SK284127B6 - Cyklické deriváty amidov acylaminokyselín substituované tioskupinou a spôsob ich prípravy - Google Patents
Cyklické deriváty amidov acylaminokyselín substituované tioskupinou a spôsob ich prípravy Download PDFInfo
- Publication number
- SK284127B6 SK284127B6 SK1275-99A SK127599A SK284127B6 SK 284127 B6 SK284127 B6 SK 284127B6 SK 127599 A SK127599 A SK 127599A SK 284127 B6 SK284127 B6 SK 284127B6
- Authority
- SK
- Slovakia
- Prior art keywords
- group
- lower alkyl
- formula
- aryl
- acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/20—Esters of monothiocarboxylic acids
- C07C327/32—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3984597P | 1997-03-20 | 1997-03-20 | |
PCT/EP1998/001584 WO1998042662A1 (fr) | 1997-03-20 | 1998-03-18 | Certains derives cycliques d'amide acylaminoacide a substitution thio |
Publications (2)
Publication Number | Publication Date |
---|---|
SK127599A3 SK127599A3 (en) | 2000-03-13 |
SK284127B6 true SK284127B6 (sk) | 2004-09-08 |
Family
ID=21907632
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SK1275-99A SK284127B6 (sk) | 1997-03-20 | 1998-03-18 | Cyklické deriváty amidov acylaminokyselín substituované tioskupinou a spôsob ich prípravy |
Country Status (24)
Country | Link |
---|---|
US (2) | US6034136A (fr) |
EP (1) | EP0966439B1 (fr) |
JP (1) | JP4275743B2 (fr) |
KR (1) | KR20000076428A (fr) |
CN (1) | CN1264817C (fr) |
AT (1) | ATE242209T1 (fr) |
AU (1) | AU734967B2 (fr) |
BR (1) | BR9808030A (fr) |
CA (1) | CA2283643C (fr) |
CZ (1) | CZ293706B6 (fr) |
DE (1) | DE69815307T2 (fr) |
DK (1) | DK0966439T3 (fr) |
ES (1) | ES2201480T3 (fr) |
HU (1) | HU226645B1 (fr) |
ID (1) | ID23808A (fr) |
IL (1) | IL131752A (fr) |
NO (1) | NO314079B1 (fr) |
NZ (1) | NZ337558A (fr) |
PL (1) | PL195389B1 (fr) |
PT (1) | PT966439E (fr) |
RU (1) | RU2193556C2 (fr) |
SK (1) | SK284127B6 (fr) |
TR (1) | TR199902303T2 (fr) |
WO (1) | WO1998042662A1 (fr) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6262277B1 (en) * | 1994-09-13 | 2001-07-17 | G.D. Searle And Company | Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
US6329372B1 (en) | 1998-01-27 | 2001-12-11 | Celltech Therapeutics Limited | Phenylalanine derivatives |
ES2226413T3 (es) | 1998-02-26 | 2005-03-16 | Celltech Therapeutics Limited | Derivados de fenilalanina como inhibidores de alfa-4 integrinas. |
GB9805655D0 (en) | 1998-03-16 | 1998-05-13 | Celltech Therapeutics Ltd | Chemical compounds |
US6521626B1 (en) | 1998-03-24 | 2003-02-18 | Celltech R&D Limited | Thiocarboxamide derivatives |
GB9811159D0 (en) | 1998-05-22 | 1998-07-22 | Celltech Therapeutics Ltd | Chemical compounds |
GB9811969D0 (en) * | 1998-06-03 | 1998-07-29 | Celltech Therapeutics Ltd | Chemical compounds |
GB9812088D0 (en) | 1998-06-05 | 1998-08-05 | Celltech Therapeutics Ltd | Chemical compounds |
GB9814414D0 (en) | 1998-07-03 | 1998-09-02 | Celltech Therapeutics Ltd | Chemical compounds |
GB9821061D0 (en) | 1998-09-28 | 1998-11-18 | Celltech Therapeutics Ltd | Chemical compounds |
GB9821222D0 (en) | 1998-09-30 | 1998-11-25 | Celltech Therapeutics Ltd | Chemical compounds |
GB9825652D0 (en) | 1998-11-23 | 1999-01-13 | Celltech Therapeutics Ltd | Chemical compounds |
GB9826174D0 (en) | 1998-11-30 | 1999-01-20 | Celltech Therapeutics Ltd | Chemical compounds |
US20040122011A1 (en) * | 1998-12-23 | 2004-06-24 | Pharmacia Corporation | Method of using a COX-2 inhibitor and a TACE inhibitors as a combination therapy |
US6518283B1 (en) | 1999-05-28 | 2003-02-11 | Celltech R&D Limited | Squaric acid derivatives |
US6534513B1 (en) | 1999-09-29 | 2003-03-18 | Celltech R&D Limited | Phenylalkanoic acid derivatives |
US6455539B2 (en) | 1999-12-23 | 2002-09-24 | Celltech R&D Limited | Squaric acid derivates |
WO2001079173A2 (fr) | 2000-04-17 | 2001-10-25 | Celltech R & D Limited | Derives de l'enamine |
US6403608B1 (en) | 2000-05-30 | 2002-06-11 | Celltech R&D, Ltd. | 3-Substituted isoquinolin-1-yl derivatives |
US6545013B2 (en) | 2000-05-30 | 2003-04-08 | Celltech R&D Limited | 2,7-naphthyridine derivatives |
