CA2335876A1 - Inhibiteurs de proteases - Google Patents
Inhibiteurs de proteases Download PDFInfo
- Publication number
- CA2335876A1 CA2335876A1 CA002335876A CA2335876A CA2335876A1 CA 2335876 A1 CA2335876 A1 CA 2335876A1 CA 002335876 A CA002335876 A CA 002335876A CA 2335876 A CA2335876 A CA 2335876A CA 2335876 A1 CA2335876 A1 CA 2335876A1
- Authority
- CA
- Canada
- Prior art keywords
- ylcarbonyl
- thiazol
- hydrazide
- methylpropyl
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Rheumatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Engineering & Computer Science (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Furan Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
L'invention porte sur des composés de diacylhydrazine et leurs sels, hydrates et solvates pharmacocompatibles inhibant les protéases, y compris la cathépsine K, sur des préparations pharmaceutiques contenant ces composés, sur de nouveaux intermédiaires de ces composés, sur des procédés de traitement des pertes osseuses excessives, ou la dégradation des matrices ou cartilages dont l'ostéoporose, les maladies gingivales dont la gingivite et la périodontite, l'arthrite et plus spécialement l'ostéoarthrite et l'arthrite chronique, la maladie de Piaget, l'hypercalcémie maligne, les troubles du métabolisme de l'os, consistant à inhiber lesdites pertes osseuses excessives, ou la dégradation des matrices ou cartilages par administration à un patient le nécessitant un des composés de la présente invention.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US9049398P | 1998-06-24 | 1998-06-24 | |
US60/090,493 | 1998-06-24 | ||
PCT/US1999/014561 WO1999066925A1 (fr) | 1998-06-24 | 1999-06-24 | Inhibiteurs de proteases |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2335876A1 true CA2335876A1 (fr) | 1999-12-29 |
Family
ID=22223011
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002335876A Abandoned CA2335876A1 (fr) | 1998-06-24 | 1999-06-24 | Inhibiteurs de proteases |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP1093367A4 (fr) |
JP (1) | JP2002518444A (fr) |
AR (1) | AR018915A1 (fr) |
AU (1) | AU4723799A (fr) |
CA (1) | CA2335876A1 (fr) |
WO (1) | WO1999066925A1 (fr) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030144175A1 (en) | 1998-12-23 | 2003-07-31 | Smithkline Beecham Corporation | Protease inhibitors |
WO2001034599A1 (fr) | 1999-11-10 | 2001-05-17 | Smithkline Beecham Corporation | Inhibiteurs de protease |
EP1229914A4 (fr) | 1999-11-10 | 2004-06-23 | Smithkline Beecham Corp | Inhibiteurs de protease |
EP1232154A4 (fr) | 1999-11-10 | 2004-06-23 | Smithkline Beecham Corp | Inhibiteurs de protease |
AU4344101A (en) | 2000-03-21 | 2001-10-03 | Smithkline Beecham Corp | Protease inhibitors |
US7282512B2 (en) | 2002-01-17 | 2007-10-16 | Smithkline Beecham Corporation | Cycloalkyl ketoamides derivatives useful as cathepsin K inhibitors |
US7176310B1 (en) | 2002-04-09 | 2007-02-13 | Ucb Sa | Pyrimidinecarboxamide derivatives and their use as anti-inflammatory agents |
US6933308B2 (en) | 2002-12-20 | 2005-08-23 | Bristol-Myers Squibb Company | Aminoalkyl thiazole derivatives as KCNQ modulators |
US7273866B2 (en) | 2002-12-20 | 2007-09-25 | Bristol-Myers Squibb Company | 2-aryl thiazole derivatives as KCNQ modulators |
