SK288123B6 - Polymer conjugates of neublastin and methods of using same - Google Patents

Polymer conjugates of neublastin and methods of using same Download PDF

Info

Publication number
SK288123B6
SK288123B6 SK971-2003A SK9712003A SK288123B6 SK 288123 B6 SK288123 B6 SK 288123B6 SK 9712003 A SK9712003 A SK 9712003A SK 288123 B6 SK288123 B6 SK 288123B6
Authority
SK
Slovakia
Prior art keywords
polypeptide
neublastin
nbn
amino acid
variant
Prior art date
Application number
SK971-2003A
Other languages
English (en)
Slovak (sk)
Other versions
SK9712003A3 (en
Inventor
Dinah W. Y. Sah
Blake R. Pepinsky
Paula Ann Borjack-Sjodin
Stephan S. Miller
Anthony Rossomando
Original Assignee
Biogen Idec Ma Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogen Idec Ma Inc. filed Critical Biogen Idec Ma Inc.
Publication of SK9712003A3 publication Critical patent/SK9712003A3/sk
Publication of SK288123B6 publication Critical patent/SK288123B6/sk

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • C07K14/4756Neuregulins, i.e. p185erbB2 ligands, glial growth factor, heregulin, ARIA, neu differentiation factor
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02Muscle relaxants, e.g. for tetanus or cramps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Psychology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biophysics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
SK971-2003A 2001-02-01 2002-01-25 Polymer conjugates of neublastin and methods of using same SK288123B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26607101P 2001-02-01 2001-02-01
PCT/US2002/002319 WO2002060929A2 (en) 2001-02-01 2002-01-25 Polymer conjugates of neublastin and methods of using same

Publications (2)

Publication Number Publication Date
SK9712003A3 SK9712003A3 (en) 2004-01-08
SK288123B6 true SK288123B6 (sk) 2013-09-03

Family

ID=23013042

Family Applications (1)

Application Number Title Priority Date Filing Date
SK971-2003A SK288123B6 (sk) 2001-02-01 2002-01-25 Polymer conjugates of neublastin and methods of using same

Country Status (36)

Country Link
EP (2) EP1355936B1 (is)
JP (2) JP4259868B2 (is)
KR (2) KR100960063B1 (is)
CN (1) CN1500095B (is)
AR (1) AR035077A1 (is)
AT (1) ATE365748T1 (is)
AU (1) AU2002247037B2 (is)
BG (1) BG66393B1 (is)
BR (1) BR0206852A (is)
CA (1) CA2436407C (is)
CY (1) CY1106886T1 (is)
CZ (1) CZ20032080A3 (is)
DE (1) DE60220879T2 (is)
DK (1) DK1355936T3 (is)
EA (1) EA009771B1 (is)
EE (1) EE05537B1 (is)
ES (1) ES2289091T3 (is)
GE (1) GEP20063916B (is)
HK (1) HK1057759A1 (is)
HU (1) HU228973B1 (is)
IL (2) IL156941A0 (is)
IS (1) IS2867B (is)
MX (1) MXPA03006805A (is)
MY (1) MY143685A (is)
NO (1) NO332150B1 (is)
NZ (1) NZ527863A (is)
PL (1) PL211162B1 (is)
PT (1) PT1355936E (is)
RS (1) RS50857B (is)
SG (1) SG149685A1 (is)
SI (1) SI1355936T1 (is)
SK (1) SK288123B6 (is)
TR (1) TR200301208T2 (is)
UA (2) UA82983C2 (is)
WO (1) WO2002060929A2 (is)
ZA (1) ZA200305733B (is)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EE05537B1 (et) * 2001-02-01 2012-04-16 Biogen, Inc. Neublastiini polmeerkonjugaadid ja meetodid nende kasutamiseks
US7442370B2 (en) 2001-02-01 2008-10-28 Biogen Idec Ma Inc. Polymer conjugates of mutated neublastin
US7276580B2 (en) 2001-03-12 2007-10-02 Biogen Idec Ma Inc. Neurotrophic factors
CN1525866B (zh) * 2001-03-28 2013-05-29 比奥根艾迪克Ma公司 神经胚活素多肽的治疗作用
NZ534708A (en) * 2002-01-18 2007-05-31 Biogen Idec Inc Polyalkylene glycol with moiety for conjugating biologically active compound
AU2004209966B9 (en) * 2003-01-31 2008-06-26 Biogen Ma Inc. Polymer conjugates of mutated neublastin
DE602004021648D1 (de) 2003-04-18 2009-07-30 Biogen Idec Inc Polymerkonjugiertes glycosiliertes Neublastin
ATE478092T1 (de) 2003-06-10 2010-09-15 Nsgene As Verbesserte sekretion von neublastin
US7598059B2 (en) 2003-10-02 2009-10-06 Biogen Idec Ma Inc. Neublastin expression constructs
PT1786454E (pt) * 2004-08-19 2010-08-18 Biogen Idec Inc Variantes de neublastina
AU2005277227B2 (en) * 2004-08-19 2011-10-06 Biogen Ma Inc. Refolding transforming growth factor beta family proteins
TWI501774B (zh) 2006-02-27 2015-10-01 Biogen Idec Inc 神經性病症之治療
ES2450065T3 (es) * 2006-03-01 2014-03-21 Biogen Idec Ma Inc. Composiciones y métodos para la administración de proteínas de la familia de ligandos del GDNF
PL2068935T3 (pl) 2006-09-15 2011-11-30 Creabilis Therapeutics S R L Polimerowe koniugaty BOX-A HMGB1 i warianty HMGB1
EP2142205B1 (en) * 2007-05-01 2014-04-02 Biogen Idec MA Inc. Neublastin peptides for use in increasing vascularisation in tissue with impaired blood flow
LT3257564T (lt) * 2011-11-02 2019-04-10 F. Hoffmann-La Roche Ag Perkrovos ir eliuentinė chromatografija
RU2488635C1 (ru) * 2012-03-22 2013-07-27 Государственное бюджетное образовательное учреждение высшего профессионального образования Первый Московский государственный медицинский университет им. И.М. Сеченова Министерства здравоохранения и социального развития Российской Федерации (ГБОУ ВПО Первый МГМУ им. И.М. Сеченова Минздравсоцразвития Способ получения рекомбинантного антиангиогенного полипептида

