SK284994B6 - Deriváty 8-azabicyklo[3.2.1]okt-2-énu, spôsob ich prípravy a ich použitie - Google Patents
Deriváty 8-azabicyklo[3.2.1]okt-2-énu, spôsob ich prípravy a ich použitie Download PDFInfo
- Publication number
- SK284994B6 SK284994B6 SK1626-99A SK162699A SK284994B6 SK 284994 B6 SK284994 B6 SK 284994B6 SK 162699 A SK162699 A SK 162699A SK 284994 B6 SK284994 B6 SK 284994B6
- Authority
- SK
- Slovakia
- Prior art keywords
- azabicyclo
- oct
- ene
- methyl
- thienyl
- Prior art date
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- 238000002360 preparation method Methods 0.000 title claims abstract description 16
- SURHOQQBDZIWSO-UHFFFAOYSA-N 8-azabicyclo[3.2.1]oct-3-ene Chemical class N1C2CCC1C=CC2 SURHOQQBDZIWSO-UHFFFAOYSA-N 0.000 title claims description 6
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- 125000003682 3-furyl group Chemical group O1C([H])=C([*])C([H])=C1[H] 0.000 claims abstract description 9
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims abstract description 5
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- 125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 claims abstract description 3
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- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims abstract description 3
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Applications Claiming Priority (5)
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| DK62797 | 1997-05-30 | ||
| DK150297 | 1997-12-19 | ||
| DK40898 | 1998-03-24 | ||
| DK53498 | 1998-04-16 | ||
| PCT/DK1998/000225 WO1998054181A1 (en) | 1997-05-30 | 1998-05-29 | 8-azabicyclo(3,2,1)oct-2-ene and octane derivatives as cholinergic ligands at nicotinic ach receptors |
Publications (2)
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| SK162699A3 SK162699A3 (en) | 2000-07-11 |
| SK284994B6 true SK284994B6 (sk) | 2006-04-06 |
Family
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| SK1626-99A SK284994B6 (sk) | 1997-05-30 | 1998-05-29 | Deriváty 8-azabicyklo[3.2.1]okt-2-énu, spôsob ich prípravy a ich použitie |
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| AT (1) | ATE267199T1 (cs) |
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| BR (1) | BR9809697A (cs) |
| CA (1) | CA2289574C (cs) |
| CZ (1) | CZ298824B6 (cs) |
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| DK (1) | DK0984965T3 (cs) |
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| IL (2) | IL132437A0 (cs) |
| IS (1) | IS2092B (cs) |
| NO (1) | NO325513B1 (cs) |
| NZ (1) | NZ500642A (cs) |
| RU (1) | RU2186780C2 (cs) |
| SK (1) | SK284994B6 (cs) |
| TR (1) | TR199902942T2 (cs) |
| WO (1) | WO1998054181A1 (cs) |
Families Citing this family (53)
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| US6350758B1 (en) * | 1996-12-02 | 2002-02-26 | Georgetown University | Tropane derivatives and method for their synthesis |
| JP2002518331A (ja) | 1998-06-19 | 2002-06-25 | イーライ・リリー・アンド・カンパニー | セロトニン再取り込みの阻害 |
| US6218383B1 (en) * | 1998-08-07 | 2001-04-17 | Targacept, Inc. | Pharmaceutical compositions for the prevention and treatment of central nervous system disorders |
| JP2002531456A (ja) | 1998-11-27 | 2002-09-24 | ニューロサーチ、アクティーゼルスカブ | ８−アザビシクロ〔３．２．１〕オクト−２−エン及び−オクタン誘導体 |
