CA2285601A1 - Inhibiteurs de proteases - Google Patents
Inhibiteurs de proteases Download PDFInfo
- Publication number
- CA2285601A1 CA2285601A1 CA002285601A CA2285601A CA2285601A1 CA 2285601 A1 CA2285601 A1 CA 2285601A1 CA 002285601 A CA002285601 A CA 002285601A CA 2285601 A CA2285601 A CA 2285601A CA 2285601 A1 CA2285601 A1 CA 2285601A1
- Authority
- CA
- Canada
- Prior art keywords
- 6alkyl
- pyrrolidin
- benzyloxycarbonylamino
- compound according
- tert
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Education & Sports Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Cette invention se rapporte à des composés représentés par la formule (I) dans laquelle X, Y et Z sont indépendamment N, O, S ou CR', à condition qu'au moins deux des éléments que sont X, Y et Z soient des hétéroatomes et qu'au moins l'un d'entre eux soit N; ou bien l'un des éléments que sont X, Y et Z est C=N, C=C ou N=N et les deux autres sont CR' ou N, à condition que X, Y et Z comportent dans leur ensemble au moins deux N; <u>- - -</u> indique une liaison simple ou double; R<1> est R", R"C(O), R"C(S), R"SO2, R"OC(O) ou R"OC(O)NR'CH(R<6>)C(O); R<2> est H, alkyle C1-6, alkényle C2-6, Ar-alkyle C0-6 ou Het-alkyle C0-6; R<3> est H, alkyle C1-6, alkényle C2-6, alkynyle C2-6, cycloalkyle C3-6- alkyle C0-6, Ar-alkyle C0-6 ou Het-alkyle C0-6; R<4> est H, alkyle C1-6, alkényle C2-6, Ar-alkyle C0-6 ou Het-alkyle C0-6; R<5> est alkyle C1-6, Ar-alkyle C0-6, Het-alkyle C0-6, CH(R<6>)NR'R<7>, CH(R<6>)Ar, CH(R<6>)OAr ou NR<8>R<9>; R6, R7, R8 et R9 étant définis dans les spécifications de l'invention; R<10> est H, alkyle C1-6, alkényle C2-6, alkynyle C2-6, cycloalkyle C3-6- alkyle C0-6, Ar-alkyle C0-6 ou Het-alkyle C0-6; et n est égal à 1, 2 ou 3. L'invention se rapporte également à des sels pharmaceutiquement acceptables de ces composés, qui sont des inhibiteurs de cystéine protéases, et notamment de la cathepsine K, et s'avèrent utiles au traitement de maladies dans lesquelles l'inhibition de la déperdition osseuse joue un rôle.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4309697P | 1997-04-15 | 1997-04-15 | |
US4453197P | 1997-04-23 | 1997-04-23 | |
US60/044,531 | 1997-04-23 | ||
US60/043,096 | 1997-04-23 | ||
PCT/US1998/007969 WO1998046582A1 (fr) | 1997-04-15 | 1998-04-15 | Inhibiteurs de proteases |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2285601A1 true CA2285601A1 (fr) | 1998-10-22 |
Family
ID=26720044
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002285601A Abandoned CA2285601A1 (fr) | 1997-04-15 | 1998-04-15 | Inhibiteurs de proteases |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0975612A4 (fr) |
JP (1) | JP2002515902A (fr) |
AR (1) | AR012374A1 (fr) |
AU (1) | AU7252398A (fr) |
CA (1) | CA2285601A1 (fr) |
CO (1) | CO4950541A1 (fr) |
WO (1) | WO1998046582A1 (fr) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000078747A1 (fr) * | 1999-06-22 | 2000-12-28 | Takeda Chemical Industries, Ltd. | Derives acylhydrazine, procede d'elaboration et utilisation |
CA2404206A1 (fr) | 2000-03-21 | 2001-09-27 | Smithkline Beecham Corporation | Inhibiteur de proteinase |
HN2002000136A (es) | 2001-06-11 | 2003-07-31 | Basf Ag | Inhibidores de la proteasa del virus hiv, compuestos que contienen a los mismos, sus usos farmaceuticos y los materiales para su sintesis |
EP1465862A1 (fr) | 2002-01-17 | 2004-10-13 | SmithKline Beecham Corporation | Derives de cetoamides a substitution cycloalkyle, utiles comme inhibiteurs de cathepsine k |
EP2714667B1 (fr) * | 2011-05-27 | 2020-11-25 | Laxman S. DESAI | Inhibiteurs d'aminooxazole de kinases dépendantes d'une cycline |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0755937B2 (ja) * | 1986-07-29 | 1995-06-14 | 日本曹達株式会社 | オキサ(チア)ゾリジン誘導体その製造方法及び殺ダニ剤 |
US5244867A (en) * | 1989-09-26 | 1993-09-14 | Basf Aktiengesellschaft | Oxazole- and thiazolecarboxamides |
US5618792A (en) * | 1994-11-21 | 1997-04-08 | Cortech, Inc. | Substituted heterocyclic compounds useful as inhibitors of (serine proteases) human neutrophil elastase |
-
1998
- 1998-04-08 AR ARP980101627A patent/AR012374A1/es unknown
- 1998-04-15 AU AU72523/98A patent/AU7252398A/en not_active Abandoned
- 1998-04-15 WO PCT/US1998/007969 patent/WO1998046582A1/fr not_active Application Discontinuation
- 1998-04-15 JP JP54437598A patent/JP2002515902A/ja active Pending
- 1998-04-15 CA CA002285601A patent/CA2285601A1/fr not_active Abandoned
- 1998-04-15 EP EP98919821A patent/EP0975612A4/fr not_active Withdrawn
- 1998-04-15 CO CO98020566A patent/CO4950541A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
AU7252398A (en) | 1998-11-11 |
EP0975612A1 (fr) | 2000-02-02 |
WO1998046582A1 (fr) | 1998-10-22 |
AR012374A1 (es) | 2000-10-18 |
EP0975612A4 (fr) | 2001-06-13 |
JP2002515902A (ja) | 2002-05-28 |
CO4950541A1 (es) | 2000-09-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Dead |