SK48698A3 - Use of imidazole derivative and pharmaceutical composition containing the same - Google Patents
Use of imidazole derivative and pharmaceutical composition containing the same Download PDFInfo
- Publication number
- SK48698A3 SK48698A3 SK486-98A SK48698A SK48698A3 SK 48698 A3 SK48698 A3 SK 48698A3 SK 48698 A SK48698 A SK 48698A SK 48698 A3 SK48698 A3 SK 48698A3
- Authority
- SK
- Slovakia
- Prior art keywords
- adrenergic
- receptors
- pharmaceutical composition
- receptor
- enantiomer
- Prior art date
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- 239000002831 pharmacologic agent Substances 0.000 description 1
- 229960005323 phenoxyethanol Drugs 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920000059 polyethylene glycol stearate Polymers 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000010453 quartz Substances 0.000 description 1
- 239000000700 radioactive tracer Substances 0.000 description 1
- 239000000018 receptor agonist Substances 0.000 description 1
- 229940044601 receptor agonist Drugs 0.000 description 1
- BJOIZNZVOZKDIG-MDEJGZGSSA-N reserpine Chemical compound O([C@H]1[C@@H]([C@H]([C@H]2C[C@@H]3C4=C([C]5C=CC(OC)=CC5=N4)CCN3C[C@H]2C1)C(=O)OC)OC)C(=O)C1=CC(OC)=C(OC)C(OC)=C1 BJOIZNZVOZKDIG-MDEJGZGSSA-N 0.000 description 1
- 229960003147 reserpine Drugs 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- MDMGHDFNKNZPAU-UHFFFAOYSA-N roserpine Natural products C1C2CN3CCC(C4=CC=C(OC)C=C4N4)=C4C3CC2C(OC(C)=O)C(OC)C1OC(=O)C1=CC(OC)=C(OC)C(OC)=C1 MDMGHDFNKNZPAU-UHFFFAOYSA-N 0.000 description 1
- 201000000980 schizophrenia Diseases 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 230000019491 signal transduction Effects 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- KHNPVTYVXFDWHI-UHFFFAOYSA-M sodium;18-oxooctadecyl sulfate Chemical compound [Na+].[O-]S(=O)(=O)OCCCCCCCCCCCCCCCCCC=O KHNPVTYVXFDWHI-UHFFFAOYSA-M 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000012265 solid product Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 210000002820 sympathetic nervous system Anatomy 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000003827 upregulation Effects 0.000 description 1
- 239000012178 vegetable wax Substances 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Epoxy Resins (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9521680.0A GB9521680D0 (en) | 1995-10-23 | 1995-10-23 | New use of imidazole derivatives |
| PCT/FI1996/000560 WO1997015302A1 (en) | 1995-10-23 | 1996-10-23 | Pharmaceutical compositions of levo-enantiomers of medetomidine derivatives and their use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK48698A3 true SK48698A3 (en) | 1999-03-12 |
Family
ID=10782758
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK486-98A SK48698A3 (en) | 1995-10-23 | 1996-10-23 | Use of imidazole derivative and pharmaceutical composition containing the same |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US5994384A (zh) |
| EP (1) | EP0858338B1 (zh) |
| JP (1) | JP2000503298A (zh) |
| KR (1) | KR19990067008A (zh) |
| CN (1) | CN1200035A (zh) |
| AT (1) | ATE218340T1 (zh) |
| AU (1) | AU707728B2 (zh) |