EP1301488A1 (fr) | 2000-07-07 | 2003-04-16 | Celltech R&D Limited | Derives d'acide squarique contenant un noyau heteroaromatique bicyclique comme antagonistes d'integrine |
AU2001275724A1 (en) | 2000-08-02 | 2002-02-13 | Celltech R&D Limited | 3-substituted isoquinolin-1-yl derivatives |
DE60120104T2 (de) * | 2001-03-20 | 2006-09-21 | Schwarz Pharma Ag | Neue Verwendung von Peptidverbindungen bei der Behandlung von nicht-neuropathischem Entzündungsschmerz |
WO2004056353A2 (fr) * | 2002-12-20 | 2004-07-08 | Novartis Ag | Dispositif et procede permettant d'administrer des inhibiteurs de mmp |
ATE509956T1 (de) * | 2006-06-08 | 2011-06-15 | Helmholtz Zentrum Muenchen | Spezifische proteaseinhibitoren und ihre verwendung in der krebstherapie |
WO2009070497A1 (fr) * | 2007-11-28 | 2009-06-04 | Smithkline Beecham Corporation | Inhibiteurs de ehs et de 11β-hsd1 et leur utilisation |
WO2019210160A1 (fr) * | 2018-04-26 | 2019-10-31 | Brandeis University | Composés antibactériens, compositions et utilisations associées |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4595700A (en) * | 1984-12-21 | 1986-06-17 | G. D. Searle & Co. | Thiol based collagenase inhibitors |
GB8729804D0 (en) * | 1987-12-22 | 1988-02-03 | Beecham Group Plc | Novel compounds |
US5407960A (en) * | 1989-12-22 | 1995-04-18 | Schering Corporation | Mercaptocycloacyl aminoacid endopeptidase inhibitors |
JPH0592948A (ja) * | 1991-02-06 | 1993-04-16 | Yoshitomi Pharmaceut Ind Ltd | プロピオン酸アミド誘導体およびその医薬用途 |
UA48121C2 (uk) * | 1993-11-04 | 2002-08-15 | Сінтекс (С.Ш.А.) Інк. | Інгібітори матричних металопротеаз і фармацетична композиція на їх основі |
GB9323165D0 (en) * | 1993-11-10 | 1994-01-05 | Chiros Ltd | Compounds |
US5432186A (en) * | 1993-11-16 | 1995-07-11 | Ciba-Geigy Corporation | Cyclic amino acid derivatives |
MX9702487A (es) * | 1994-10-05 | 1998-04-30 | Darwin Discovery Ltd | Compuestos peptidilo y su uso terapeutico como inhibidores de las metaloproteasas. |
US5831004A (en) * | 1994-10-27 | 1998-11-03 | Affymax Technologies N.V. | Inhibitors of metalloproteases, pharmaceutical compositions comprising same and methods of their use |
-
1998
- 1998-03-17 US US09/040,093 patent/US6034136A/en not_active Expired - Fee Related
- 1998-03-18 BR BR9808030-0A patent/BR9808030A/pt not_active IP Right Cessation
- 1998-03-18 JP JP54484598A patent/JP4275743B2/ja not_active Expired - Fee Related
- 1998-03-18 SK SK1275-99A patent/SK284127B6/sk not_active IP Right Cessation
- 1998-03-18 CA CA002283643A patent/CA2283643C/fr not_active Expired - Fee Related
- 1998-03-18 AT AT98917000T patent/ATE242209T1/de not_active IP Right Cessation
- 1998-03-18 RU RU99121844/04A patent/RU2193556C2/ru active
- 1998-03-18 PL PL98335607A patent/PL195389B1/pl not_active IP Right Cessation
- 1998-03-18 EP EP98917000A patent/EP0966439B1/fr not_active Expired - Lifetime
- 1998-03-18 WO PCT/EP1998/001584 patent/WO1998042662A1/fr not_active Application Discontinuation
- 1998-03-18 KR KR1019997008532A patent/KR20000076428A/ko not_active Application Discontinuation
- 1998-03-18 DE DE69815307T patent/DE69815307T2/de not_active Expired - Fee Related
- 1998-03-18 IL IL13175298A patent/IL131752A/en not_active IP Right Cessation
- 1998-03-18 ES ES98917000T patent/ES2201480T3/es not_active Expired - Lifetime
- 1998-03-18 NZ NZ337558A patent/NZ337558A/en unknown
- 1998-03-18 CZ CZ19993325A patent/CZ293706B6/cs not_active IP Right Cessation
- 1998-03-18 CN CNB988034859A patent/CN1264817C/zh not_active Expired - Fee Related
- 1998-03-18 PT PT98917000T patent/PT966439E/pt unknown
- 1998-03-18 HU HU0002122A patent/HU226645B1/hu not_active IP Right Cessation
- 1998-03-18 ID IDW991045A patent/ID23808A/id unknown
- 1998-03-18 AU AU70372/98A patent/AU734967B2/en not_active Ceased
- 1998-03-18 DK DK98917000T patent/DK0966439T3/da active
- 1998-03-18 TR TR1999/02303T patent/TR199902303T2/xx unknown
-
1999
- 1999-09-16 NO NO19994482A patent/NO314079B1/no not_active IP Right Cessation
- 1999-11-08 US US09/435,550 patent/US6201133B1/en not_active Expired - Fee Related
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Patent lapsed due to non-payment of maintenance fees |
Effective date: 20100318 |