SK287304B6 - Substituované amínové deriváty ako inhibítory GlyT-1, farmaceutické prostriedky s ich obsahom, ich použitie, spôsob ich prípravy, ich medziprodukty a spôsob ich prípravy - Google Patents

Substituované amínové deriváty ako inhibítory GlyT-1, farmaceutické prostriedky s ich obsahom, ich použitie, spôsob ich prípravy, ich medziprodukty a spôsob ich prípravy Download PDF

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Publication number
SK287304B6
SK287304B6 SK1144-2003A SK11442003A SK287304B6 SK 287304 B6 SK287304 B6 SK 287304B6 SK 11442003 A SK11442003 A SK 11442003A SK 287304 B6 SK287304 B6 SK 287304B6
Authority
SK
Slovakia
Prior art keywords
thienyl
phenyl
sarcosine
prop
compound
Prior art date
Application number
SK1144-2003A
Other languages
English (en)
Slovak (sk)
Other versions
SK11442003A3 (sk
Inventor
Ian Egle
William Delaney
Zhaoqing Wang
Richard Shumacher
Allen T. Hopper
Ashok Tehim
Shawn Maddaford
Original Assignee
Nps Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23026417&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SK287304(B6) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Nps Pharmaceuticals, Inc. filed Critical Nps Pharmaceuticals, Inc.
Publication of SK11442003A3 publication Critical patent/SK11442003A3/sk
Publication of SK287304B6 publication Critical patent/SK287304B6/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Epoxy Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SK1144-2003A 2001-02-16 2002-02-15 Substituované amínové deriváty ako inhibítory GlyT-1, farmaceutické prostriedky s ich obsahom, ich použitie, spôsob ich prípravy, ich medziprodukty a spôsob ich prípravy SK287304B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26924101P 2001-02-16 2001-02-16
PCT/CA2002/000176 WO2002066456A2 (fr) 2001-02-16 2002-02-15 Inhibiteurs de glyt-1

Publications (2)

Publication Number Publication Date
SK11442003A3 SK11442003A3 (sk) 2004-03-02
SK287304B6 true SK287304B6 (sk) 2010-06-07

Family

ID=23026417

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1144-2003A SK287304B6 (sk) 2001-02-16 2002-02-15 Substituované amínové deriváty ako inhibítory GlyT-1, farmaceutické prostriedky s ich obsahom, ich použitie, spôsob ich prípravy, ich medziprodukty a spôsob ich prípravy

Country Status (31)

Country Link
US (1) US6667336B2 (fr)
EP (1) EP1368336B9 (fr)
JP (2) JP2004523548A (fr)
KR (1) KR100900020B1 (fr)
CN (1) CN1219776C (fr)
AT (1) ATE327986T1 (fr)
AU (1) AU2002235682C1 (fr)
BG (1) BG108164A (fr)
BR (1) BR0207307A (fr)
CA (1) CA2438367A1 (fr)
CY (1) CY1105529T1 (fr)
CZ (1) CZ20032503A3 (fr)
DE (1) DE60211866T2 (fr)
DK (1) DK1368336T3 (fr)
EA (1) EA006636B1 (fr)
EE (1) EE05329B1 (fr)
ES (1) ES2266446T3 (fr)
HK (1) HK1061025A1 (fr)
HR (1) HRP20030696A2 (fr)
HU (1) HUP0303185A3 (fr)
IL (1) IL157194A (fr)
MX (1) MXPA03007309A (fr)
NO (1) NO329038B1 (fr)
NZ (1) NZ527695A (fr)
PL (1) PL365024A1 (fr)
PT (1) PT1368336E (fr)
SI (1) SI1368336T1 (fr)
SK (1) SK287304B6 (fr)
UA (1) UA75114C2 (fr)
WO (1) WO2002066456A2 (fr)
ZA (1) ZA200307201B (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6191165B1 (en) * 1996-05-31 2001-02-20 Allelix Neuroscience Inc. Pharmaceutical for treatment of neurological and neuropsychiatric disorders
PL1830833T3 (pl) * 2004-12-16 2010-06-30 Janssen Pharmaceutica Nv Połączenie inhibitora transportera glicyny (GLYT1) i środka przeciwpsychotycznego do leczenia objawów schizofrenii jak również sposoby jego wytwarzania oraz zastosowanie
US20090253918A1 (en) * 2006-10-02 2009-10-08 Janssen Pharmaceuticals, N.V. Novel intermediate for glyt1 inhibitor
WO2008065500A2 (fr) * 2006-11-30 2008-06-05 Pfizer Products Inc. Hétéroaryl amides comme inhibiteurs du transport de la glycine de type i
CN103374057B (zh) * 2012-04-16 2015-08-19 中国医药集团总公司四川抗菌素工业研究所 一种对甘氨酸转运子具有抑制活性的化合物

