SK278365B6 - Therapeuticly effective xanthine derivative, preparation method thereof and pharmaceutical agent containing its - Google Patents

Therapeuticly effective xanthine derivative, preparation method thereof and pharmaceutical agent containing its Download PDF

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Publication number
SK278365B6
SK278365B6 SK6341-90A SK634190A SK278365B6 SK 278365 B6 SK278365 B6 SK 278365B6 SK 634190 A SK634190 A SK 634190A SK 278365 B6 SK278365 B6 SK 278365B6
Authority
SK
Slovakia
Prior art keywords
xanthine
formula
pharmaceutically acceptable
alkali metal
hydrogen
Prior art date
Application number
SK6341-90A
Other languages
English (en)
Slovak (sk)
Inventor
Armando V Noverola
Jose M P Soto
Jacinto M Mauri
Robert W Gristwood
Original Assignee
Noverola Armando V.
Soto Jose M. P.
Mauri Jacinto M.
Gristwood Robert W.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Noverola Armando V., Soto Jose M. P., Mauri Jacinto M., Gristwood Robert W. filed Critical Noverola Armando V.
Publication of SK278365B6 publication Critical patent/SK278365B6/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Peptides Or Proteins (AREA)
SK6341-90A 1989-12-27 1990-12-18 Therapeuticly effective xanthine derivative, preparation method thereof and pharmaceutical agent containing its SK278365B6 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB898929208A GB8929208D0 (en) 1989-12-27 1989-12-27 New xanthine derivatives

Publications (1)

Publication Number Publication Date
SK278365B6 true SK278365B6 (en) 1997-01-08

Family

ID=10668520

Family Applications (1)

Application Number Title Priority Date Filing Date
SK6341-90A SK278365B6 (en) 1989-12-27 1990-12-18 Therapeuticly effective xanthine derivative, preparation method thereof and pharmaceutical agent containing its

Country Status (30)

Country Link
US (1) US5223504A (no)
EP (1) EP0435811B1 (no)
JP (1) JPH089617B2 (no)
KR (1) KR970001528B1 (no)
CN (1) CN1029967C (no)
AT (1) ATE93860T1 (no)
AU (1) AU635104B2 (no)
BR (1) BR9007258A (no)
CA (1) CA2045478C (no)
CZ (1) CZ278328B6 (no)
DE (1) DE69003087T2 (no)
DK (1) DK0435811T3 (no)
EG (1) EG19436A (no)
ES (1) ES2058864T3 (no)
FI (1) FI96207C (no)
GB (1) GB8929208D0 (no)
HU (2) HU208825B (no)
IE (1) IE64065B1 (no)
IL (1) IL96708A (no)
MX (1) MX23884A (no)
MY (1) MY105303A (no)
NO (1) NO178111C (no)
NZ (1) NZ236517A (no)
PL (1) PL166152B1 (no)
PT (1) PT96332B (no)
RU (1) RU2073679C1 (no)
SK (1) SK278365B6 (no)
UA (1) UA32512C2 (no)
WO (1) WO1991009859A1 (no)
ZA (1) ZA9010240B (no)

Families Citing this family (43)

