SK287216B6 - Hydrochloridová etanolová solvátová forma (-)-cis-2-(2- chlórfenyl)-5,7-dihydroxy-8[4R-(3S-hydroxy-1-metyl)piperidinyl]- 4H-1-benzopyran-4-ónu, spôsob jej prípravy, farmaceutická kompozícia, ktorá ju obsahuje, a jej použitie - Google Patents

Hydrochloridová etanolová solvátová forma (-)-cis-2-(2- chlórfenyl)-5,7-dihydroxy-8[4R-(3S-hydroxy-1-metyl)piperidinyl]- 4H-1-benzopyran-4-ónu, spôsob jej prípravy, farmaceutická kompozícia, ktorá ju obsahuje, a jej použitie Download PDF

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Publication number
SK287216B6
SK287216B6 SK1037-2002A SK10372002A SK287216B6 SK 287216 B6 SK287216 B6 SK 287216B6 SK 10372002 A SK10372002 A SK 10372002A SK 287216 B6 SK287216 B6 SK 287216B6
Authority
SK
Slovakia
Prior art keywords
hydroxy
methyl
chlorophenyl
benzopyran
piperidinyl
Prior art date
Application number
SK1037-2002A
Other languages
English (en)
Slovak (sk)
Other versions
SK10372002A3 (sk
Inventor
Kurt M. Kesseler
Original Assignee
Aventis Pharmaceuticals Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharmaceuticals Inc. filed Critical Aventis Pharmaceuticals Inc.
Publication of SK10372002A3 publication Critical patent/SK10372002A3/sk
Publication of SK287216B6 publication Critical patent/SK287216B6/sk

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/453—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
SK1037-2002A 2000-01-18 2001-01-08 Hydrochloridová etanolová solvátová forma (-)-cis-2-(2- chlórfenyl)-5,7-dihydroxy-8[4R-(3S-hydroxy-1-metyl)piperidinyl]- 4H-1-benzopyran-4-ónu, spôsob jej prípravy, farmaceutická kompozícia, ktorá ju obsahuje, a jej použitie SK287216B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48781500A 2000-01-18 2000-01-18
PCT/US2001/000520 WO2001053294A1 (en) 2000-01-18 2001-01-08 Ethanol solvate of (-)-cis-2-(2-chlorophenyl)-5,7-dihydroxy-8[4r-(3s-hydroxy-1-methyl)piperidinyl]-4h-1-benzopyran-4-one

Publications (2)

Publication Number Publication Date
SK10372002A3 SK10372002A3 (sk) 2002-12-03
SK287216B6 true SK287216B6 (sk) 2010-03-08

Family

ID=23937213

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1037-2002A SK287216B6 (sk) 2000-01-18 2001-01-08 Hydrochloridová etanolová solvátová forma (-)-cis-2-(2- chlórfenyl)-5,7-dihydroxy-8[4R-(3S-hydroxy-1-metyl)piperidinyl]- 4H-1-benzopyran-4-ónu, spôsob jej prípravy, farmaceutická kompozícia, ktorá ju obsahuje, a jej použitie

Country Status (26)

Country Link
EP (1) EP1252155B1 (ru)
JP (1) JP2003520798A (ru)
KR (1) KR100825530B1 (ru)
CN (1) CN1395577A (ru)
AR (1) AR027226A1 (ru)
AT (1) ATE284400T1 (ru)
AU (1) AU2001230869A1 (ru)
BR (1) BR0107724A (ru)
CA (1) CA2397594C (ru)
CZ (1) CZ301235B6 (ru)
DE (1) DE60107652T2 (ru)
DK (1) DK1252155T3 (ru)
EA (1) EA005182B1 (ru)
ES (1) ES2228800T3 (ru)
HU (1) HU225155B1 (ru)
IL (2) IL150643A0 (ru)
MX (1) MXPA02006965A (ru)
NO (1) NO322626B1 (ru)
NZ (1) NZ520281A (ru)
PL (1) PL201690B1 (ru)
PT (1) PT1252155E (ru)
SI (1) SI1252155T1 (ru)
SK (1) SK287216B6 (ru)
TW (1) TWI293072B (ru)
WO (1) WO2001053294A1 (ru)
ZA (1) ZA200205640B (ru)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL264950B2 (en) 2016-08-23 2024-01-01 Eisai R&D Man Co Ltd Combined treatments for the treatment of malignant liver cell carcinoma
IL269357B1 (en) 2017-03-16 2024-06-01 Eisai R&D Man Co Ltd A combination of Era inhibitors and a CDK4/6 inhibitor to be used in a method to treat breast cancer