| US6432975B1 (en) * | 1998-12-11 | 2002-08-13 | Targacept, Inc. | Pharmaceutical compositions and methods for use |
| US6953855B2 (en) | 1998-12-11 | 2005-10-11 | Targacept, Inc. | 3-substituted-2(arylalkyl)-1-azabicycloalkanes and methods of use thereof |
| ATE258176T1 (de) * | 1999-01-28 | 2004-02-15 | Neurosearch As | Neue azabicyclo derivate und ihre verwendung |
| IL144340A0 (en) * | 1999-01-29 | 2002-05-23 | Abbott Lab | Diazabicyclic derivatives as nicotinic acetylcholine receptor ligands |
| US7265115B2 (en) | 1999-01-29 | 2007-09-04 | Abbott Laboratories | Diazabicyclic CNS active agents |
| EP1177196B1 (en) | 1999-05-04 | 2004-03-10 | Neurosearch A/S | Heteroaryl diazabicycloalkanes, their preparation and use |
| US6890935B2 (en) | 1999-11-01 | 2005-05-10 | Targacept, Inc. | Pharmaceutical compositions and methods for use |
| MY145722A (en) * | 2000-04-27 | 2012-03-30 | Abbott Lab | Diazabicyclic central nervous system active agents |
| US7060699B2 (en) | 2000-07-04 | 2006-06-13 | Neurosearch A/S | Aryl and heteroaryl diazabicycloalkanes, their preparation and use |
| NZ524202A (en) * | 2000-10-13 | 2004-08-27 | Neurosearch As | Treatment of affective disorders by the combined action of a nicotinic receptor agonist and a monoaminergic substance |
| AP1635A (en) * | 2001-10-02 | 2006-07-14 | Upjohn Co | Azabicyclic-substituted fused-heteroaryl compounds for the treatment of disease. |
| DE10164139A1 (de) | 2001-12-27 | 2003-07-10 | Bayer Ag | 2-Heteroarylcarbonsäureamide |
| AU2003219690A1 (en) | 2002-02-19 | 2003-09-09 | Pharmacia And Upjohn Company | Fused bicyclic-n-bridged-heteroaromatic carboxamides for the treatment of disease |
| US7378526B2 (en) | 2002-05-07 | 2008-05-27 | Neurosearch A/S | Azacyclic ethynyl derivatives |
| GB2398636A (en) * | 2003-02-21 | 2004-08-25 | Ipsen Ltd | Method for determining the quantity of pre-synaptic neuromuscular blocking substance contained in a sample |
| ATE393766T1 (de) * | 2003-02-28 | 2008-05-15 | Schering Corp | Biaryltetrahydroisochinolin-piperidine als selektive mch-rezeptor-antagonisten zur behandlung von adipositas und verwandten erkrankungen |
| EP1608648B1 (en) | 2003-03-12 | 2012-07-18 | Pfizer Products Inc. | Pyridyloxymethyl and benzisoxazole azabicyclic derivatives |
| JP5254616B2 (ja) | 2004-09-13 | 2013-08-07 | クロノ セラピューティクス、インコーポレイテッド | 生物学的同調性（ｂｉｏｓｙｎｃｈｒｏｎｏｕｓ）経皮的薬物送達 |
| US20060173037A1 (en) * | 2005-01-10 | 2006-08-03 | Nathalie Schlienger | Aminophenyl derivatives as selective androgen receptor modulators |
| US7662812B2 (en) | 2005-02-16 | 2010-02-16 | Neurosearch A/S | Diazabicyclic aryl derivatives and their use as chinolinergic ligands at nicotinic acetylcholine receptors |
| DE102005007859A1 (de) * | 2005-02-21 | 2006-08-24 | Lts Lohmann Therapie-Systeme Ag | Vefahren für eine medikamentöse Kombinations-Behandlung, sowie hierfür geeignete Arzneimittel-Kombinationen |
| US20090030208A1 (en) * | 2005-04-08 | 2009-01-29 | Dan Peters | (+) - and (-) -8-Alkyl-3-(Trifluoralkylsulfonyloxy)-8-Azabicyclo(3.2.1.)Oct-2-Ene |
| FR2889701B1 (fr) | 2005-08-12 | 2007-10-05 | Sanofi Aventis Sa | Derives de 5-pyridinyl-1-azabicyclo[3.2.1]octane, leur preparation en therapeutique. |
