SK281901B6 - Spôsob výroby derivátov n-beta-hydroxyalkyl-tri-n-karboxyalkyl- 1,4,7,10-tetraazacyklododekánu a n-beta-hydroxyalkyl-tri-n- karboxyalkyl-1,4,8,11-tetraazacyklotetradekánu a ich kovových komplexov - Google Patents

Spôsob výroby derivátov n-beta-hydroxyalkyl-tri-n-karboxyalkyl- 1,4,7,10-tetraazacyklododekánu a n-beta-hydroxyalkyl-tri-n- karboxyalkyl-1,4,8,11-tetraazacyklotetradekánu a ich kovových komplexov Download PDF

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Publication number
SK281901B6
SK281901B6 SK1487-94A SK148794A SK281901B6 SK 281901 B6 SK281901 B6 SK 281901B6 SK 148794 A SK148794 A SK 148794A SK 281901 B6 SK281901 B6 SK 281901B6
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SK
Slovakia
Prior art keywords
carbon atoms
tetraazacyclododecane
groups
group
optionally
Prior art date
Application number
SK1487-94A
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English (en)
Slovak (sk)
Other versions
SK148794A3 (en
Inventor
Ulf Tilstam
Helmut B�Rner
Klaus Nickisch
Heinz Gries
Johannes Platzek
Original Assignee
Schering Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Schering Aktiengesellschaft filed Critical Schering Aktiengesellschaft
Publication of SK148794A3 publication Critical patent/SK148794A3/sk
Publication of SK281901B6 publication Critical patent/SK281901B6/sk

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
SK1487-94A 1992-06-04 1993-05-28 Spôsob výroby derivátov n-beta-hydroxyalkyl-tri-n-karboxyalkyl- 1,4,7,10-tetraazacyklododekánu a n-beta-hydroxyalkyl-tri-n- karboxyalkyl-1,4,8,11-tetraazacyklotetradekánu a ich kovových komplexov SK281901B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4218744A DE4218744C2 (de) 1992-06-04 1992-06-04 Verfahren zur Herstellung von N-ß-Hxdroxyalkyl-tri-N-carboxylalkyl-1,4,7,10-tetraazacyclododecan- und N-ß-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivaten und deren Metallkomplexe
PCT/EP1993/001362 WO1993024469A1 (fr) 1992-06-04 1993-05-28 PROCEDE DE PRODUCTION DE DERIVES DE N-β-HYDROXYALKYLE-TRI-N-CARBOXYALKYLE-1,4,7,10-TETRAAZACYCLODODECANE ET DE N-β-HYDROXYALKYLE-TRI-N-CARBOXYALKYLE-1,4,8,11-TETRAAZACYCLOTETRADECANE ET DE LEURS COMPLEXES METALLIQUES

Publications (2)

Publication Number Publication Date
SK148794A3 SK148794A3 (en) 1995-07-11
SK281901B6 true SK281901B6 (sk) 2001-09-11

Family

ID=6460555

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1487-94A SK281901B6 (sk) 1992-06-04 1993-05-28 Spôsob výroby derivátov n-beta-hydroxyalkyl-tri-n-karboxyalkyl- 1,4,7,10-tetraazacyklododekánu a n-beta-hydroxyalkyl-tri-n- karboxyalkyl-1,4,8,11-tetraazacyklotetradekánu a ich kovových komplexov

Country Status (16)

Country Link
US (1) US5386028A (fr)
EP (1) EP0643705B1 (fr)
JP (1) JP3565843B2 (fr)
KR (1) KR100269081B1 (fr)
AT (1) ATE178321T1 (fr)
CA (1) CA2137243C (fr)
CZ (1) CZ282873B6 (fr)
DE (2) DE4218744C2 (fr)
DK (1) DK0643705T3 (fr)
ES (1) ES2131582T3 (fr)
GR (1) GR3030604T3 (fr)
HU (1) HU213951B (fr)
IL (1) IL105807A (fr)
NO (1) NO302232B1 (fr)
SK (1) SK281901B6 (fr)
WO (1) WO1993024469A1 (fr)

