-11-15 | Baker Norton Pharmaceuticals, Inc. | Oral pharmaceutical compositions containing taxanes and methods of treatment employing the same |
| BR9809694A (pt) * | 1997-05-27 | 2000-10-03 | Baker Norton Pharma | Processo e composição para administração de taxanos oralmente a pacientes humanos |
| US8853260B2 (en) | 1997-06-27 | 2014-10-07 | Abraxis Bioscience, Llc | Formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof |
| GB9718903D0 (en) | 1997-09-05 | 1997-11-12 | Glaxo Group Ltd | Method,compositions and kits for increasing the oral bioavailability of pharmaceutical agents |
| US6495591B1 (en) | 1997-10-02 | 2002-12-17 | Essential Therapeutics, Inc. | Fungal efflux pump inhibitors |
| EP1091745B1 (de) * | 1998-06-29 | 2008-10-01 | Children's Hospital Of Los Angeles | Behandlung hyperproliferativer erkrankungen |
| EP1749540B1 (de) | 1999-05-17 | 2010-10-13 | Cancer Research Ventures Limited | Zubereitungen zur Erhöhung der Bioverfügbarkeit von oral verabreichten pharmazeutischen Verbindungen |
| EP1479382A1 (de) * | 1999-06-18 | 2004-11-24 | IVAX Research, Inc. | Taxane enthaltende orale Pharmazeutische Zusammensetzungen sowie Behandlungsverfahren unter deren Verwendung |
| GB9920548D0 (en) * | 1999-08-31 | 1999-11-03 | Rhone Poulenc Rorer Sa | Treatment of hepatocellular carcinoma |
| US20020147197A1 (en) * | 1999-10-08 | 2002-10-10 | Newman Michael J. | Methods and compositions for enhancing pharmaceutical treatments |
| IL149360A0 (en) * | 1999-10-27 | 2002-11-10 | Baker Norton Pharma | Method and compositions for administering taxanes orally to human patients |
| US6638973B2 (en) * | 2000-02-02 | 2003-10-28 | Fsu Research Foundation, Inc. | Taxane formulations |
| US6750246B1 (en) | 2000-02-03 | 2004-06-15 | Bristol-Myers Squibb Company | C-4 carbonate taxanes |
| AU2001236009A1 (en) * | 2000-03-02 | 2001-09-12 | Hisamitsu Pharmaceutical Co. Inc. | P-glycoprotein modifier-containing medicinal compositions to be delivered to thelarge intestine |
| US6362217B2 (en) | 2000-03-17 | 2002-03-26 | Bristol-Myers Squibb Company | Taxane anticancer agents |
| US20030144312A1 (en) * | 2001-10-30 | 2003-07-31 | Schoenhard Grant L. | Inhibitors of ABC drug transporters in multidrug resistant cancer cells |
| JP2005508990A (ja) * | 2001-11-07 | 2005-04-07 | ファルマシア・コーポレーション | 真核細胞におけるポリアミドの取込みおよび核蓄積を促進する方法 |
| GEP20063806B (en) * | 2001-12-20 | 2006-04-25 | Bristol Myers Squibb Co | Pharmaceutical compositions of orally active taxane derivatives having enhanced bioavailability |
| WO2004098570A1 (en) * | 2002-10-30 | 2004-11-18 | Spherics, Inc. | Nanoparticulate bioactive agents |
| US20050113324A1 (en) * | 2003-01-15 | 2005-05-26 | Bondarev Igor E. | Modulation of line-1 reverse transcriptase |
| US20060014677A1 (en) * | 2004-07-19 | 2006-01-19 | Isotechnika International Inc. | Method for maximizing efficacy and predicting and minimizing toxicity of calcineurin inhibitor compounds |
| US20070087977A1 (en) * | 2004-11-16 | 2007-04-19 | Wendye Robbins | Methods and compositions for treating pain |
| US20060111308A1 (en) * | 2004-11-16 | 2006-05-25 | Wendye Robbins | Methods and compositions for therapeutic treatment |
| US7745400B2 (en) * | 2005-10-14 | 2010-06-29 | Gregg Feinerman | Prevention and treatment of ocular side effects with a cyclosporin |
| US9839667B2 (en) | 2005-10-14 | 2017-12-12 | Allergan, Inc. | Prevention and treatment of ocular side effects with a cyclosporin |
| EP2153842B1 (de) * | 2005-10-14 | 2016-04-13 | Allergan, Inc. | Prävention von mit arzneimitteln in zusammenhang stehenden keratokonjunctivitis mit cyclosporin |
| WO2009002425A2 (en) * | 2007-06-22 | 2008-12-31 | Scidose Llc | Solubilized formulation of docetaxel without tween 80 |
| US20090111736A1 (en) * | 2007-10-29 | 2009-04-30 | Sri International | Orally-Absorbed Solid Dose Formulation for Vancomycin |
| CN101559059B (zh) * | 2008-04-16 | 2012-12-05 | 北京万全阳光医学技术有限公司 | 一种含有盐酸阿米洛利的药物组合物及其制备方法 |
| US20090318561A1 (en) * | 2008-06-23 | 2009-12-24 | Mutual Pharmaceutical Company, Inc. | Colchicine products, method of manufacture, and methods of use |
| JP2011530532A (ja) * | 2008-08-07 | 2011-12-22 | シェーリング コーポレイション | 固体分子分散物中のｈｃｖプロテアーゼインヒビターの薬学的処方物 |