| EP2246352A1 (en) | 2005-12-06 | 2010-11-03 | NeuroSearch AS | Novel diazabicyclic aryl derivatives and their medical use |
| US20070134169A1 (en) * | 2005-12-11 | 2007-06-14 | Rabinoff Michael D | Methods for smoking cessation or alcohol cessation or other addiction cessation |
| WO2007090887A1 (en) | 2006-02-10 | 2007-08-16 | Neurosearch A/S | 3, 9-diazabicyclo [3.3. 1]nonane derivatives and their use as monoamine?neurotransmitter re-uptake inhibitors |
| US7700596B2 (en) | 2006-02-10 | 2010-04-20 | Neurosearch A/S | 3,9-diazabicyclo[3.3.1]nonane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| CA2641685A1 (en) | 2006-02-10 | 2007-08-16 | Neurosearch A/S | 3-heteroaryl-3,9-diazabicyclo[3.3.1]nonane derivatives as nicotinic acetylcholine receptor agonists |
| BRPI0712843A2 (pt) * | 2006-06-12 | 2012-07-31 | Pfizer Prod Inc | antagonista de ccr5 e seus usos |
| EP2322167A1 (en) | 2007-04-02 | 2011-05-18 | Parkinson's Institute | Methods and Compositions for Reduction of Side Effects of Therapeutic Treatments |
| TWI415850B (zh) * | 2007-07-20 | 2013-11-21 | Theravance Inc | 製備ｍｕ類鴉片受體拮抗劑之中間物的方法 |
| SA08290475B1 (ar) | 2007-08-02 | 2013-06-22 | Targacept Inc | (2s، 3r)-n-(2-((3-بيردينيل)ميثيل)-1-آزا بيسيكلو[2، 2، 2]أوكت-3-يل)بنزو فيوران-2-كربوكساميد، وصور أملاحه الجديدة وطرق استخدامه |
| US8697722B2 (en) * | 2007-11-02 | 2014-04-15 | Sri International | Nicotinic acetylcholine receptor modulators |
| WO2010014257A2 (en) | 2008-08-01 | 2010-02-04 | Purdue Pharma L.P. | Tetrahydropyridinyl and dihydropyrrolyl compounds and the use thereof |
| US8633218B2 (en) * | 2008-11-18 | 2014-01-21 | Aniona Aps | 8-azabicyclo[3.2.1]oct-2-ene derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| PL2540297T3 (pl) | 2008-11-19 | 2015-12-31 | Forum Pharmaceuticals Inc | Leczenie zaburzeń funkcji poznawczych(R)-7-chloro-N-(chinuklidyn-3-ylo)benzo[b]tiofeno-2-karboksyamidem i jego farmaceutyczne dopuszczalnymi solami |
| TW201031664A (en) | 2009-01-26 | 2010-09-01 | Targacept Inc | Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide |
| CN102802620A (zh) * | 2009-05-11 | 2012-11-28 | 英维沃医药有限公司 | 使用某种α-7烟酸受体与乙酰胆碱酯酶抑制剂结合治疗认知障碍 |
| CN102905527B (zh) * | 2010-01-11 | 2016-08-24 | 阿斯特来亚治疗有限责任公司 | 烟碱型乙酰胆碱受体调节剂 |
| KR101698250B1 (ko) | 2010-05-17 | 2017-01-19 | 포럼 파마슈티칼즈 인크. | (R)-7-클로로-N-(퀴누클리딘-3-일)벤조[b]티오펜-2-카르복사미드 히드로클로리드 모노히드레이트의 결정질 형태 |
| RU2635522C2 (ru) | 2012-05-08 | 2017-11-13 | Форум Фармасьютикалз, Инк. | Способы поддержания, лечения или улучшения когнитивной функции |
| WO2014011768A1 (en) * | 2012-07-10 | 2014-01-16 | Adispell, Inc. | Anti-anxiety treatment |
| CA2974324A1 (en) | 2015-01-28 | 2016-08-04 | Zita S. Netzel | Drug delivery methods and systems |
| US9724340B2 (en) | 2015-07-31 | 2017-08-08 | Attenua, Inc. | Antitussive compositions and methods |
| CA3049529A1 (en) | 2017-01-06 | 2018-07-12 | Chrono Therapeutics Inc. | Transdermal drug delivery devices and methods |
| JP7420797B2 (ja) | 2018-05-29 | 2024-01-23 | モーニングサイド ベンチャー インベストメンツ リミテッド | 薬剤送達の方法及びシステム |
| EP3880175A4 (en) | 2018-11-16 | 2022-08-17 | Morningside Venture Investments Limited | TEMPERATURE-REGULATING TRANSDERMAL DRUG DELIVERY SYSTEM |
