SK282179B6 - Spôsob čistenia a izolácie (rr,ss)-2-dimetylaminometyl-1-(3-metoxyfenyl)cyklohexanolu - Google Patents

Spôsob čistenia a izolácie (rr,ss)-2-dimetylaminometyl-1-(3-metoxyfenyl)cyklohexanolu Download PDF

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Publication number
SK282179B6
SK282179B6 SK1503-96A SK150396A SK282179B6 SK 282179 B6 SK282179 B6 SK 282179B6 SK 150396 A SK150396 A SK 150396A SK 282179 B6 SK282179 B6 SK 282179B6
Authority
SK
Slovakia
Prior art keywords
isomer
mixture
methoxyphenyl
tramadol
isomers
Prior art date
Application number
SK1503-96A
Other languages
English (en)
Slovak (sk)
Other versions
SK150396A3 (en
Inventor
Ori Lerman
Michael Tennenbaum
Erez Gal
Joseph Kaspi
Original Assignee
Chemagis Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemagis Ltd. filed Critical Chemagis Ltd.
Publication of SK150396A3 publication Critical patent/SK150396A3/sk
Publication of SK282179B6 publication Critical patent/SK282179B6/sk

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/10—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SK1503-96A 1995-12-07 1996-11-22 Spôsob čistenia a izolácie (rr,ss)-2-dimetylaminometyl-1-(3-metoxyfenyl)cyklohexanolu SK282179B6 (sk)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL11628195A IL116281A (en) 1995-12-07 1995-12-07 Process for the purification of (rr,ss)-2-dimethylaminomethyl-1-(3-methoxyphenyl) cyclohexanol and its salts

Publications (2)

Publication Number Publication Date
SK150396A3 SK150396A3 (en) 1997-07-09
SK282179B6 true SK282179B6 (sk) 2001-11-06

Family

ID=11068279

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1503-96A SK282179B6 (sk) 1995-12-07 1996-11-22 Spôsob čistenia a izolácie (rr,ss)-2-dimetylaminometyl-1-(3-metoxyfenyl)cyklohexanolu

Country Status (12)

Country Link
US (1) US5672755A (fr)
EP (1) EP0778262B1 (fr)
AT (1) ATE198879T1 (fr)
AU (1) AU713304B2 (fr)
CA (1) CA2192155C (fr)
DE (1) DE69611663T2 (fr)
DK (1) DK0778262T3 (fr)
ES (1) ES2154792T3 (fr)
GR (1) GR3035602T3 (fr)
IL (1) IL116281A (fr)
PT (1) PT778262E (fr)
SK (1) SK282179B6 (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL119121A (en) * 1996-08-22 2000-11-21 Chemagis Ltd Process for the purification of (RR-SS)-2-dimethylaminomethyl-1-(3-methoxyphenyl)cyclohexanol hydrochloride
AU730530B2 (en) * 1997-07-15 2001-03-08 Russinsky Limited Tramadol, salts thereof and process for their preparation
US5877351A (en) * 1997-12-24 1999-03-02 Wyckoff Chemical Company, Inc. Preparation and purification process for 2- (dimethylamino) methyl!-1-(3-methoxphenyl)-cyclohexanol and its salts
IT1298597B1 (it) 1998-03-06 2000-01-12 Secifarma Spa Processo per la purificazione dell'(rr,ss)-2-(dimetilammino)metil- 1-(3-metossifenil)-cicloesanolo dall'(rs,sr)-2-(dimetilammino)
CA2330142A1 (fr) * 1998-05-22 1999-12-02 Mallinckrodt, Inc. Synthese et purification perfectionnee de chlorhydrate de (r*,r*)-2-[ (dimethylamino) methyl]-1-( 3-methoxyphenyl) cyclohexanol
DK1082300T3 (da) * 1998-05-29 2003-12-15 Upjohn Co 3-[1'-N-Methylamino)ethyl-N-benzyl]pyrrolidin-monomethansulfonat
JP2003502400A (ja) * 1999-06-22 2003-01-21 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング ２−［（ジメチルアミノ）メチル］−１−（３−メトキシフェニル）−シクロヘキサノールのジアステレオマー塩基の分割方法
GB0010437D0 (en) * 2000-04-28 2000-06-14 Darwin Discovery Ltd Process
DE10108308A1 (de) * 2001-02-21 2002-08-29 Gruenenthal Gmbh Verfahren zur Isolierung und Reinigung von (1RS,2RS)-2[(Dimethylamino)methyl]-1-(3-methoxyphenyl)-cyclohexanol
US6649783B2 (en) 2001-10-03 2003-11-18 Euro-Celtique, S.A. Synthesis of (+/-)-2-((dimethylamino)methyl)-1-(aryl)cyclohexanols
US6780891B2 (en) 2001-11-30 2004-08-24 Sepracor Inc. Tramadol analogs and uses thereof
TWI319713B (en) * 2002-10-25 2010-01-21 Sustained-release tramadol formulations with 24-hour efficacy
US8487002B2 (en) 2002-10-25 2013-07-16 Paladin Labs Inc. Controlled-release compositions
US20060172006A1 (en) * 2003-10-10 2006-08-03 Vincent Lenaerts Sustained-release tramadol formulations with 24-hour clinical efficacy
DE102005031041A1 (de) * 2005-07-02 2007-01-04 Palitzsch, Peter Verfahren zur Isomerisierung von Tramadol
JP2009507047A (ja) 2005-09-09 2009-02-19 ラボファーム インコーポレイテッド 持続性薬物放出組成物
EP1785412A1 (fr) * 2005-11-14 2007-05-16 IPCA Laboratories Limited Procédé de récuperation de Tramadol

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1219503B (de) 1960-08-20 1966-06-23 Firth Cleveland Ltd Heiz- und/oder Kuehlgeraet
US3652589A (en) * 1967-07-27 1972-03-28 Gruenenthal Chemie 1-(m-substituted phenyl)-2-aminomethyl cyclohexanols
US3653589A (en) 1970-07-27 1972-04-04 Carrier Corp Air conditioning system
IL103096A (en) * 1992-09-08 1996-12-05 Chemagis Ltd Process for purification 2 -]) Dimethylamino (methyl-1-) 3-methoxycinyl (cyclohexanol and its salts.

Also Published As

Publication number Publication date
CA2192155C (fr) 2005-06-14
ATE198879T1 (de) 2001-02-15
US5672755A (en) 1997-09-30
AU713304B2 (en) 1999-11-25
DK0778262T3 (da) 2001-03-05
AU7181896A (en) 1997-06-12
CA2192155A1 (fr) 1997-06-08
EP0778262A2 (fr) 1997-06-11
DE69611663D1 (de) 2001-03-01
EP0778262A3 (fr) 1998-04-29
DE69611663T2 (de) 2001-06-13
ES2154792T3 (es) 2001-04-16
IL116281A0 (en) 1996-03-31
GR3035602T3 (en) 2001-06-29
IL116281A (en) 1999-06-20
EP0778262B1 (fr) 2001-01-24
PT778262E (pt) 2001-05-31
SK150396A3 (en) 1997-07-09

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