SK287113B6 - Substituovaný homopiperidylový analóg benzimidazolu, spôsob jeho prípravy, jeho použitie a farmaceutický prípravok s jeho obsahom - Google Patents

Substituovaný homopiperidylový analóg benzimidazolu, spôsob jeho prípravy, jeho použitie a farmaceutický prípravok s jeho obsahom Download PDF

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Publication number
SK287113B6
SK287113B6 SK854-2002A SK8542002A SK287113B6 SK 287113 B6 SK287113 B6 SK 287113B6 SK 8542002 A SK8542002 A SK 8542002A SK 287113 B6 SK287113 B6 SK 287113B6
Authority
SK
Slovakia
Prior art keywords
formula
group
alkyl
phenylmethyl
hydroxy
Prior art date
Application number
SK854-2002A
Other languages
English (en)
Slovak (sk)
Other versions
SK8542002A3 (en
Inventor
Frans Eduard Janssens
J�Rome Emile Georges Guillemont
Fran�Ois Maria Sommen
Original Assignee
Janssen Pharmaceutica N. V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N. V. filed Critical Janssen Pharmaceutica N. V.
Publication of SK8542002A3 publication Critical patent/SK8542002A3/sk
Publication of SK287113B6 publication Critical patent/SK287113B6/sk

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cosmetics (AREA)
SK854-2002A 1999-12-21 2000-12-14 Substituovaný homopiperidylový analóg benzimidazolu, spôsob jeho prípravy, jeho použitie a farmaceutický prípravok s jeho obsahom SK287113B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99204441 1999-12-21
PCT/EP2000/012858 WO2001046189A1 (en) 1999-12-21 2000-12-14 Substituted homopiperidinyl benzimidazole analogues as fundic relaxants

Publications (2)

Publication Number Publication Date
SK8542002A3 SK8542002A3 (en) 2003-07-01
SK287113B6 true SK287113B6 (sk) 2009-12-07

Family

ID=8241040

Family Applications (1)

Application Number Title Priority Date Filing Date
SK854-2002A SK287113B6 (sk) 1999-12-21 2000-12-14 Substituovaný homopiperidylový analóg benzimidazolu, spôsob jeho prípravy, jeho použitie a farmaceutický prípravok s jeho obsahom

Country Status (33)

Country Link
US (1) US7304052B2 (da)
EP (1) EP1250337B1 (da)
JP (1) JP4852210B2 (da)
KR (1) KR100715351B1 (da)
CN (1) CN100343251C (da)
AT (1) ATE416174T1 (da)
AU (1) AU781144B2 (da)
BG (1) BG65784B1 (da)
BR (1) BRPI0016638B8 (da)
CA (1) CA2393158C (da)
CY (1) CY1108844T1 (da)
CZ (1) CZ299803B6 (da)
DE (1) DE60041001D1 (da)
DK (1) DK1250337T3 (da)
EA (1) EA005851B1 (da)
EE (1) EE05182B1 (da)
ES (1) ES2317856T3 (da)
HK (1) HK1053109B (da)
HR (1) HRP20020518B1 (da)
HU (1) HU229929B1 (da)
IL (2) IL150310A0 (da)
MX (1) MXPA02006346A (da)
MY (1) MY127758A (da)
NO (1) NO322362B1 (da)
NZ (1) NZ518816A (da)
PL (1) PL199678B1 (da)
PT (1) PT1250337E (da)
SI (1) SI1250337T1 (da)
SK (1) SK287113B6 (da)
TW (1) TWI225488B (da)
UA (1) UA73963C2 (da)
WO (1) WO2001046189A1 (da)
ZA (1) ZA200204983B (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI225488B (en) 1999-12-21 2004-12-21 Janssen Pharmaceutica Nv Derivatives of homopiperidinyl substituted benzimidazole analogues
JO2352B1 (en) * 2000-06-22 2006-12-12 جانسين فارماسيوتيكا ان. في Compounds for the treatment of non-adaptation of the bottom of the uterus
JP2005532991A (ja) 2002-01-10 2005-11-04 ニューロジェン・コーポレーション メラニン凝集ホルモン受容体リガンド：置換２−（４−ベンジル−ピペラジン−１−イルメチル）−及び２−（４−ベンジル−ジアゼパン−１−イルメチル）−１ｈ−ベンゾイミダゾールアナログ
JPWO2005080348A1 (ja) * 2004-02-19 2007-08-02 萬有製薬株式会社 新規スルホンアミド誘導体
JP5437814B2 (ja) * 2007-01-25 2014-03-12 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ２−ピペラジン−１−イル−３Ｈ−イミダゾ［４，５−ｂ］ピリジン誘導体
SG10201505022WA (en) 2010-06-24 2015-07-30 Gilead Sciences Inc Pyrazolo [1, 5 -a] pyrimidines as antiviral agents
US20130303782A1 (en) * 2010-11-24 2013-11-14 Sequent Scientific Limited Process for preparation of albendazole
JP2014159375A (ja) * 2011-06-15 2014-09-04 Takeda Chem Ind Ltd アゼパン化合物
AU2012358805B2 (en) 2011-12-22 2017-07-20 Gilead Sciences, Inc. Pyrazolo[1,5-a]pyrimidines as antiviral agents
DK2838900T3 (da) 2012-04-17 2019-10-14 Gilead Sciences Inc Forbindelser og fremgangsmåder til antiviral behandling
WO2015091584A1 (en) * 2013-12-18 2015-06-25 F. Hoffmann-La Roche Ag Thiazolopyridine compounds, compositions and their use as tyk2 kinase inhibitors