| BG (1) | BG102396A (zh) |
| CA (1) | CA2232336A1 (zh) |
| CZ (1) | CZ120498A3 (zh) |
| DE (1) | DE69621633T2 (zh) |
| EE (1) | EE9800131A (zh) |
| ES (1) | ES2178717T3 (zh) |
| GB (1) | GB9521680D0 (zh) |
| HU (1) | HUP9900027A3 (zh) |
| IL (1) | IL123999A (zh) |
| NO (1) | NO981799L (zh) |
| NZ (1) | NZ320289A (zh) |
| PL (1) | PL326562A1 (zh) |
| RU (1) | RU2193404C2 (zh) |
| SK (1) | SK48698A3 (zh) |
| WO (1) | WO1997015302A1 (zh) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6329369B1 (en) | 1997-12-04 | 2001-12-11 | Allergan Sales, Inc. | Methods of treating pain and other conditions |
| US6841684B2 (en) | 1997-12-04 | 2005-01-11 | Allergan, Inc. | Imidiazoles having reduced side effects |
| AU5331200A (en) * | 1999-06-11 | 2001-01-02 | Ohio State University Research Foundation, The | Methods and compositions for treating raynaud's phenomenon and scleroderma |
| US6444681B1 (en) | 2000-06-09 | 2002-09-03 | The Ohio State University Research Foundation | Methods and compositions for treating Raynaud's Phenomenon and scleroderma |
| NZ527142A (en) * | 2003-07-23 | 2006-03-31 | Douglas Pharmaceuticals Ltd | A stable suspension formulation |
| CA2637308C (en) | 2006-01-27 | 2014-02-25 | F. Hoffmann-La Roche Ag | Use of 4-imidazole derivatives for cns disorders |
| CN101671305A (zh) * | 2009-09-29 | 2010-03-17 | 北京华禧联合科技发展有限公司 | 一种拆分美托咪定的左旋及右旋对映体的方法 |
| EP2782569A1 (en) * | 2011-11-21 | 2014-10-01 | Allergan, Inc. | Pharmaceutical compositions comprising 4-[1-(2,3-dimethylphenyl)ethyl]-3h-imidazole derivatives for treating retinal diseases |
| CN105473669A (zh) * | 2013-07-24 | 2016-04-06 | I-技术有限公司 | 作为抑制剂的对映异构体左旋美托咪啶在海洋生物污损表面附着的应用 |
| US10772871B2 (en) | 2013-10-07 | 2020-09-15 | Teikoku Pharma Usa, Inc. | Dexmedetomidine transdermal delivery devices and methods for using the same |
| TWI709417B (zh) | 2013-10-07 | 2020-11-11 | 美商帝國製藥美國股份有限公司 | 使用右美托咪啶經皮組成物用於治療注意力不足過動症、焦慮及失眠的方法及組成物 |
| EP3054930B1 (en) | 2013-10-07 | 2020-12-02 | Teikoku Pharma USA, Inc. | Methods and compositions for transdermal delivery of a non-sedative amount of dexmedetomidine |
| RU2648817C2 (ru) * | 2013-10-07 | 2018-03-28 | ТЕЙКОКУ ФАРМА ЮЭсЭй, ИНК. | Способы и композиции для лечения абстинентных синдромов с использованием неседативных трансдермальных композиций на основе дексмедетомидина |
| CN106442765A (zh) * | 2016-08-31 | 2017-02-22 | 辰欣药业股份有限公司 | 一种盐酸右美托咪定粗品中异构体的检测方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2101114B (en) * | 1981-07-10 | 1985-05-22 | Farmos Group Ltd | Substituted imidazole derivatives and their preparation and use |
| GB8626287D0 (en) * | 1986-11-04 | 1986-12-03 | Ucb Sa | Substituted 1h-imidazoles |
| GB2206880B (en) * | 1987-07-16 | 1991-04-24 | Farmos Oy | Optical isomers of an imidazole derivative |
| GB8810067D0 (en) * | 1988-04-28 | 1988-06-02 | Ucb Sa | Substituted 1-(1h-imidazol-4-yl)alkyl-benzamides |
| US5124157A (en) * | 1989-08-18 | 1992-06-23 | Cygnus Therapeutic Systems | Method and device for administering dexmedetomidine transdermally |
