SK288086B6 - Polynucleotide molecule comprising mutated nucleotide sequence of Streptomyces avermitilis aveC allele, vector and host cell, method of making strain of S. avermitilis and process for producing avermectins and final composition - Google Patents
Polynucleotide molecule comprising mutated nucleotide sequence of Streptomyces avermitilis aveC allele, vector and host cell, method of making strain of S. avermitilis and process for producing avermectins and final composition Download PDFInfo
- Publication number
- SK288086B6 SK288086B6 SK139-2002A SK1392002A SK288086B6 SK 288086 B6 SK288086 B6 SK 288086B6 SK 1392002 A SK1392002 A SK 1392002A SK 288086 B6 SK288086 B6 SK 288086B6
- Authority
- SK
- Slovakia
- Prior art keywords
- amino acid
- seq
- avec
- avec allele
- nucleotide
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
- C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
- C12P19/623—Avermectin; Milbemycin; Ivermectin; C-076
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14864599P | 1999-08-12 | 1999-08-12 | |
PCT/IB2000/001017 WO2001012821A1 (en) | 1999-08-12 | 2000-07-24 | Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins |
Publications (2)
Publication Number | Publication Date |
---|---|
SK1392002A3 SK1392002A3 (en) | 2002-12-03 |
SK288086B6 true SK288086B6 (sk) | 2013-06-03 |
Family
ID=22526696
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SK139-2002A SK288086B6 (sk) | 1999-08-12 | 2000-07-24 | Polynucleotide molecule comprising mutated nucleotide sequence of Streptomyces avermitilis aveC allele, vector and host cell, method of making strain of S. avermitilis and process for producing avermectins and final composition |
Country Status (39)
Country | Link |
---|---|
US (3) | US6632673B1 (xx) |
EP (1) | EP1200606B1 (xx) |
JP (1) | JP3884651B2 (xx) |
KR (1) | KR100489856B1 (xx) |
CN (1) | CN1186446C (xx) |
AP (1) | AP2002002418A0 (xx) |
AR (1) | AR022646A1 (xx) |
AT (1) | ATE341632T1 (xx) |
AU (1) | AU778837B2 (xx) |
BG (1) | BG65902B1 (xx) |
BR (1) | BRPI0013119B8 (xx) |
CA (1) | CA2380872C (xx) |
CO (1) | CO5290295A1 (xx) |
CY (1) | CY1105778T1 (xx) |
CZ (1) | CZ304402B6 (xx) |
DE (1) | DE60031126T2 (xx) |
DK (1) | DK1200606T3 (xx) |
EA (1) | EA200200056A1 (xx) |
ES (1) | ES2272299T3 (xx) |
GT (1) | GT200000136A (xx) |
HK (1) | HK1046710B (xx) |
HR (1) | HRP20020130A2 (xx) |
HU (1) | HU230600B1 (xx) |
IL (2) | IL147563A0 (xx) |
IS (1) | IS6250A (xx) |
MA (1) | MA26813A1 (xx) |
MX (1) | MXPA02001513A (xx) |
NO (1) | NO20020664L (xx) |
NZ (1) | NZ516517A (xx) |
OA (1) | OA11998A (xx) |
PA (1) | PA8499501A1 (xx) |
PE (1) | PE20010690A1 (xx) |
PL (1) | PL203818B1 (xx) |
PT (1) | PT1200606E (xx) |
SK (1) | SK288086B6 (xx) |
TN (1) | TNSN00171A1 (xx) |
UY (1) | UY26286A1 (xx) |
WO (1) | WO2001012821A1 (xx) |
ZA (1) | ZA200201072B (xx) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100489856B1 (ko) * | 1999-08-12 | 2005-05-17 | 화이자 프로덕츠 인코포레이티드 | B2:b1 아베르멕틴의 비율을 제어하는 스트렙토마이세스아베르미틸리스 유전자 |
BRPI0307620B8 (pt) * | 2002-02-12 | 2016-09-13 | Pah Usa 15 Llc | moléculas de polinucleotídeo codificando variantes de avec, métodos para produzir uma cepa recombinante de streptomyces avermitilis, bem como as referidas células recombinantes e composição de avermectinas |
US7943160B2 (en) * | 2002-05-09 | 2011-05-17 | Scimetrics Limited Corp. | Pest control methods |
US9493744B2 (en) * | 2012-06-20 | 2016-11-15 | Genentech, Inc. | Methods for viral inactivation and other adventitious agents |
