SK281051B6 - Derivát alkylbenzolguanidínu, spôsob jeho prípravy, jeho použitie a farmaceutický prostriedok, ktorý ho obsahuje - Google Patents

Derivát alkylbenzolguanidínu, spôsob jeho prípravy, jeho použitie a farmaceutický prostriedok, ktorý ho obsahuje Download PDF

Info

Publication number
SK281051B6
SK281051B6 SK1055-95A SK105595A SK281051B6 SK 281051 B6 SK281051 B6 SK 281051B6 SK 105595 A SK105595 A SK 105595A SK 281051 B6 SK281051 B6 SK 281051B6
Authority
SK
Slovakia
Prior art keywords
diaminomethylene
methylsulfonyl
methyl ester
methylsulfonylbenzamide
ethyl
Prior art date
Application number
SK1055-95A
Other languages
English (en)
Slovak (sk)
Other versions
SK105595A3 (en
Inventor
Rolf Gericke
Dieter Dorsch
Manfred Baumgarth
Klaus-Otto Minck
Norbert Beier
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of SK105595A3 publication Critical patent/SK105595A3/sk
Publication of SK281051B6 publication Critical patent/SK281051B6/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicinal Preparation (AREA)
SK1055-95A 1994-08-31 1995-08-25 Derivát alkylbenzolguanidínu, spôsob jeho prípravy, jeho použitie a farmaceutický prostriedok, ktorý ho obsahuje SK281051B6 (sk)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4430916A DE4430916A1 (de) 1994-08-31 1994-08-31 Alkyl-benzoylguanidin-Derivate

Publications (2)

Publication Number Publication Date
SK105595A3 SK105595A3 (en) 1996-03-06
SK281051B6 true SK281051B6 (sk) 2000-11-07

Family

ID=6527018

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1055-95A SK281051B6 (sk) 1994-08-31 1995-08-25 Derivát alkylbenzolguanidínu, spôsob jeho prípravy, jeho použitie a farmaceutický prostriedok, ktorý ho obsahuje

Country Status (20)

Country Link
US (1) US5840761A (ja)
EP (1) EP0699663B1 (ja)
JP (1) JP3732873B2 (ja)
KR (1) KR100406687B1 (ja)
CN (1) CN1055920C (ja)
AT (1) ATE172962T1 (ja)
AU (1) AU701558B2 (ja)
BR (1) BR9503854A (ja)
CA (1) CA2157143C (ja)
CZ (1) CZ288015B6 (ja)
DE (2) DE4430916A1 (ja)
ES (1) ES2126190T3 (ja)
HU (1) HU222401B1 (ja)
NO (1) NO305901B1 (ja)
PL (1) PL180902B1 (ja)
RU (1) RU2142940C1 (ja)
SK (1) SK281051B6 (ja)
TW (1) TW397814B (ja)
UA (1) UA41353C2 (ja)
ZA (1) ZA957283B (ja)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4328352A1 (de) 1993-08-24 1995-03-02 Hoechst Ag Substituierte N,N'-Di-benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19517848A1 (de) * 1995-05-16 1996-11-21 Merck Patent Gmbh Fluorhaltige Benzoylguanidine
DE19529612A1 (de) * 1995-08-11 1997-02-13 Merck Patent Gmbh Sulfonyl- oder Sulfinyl-benzoylguanidin-Derivate
DE19531138A1 (de) * 1995-08-24 1997-02-27 Merck Patent Gmbh Alkenyl-benzoylguanidin-Derivate
NZ314105A (en) * 1996-02-02 1997-12-19 Sumitomo Pharma Guanidine derivative substituted with a substituted indole which is peri condensed with a heterocyclic ring
DE19624178A1 (de) * 1996-06-18 1998-01-08 Hoechst Ag Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
PL348152A1 (en) * 1998-11-26 2002-05-06 Merck Patent Gmbh Use of benzoylguanidines for the treatment of non-insulin-dependent diabetes mellitus
DE10001879A1 (de) 2000-01-19 2001-07-19 Aventis Pharma Gmbh Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
JP2006509014A (ja) * 2002-12-04 2006-03-16 ジーン ロジック インコーポレイテッド メラノコルチンレセプターの調節因子
BRPI0410022A (pt) * 2003-05-06 2006-04-25 Merck Patent Gmbh processo para a cristalização de sais de guanidìnio
USD781236S1 (en) 2016-01-14 2017-03-14 Premier Accessory Group LLC Charging device
WO2018058109A1 (en) 2016-09-26 2018-03-29 Nusirt Sciences, Inc. Compositions and methods for treating metabolic disorders