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US5521315A (en) * 1993-01-12 1996-05-28 Cell Therapeutics, Inc. Olefin substituted long chain compounds
GB9312853D0 (en) 1993-06-22 1993-08-04 Euro Celtique Sa Chemical compounds
US5922751A (en) 1994-06-24 1999-07-13 Euro-Celtique, S.A. Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same
US5591776A (en) 1994-06-24 1997-01-07 Euro-Celtique, S.A. Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV
US5661153A (en) * 1994-07-19 1997-08-26 Japan Energy Corporation 1-arylpyrimidine derivatives and pharmaceutical use thereof
WO1996018399A1 (en) * 1994-12-13 1996-06-20 Euro-Celtique, S.A. Aryl thioxanthines
US6025361A (en) * 1994-12-13 2000-02-15 Euro-Celtique, S.A. Trisubstituted thioxanthines
ATE247655T1 (de) 1994-12-13 2003-09-15 Euro Celtique Sa Dreifachsubstituierte thioxanthine
CA2218548A1 (en) * 1995-05-19 1996-11-21 Chiroscience Limited Xanthines and their therapeutic use
US6166041A (en) 1995-10-11 2000-12-26 Euro-Celtique, S.A. 2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for the treatment of asthma
US6075016A (en) 1996-04-10 2000-06-13 Euro-Celtique S.A. 6,5-fused aromatic ring systems having enhanced phosphodiesterase IV inhibitory activity
US5864037A (en) * 1996-06-06 1999-01-26 Euro-Celtique, S.A. Methods for the synthesis of chemical compounds having PDE-IV inhibitory activity
US5958926A (en) 1996-11-01 1999-09-28 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
US5874437A (en) * 1996-11-01 1999-02-23 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
US6331543B1 (en) * 1996-11-01 2001-12-18 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use
EP0941086A4 (en) * 1996-11-01 2000-07-12 Nitromed Inc NITROSIZED AND NITROSYLATED PHOSPHODIESTERASE INHIBITING COMPOUNDS, COMPOSITIONS AND THEIR USE
USRE37234E1 (en) * 1996-11-01 2001-06-19 Nitromed, Inc. Nitrosated and nitrosylated phosphodiestrase inhibitor compounds, compositions and their uses
GB9623859D0 (en) * 1996-11-15 1997-01-08 Chiroscience Ltd Novel compounds
US6472425B1 (en) 1997-10-31 2002-10-29 Nitromed, Inc. Methods for treating female sexual dysfunctions
IL132407A0 (en) * 1998-10-21 2001-03-19 Pfizer Prod Inc Method for treating congestive heart failure
SI1176960T1 (en) 1999-05-04 2005-04-30 Altana Pharma Ag Synergistic combination comprising roflumilast and a pde-3 inhibitor
SI1212089T1 (sl) 1999-08-21 2006-08-31 Altana Pharma Ag Sinergisticna kombinacija roflumilasta in salmeterola
GB0005199D0 (en) * 2000-03-04 2000-04-26 Imp College Innovations Ltd Modulation of histone deacetylase
CA2402384A1 (en) * 2000-03-16 2001-09-20 Inflazyme Pharmaceuticals Ltd. Benzylated pde4 inhibitors
EP1389467B1 (en) * 2001-05-23 2013-07-03 Mitsubishi Tanabe Pharma Corporation Therapeutic composition for the regenerative treatment of cartilage diseases
US20040146561A1 (en) * 2001-05-23 2004-07-29 Naoki Sakurai Compositions for promoting healing of bone fracture
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
JP2006522151A (ja) 2003-04-01 2006-09-28 アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ フェンノートシャップ 不妊症におけるホスホジエステラーゼ阻害剤
EA020466B1 (ru) 2007-06-04 2014-11-28 Синерджи Фармасьютикалз Инк. Агонисты гуанилатциклазы, пригодные для лечения желудочно-кишечных нарушений, воспаления, рака и других заболеваний
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
EP2810951B1 (en) 2008-06-04 2017-03-15 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
ES2624828T3 (es) 2008-07-16 2017-07-17 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
EA201391254A1 (ru) 2011-03-01 2014-02-28 Синерджи Фармасьютикалз Инк. Способ получения агонистов гуанилатциклазы c
EP2958577A2 (en) 2013-02-25 2015-12-30 Synergy Pharmaceuticals Inc. Guanylate cyclase receptor agonists for use in colonic cleansing
CA2905438A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
CA2905435A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
PT3004138T (pt) 2013-06-05 2024-06-18 Bausch Health Ireland Ltd Agonistas ultrapuros de guanilato ciclase c, método de produção e utilização dos mesmos
AU2014305843B2 (en) 2013-08-09 2019-08-29 Ardelyx, Inc. Compounds and methods for inhibiting phosphate transport
EP3165224A1 (en) 2015-11-09 2017-05-10 Albert-Ludwigs-Universität Freiburg Use of pde4 inhibitors for the prophylaxis and/or therapy of dyslipoproteinaemia and related disorders
WO2017089347A1 (en) 2015-11-25 2017-06-01 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods and pharmaceutical compositions for the treatment of braf inhibitor resistant melanomas
AR115689A1 (es) 2018-07-05 2021-02-17 Sumitomo Chemical Co Compuestos de uracilo y su utilización
WO2020237096A1 (en) 2019-05-21 2020-11-26 Ardelyx, Inc. Combination for lowering serum phosphate in a patient

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1245969B (de) * 1967-08-03 VEB Arzneimittelwerk Dresden, Radebeul Verfahren zur Herstellung von Xanthinderivaten
CH629788A5 (de) * 1977-07-20 1982-05-14 Lonza Ag Verfahren zur herstellung von 5,6-diaminouracil.
SE416810C (sv) * 1977-10-14 1982-07-19 Draco Ab Forfarande for framstellning av xantinderivat med antiallergisk aktivitet
GB8826595D0 (en) * 1988-11-14 1988-12-21 Beecham Wuelfing Gmbh & Co Kg Active compounds

Also Published As

Publication number Publication date
CZ278328B6 (en) 1993-11-17
MY105303A (en) 1994-09-30
EG19436A (en) 1995-02-28
JPH05500226A (ja) 1993-01-21
NZ236517A (en) 1992-09-25
PT96332B (pt) 1998-06-30
FI96207C (fi) 1996-05-27
HU211573A9 (en) 1995-12-28
ATE93860T1 (de) 1993-09-15
WO1991009859A1 (en) 1991-07-11
GB8929208D0 (en) 1990-02-28
PL166152B1 (en) 1995-04-28
BR9007258A (pt) 1992-02-25
IL96708A0 (en) 1991-09-16
DK0435811T3 (da) 1993-11-01
CA2045478C (en) 1998-12-29
CA2045478A1 (en) 1991-06-28
HUT57766A (en) 1991-12-30
CN1029967C (zh) 1995-10-11
CN1052858A (zh) 1991-07-10
DE69003087D1 (de) 1993-10-07
NO913236D0 (no) 1991-08-19
AU6976891A (en) 1991-07-24
DE69003087T2 (de) 1993-12-16
KR970001528B1 (ko) 1997-02-11
JPH089617B2 (ja) 1996-01-31
AU635104B2 (en) 1993-03-11
NO913236L (no) 1991-08-19
KR920701207A (ko) 1992-08-11
NO178111B (no) 1995-10-16
UA32512C2 (uk) 2001-02-15
MX23884A (es) 1993-09-01
NO178111C (no) 1996-01-24
ZA9010240B (en) 1991-10-30
EP0435811B1 (en) 1993-09-01
EP0435811A1 (en) 1991-07-03
IE904634A1 (en) 1991-07-17
IE64065B1 (en) 1995-07-12
IL96708A (en) 1994-06-24
RU2073679C1 (ru) 1997-02-20
US5223504A (en) 1993-06-29
FI96207B (fi) 1996-02-15
ES2058864T3 (es) 1994-11-01
PT96332A (pt) 1991-09-30
FI914014A0 (fi) 1991-08-26
HU208825B (en) 1994-01-28

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