KR102657859B1 (ko) | 2021-04-07 | 2024-04-16 | 윤재식 | 일체형 내화 소켓 |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5234831A (en) | 1987-01-23 | 1993-08-10 | Pfizer Inc | Cultures for production of B avermectins |
US5525506A (en) | 1987-01-23 | 1996-06-11 | Pfizer Inc. | Process for production of avermectins and cultures therefor |
US5238848A (en) | 1987-01-23 | 1993-08-24 | Pfizer Inc | Cultures for production of avermectins |
IN167980B (xx) * | 1987-01-23 | 1991-01-19 | Pfizer | |
US5240850A (en) | 1987-10-23 | 1993-08-31 | Pfizer Inc. | Cultures for production of avermectin aglycones |
ATE89604T1 (de) | 1987-10-23 | 1993-06-15 | Pfizer | Verfahren zur herstellung von aglykonen von avermectin und sie enthaltende kulturen. |
DE69023036T2 (de) | 1989-03-31 | 1996-06-13 | Merck & Co Inc | Klonierung von Streptomyces avermitilis Genen zur Biosynthese von Avermectin und Verfahren zu ihrer Verwendung. |
US5252474A (en) | 1989-03-31 | 1993-10-12 | Merck & Co., Inc. | Cloning genes from Streptomyces avermitilis for avermectin biosynthesis and the methods for their use |
WO1995004150A1 (en) | 1993-07-30 | 1995-02-09 | Pfizer Inc. | Genes encoding branched-chain alpha-ketoacid dehydrogenase complex from streptomyces avermitilis |
FI942725A (fi) | 1993-12-16 | 1995-06-17 | Pfizer | Haaraketjuista alfaketohappodenydrogenaasikompleksia koodaavia geenejä Streptomyces avermitiliksesta |
US6117679A (en) | 1994-02-17 | 2000-09-12 | Maxygen, Inc. | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination |
US5837458A (en) | 1994-02-17 | 1998-11-17 | Maxygen, Inc. | Methods and compositions for cellular and metabolic engineering |
US6335160B1 (en) | 1995-02-17 | 2002-01-01 | Maxygen, Inc. | Methods and compositions for polypeptide engineering |
US5605793A (en) | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
US6096548A (en) | 1996-03-25 | 2000-08-01 | Maxygen, Inc. | Method for directing evolution of a virus |
JP2001504325A (ja) | 1996-09-27 | 2001-04-03 | マキシジェン,インコーポレイテッド | 回帰的配列シャフリングおよび選択による遺伝子治療の最適化のための方法 |
WO1998031837A1 (en) | 1997-01-17 | 1998-07-23 | Maxygen, Inc. | Evolution of whole cells and organisms by recursive sequence recombination |
EP1690868A1 (en) | 1997-10-31 | 2006-08-16 | Maxygen, Inc. | Modification of virus tropism and host range by viral genome shuffling |
NZ518657A (en) * | 1998-02-13 | 2003-10-31 | Pfizer Prod Inc | Streptomyces hygroscopicus directing the ratio of B2:B1 avermectins |
US6248579B1 (en) * | 1998-02-13 | 2001-06-19 | Pfizer Inc | Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins |
KR100489856B1 (ko) * | 1999-08-12 | 2005-05-17 | 화이자 프로덕츠 인코포레이티드 | B2:b1 아베르멕틴의 비율을 제어하는 스트렙토마이세스아베르미틸리스 유전자 |
-
2000
- 2000-07-24 KR KR10-2002-7001807A patent/KR100489856B1/ko active IP Right Grant
- 2000-07-24 EP EP00944154A patent/EP1200606B1/en not_active Expired - Lifetime
- 2000-07-24 AP APAP/P/2002/002418A patent/AP2002002418A0/en unknown
- 2000-07-24 NZ NZ516517A patent/NZ516517A/en unknown
- 2000-07-24 PL PL353874A patent/PL203818B1/pl unknown
- 2000-07-24 AT AT00944154T patent/ATE341632T1/de active
- 2000-07-24 BR BRPI0013119A patent/BRPI0013119B8/pt not_active IP Right Cessation
- 2000-07-24 MX MXPA02001513A patent/MXPA02001513A/es active IP Right Grant
- 2000-07-24 WO PCT/IB2000/001017 patent/WO2001012821A1/en active Application Filing
- 2000-07-24 CN CNB008117470A patent/CN1186446C/zh not_active Expired - Lifetime