| WO1992004054A1 (en) * | 1990-08-30 | 1992-03-19 | STATE OF OREGON, acting by and through THE OREGON STATE BOARD OF HIGHER EDUCATION, acting for and on behalf of THE OREGON HEALTH SCIENCES UNIVERSITY, PORTLAND, OREGON, and THE UNIVERSITY OF OREGON, EUGENE, OREGON, Johnson Hall, University of Oregon | Substituted amidines having high binding to the sigma receptor and the use thereof |
| GB9111732D0 (en) * | 1991-05-31 | 1991-07-24 | Orion Yhtymae Oy | The use of certain salts of medetomidine and its optically active enantiomers to regulate the rate of transdermal administration of the drugs |
| GB9310965D0 (en) * | 1993-05-27 | 1993-07-14 | Ucb Sa | 2-hydroxy-3-(1h-imidazol-4-yl)alkyl)benzenecarboximidamides |
-
1995
- 1995-10-23 GB GBGB9521680.0A patent/GB9521680D0/en active Pending
-
1996
- 1996-10-23 AT AT96934847T patent/ATE218340T1/de not_active IP Right Cessation
- 1996-10-23 KR KR1019980702944A patent/KR19990067008A/ko not_active Application Discontinuation
- 1996-10-23 ES ES96934847T patent/ES2178717T3/es not_active Expired - Lifetime
- 1996-10-23 SK SK486-98A patent/SK48698A3/sk unknown
- 1996-10-23 EE EE9800131A patent/EE9800131A/xx unknown
- 1996-10-23 EP EP96934847A patent/EP0858338B1/en not_active Expired - Lifetime
- 1996-10-23 AU AU73019/96A patent/AU707728B2/en not_active Ceased
- 1996-10-23 RU RU98109949/14A patent/RU2193404C2/ru not_active IP Right Cessation
- 1996-10-23 NZ NZ320289A patent/NZ320289A/xx unknown
- 1996-10-23 IL IL12399996A patent/IL123999A/en not_active IP Right Cessation
- 1996-10-23 PL PL96326562A patent/PL326562A1/xx unknown
- 1996-10-23 CZ CZ981204A patent/CZ120498A3/cs unknown
- 1996-10-23 HU HU9900027A patent/HUP9900027A3/hu unknown
- 1996-10-23 CA CA002232336A patent/CA2232336A1/en not_active Abandoned
- 1996-10-23 JP JP9516319A patent/JP2000503298A/ja active Pending
- 1996-10-23 WO PCT/FI1996/000560 patent/WO1997015302A1/en not_active Application Discontinuation
- 1996-10-23 US US09/043,107 patent/US5994384A/en not_active Expired - Fee Related
- 1996-10-23 CN CN96197793A patent/CN1200035A/zh active Pending
- 1996-10-23 DE DE69621633T patent/DE69621633T2/de not_active Expired - Fee Related
-
1998
- 1998-04-21 BG BG102396A patent/BG102396A/xx unknown
- 1998-04-22 NO NO981799A patent/NO981799L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL326562A1 (en) | 1998-09-28 |
| KR19990067008A (ko) | 1999-08-16 |
| DE69621633T2 (de) | 2003-02-06 |
| JP2000503298A (ja) | 2000-03-21 |
| ATE218340T1 (de) | 2002-06-15 |
| EP0858338B1 (en) | 2002-06-05 |
| RU2193404C2 (ru) | 2002-11-27 |
| GB9521680D0 (en) | 1996-01-03 |
| WO1997015302A1 (en) | 1997-05-01 |
| BG102396A (en) | 1999-01-29 |
| HUP9900027A3 (en) | 1999-11-29 |
| NO981799D0 (no) | 1998-04-22 |
| EE9800131A (et) | 1998-10-15 |
| EP0858338A1 (en) | 1998-08-19 |
| CA2232336A1 (en) | 1997-05-01 |
| US5994384A (en) | 1999-11-30 |
| NZ320289A (en) | 1999-08-30 |
| NO981799L (no) | 1998-04-22 |
| CN1200035A (zh) | 1998-11-25 |
| AU7301996A (en) | 1997-05-15 |
| AU707728B2 (en) | 1999-07-15 |
| ES2178717T3 (es) | 2003-01-01 |
| DE69621633D1 (de) | 2002-07-11 |
| HUP9900027A2 (hu) | 1999-04-28 |
| IL123999A (en) | 2002-09-12 |
| CZ120498A3 (cs) | 1998-09-16 |
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