SK283489B6 - Piperazinylalkyltiopyrimidínové deriváty, spôsob ich prípravy, farmaceutické kompozície s ich obsahom a ich použitie - Google Patents
Piperazinylalkyltiopyrimidínové deriváty, spôsob ich prípravy, farmaceutické kompozície s ich obsahom a ich použitie Download PDFInfo
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- SK283489B6 SK283489B6 SK475-98A SK47598A SK283489B6 SK 283489 B6 SK283489 B6 SK 283489B6 SK 47598 A SK47598 A SK 47598A SK 283489 B6 SK283489 B6 SK 283489B6
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- Slovakia
- Prior art keywords
- group
- hydrogen
- alkyl
- alkoxy
- independently
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- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 20
- 238000004519 manufacturing process Methods 0.000 title claims 2
- 238000000034 method Methods 0.000 title abstract description 124
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- 201000010099 disease Diseases 0.000 claims abstract description 8
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- -1 hydroxy, benzyloxy Chemical group 0.000 claims description 163
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- 229910052801 chlorine Inorganic materials 0.000 claims description 83
- 239000001257 hydrogen Substances 0.000 claims description 47
- 150000003839 salts Chemical class 0.000 claims description 47
- 239000002253 acid Substances 0.000 claims description 45
- 125000001424 substituent group Chemical group 0.000 claims description 34
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- 150000002431 hydrogen Chemical class 0.000 claims description 31
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 24
- 125000001153 fluoro group Chemical group F* 0.000 claims description 20
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 19
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 18
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 17
- 229910052736 halogen Inorganic materials 0.000 claims description 17
- 150000002367 halogens Chemical class 0.000 claims description 17
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 15
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 14
- 125000000217 alkyl group Chemical group 0.000 claims description 12
- 229910052731 fluorine Inorganic materials 0.000 claims description 12
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims description 11
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 11
- 125000001309 chloro group Chemical group Cl* 0.000 claims description 11
- 230000000694 effects Effects 0.000 claims description 11
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 11
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- 125000003545 alkoxy group Chemical group 0.000 claims description 8
- 125000005843 halogen group Chemical group 0.000 claims description 8
- 125000003277 amino group Chemical group 0.000 claims description 7
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims description 7
- 125000003754 ethoxycarbonyl group Chemical group C(=O)(OCC)* 0.000 claims description 7
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims description 7
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 6
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- 231100000915 pathological change Toxicity 0.000 claims description 5
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- 125000004210 cyclohexylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims description 3
- 125000002861 (C1-C4) alkanoyl group Chemical group 0.000 claims description 2
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- 239000012050 conventional carrier Substances 0.000 claims description 2
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- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims 1
- 125000006705 (C5-C7) cycloalkyl group Chemical group 0.000 claims 1
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- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
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- JUQLTPCYUFPYKE-UHFFFAOYSA-N ritanserin Chemical compound CC=1N=C2SC=CN2C(=O)C=1CCN(CC1)CCC1=C(C=1C=CC(F)=CC=1)C1=CC=C(F)C=C1 JUQLTPCYUFPYKE-UHFFFAOYSA-N 0.000 description 1
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- XGVXKJKTISMIOW-ZDUSSCGKSA-N simurosertib Chemical compound N1N=CC(C=2SC=3C(=O)NC(=NC=3C=2)[C@H]2N3CCC(CC3)C2)=C1C XGVXKJKTISMIOW-ZDUSSCGKSA-N 0.000 description 1
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- UIIMBOGNXHQVGW-UHFFFAOYSA-M sodium bicarbonate Substances [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 239000001593 sorbitan monooleate Substances 0.000 description 1