| US7820681B1 (en) | 2009-01-14 | 2010-10-26 | Mutual Pharmaceutical Company, Inc. | Methods for concomitant administration of colchicine and a second active agent |
| US20110046228A1 (en) * | 2009-08-20 | 2011-02-24 | Mutual Pharmaceutical Company, Inc. | Methods for administration of colchicine with grapefruit juice |
| US7772274B1 (en) | 2009-10-19 | 2010-08-10 | Scidose, Llc | Docetaxel formulations with lipoic acid |
| US8541465B2 (en) * | 2009-10-19 | 2013-09-24 | Scidose, Llc | Docetaxel formulations with lipoic acid and/or dihydrolipoic acid |
| US8912228B2 (en) | 2009-10-19 | 2014-12-16 | Scidose Llc | Docetaxel formulations with lipoic acid |
| US20110092579A1 (en) * | 2009-10-19 | 2011-04-21 | Scidose Llc | Solubilized formulation of docetaxel |
| US20110142889A1 (en) * | 2009-12-16 | 2011-06-16 | Nod Pharmaceuticals, Inc. | Compositions and methods for oral drug delivery |
| BR112012028037A2 (pt) | 2010-05-03 | 2016-08-02 | Teikoku Pharma Usa Inc | formulação de pró-emulsão líquida de taxano não aquosa, métodos para administrar um taxano a um paciente e para fabricar uma formulação de pró-emulsão de taxano, composição de emulsão de taxano, e, kit |
| US20120295932A1 (en) * | 2011-05-17 | 2012-11-22 | Western Connecticut Health Network, Inc. | Method for the treatment of cancer |
| JO3685B1 (ar) | 2012-10-01 | 2020-08-27 | Teikoku Pharma Usa Inc | صيغ التشتيت الجسيمي للتاكسين غير المائي وطرق استخدامها |
| TWI752750B (zh) | 2015-09-30 | 2022-01-11 | 香港商慧源香港創新有限公司 | 口服紫杉烷組合物及方法 |
| CN107843966B (zh) | 2016-09-18 | 2021-05-04 | 中芯国际集成电路制造(上海)有限公司 | 用于装配微透镜阵列组件的方法和系统 |
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1996
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- 1996-10-24 BR BR9607066-8A patent/BR9607066A/pt not_active Application Discontinuation
- 1996-10-24 CN CN96191685A patent/CN1119146C/zh not_active Expired - Fee Related
- 1996-10-24 DE DE0794794T patent/DE794794T1/de active Pending
- 1996-10-24 CA CA002205534A patent/CA2205534A1/en not_active Abandoned
- 1996-10-24 PL PL368566A patent/PL192544B1/pl unknown
- 1996-10-24 ES ES96943268T patent/ES2109899T3/es not_active Expired - Lifetime
- 1996-10-24 DE DE69636531T patent/DE69636531T2/de not_active Expired - Fee Related
- 1996-10-24 IL IL12116096A patent/IL121160A0/xx unknown
- 1996-10-24 RU RU97112888/14A patent/RU2217135C2/ru not_active IP Right Cessation
- 1996-10-24 CN CNB031458033A patent/CN100335123C/zh not_active Expired - Fee Related
- 1996-10-24 MX MX9704629A patent/MX9704629A/es not_active IP Right Cessation
- 1996-10-24 HU HU9900457A patent/HUP9900457A3/hu unknown
- 1996-10-24 NZ NZ324801A patent/NZ324801A/xx unknown
- 1996-10-24 JP JP51644997A patent/JP3361102B2/ja not_active Expired - Fee Related
- 1996-10-24 DK DK96943268T patent/DK0794794T3/da active
- 1996-10-24 AU AU12056/97A patent/AU698142B2/en not_active Ceased
- 1996-10-24 WO PCT/IB1996/001485 patent/WO1997015269A2/en active IP Right Grant
- 1996-10-24 AT AT96943268T patent/ATE311903T1/de not_active IP Right Cessation
- 1996-10-24 SK SK859-97A patent/SK85997A3/sk unknown
- 1996-10-24 PL PL96321791A patent/PL188281B1/pl not_active IP Right Cessation
- 1996-10-24 CZ CZ972028A patent/CZ202897A3/cs unknown
- 1996-10-24 EP EP96943268A patent/EP0794794B1/de not_active Expired - Lifetime
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1997
- 1997-06-25 NO NO19972968A patent/NO321091B1/no unknown
-
1998
- 1998-02-11 HK HK98101042A patent/HK1001960A1/xx not_active IP Right Cessation
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2001
- 2001-04-10 US US09/829,846 patent/US6610735B2/en not_active Expired - Fee Related
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2002
- 2002-09-12 US US10/242,050 patent/US6818615B2/en not_active Expired - Fee Related
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2004
- 2004-03-15 US US10/800,990 patent/US7041640B2/en not_active Expired - Fee Related
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2005
- 2005-04-13 US US11/105,081 patent/US20050238634A1/en not_active Abandoned
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2006
- 2006-08-14 US US11/503,607 patent/US20070060635A1/en not_active Abandoned
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