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN164232B (ru) * 1986-04-11 1989-02-04 Hoechst India
DE3836676A1 (de) * 1988-10-28 1990-05-03 Hoechst Ag Die verwendung von 4h-1-benzopyran-4-on-derivaten, neue 4h-1-benzopyran-4-on-derivate und diese enthaltende arzneimittel
US5284856A (en) * 1988-10-28 1994-02-08 Hoechst Aktiengesellschaft Oncogene-encoded kinases inhibition using 4-H-1-benzopyran-4-one derivatives
US5908934A (en) * 1996-09-26 1999-06-01 Bristol-Myers Squibb Company Process for the preparation of chiral ketone intermediates useful for the preparation of flavopiridol and analogs

Also Published As

Publication number Publication date
KR100825530B1 (ko) 2008-04-25
WO2001053294A1 (en) 2001-07-26
NO20023385D0 (no) 2002-07-12
JP2003520798A (ja) 2003-07-08
ES2228800T3 (es) 2005-04-16
AU2001230869A1 (en) 2001-07-31
NO20023385L (no) 2002-08-27
EA200200776A1 (ru) 2002-12-26
PT1252155E (pt) 2005-04-29
CA2397594C (en) 2010-03-23
EP1252155B1 (en) 2004-12-08
EP1252155A1 (en) 2002-10-30
SK10372002A3 (sk) 2002-12-03
ZA200205640B (en) 2003-11-26
SI1252155T1 (en) 2005-06-30
PL355992A1 (en) 2004-05-31
TWI293072B (en) 2008-02-01
AR027226A1 (es) 2003-03-19
DE60107652T2 (de) 2005-12-22
HU225155B1 (en) 2006-07-28
HUP0204297A2 (hu) 2003-04-28
DK1252155T3 (da) 2005-04-04
IL150643A0 (en) 2003-02-12
CA2397594A1 (en) 2001-07-26
MXPA02006965A (es) 2004-09-06
HUP0204297A3 (en) 2005-04-28
IL150643A (en) 2009-08-03
NZ520281A (en) 2004-04-30
CZ301235B6 (cs) 2009-12-16
ATE284400T1 (de) 2004-12-15
BR0107724A (pt) 2002-10-01
NO322626B1 (no) 2006-11-06
PL201690B1 (pl) 2009-04-30
KR20020069514A (ko) 2002-09-04
CN1395577A (zh) 2003-02-05
CZ20022467A3 (cs) 2002-10-16
EA005182B1 (ru) 2004-12-30
DE60107652D1 (de) 2005-01-13

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Legal Events

Date Code Title Description
PC4A Assignment and transfer of rights

Owner name: AVENTIS HOLDINGS INC., GREENVILLE, DELAWARE, US

Free format text: FORMER OWNER: HMR PHARMA, INC., GREENVILLE, DELAWARE, US

Effective date: 20011228

Owner name: HMR PHARMA, INC., GREENVILLE, DELAWARE, US

Free format text: FORMER OWNER: AVENTIS PHARMACEUTICALS INC., BRIDGEWATER, NJ, US

Effective date: 20011228

PC4A Assignment and transfer of rights

Owner name: AVENTISUB II INC., GREENVILLE, DELAWARE, US

Free format text: FORMER OWNER: AVENTIS HOLDINGS INC., GREENVILLE, DELAWARE, US

Effective date: 20100303

MM4A Patent lapsed due to non-payment of maintenance fees

Effective date: 20140108