- 235000011069 sorbitan monooleate Nutrition 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/20—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D239/22—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/38—One sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Psychiatry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU9503099A HUT76266A (en) | 1995-10-31 | 1995-10-31 | New piperazinyl-alkylthio-pyrimidine derivatives, pharmaceutical compositions containing them, and process for producing the active components |
| PCT/HU1996/000061 WO1997016429A1 (en) | 1995-10-31 | 1996-10-25 | Novel piperazinylalkylthiopyrimidine derivatives, pharmaceutical compositions containing the same and a process for the preparation of the novel compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SK47598A3 SK47598A3 (en) | 1998-12-02 |
| SK283489B6 true SK283489B6 (sk) | 2003-08-05 |
Family
ID=10987317
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK475-98A SK283489B6 (sk) | 1995-10-31 | 1996-10-25 | Piperazinylalkyltiopyrimidínové deriváty, spôsob ich prípravy, farmaceutické kompozície s ich obsahom a ich použitie |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US6130215A (cs) |
| EP (1) | EP0901473B1 (cs) |
| JP (1) | JPH11514641A (cs) |
| KR (1) | KR19990067137A (cs) |
| CN (1) | CN1207733A (cs) |
| AT (1) | ATE214375T1 (cs) |
| AU (1) | AU707166B2 (cs) |
| CZ (1) | CZ112198A3 (cs) |
| DE (1) | DE69619868T2 (cs) |
| HU (1) | HUT76266A (cs) |
| NZ (1) | NZ320522A (cs) |
| PL (1) | PL327461A1 (cs) |
| SK (1) | SK283489B6 (cs) |
| WO (1) | WO1997016429A1 (cs) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4425143A1 (de) * | 1994-07-15 | 1996-01-18 | Basf Ag | Substituierte Pyrimidinverbindungen und deren Verwendung |
| CA2376307A1 (en) * | 1999-06-29 | 2001-01-04 | Egis Gyogyszergyar Rt. | Novel piperazinylalkylthiopyrimidine derivatives,pharmaceutical composi tions containing the same,and a process for the preparation of the active substance |
| US20040014966A1 (en) * | 2000-06-20 | 2004-01-22 | Jacobsen Eric Jon | Bis-arylsulfones |
| US6586592B2 (en) | 2000-06-20 | 2003-07-01 | Pharmacia & Upjohn Company | Bis-arylsulfones |
| PE20020063A1 (es) | 2000-06-20 | 2002-01-30 | Upjohn Co | Bis-arilsulfonas como ligandos del receptor de 5-ht |
| DE112009001776B4 (de) | 2008-07-30 | 2021-01-21 | Asahi Kasei Chemicals Corporation | Verfahren zur Herstellung von Cycloolefin und Vorrichtung zur Herstellung desselben |
| US10315655B2 (en) | 2017-03-07 | 2019-06-11 | Deere & Company | Vehicle control based on soil compaction |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE792206A (cs) * | 1971-12-02 | 1973-06-01 | Byk Gulden Lomberg Chem Fab | |
| JPS61271278A (ja) * | 1985-05-20 | 1986-12-01 | イ− ア−ル スクイブ アンド サンズ インコ−ポレ−テツド | ２−置換チオまたはオキソ−４−アリ−ルまたはヘテロシクロ−５−カルボキシ−１，４−ジヒドロピリミジン |
-
1995
- 1995-10-31 HU HU9503099A patent/HUT76266A/hu unknown
-
1996
- 1996-10-25 SK SK475-98A patent/SK283489B6/sk unknown
- 1996-10-25 JP JP9517175A patent/JPH11514641A/ja active Pending
- 1996-10-25 DE DE69619868T patent/DE69619868T2/de not_active Expired - Fee Related
- 1996-10-25 US US09/066,465 patent/US6130215A/en not_active Expired - Fee Related
- 1996-10-25 AU AU73262/96A patent/AU707166B2/en not_active Ceased
- 1996-10-25 KR KR1019980703083A patent/KR19990067137A/ko not_active Withdrawn
- 1996-10-25 CZ CZ981121A patent/CZ112198A3/cs unknown
- 1996-10-25 EP EP96935194A patent/EP0901473B1/en not_active Expired - Lifetime
- 1996-10-25 NZ NZ320522A patent/NZ320522A/xx unknown
- 1996-10-25 WO PCT/HU1996/000061 patent/WO1997016429A1/en not_active Ceased
- 1996-10-25 CN CN96198654A patent/CN1207733A/zh active Pending
- 1996-10-25 AT AT96935194T patent/ATE214375T1/de not_active IP Right Cessation
- 1996-10-25 PL PL96327461A patent/PL327461A1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US6130215A (en) | 2000-10-10 |
| HUT76266A (en) | 1997-07-28 |
| KR19990067137A (ko) | 1999-08-16 |
| HU9503099D0 (en) | 1995-12-28 |
| ATE214375T1 (de) | 2002-03-15 |
| NZ320522A (en) | 1999-03-29 |
| SK47598A3 (en) | 1998-12-02 |
| EP0901473B1 (en) | 2002-03-13 |
| WO1997016429A1 (en) | 1997-05-09 |
| AU7326296A (en) | 1997-05-22 |
| JPH11514641A (ja) | 1999-12-14 |
| DE69619868D1 (de) | 2002-04-18 |
| PL327461A1 (en) | 1998-12-07 |
| EP0901473A1 (en) | 1999-03-17 |
| CZ112198A3 (cs) | 1998-09-16 |
| AU707166B2 (en) | 1999-07-01 |
| CN1207733A (zh) | 1999-02-10 |
| DE69619868T2 (de) | 2002-10-10 |
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