CO4950541A1 - Inhibidores de proteasas - Google Patents

Inhibidores de proteasas

Info

Publication number
CO4950541A1
CO4950541A1 CO98020566A CO98020566A CO4950541A1 CO 4950541 A1 CO4950541 A1 CO 4950541A1 CO 98020566 A CO98020566 A CO 98020566A CO 98020566 A CO98020566 A CO 98020566A CO 4950541 A1 CO4950541 A1 CO 4950541A1
Authority
CO
Colombia
Prior art keywords
alkyl
het
alkenyl
cycloalkyl
alkoxy
Prior art date
Application number
CO98020566A
Other languages
English (en)
Inventor
Kevin J Duffy
Scott K Thompson
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of CO4950541A1 publication Critical patent/CO4950541A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Un compuesto de acuerdo con la fórmula (I):en la cual: X, Y y Z son independientemente N, O, S o CR´, con la condición de que al menos dos de X, Y y Z son heteroátomos y al menos uno de X, Y y Z es N; o uno de X, Y y Z es C=N, C=C o N=N y los otros dos son CR´ o N, con la condición de que X, Y y Z juntos comprenden al menos dos N; --- indica un enlace simple o doble; R1 es R", R"C(O), R"C(S), R"SO2 , R"OC(O), o R"OC(O)NR´CH(R6 )C(O); R2 es H, alquilo C1-6 , alquenilo C2-6 , Ar-alquilo CO-6 , o Het-alquilo C0-6 ; R3 es H, alquilo C1-6 , alquenilo C2-6 , alquinilo C2-6 , cicloalquil C3-6 -alquilo C0-6 , Ar-alquilo C0-6 , o Het-alquilo C0-6 ; R4 es H, alquilo C1-6 , alquenilo C2-6 , Ar-alquilo C0-6 , o Het-alquilo C0-6 ;R5 es alquilo C1-6 , Ar-alquilo C0-6 , Het-alquilo C0-6 , CH(R6 )NR´R7 , CH(R6 )Ar, CH(R6 )OAr o NR8 R9 ; cada R6 es independientemente H, alquilo C1-6 , alquenilo C2-6 , cicloalquil C3-6 -alquilo C0-6 , Ar-alquilo C0-6 , Het-alquilo C0-6 ; R7 es R", R"C(O), R"C(S), R"SO2 , R"OC(O), o R"OC(O)NR´CH(R6 )C(O); R8 es H, alquilo C1-6 , alquenilo C2-6 , cicloalquil C3-6 -alquilo C0-6 , Ar-alquilo C0-6 , o Het-alquilo C0-6 , y R9 es alquilo C1-6 , cicloalquil C3-6 -alquilo C0-6 , Ar-alquilo C0-6 , o Het-alquilo C0-6 ; o R8 y R9 se combinan para formar un anillo carbocíclico o heterocíclico monocíclico de 3-7 miembros o bicíclico de 7-10 miembros, sustituido opcionalmente con 1-4 de alquilo C1-6 , Ar-alquilo C0-6 , Het-alquilo C0-6 , alcoxi C1-6 , Ar-alcoxi C0-6 , Het-alcoxi C0-6 , OH, (CH2 )1-6 NR´R", u O(CH2 )1-6 NR´R" ; ...
CO98020566A 1997-04-15 1998-04-15 Inhibidores de proteasas CO4950541A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4309697P 1997-04-15 1997-04-15
US4453197P 1997-04-23 1997-04-23

Publications (1)

Publication Number Publication Date
CO4950541A1 true CO4950541A1 (es) 2000-09-01

Family

ID=26720044

Family Applications (1)

Application Number Title Priority Date Filing Date
CO98020566A CO4950541A1 (es) 1997-04-15 1998-04-15 Inhibidores de proteasas

Country Status (7)

Country Link
EP (1) EP0975612A4 (es)
JP (1) JP2002515902A (es)
AR (1) AR012374A1 (es)
AU (1) AU7252398A (es)
CA (1) CA2285601A1 (es)
CO (1) CO4950541A1 (es)
WO (1) WO1998046582A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2383492A1 (en) 1999-06-22 2000-12-28 Takeda Chemical Industries, Ltd. Acylhydrazine derivatives, their production and use
EA005893B1 (ru) 2000-03-21 2005-06-30 Смитклайн Бичам Корпорейшн Ингибиторы протеаз
HN2002000136A (es) 2001-06-11 2003-07-31 Basf Ag Inhibidores de la proteasa del virus hiv, compuestos que contienen a los mismos, sus usos farmaceuticos y los materiales para su sintesis
WO2003062192A1 (en) 2002-01-17 2003-07-31 Smithkline Beecham Corporation Cycloalkyl ketoamides derivatives useful as cathepsin k inhibitors
EP2714667B1 (en) * 2011-05-27 2020-11-25 Laxman S. DESAI Aminooxazole inhibitors of cyclin dependent kinases

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0755937B2 (ja) * 1986-07-29 1995-06-14 日本曹達株式会社 オキサ（チア）ゾリジン誘導体その製造方法及び殺ダニ剤
US5244867A (en) * 1989-09-26 1993-09-14 Basf Aktiengesellschaft Oxazole- and thiazolecarboxamides
US5618792A (en) * 1994-11-21 1997-04-08 Cortech, Inc. Substituted heterocyclic compounds useful as inhibitors of (serine proteases) human neutrophil elastase

Also Published As

Publication number Publication date
AR012374A1 (es) 2000-10-18
JP2002515902A (ja) 2002-05-28
CA2285601A1 (en) 1998-10-22
EP0975612A4 (en) 2001-06-13
AU7252398A (en) 1998-11-11
WO1998046582A1 (en) 1998-10-22
EP0975612A1 (en) 2000-02-02

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