SK80395A3 - Guanidines of phenylsubstituted alkenylcarboxilic acid bearing perfluororalkyl groups, their preparation method, their use for drug preparation or diagnostic substance, as well as drug containing them - Google Patents

Guanidines of phenylsubstituted alkenylcarboxilic acid bearing perfluororalkyl groups, their preparation method, their use for drug preparation or diagnostic substance, as well as drug containing them Download PDF

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Publication number
SK80395A3
SK80395A3 SK803-95A SK80395A SK80395A3 SK 80395 A3 SK80395 A3 SK 80395A3 SK 80395 A SK80395 A SK 80395A SK 80395 A3 SK80395 A3 SK 80395A3
Authority
SK
Slovakia
Prior art keywords
formula
alkyl
compound
group
independently
Prior art date
Application number
SK803-95A
Other languages
English (en)
Slovak (sk)
Inventor
Jan-Robert Schwark
Heinz-Werner Kleemann
Hans-Jochen Lang
Andreas Weichert
Wolfgang Scholz
Udo Albus
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of SK80395A3 publication Critical patent/SK80395A3/sk

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
SK803-95A 1994-06-20 1995-06-19 Guanidines of phenylsubstituted alkenylcarboxilic acid bearing perfluororalkyl groups, their preparation method, their use for drug preparation or diagnostic substance, as well as drug containing them SK80395A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4421536A DE4421536A1 (de) 1994-06-20 1994-06-20 Perfluoralkylgruppen tragende phenylsubstituierte Alkenylcarbonsäure-guanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

Publications (1)

Publication Number Publication Date
SK80395A3 true SK80395A3 (en) 1996-06-05

Family

ID=6521042

Family Applications (1)

Application Number Title Priority Date Filing Date
SK803-95A SK80395A3 (en) 1994-06-20 1995-06-19 Guanidines of phenylsubstituted alkenylcarboxilic acid bearing perfluororalkyl groups, their preparation method, their use for drug preparation or diagnostic substance, as well as drug containing them

Country Status (22)

Country Link
US (1) US6025349A (da)
EP (1) EP0688766B1 (da)
JP (1) JP3718257B2 (da)
KR (1) KR100368513B1 (da)
CN (1) CN1062858C (da)
AT (1) ATE178050T1 (da)
AU (1) AU692539B2 (da)
CA (1) CA2152137C (da)
CZ (1) CZ287263B6 (da)
DE (2) DE4421536A1 (da)
DK (1) DK0688766T3 (da)
ES (1) ES2130472T3 (da)
FI (1) FI953003A (da)
GR (1) GR3030231T3 (da)
HU (1) HU217971B (da)
IL (1) IL114216A (da)
NO (1) NO304264B1 (da)
NZ (1) NZ272373A (da)
PL (1) PL179395B1 (da)
SK (1) SK80395A3 (da)
TW (1) TW332812B (da)
ZA (1) ZA955027B (da)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19518796A1 (de) 1995-05-22 1996-11-28 Hoechst Ag Fluorphenylsubstituierte Alkenylcarbonsäure-guanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19532553A1 (de) * 1995-09-04 1997-03-06 Hoechst Ag Verfahren zur Herstellung substituierter N-Ethyl-Glycinderivate
EP0765867A1 (de) * 1995-09-27 1997-04-02 Hoechst Aktiengesellschaft Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Antiarrhytmika oder Diagnostikum sowie sie enthaltendes Medikament
DE19546736A1 (de) * 1995-12-14 1997-06-19 Hoechst Ag Substituierte Chromanylsulfonyl(thio)harnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung pharmazeutischer Präparate
CA2195697A1 (en) * 1996-02-02 1997-08-03 Masahumi Kitano Novel substituted guanidine derivatives, process for production thereof, and pharmaceutical uses thereof
DE19605610A1 (de) * 1996-02-15 1997-08-21 Hoechst Ag Substituierte Thiophenylalkenylcarbonsäureguanidide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
WO1997031611A2 (en) * 1996-03-01 1997-09-04 Chiron Corporation Treatment of begnin prostatic hyperplasia
EP0837055A1 (en) * 1996-07-30 1998-04-22 Hoechst Aktiengesellschaft Substituted Indanylidineacetylguanidines, process for their preparation, their use as medicaments or diagnostic and medicaments containing them
DE19633966A1 (de) * 1996-08-22 1998-02-26 Hoechst Ag Phenylsubstituierte Alkenylcarbonsäure-guanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19737224A1 (de) 1997-08-27 1999-03-18 Hoechst Marion Roussel De Gmbh Pharmazeutisches Kombinationspräparat aus einem Inhibitor des Natrium-Wasserstoff-Austauschers und einem Arzneimittel zur Behandlung von Herz-Kreislauferkrankungen
US6958324B2 (en) 1998-12-02 2005-10-25 Inotek Pharmaceuticals Corporation Inosine compounds and their use for treating or preventing an inflamation or a reperfusion disease
WO2001052860A2 (en) * 2000-01-24 2001-07-26 Inotek Corporation Method and composition for modulating an immune response
DE10024319A1 (de) * 2000-05-17 2001-11-22 Merck Patent Gmbh Bisacylguanidine
DE10219545A1 (de) * 2002-04-26 2003-11-06 Lang Florian Regulation der Apoptose
EP2617709B8 (en) * 2003-06-26 2022-12-21 Biotron Limited Guanidine derivatives as antiviral agents
AU2013205388B2 (en) * 2005-06-24 2016-05-05 Biotron Limited Antiviral compounds and methods
ES2710662T3 (es) 2005-06-24 2019-04-26 Biotron Ltd Compuestos de acilguanidina con actividad antiviral
US7840502B2 (en) * 2007-06-13 2010-11-23 Microsoft Corporation Classification of images as advertisement images or non-advertisement images of web pages
DE102007039246A1 (de) * 2007-08-20 2009-02-26 Robert Bosch Gmbh Formmasse und Verfahren zur Herstellung einer Formmasse
AR085073A1 (es) * 2012-01-11 2013-09-11 Richmond Sa Com Ind Y Financiera Lab Compuestos con actividad antibacteriana, un procedimiento para su obtencion y composiciones farmaceuticas que los comprenden