- 2000-07-24 EA EA200200056A patent/EA200200056A1/ru unknown
- 2000-07-24 ES ES00944154T patent/ES2272299T3/es not_active Expired - Lifetime
- 2000-07-24 DE DE60031126T patent/DE60031126T2/de not_active Expired - Lifetime
- 2000-07-24 DK DK00944154T patent/DK1200606T3/da active
- 2000-07-24 JP JP2001516908A patent/JP3884651B2/ja not_active Expired - Lifetime
- 2000-07-24 OA OA1200200025A patent/OA11998A/en unknown
- 2000-07-24 SK SK139-2002A patent/SK288086B6/sk not_active IP Right Cessation
- 2000-07-24 PT PT00944154T patent/PT1200606E/pt unknown
- 2000-07-24 HU HU0202487A patent/HU230600B1/hu unknown
- 2000-07-24 IL IL14756300A patent/IL147563A0/xx unknown
- 2000-07-24 AU AU58386/00A patent/AU778837B2/en not_active Expired
- 2000-07-24 CZ CZ2002-296A patent/CZ304402B6/cs not_active IP Right Cessation
- 2000-07-24 CA CA002380872A patent/CA2380872C/en not_active Expired - Lifetime
- 2000-08-04 CO CO00058605A patent/CO5290295A1/es not_active Application Discontinuation
- 2000-08-10 GT GT200000136A patent/GT200000136A/es unknown
- 2000-08-10 AR ARP000104131A patent/AR022646A1/es active IP Right Grant
- 2000-08-10 UY UY26286A patent/UY26286A1/es not_active Application Discontinuation
- 2000-08-10 PE PE2000000812A patent/PE20010690A1/es not_active Application Discontinuation
- 2000-08-10 US US09/637,040 patent/US6632673B1/en not_active Expired - Lifetime
- 2000-08-10 PA PA20008499501A patent/PA8499501A1/es unknown
- 2000-08-11 TN TNTNSN00171A patent/TNSN00171A1/fr unknown
-
2002
- 2002-01-10 IL IL147563A patent/IL147563A/en active IP Right Grant
- 2002-01-25 IS IS6250A patent/IS6250A/is unknown
- 2002-02-07 ZA ZA200201072A patent/ZA200201072B/en unknown
- 2002-02-07 MA MA26513A patent/MA26813A1/fr unknown
- 2002-02-11 NO NO20020664A patent/NO20020664L/no not_active Application Discontinuation
- 2002-02-12 HR HR20020130A patent/HRP20020130A2/hr not_active Application Discontinuation
- 2002-03-05 BG BG106479A patent/BG65902B1/bg unknown
- 2002-11-19 HK HK02108367.6A patent/HK1046710B/zh unknown
-
2003
- 2003-06-11 US US10/412,450 patent/US7858340B2/en not_active Expired - Fee Related
- 2003-06-11 US US10/412,444 patent/US20040009560A1/en not_active Abandoned
-
2006
- 2006-11-13 CY CY20061101647T patent/CY1105778T1/el unknown
Also Published As
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US8008078B2 (en) | Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins | |
KR100499214B1 (ko) | 아베르멕틴의 b2:b1의 비를 제어할 수 있는 스트렙토마이세스 아베르미틸리스 유전자 | |
SK288086B6 (sk) | Polynucleotide molecule comprising mutated nucleotide sequence of Streptomyces avermitilis aveC allele, vector and host cell, method of making strain of S. avermitilis and process for producing avermectins and final composition |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC4A | Assignment and transfer of rights |
Owner name: PAH USA 15 LLC, NEW YORK, NY, US Free format text: FORMER OWNER: PFIZER PRODUCTS INC., GROTON, CT, US Effective date: 20121001 |
|
TC4A | Change of owner's name |
Owner name: ZOETIS P LLC, FLORHAM PARK, NEW JERSEY, US Effective date: 20130703 |
|
PC4A | Assignment and transfer of rights |
Owner name: ZOETIS SERVICES LLC, FLORHAM PARK, NJ, US Free format text: FORMER OWNER: ZOETIS P LLC, FLORHAM PARK, NEW JERSEY, US Effective date: 20151012 |
|
TE4A | Change of owner's address |
Owner name: ZOETIS SERVICES LLC, PARSIPPANY, NEW JERSEY, US Effective date: 20170314 |
|
MK4A | Patent expired |
Expiry date: 20200724 |