| KR102272452B1 (ko) | 2020-12-11 | 2021-07-05 | (주)예광솔라 | 스파이럴 파일 공법 및 이에 적용되는 스파이럴 파일 |
| KR200497569Y1 (ko) | 2021-02-18 | 2023-12-21 | 주식회사 알파인랩 | 지주 기초용 스크루 파일 |
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| US3133073A (en) * | 1959-12-10 | 1964-05-12 | Sterling Drug Inc | 3-aryl-1, 5-iminocycloalkanes and preparation thereof |
| US3657257A (en) * | 1970-08-31 | 1972-04-18 | Robins Co Inc A H | 3-aryl-8-carbamoyl nortropanes |
| CA1244028A (en) | 1983-04-14 | 1988-11-01 | Hans Maag | Pyrimidine derivatives |
| GB9019973D0 (en) | 1990-09-12 | 1990-10-24 | Wyeth John & Brother Ltd | Azabicyclic derivatives |
| US5045546A (en) | 1990-10-26 | 1991-09-03 | Hoechst-Roussel Pharmaceuticals Inc. | 8-azabicyclo[3.2.1]octylalkylthiazolidines |
| FI111367B (fi) | 1991-02-04 | 2003-07-15 | Aventis Pharma Inc | Menetelmä terapeuttisesti käyttökelpoisten N-(aryylioksialkyyli)heteroaryyli-8-atsabisyklo[3.2.1]oktaanijohdannaisten valmistamiseksi ja menetelmässä käytetyt välituotteet |
| WO1992021339A1 (en) * | 1991-05-29 | 1992-12-10 | Abbott Laboratories | Isoxazole and isothiazole compounds that enhance cognitive function |
| US5731317A (en) * | 1995-03-10 | 1998-03-24 | Merck & Co., Inc. | Bridged piperidines promote release of growth hormone |
| GB9507203D0 (en) * | 1995-04-07 | 1995-05-31 | Smithkline Beecham Plc | Novel compounds |
| JPH11512443A (ja) * | 1995-09-22 | 1999-10-26 | ノボ ノルディスク アクティーゼルスカブ | 新規な置換アザ環式またはアザ二環式化合物 |
| CZ285093B6 (cs) * | 1995-10-13 | 1999-05-12 | Neurosearch A/S | Deriváty 8-azabicyklo[3,2,1]okt-2-enu, způsob jejich přípravy a jejich použití |
| GB9706222D0 (en) * | 1997-03-26 | 1997-05-14 | Zeneca Ltd | Bicyclic amine derivatives |
| EP0955301A3 (en) | 1998-04-27 | 2001-04-18 | Pfizer Products Inc. | 7-aza-bicyclo[2.2.1]-heptane derivatives, their preparation and use according to their affinity for neuronal nicotinic acetylcholine receptors |
| JP2002518331A (ja) * | 1998-06-19 | 2002-06-25 | イーライ・リリー・アンド・カンパニー | セロトニン再取り込みの阻害 |
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- 1998-05-29 KR KR1019997011137A patent/KR100589872B1/ko not_active Expired - Fee Related
- 1998-05-29 TR TR1999/02942T patent/TR199902942T2/xx unknown
- 1998-05-29 NZ NZ500642A patent/NZ500642A/en unknown
- 1998-05-29 DK DK98921378T patent/DK0984965T3/da active
- 1998-05-29 WO PCT/DK1998/000225 patent/WO1998054181A1/en not_active Ceased
- 1998-05-29 AU AU74261/98A patent/AU745964B2/en not_active Ceased
- 1998-05-29 IL IL13243798A patent/IL132437A0/xx active IP Right Grant
- 1998-05-29 EP EP98921378A patent/EP0984965B1/en not_active Expired - Lifetime
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1999
- 1999-10-17 IL IL132437A patent/IL132437A/en not_active IP Right Cessation
- 1999-11-10 IS IS5243A patent/IS2092B/is unknown
- 1999-11-29 NO NO19995850A patent/NO325513B1/no not_active IP Right Cessation
- 1999-11-29 US US09/450,637 patent/US6645977B1/en not_active Expired - Fee Related
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2003
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Patent lapsed due to non-payment of maintenance fees |
Effective date: 20110529 |