SK287888B6 - Cell derived from fusion of cell 293 with cell 2B8, cell line and method for formation of human hybrid cells useful for expression of heterologous protein - Google Patents

Cell derived from fusion of cell 293 with cell 2B8, cell line and method for formation of human hybrid cells useful for expression of heterologous protein Download PDF

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Publication number
SK287888B6
SK287888B6 SK791-2001A SK7912001A SK287888B6 SK 287888 B6 SK287888 B6 SK 287888B6 SK 7912001 A SK7912001 A SK 7912001A SK 287888 B6 SK287888 B6 SK 287888B6
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SK
Slovakia
Prior art keywords
cells
cell
protein
cell line
human
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SK791-2001A
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English (en)
Slovak (sk)
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SK7912001A3 (en
Inventor
Myung-Sam Cho
Original Assignee
Bayer Corporation
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Filing date
Publication date
Application filed by Bayer Corporation filed Critical Bayer Corporation
Publication of SK7912001A3 publication Critical patent/SK7912001A3/sk
Publication of SK287888B6 publication Critical patent/SK287888B6/sk

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/02—Preparation of hybrid cells by fusion of two or more cells, e.g. protoplast fusion
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • C12N5/16—Animal cells
    • C12N5/163—Animal cells one of the fusion partners being a B or a T lymphocyte
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
SK791-2001A 1998-12-10 1999-12-08 Cell derived from fusion of cell 293 with cell 2B8, cell line and method for formation of human hybrid cells useful for expression of heterologous protein SK287888B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/209,920 US6136599A (en) 1998-12-10 1998-12-10 Human hybrid host cell for mammalian gene expression
PCT/US1999/029332 WO2000034462A1 (en) 1998-12-10 1999-12-08 Human hybrid host cell for mammalian gene expression

Publications (2)

Publication Number Publication Date
SK7912001A3 SK7912001A3 (en) 2002-03-05
SK287888B6 true SK287888B6 (sk) 2012-03-02

Family

ID=22780882

Family Applications (1)

Application Number Title Priority Date Filing Date
SK791-2001A SK287888B6 (sk) 1998-12-10 1999-12-08 Cell derived from fusion of cell 293 with cell 2B8, cell line and method for formation of human hybrid cells useful for expression of heterologous protein

Country Status (27)

Country Link
US (1) US6136599A (es)
EP (1) EP1137768B1 (es)
JP (3) JP4332300B2 (es)
KR (1) KR100627753B1 (es)
CN (1) CN1230532C (es)
AT (1) ATE306547T1 (es)
AU (1) AU757188B2 (es)
BG (1) BG65263B1 (es)
BR (1) BRPI9916095B8 (es)
CA (1) CA2353698C (es)
CU (2) CU23382A3 (es)
CZ (1) CZ302677B6 (es)
DE (1) DE69927707T2 (es)
DK (1) DK1137768T3 (es)
ES (1) ES2249929T3 (es)
HU (1) HU229775B1 (es)
ID (1) ID30448A (es)
IL (2) IL143351A0 (es)
NO (1) NO330548B1 (es)
PL (1) PL205549B1 (es)
RO (1) RO121563B1 (es)
RU (1) RU2228355C2 (es)
SI (1) SI20693B (es)
SK (1) SK287888B6 (es)
TR (1) TR200101642T2 (es)
UA (1) UA77642C2 (es)
WO (1) WO2000034462A1 (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6358703B1 (en) 1998-12-10 2002-03-19 Bayer Corporation Expression system for factor VIII
US6136599A (en) * 1998-12-10 2000-10-24 Bayer Corporation Human hybrid host cell for mammalian gene expression
US6348192B1 (en) * 1999-05-11 2002-02-19 Bayer Corporation Interleukin-2 mutein expressed from mammalian cells
US20040235715A1 (en) * 1999-11-12 2004-11-25 Bayer Corporation Method of producing glycosylated bikunin
US6569657B1 (en) * 2000-06-27 2003-05-27 Millennium Pharmaceuticals, Inc. 32140, a novel human aldehyde dehydrogenase and uses therefor
US7094587B2 (en) * 2000-06-27 2006-08-22 Millennium Pharmaceuticals, Inc. 16002 Molecules and uses therefor
MY139948A (en) * 2000-09-28 2009-11-30 Bayer Corp Enhanced transfection system
US7723102B2 (en) * 2000-09-28 2010-05-25 Bayer Corporation Enhanced transfection system
US20060073141A1 (en) * 2001-06-28 2006-04-06 Domantis Limited Compositions and methods for treating inflammatory disorders
KR100496861B1 (ko) 2002-09-26 2005-06-22 삼성전자주식회사 하나의 핸들러에 2개 이상의 테스트 보드를 갖는 테스트장비 및 그 테스트 방법
AU2003298816C1 (en) 2002-12-02 2010-12-16 Amgen Fremont, Inc. Antibodies directed to Tumor Necrosis Factor and uses thereof
US7244616B2 (en) 2003-06-27 2007-07-17 Bayer Pharmaceuticals Corporation Use of molecular chaperones for the enhanced production of secreted, recombinant proteins in mammalian cells
HUE033776T2 (en) 2004-11-12 2018-01-29 Bayer Healthcare Llc FVIII site-specific modification
KR20100040840A (ko) 2007-06-06 2010-04-21 도만티스 리미티드 폴리펩티드，항체 가변 도메인 및 길항제
CA2720610C (en) 2008-04-07 2016-08-23 Bayer Healthcare Llc Methods of recombinant production of glycoproteins
KR101005967B1 (ko) * 2008-04-12 2011-01-05 (주)셀트리온 우수한 재조합 단백질을 생산하기 위한 인간 숙주 세포
US9090948B2 (en) 2008-09-30 2015-07-28 Abbott Molecular Inc. Primers and probes for detecting human papillomavirus and human beta globin sequences in test samples
DK2440653T3 (en) * 2009-06-10 2019-03-18 Bts Res International Pty Ltd Methods for generating hybrid / chimeric cells and their applications
US11401514B2 (en) 2016-07-19 2022-08-02 Brandeis University Compositions and methods for identifying RNA binding polypeptide targets
CN112118869B (zh) 2018-05-16 2024-10-25 莫佛塞斯公司 靶向糖蛋白vi的抗体
WO2020182974A1 (en) 2019-03-14 2020-09-17 Morphosys Ag Antibodies targeting c5ar
JP2022543522A (ja) * 2019-06-10 2022-10-13 チョー プラス インコーポレイティド タンパク質ベースの医薬品の高レベル生産のための細胞株
US20230357398A1 (en) 2020-09-24 2023-11-09 Morphosys Ag Novel human antibodies binding to human cd3 epsilon
CN113604425B (zh) * 2021-06-22 2022-10-18 中山康天晟合生物技术有限公司 一种适应无血清培养基环境的wayne293 lvpro细胞及其应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6045849B2 (ja) * 1980-08-25 1985-10-12 林原 健 ヒトエリトロポエチンの製造方法
US6136599A (en) * 1998-12-10 2000-10-24 Bayer Corporation Human hybrid host cell for mammalian gene expression