AU2004289305A1 (en) * | 2003-11-10 | 2005-05-26 | Synta Pharmaceuticals, Corp. | Heteroaryl-Hydrazone compounds |
MY147780A (en) * | 2006-12-29 | 2013-01-31 | Abbvie Deutschland | Carboxamide compounds and their use as calpain inhibitors |
TWI453019B (zh) * | 2007-12-28 | 2014-09-21 | Abbvie Deutschland | 甲醯胺化合物 |
CN102408387A (zh) * | 2010-09-26 | 2012-04-11 | 韩南银 | 一种具有抗肿瘤作用的金属络合物 |
EA201590197A1 (ru) * | 2012-08-23 | 2015-07-30 | Алиос Биофарма, Инк. | Соединения для лечения парамиксовирусных вирусных инфекций |
CN103113300A (zh) * | 2013-03-06 | 2013-05-22 | 广西中医药大学 | 一种具有抗肿瘤活性的化合物的制备方法和用途 |
WO2014179943A1 (fr) * | 2013-05-08 | 2014-11-13 | Yang Yongliang | Composé amide maléique, son procédé de préparation et application associée |
CN103242321A (zh) * | 2013-05-21 | 2013-08-14 | 苏州科捷生物医药有限公司 | 苄基哌嗪类化合物及其抗肿瘤用途 |
SG11201600977XA (en) | 2013-08-21 | 2016-03-30 | Alios Biopharma Inc | Antiviral compounds |
CN103880701B (zh) * | 2014-03-14 | 2016-04-13 | 浙江工业大学 | O-肉桂酰-氟苯水杨酰胺类化合物及其在制备抗人宫颈鳞状癌药物中的应用 |
CN103880703B (zh) * | 2014-03-14 | 2016-04-13 | 浙江工业大学 | O-肉桂酰-氟苯水杨酰胺类化合物及其在制备抗人胎盘绒毛癌药物中的应用 |
CN103880702B (zh) * | 2014-03-14 | 2016-04-13 | 浙江工业大学 | O-肉桂酰-氟苯水杨酰胺类化合物及其在制备抗白血病药物中的应用 |
MA41614A (fr) | 2015-02-25 | 2018-01-02 | Alios Biopharma Inc | Composés antiviraux |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AP9801222A0 (en) * | 1995-10-30 | 1998-06-30 | Smithkline Beecham Corp | Proatease inhibitors. |
-
1999
- 1999-06-22 AR ARP990102984A patent/AR018915A1/es unknown
- 1999-06-24 WO PCT/US1999/014561 patent/WO1999066925A1/fr not_active Application Discontinuation
- 1999-06-24 JP JP2000555611A patent/JP2002518444A/ja not_active Withdrawn
- 1999-06-24 EP EP99930779A patent/EP1093367A4/fr not_active Withdrawn
- 1999-06-24 CA CA002335876A patent/CA2335876A1/fr not_active Abandoned
- 1999-06-24 AU AU47237/99A patent/AU4723799A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP1093367A4 (fr) | 2003-03-05 |
WO1999066925A1 (fr) | 1999-12-29 |
EP1093367A1 (fr) | 2001-04-25 |
AU4723799A (en) | 2000-01-10 |
AR018915A1 (es) | 2001-12-12 |
JP2002518444A (ja) | 2002-06-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2335876A1 (fr) | Inhibiteurs de proteases | |
US6369077B1 (en) | Protease inhibitors | |
US6331542B1 (en) | Protease inhibitors | |
EP1019046A1 (fr) | Inhibiteurs de proteases | |
AU734302B2 (en) | Protease inhibitors | |
CA2327282A1 (fr) | Traitement de maladies parasitaires par l'inhibition des cysteine-proteases de la superfamille de la papaine | |
US6518267B1 (en) | Protease inhibitors | |
WO1998008802A1 (fr) | Inhibiteurs de cysteine protease | |
CA2287567A1 (fr) | Inhibiteurs de proteases | |
CA2332492A1 (fr) | Inhibiteurs de la protease | |
US20020049316A1 (en) | Protease inhibitors | |
EP1153022A1 (fr) | Inhibiteurs de protease | |
JP2001514257A (ja) | プロテアーゼ阻害剤 | |
JP2002533452A (ja) | プロテアーゼ阻害剤 | |
JP2002540199A (ja) | プロテアーゼ阻害剤 | |
CA2285601A1 (fr) | Inhibiteurs de proteases | |
US20020173469A1 (en) | Protease inhibitors | |
US20020165222A1 (en) | Protease inhibitors | |
CZ380999A3 (cs) | Inhibitory proteáz | |
CZ393499A3 (cs) | Inhibitory proteasy | |
MXPA99009976A (en) | Protease inhibitors | |
AU2260400A (en) | Protease inhibitors - IV | |
AU2260500A (en) | Protease inhibitors - III | |
AU2260300A (en) | Protease inhibitors - II |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Dead |