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6472178B1 (en) * 1998-02-27 2002-10-29 Regeneron Pharmaceuticals, Inc. Nucleic acids encoding a modified ciliary neurotrophic factor and method of making thereof
US5770577A (en) * 1994-11-14 1998-06-23 Amgen Inc. BDNF and NT-3 polypeptides selectively linked to polyethylene glycol
US6593133B1 (en) * 1998-07-06 2003-07-15 Nsgene A/S Neurotrophic factors
EP1137774A2 (en) * 1998-12-09 2001-10-04 Amgen Inc. Grnf4, a gdnf-related neurotrophic factor
EE05537B1 (et) * 2001-02-01 2012-04-16 Biogen, Inc. Neublastiini polmeerkonjugaadid ja meetodid nende kasutamiseks

Also Published As

Publication number Publication date
JP4423338B2 (ja) 2010-03-03
KR20080098662A (ko) 2008-11-11
CN1500095B (zh) 2010-06-16
EP1355936A2 (en) 2003-10-29
JP4259868B2 (ja) 2009-04-30
RS50857B (sr) 2010-08-31
AR035077A1 (es) 2004-04-14
TR200301208T2 (tr) 2005-05-23
KR100960063B1 (ko) 2010-05-31
AU2002247037B2 (en) 2007-08-16
HUP0500637A3 (en) 2010-01-28
BG66393B1 (bg) 2013-11-29
WO2002060929A2 (en) 2002-08-08
PL211162B1 (pl) 2012-04-30
EA200300852A1 (ru) 2004-06-24
UA100967C2 (ru) 2013-02-25
EP1355936B1 (en) 2007-06-27
SG149685A1 (en) 2009-02-27
ES2289091T3 (es) 2008-02-01
JP2005503763A (ja) 2005-02-10
MXPA03006805A (es) 2003-11-13
UA82983C2 (ru) 2008-06-10
ATE365748T1 (de) 2007-07-15
CA2436407C (en) 2011-08-30
IS2867B (is) 2014-02-15
BR0206852A (pt) 2005-05-03
CY1106886T1 (el) 2012-09-26
BG108111A (bg) 2004-12-30
SK9712003A3 (en) 2004-01-08
HUP0500637A2 (hu) 2005-09-28
NO20033441L (no) 2003-10-01
NO332150B1 (no) 2012-07-09
JP2009039135A (ja) 2009-02-26
PL372101A1 (en) 2005-07-11
SI1355936T1 (sl) 2007-12-31
IS6879A (is) 2003-07-17
IL156941A (en) 2008-11-03
KR20030074766A (ko) 2003-09-19
NZ527863A (en) 2006-09-29
PT1355936E (pt) 2007-09-28
HU228973B1 (en) 2013-07-29
EA009771B1 (ru) 2008-04-28
EE200300355A (et) 2003-10-15
DK1355936T3 (da) 2007-10-29
WO2002060929A3 (en) 2003-03-06
DE60220879T2 (de) 2008-03-06
CA2436407A1 (en) 2002-08-08
EP1862475A1 (en) 2007-12-05
DE60220879D1 (de) 2007-08-09
IL156941A0 (en) 2004-02-08
HK1057759A1 (en) 2004-04-16
ZA200305733B (en) 2005-02-23
CN1500095A (zh) 2004-05-26
CZ20032080A3 (cs) 2003-10-15
EE05537B1 (et) 2012-04-16
NO20033441D0 (no) 2003-08-01
YU61003A (sh) 2006-05-25
KR100872807B1 (ko) 2008-12-09
MY143685A (en) 2011-06-30
GEP20063916B (en) 2006-09-11

Similar Documents

Publication Publication Date Title
JP4423338B2 (ja) ニューブラスチンのポリマー結合体および同様の使用方法。
US8119114B2 (en) Polymer conjugates of mutated neublastin
AU2002247037A1 (en) Polymer conjugates of neublastin and methods of using same
JP2011078434A (ja) 変異ニューブラスチンのポリマー結合体

Legal Events

Date Code Title Description
MM4A Patent lapsed due to non-payment of maintenance fees

Effective date: 20160125