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2060197C3 (de) 1970-12-08 1979-02-22 Bayer Ag, 5090 Leverkusen Verfahren zur Herstellung von 2-Aminobenzothiazol und dessen N-Alkylsubstitutionsprodukten
US4093726A (en) 1976-12-02 1978-06-06 Abbott Laboratories N-(2-benzimidazolyl)-piperazines
ES8101067A1 (es) * 1978-08-25 1980-12-01 Thomae Gmbh Dr K Procedimiento para la preparacion de nuevos bencimidazoles sustituidos en posicion 5 o 6 con un anillo de piridazinona
JPS5879983A (ja) 1981-11-06 1983-05-13 Kanebo Ltd 新規なベンズイミダゾ−ル誘導体、その製造法およびその医薬組成物
FR2528526A1 (fr) * 1982-06-09 1983-12-16 Sfr Sa Robinetterie Butee se fixant dans un alesage d'un dispositif
DE3224512A1 (de) * 1982-07-01 1984-01-05 Dr. Karl Thomae Gmbh, 7950 Biberach Neue imidazolderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel
PH23995A (en) * 1984-01-09 1990-02-09 Janssen Pharmaceutica Nv 4((bicycle heterocyclyl)-methyl and hetero)piperidines
DE3634066A1 (de) * 1986-10-07 1988-04-21 Boehringer Mannheim Gmbh Neue 5-alkylbenzimidazole, verfahren zu ihrer herstellung sowie arzneimittel
JPH0260197A (ja) * 1988-08-26 1990-02-28 Nec Corp パッケージ構造
FR2674856B1 (fr) * 1991-04-05 1993-07-30 Esteve Labor Dr Nouveaux antihistaminiques non sedatifs, derives de benzimidazole, leur procede de preparation et leur utilisation en tant que medicaments.
IL101851A (en) * 1991-06-13 1996-05-14 Janssen Pharmaceutica Nv History 01 -) 4 - Pipridinyl - and Pipridinylidene (- Imidazo] A-1,2 [Pirolo, Thiano or Purano (] 3,2 [Azpin, their preparation and pharmaceutical preparations containing them and composition
DE4237656A1 (de) * 1992-06-13 1993-12-16 Merck Patent Gmbh Benzimidazolderivate
WO1994001107A1 (en) * 1992-07-08 1994-01-20 Monsanto Company Benzimidazoles for alleviating stomach ulcers in swine
ES2048109B1 (es) * 1992-07-20 1994-12-16 Espanola Prod Quimicos Procedimiento de preparacion de nuevos derivados piperidicos del bencimidazol.
DE69525418T2 (de) * 1994-05-31 2002-10-17 Mitsui Chemicals Inc Benzimidazol-derivate
FR2766822B1 (fr) * 1997-07-30 2001-02-23 Adir Nouveaux derives de benzimidazole, de benzoxazole et de benzothiazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US6150379A (en) * 1997-11-26 2000-11-21 Axys Pharmaceuticals, Inc. Compounds and compositions as anticoagulants
TWI225488B (en) 1999-12-21 2004-12-21 Janssen Pharmaceutica Nv Derivatives of homopiperidinyl substituted benzimidazole analogues

Also Published As

Publication number Publication date
CA2393158A1 (en) 2001-06-28
TWI225488B (en) 2004-12-21
CZ20022055A3 (cs) 2003-06-18
EE200200326A (et) 2003-10-15
HK1053109B (zh) 2008-08-01
KR100715351B1 (ko) 2007-05-08
ES2317856T3 (es) 2009-05-01
EP1250337A1 (en) 2002-10-23
ATE416174T1 (de) 2008-12-15
BR0016638B1 (pt) 2013-02-05
CY1108844T1 (el) 2014-07-02
MXPA02006346A (es) 2002-12-13
PL199678B1 (pl) 2008-10-31
ZA200204983B (en) 2003-09-22
KR20020062643A (ko) 2002-07-26
CN100343251C (zh) 2007-10-17
HU229929B1 (en) 2015-01-28
AU781144B2 (en) 2005-05-05
HK1053109A1 (en) 2003-10-10
EA005851B1 (ru) 2005-06-30
US20030139393A1 (en) 2003-07-24
EA200200700A1 (ru) 2003-06-26
CA2393158C (en) 2010-10-19
BG106749A (en) 2003-01-31
EE05182B1 (et) 2009-06-15
US7304052B2 (en) 2007-12-04
DK1250337T3 (da) 2009-03-30
HUP0203847A2 (hu) 2003-03-28
IL150310A (en) 2008-07-08
BG65784B1 (bg) 2009-11-30
NO322362B1 (no) 2006-09-25
CZ299803B6 (cs) 2008-12-03
CN1411460A (zh) 2003-04-16
IL150310A0 (en) 2002-12-01
HUP0203847A3 (en) 2004-07-28
HRP20020518A2 (en) 2004-08-31
PL355442A1 (en) 2004-04-19
PT1250337E (pt) 2009-03-05
JP4852210B2 (ja) 2012-01-11
JP2003518118A (ja) 2003-06-03
BR0016638A (pt) 2002-10-01
UA73963C2 (uk) 2005-10-17
AU2167301A (en) 2001-07-03
SK8542002A3 (en) 2003-07-01
BRPI0016638B8 (pt) 2017-04-25
DE60041001D1 (de) 2009-01-15
EP1250337B1 (en) 2008-12-03
NO20022977D0 (no) 2002-06-20
NO20022977L (no) 2002-08-08
NZ518816A (en) 2003-01-31
WO2001046189A1 (en) 2001-06-28
SI1250337T1 (sl) 2009-04-30
MY127758A (en) 2006-12-29
HRP20020518B1 (en) 2009-02-28

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Legal Events

Date Code Title Description
MM4A Patent lapsed due to non-payment of maintenance fees

Effective date: 20181214