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3929582A1 (de) 1989-09-06 1991-03-07 Hoechst Ag Benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltendes medikament
DE59307360D1 (de) * 1992-02-15 1997-10-23 Hoechst Ag Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
CZ284456B6 (cs) * 1992-02-15 1998-12-16 Hoechst Aktiengesellschaft Aminosubstituované benzoylguanidiny, způsob jejich přípravy, jejich použití jako léčiv a léčivo, které je obsahuje
EP0556674B1 (de) * 1992-02-15 1996-06-19 Hoechst Aktiengesellschaft 3,5-Substituierte Benzoylguanidine, mit antiarrythmischer Wirkung und inhibierender Wirkung auf die Proliferationen von Zellen
ES2092729T3 (es) * 1992-07-01 1996-12-01 Hoechst Ag Benzoilguanidinas 3,4,5-sustituidas, procedimiento para su preparacion, su empleo como medicamento o agente de diagnostico, asi como medicamento que las contiene.
ATE147375T1 (de) * 1992-09-22 1997-01-15 Hoechst Ag Benzoylguanidine, verfahren zu ihrer herstellung, sowie ihre verwendung als antiarrhythmika
TW250479B (ja) * 1992-12-15 1995-07-01 Hoechst Ag
ES2100435T3 (es) * 1992-12-16 1997-06-16 Hoechst Ag Aminobenzoilguanidinas 3,5-sustituidas, procedimiento para su preparacion, su empleo como medicamento o agente de diagnostico, asi como medicamento que las contiene.
MY128187A (en) * 1993-06-23 2007-01-31 Icn Switzerland Ag Preparation for skin and mucous membrane
DE4328869A1 (de) * 1993-08-27 1995-03-02 Hoechst Ag Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE4417004A1 (de) * 1994-05-13 1995-11-16 Hoechst Ag Perfluoralkyl-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

Also Published As

Publication number Publication date
US5840761A (en) 1998-11-24
ES2126190T3 (es) 1999-03-16
AU3025195A (en) 1996-02-15
CA2157143C (en) 2009-02-17
SK105595A3 (en) 1996-03-06
ATE172962T1 (de) 1998-11-15
JP3732873B2 (ja) 2006-01-11
EP0699663B1 (de) 1998-11-04
RU2142940C1 (ru) 1999-12-20
HU9502501D0 (en) 1995-10-30
DE59504122D1 (de) 1998-12-10
PL310225A1 (en) 1996-03-04
CN1128753A (zh) 1996-08-14
NO953405L (no) 1996-03-01
PL180902B1 (pl) 2001-04-30
NO305901B1 (no) 1999-08-16
BR9503854A (pt) 1996-09-17
CA2157143A1 (en) 1996-03-01
CZ220395A3 (en) 1996-03-13
TW397814B (en) 2000-07-11
KR100406687B1 (ko) 2004-07-19
CZ288015B6 (cs) 2001-04-11
NO953405D0 (no) 1995-08-30
HUT75094A (en) 1997-04-28
KR960007538A (ko) 1996-03-22
DE4430916A1 (de) 1996-03-07
CN1055920C (zh) 2000-08-30
AU701558B2 (en) 1999-01-28
EP0699663A1 (de) 1996-03-06
ZA957283B (en) 1996-04-02
JPH08188568A (ja) 1996-07-23
UA41353C2 (uk) 2001-09-17
HU222401B1 (hu) 2003-06-28

Similar Documents

Publication Publication Date Title
JP4023841B2 (ja) ヘテロサイクリル−ベンゾイルグアニジン化合物
SK281051B6 (sk) Derivát alkylbenzolguanidínu, spôsob jeho prípravy, jeho použitie a farmaceutický prostriedok, ktorý ho obsahuje
JP3901766B2 (ja) ４−スルホニル−または４−スルフィニルベンゾイルグアニジン誘導体
US5747539A (en) Fluorine-containing benzoylguanidines
SK281135B6 (sk) Derivát arylbenzoylguanidínu, spôsob jeho prípravy, jeho použitie a farmaceutický prostriedok, ktorý ho obsahuje
RU2160728C2 (ru) 4-амино-бензоилгуанидины, способы их получения, фармацевтическая композиция и способ ингибирования целлюлярного na+/h+-антипортера
RU2160732C2 (ru) Гетероциклилокси-бензоилгуанидины, способы их получения, их фармацевтическая композиция и способ ее получения
CA2168319C (en) 4-mercaptobenzoylguanidine derivatives