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DE19652386A1 (de) * 1996-12-04 1998-06-10 Schering Ag Verfahren zur Herstellung von Metallkomplexcarbonsäureamiden
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IT1292128B1 (it) * 1997-06-11 1999-01-25 Bracco Spa Processo per la preparazione di chelanti macrociclici e loro chelati con ioni metallici paramagnetici
IT1292130B1 (it) * 1997-06-11 1999-01-25 Bracco Spa Processo per la preparazione dell'acido 1,4,7,10-tetraazaciclododecan -1,4,7-triacetico e suoi derivati
IT1297035B1 (it) 1997-12-30 1999-08-03 Bracco Spa Derivati dell'acido 1,4,7,10-tetraazaciclododecan-1,4-diacetico
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US8969353B2 (en) 2008-11-07 2015-03-03 Massachusetts Institute Of Technology Aminoalcohol lipidoids and uses thereof
DE102009053171B4 (de) 2009-11-04 2011-07-21 Bayer Schering Pharma Aktiengesellschaft, 13353 Verfahren zur Herstellung des Calcium-Komplexes von Dihydroxy-hydroxy-methylpropyl-tetraazacyclododecan-triessigsäure (Calcobutrol)
CA2831392C (fr) * 2011-03-28 2020-04-28 Massachusetts Institute Of Technology Lipomeres conjugues et utilisations associees
PT2896405T (pt) * 2011-04-21 2020-03-31 Bayer Ip Gmbh Preparação de gadobutrol de pureza elevada
JP6151707B2 (ja) 2011-10-27 2017-06-21 マサチューセッツ インスティテュート オブ テクノロジー 薬物内包微小球の形成が可能なｎ−末端で官能基化されたアミノ酸誘導体
EP3102566B1 (fr) * 2014-02-06 2018-09-12 T2Pharma GmbH Procédé de purification de l'acide 1,4,7,10-tétraazacyclododécane-1,4,7,10-tétraacétique
KR101693400B1 (ko) * 2014-09-17 2017-01-05 에스티팜 주식회사 칼코부트롤의 제조방법
KR101653064B1 (ko) * 2014-12-26 2016-09-09 에스티팜 주식회사 가도부트롤의 제조방법
HRP20230494T1 (hr) 2015-06-19 2023-08-04 Massachusetts Institute Of Technology Alkenil supstituirani 2,5-piperazindioni i njihova upotreba u pripravcima za isporuku sredstva subjektu ili stanici
WO2018059914A1 (fr) 2016-09-27 2018-04-05 Bayer Pharma Aktiengesellschaft Procédé de production de la forme cristalline de modification a de calcobutrol
KR101971435B1 (ko) * 2017-08-29 2019-04-24 주식회사 엔지켐생명과학 가도부트롤 중간체 및 이를 이용한 가도부트롤의 제조 방법
KR102033964B1 (ko) * 2018-01-19 2019-10-18 주식회사 엔지켐생명과학 가도테리돌 중간체 및 이를 이용한 가도테리돌 제조방법
WO2020012372A1 (fr) * 2018-07-10 2020-01-16 Biophore India Pharmaceuticals Pvt. Ltd Procédé de préparation d'acide 2,2',2''-(10-((2r,3s)-1,3,4-trihydroxy butan-2-yl)-1,4,7,10-tétraazacyclododécane-1,4,7-triyl) triacétique et de ses complexes
KR101979836B1 (ko) * 2019-01-02 2019-05-21 동국생명과학 주식회사 칼코부트롤의 제조방법
WO2024030772A1 (fr) * 2022-08-01 2024-02-08 Portland State University Agents de contraste à haute relaxivité et préparation stéréosélective

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Also Published As

Publication number Publication date
CA2137243A1 (fr) 1993-12-09
NO944691D0 (no) 1994-12-05
GR3030604T3 (en) 1999-10-29
CA2137243C (fr) 2005-09-20
DK0643705T3 (da) 1999-10-25
IL105807A (en) 1998-12-06
EP0643705A1 (fr) 1995-03-22
HUT71263A (en) 1995-11-28
KR950701918A (ko) 1995-05-17
WO1993024469A1 (fr) 1993-12-09
JPH07507067A (ja) 1995-08-03
DE4218744A1 (de) 1993-12-09
SK148794A3 (en) 1995-07-11
NO944691L (no) 1994-12-05
IL105807A0 (en) 1993-09-22
NO302232B1 (no) 1998-02-09
HU9403464D0 (en) 1995-03-28
EP0643705B1 (fr) 1999-03-31
CZ301594A3 (en) 1995-08-16
ES2131582T3 (es) 1999-08-01
KR100269081B1 (ko) 2000-10-16
DE59309488D1 (de) 1999-05-06
US5386028A (en) 1995-01-31
DE4218744C2 (de) 1997-11-06
ATE178321T1 (de) 1999-04-15
JP3565843B2 (ja) 2004-09-15
HU213951B (en) 1997-11-28
CZ282873B6 (cs) 1997-11-12

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