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3050800C2 (fr) 1979-03-22 1989-06-22 Continental Pharma Inc., Bruessel/Bruxelles, Be
BE885303A (fr) 1980-09-19 1981-03-19 Continental Pharma Glycinamides
AU552050B2 (en) 1981-05-26 1986-05-22 Smithkline Beckman Corporation N-substituted azeheterocyclic carboxylic acids and their esters
US4383999A (en) 1981-05-26 1983-05-17 Smithkline Beckman Corporation Inhibition of GABA uptake by N-substituted azaheterocyclic carboxylic acids and their esters
US4514414A (en) 1982-10-25 1985-04-30 Smithkline Beckman Corporation N-Substituted pyrrolidineacetic acids and their esters
DK288385D0 (da) 1985-06-26 1985-06-26 Novo Industri As Aminosyrederivater
US4772615A (en) 1985-11-08 1988-09-20 Warner-Lambert Company Various N-substituted 3-piperidine carboxylic acids or N-substituted 3-pyridinecarboxylic acids and derivatives thereof
FI864246A (fi) 1985-11-08 1987-05-09 Warner Lambert Co N-substituerade 3-piperidin- eller 3-pyridinkarboxylsyror samt deras derivat.
IL81179A (en) 1986-01-07 1992-02-16 Novo Nordisk As N-phenylbutenyl substituted azaheterocyclic carboxylic acids,their preparation and pharmaceutical compositions comprising them
JPH02129158A (ja) 1988-11-07 1990-05-17 Nippon Steel Corp 光学活性なグリシン誘導体及びその製造方法
IE913279A1 (en) * 1990-09-26 1992-04-08 Astra Ab (2-Thienyl)alkylamine Derivatives Having Neuroprotective¹Properties
ES2036926B1 (es) 1991-08-08 1994-01-16 Uriach & Cia Sa J "procedimiento para la obtencion de derivados de la (2-alquil-3-piridil)metilpiperazina".
WO1997020553A1 (fr) 1995-12-07 1997-06-12 Javitt Daniel C Traitement des symptomes negatifs et cognitifs de la schizophrenie par des antagonistes de l'assimilation de la glycine
US6191165B1 (en) 1996-05-31 2001-02-20 Allelix Neuroscience Inc. Pharmaceutical for treatment of neurological and neuropsychiatric disorders
ATE334668T1 (de) * 1996-05-31 2006-08-15 Allelix Neuroscience Inc Pharmazeutische zusammensetzung zur behandlung von neurologischen und neuropsychiatrischen erkrankungen
DE69734215T2 (de) * 1996-07-22 2006-06-29 Novo Nordisk A/S Verbindungen mit Wachstumshormon-freisetzenden Eigenschaften
EP1047665B1 (fr) * 1998-01-09 2003-10-22 Pfizer Limited Inhibiteurs de metalloproteases matricielles
US6103743A (en) * 1999-08-06 2000-08-15 Allelix Neuroscience, Inc. Unsaturated amino acid derivatives

Also Published As

Publication number Publication date
ZA200307201B (en) 2004-07-28
SK11442003A3 (sk) 2004-03-02
CY1105529T1 (el) 2010-07-28
NO20033634D0 (no) 2003-08-15
NO20033634L (no) 2003-10-08
DE60211866D1 (de) 2006-07-06
KR100900020B1 (ko) 2009-06-01
PL365024A1 (en) 2004-12-27
WO2002066456A2 (fr) 2002-08-29
US6667336B2 (en) 2003-12-23
EP1368336B9 (fr) 2007-02-14
EA200300900A1 (ru) 2004-02-26
AU2002235682C1 (en) 2008-12-11
ES2266446T3 (es) 2007-03-01
UA75114C2 (en) 2006-03-15
US20030176489A1 (en) 2003-09-18
EE05329B1 (et) 2010-08-16
NZ527695A (en) 2005-05-27
PT1368336E (pt) 2006-10-31
BG108164A (en) 2004-07-30
HUP0303185A3 (en) 2008-12-29
HRP20030696A2 (en) 2005-04-30
DE60211866T2 (de) 2007-06-14
CN1219776C (zh) 2005-09-21
CN1491221A (zh) 2004-04-21
CZ20032503A3 (cs) 2004-02-18
MXPA03007309A (es) 2004-06-30
ATE327986T1 (de) 2006-06-15
EA006636B1 (ru) 2006-02-24
HK1061025A1 (en) 2004-09-03
SI1368336T1 (sl) 2006-10-31
CA2438367A1 (fr) 2002-08-29
DK1368336T3 (da) 2006-10-02
NO329038B1 (no) 2010-08-02
EP1368336B1 (fr) 2006-05-31
BR0207307A (pt) 2004-08-17
EE200300394A (et) 2003-12-15
KR20040028719A (ko) 2004-04-03
JP2010059182A (ja) 2010-03-18
IL157194A (en) 2006-12-31
WO2002066456A3 (fr) 2002-10-17
EP1368336A2 (fr) 2003-12-10
JP2004523548A (ja) 2004-08-05
AU2002235682B2 (en) 2007-04-26
HUP0303185A2 (hu) 2003-12-29

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Legal Events

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MM4A Patent lapsed due to non-payment of maintenance fees

Effective date: 20100412