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1298112A (en) * 1969-02-20 1972-11-29 Wander Ag Dr A Phenyl acetyl guanidine derivatives
US3780027A (en) * 1970-04-29 1973-12-18 Merck & Co Inc Anthranilic acid derivatives
US4101675A (en) * 1973-11-09 1978-07-18 Akzona Incorporated Novel 2,6-di-substituted phenyl-aminoquanidine containing compositions and methods of using same and pharmaceutical compositions containing the same and therapeutic method
GB1519762A (en) * 1974-08-09 1978-08-02 Wellcome Found Cinnamamides their preparation and pharmaceutical compositions containing them
DE2931735A1 (de) * 1979-08-04 1981-02-19 Beiersdorf Ag Neue substituierte phenylacetylguanidine und verfahren zu ihrer herstellung
US4544670A (en) * 1982-08-24 1985-10-01 William H. Rorer, Inc. Method of treating coccidiosis with acyl guanidines
DE59403818D1 (de) * 1993-02-20 1997-10-02 Hoechst Ag Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, als Inhibitoren des zellulären Na+/H+-Austauschs oder als Diagnostikum sowie sie enthaltendes Medikament
JPH06256210A (ja) * 1993-03-10 1994-09-13 Hoechst Japan Ltd 骨関連転写制御因子様タンパク質およびその製造法
DE4318756A1 (de) * 1993-06-05 1994-12-08 Hoechst Ag Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

Also Published As

Publication number Publication date
AU2172095A (en) 1996-01-04
JP3718257B2 (ja) 2005-11-24
JPH0827093A (ja) 1996-01-30
HU217971B (hu) 2000-05-28
CA2152137A1 (en) 1995-12-21
EP0688766A1 (de) 1995-12-27
HUT74002A (en) 1996-10-28
PL179395B1 (pl) 2000-08-31
FI953003A0 (fi) 1995-06-16
CN1062858C (zh) 2001-03-07
NO952450D0 (no) 1995-06-19
CZ287263B6 (en) 2000-10-11
NZ272373A (en) 1996-07-26
US6025349A (en) 2000-02-15
DE59505412D1 (de) 1999-04-29
TW332812B (en) 1998-06-01
ZA955027B (en) 1996-02-08
ES2130472T3 (es) 1999-07-01
CA2152137C (en) 2007-11-13
CZ160795A3 (en) 1996-05-15
ATE178050T1 (de) 1999-04-15
EP0688766B1 (de) 1999-03-24
GR3030231T3 (en) 1999-08-31
CN1122329A (zh) 1996-05-15
NO304264B1 (no) 1998-11-23
PL309168A1 (en) 1995-12-27
KR100368513B1 (ko) 2003-03-19
NO952450L (no) 1995-12-21
IL114216A0 (en) 1995-10-31
FI953003A (fi) 1995-12-21
HU9501796D0 (en) 1995-08-28
AU692539B2 (en) 1998-06-11
DE4421536A1 (de) 1995-12-21
KR960000861A (ko) 1996-01-25
IL114216A (en) 2001-01-11
DK0688766T3 (da) 1999-10-11

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