Also Published As

Publication number Publication date
DE69927707D1 (de) 2006-02-23
CA2353698A1 (en) 2000-06-15
KR20020002360A (ko) 2002-01-09
US6136599A (en) 2000-10-24
ID30448A (id) 2001-12-06
JP2009148295A (ja) 2009-07-09
SK7912001A3 (en) 2002-03-05
SI20693A (sl) 2002-04-30
EP1137768B1 (en) 2005-10-12
CU23238A1 (es) 2007-09-26
CU23382A3 (es) 2009-06-25
CZ20012023A3 (cs) 2001-10-17
CN1230532C (zh) 2005-12-07
BR9916095A (pt) 2001-09-04
IL143351A0 (en) 2002-04-21
HUP0104681A2 (hu) 2002-04-29
PL205549B1 (pl) 2010-04-30
JP5508740B2 (ja) 2014-06-04
UA77642C2 (en) 2007-01-15
BRPI9916095B1 (pt) 2015-10-13
EP1137768A1 (en) 2001-10-04
BG65263B1 (bg) 2007-10-31
NO20012806D0 (no) 2001-06-07
NO20012806L (no) 2001-06-07
IL143351A (en) 2009-12-24
ATE306547T1 (de) 2005-10-15
TR200101642T2 (tr) 2001-11-21
KR100627753B1 (ko) 2006-09-26
CZ302677B6 (cs) 2011-08-31
ES2249929T3 (es) 2006-04-01
HUP0104681A3 (en) 2005-10-28
DE69927707T2 (de) 2006-07-13
EP1137768A4 (en) 2002-09-18
JP5826311B2 (ja) 2015-12-02
JP2002531125A (ja) 2002-09-24
JP4332300B2 (ja) 2009-09-16
HU229775B1 (en) 2014-07-28
BRPI9916095B8 (pt) 2021-05-25
JP2014131513A (ja) 2014-07-17
CA2353698C (en) 2012-02-21
AU1938300A (en) 2000-06-26
SI20693B (sl) 2008-12-31
NO330548B1 (no) 2011-05-16
CN1339063A (zh) 2002-03-06
BG105566A (en) 2002-03-29
DK1137768T3 (da) 2005-12-19
RU2228355C2 (ru) 2004-05-10
AU757188B2 (en) 2003-02-06
RO121563B1 (ro) 2007-11-30
WO2000034462A1 (en) 2000-06-15

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MK4A Patent expired

Expiry date: 20191208