DE69003087D1 - Xanthinderivate. - Google Patents

Xanthinderivate.

Info

Publication number
DE69003087D1
DE69003087D1 DE90500126T DE69003087T DE69003087D1 DE 69003087 D1 DE69003087 D1 DE 69003087D1 DE 90500126 T DE90500126 T DE 90500126T DE 69003087 T DE69003087 T DE 69003087T DE 69003087 D1 DE69003087 D1 DE 69003087D1
Authority
DE
Germany
Prior art keywords
treating
formamide
excess
compounds
making
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE90500126T
Other languages
English (en)
Other versions
DE69003087T2 (de
Inventor
Armando Vega Noverola
Jose Manuel Prieto Soto
Jacinto Moragues Mauri
Robert W Gristwood
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Almirall SA
Original Assignee
Laboratorios Almirall SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios Almirall SA filed Critical Laboratorios Almirall SA
Application granted granted Critical
Publication of DE69003087D1 publication Critical patent/DE69003087D1/de
Publication of DE69003087T2 publication Critical patent/DE69003087T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
DE90500126T 1989-12-27 1990-12-19 Xanthinderivate. Expired - Fee Related DE69003087T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB898929208A GB8929208D0 (en) 1989-12-27 1989-12-27 New xanthine derivatives

Publications (2)

Publication Number Publication Date
DE69003087D1 true DE69003087D1 (de) 1993-10-07
DE69003087T2 DE69003087T2 (de) 1993-12-16

Family

ID=10668520

Family Applications (1)

Application Number Title Priority Date Filing Date
DE90500126T Expired - Fee Related DE69003087T2 (de) 1989-12-27 1990-12-19 Xanthinderivate.

Country Status (30)

Country Link
US (1) US5223504A (de)
EP (1) EP0435811B1 (de)
JP (1) JPH089617B2 (de)
KR (1) KR970001528B1 (de)
CN (1) CN1029967C (de)
AT (1) ATE93860T1 (de)
AU (1) AU635104B2 (de)
BR (1) BR9007258A (de)
CA (1) CA2045478C (de)
CZ (1) CZ278328B6 (de)
DE (1) DE69003087T2 (de)
DK (1) DK0435811T3 (de)
EG (1) EG19436A (de)
ES (1) ES2058864T3 (de)
FI (1) FI96207C (de)
GB (1) GB8929208D0 (de)
HU (2) HU208825B (de)
IE (1) IE64065B1 (de)
IL (1) IL96708A (de)
MX (1) MX23884A (de)
MY (1) MY105303A (de)
NO (1) NO178111C (de)
NZ (1) NZ236517A (de)
PL (1) PL166152B1 (de)
PT (1) PT96332B (de)
RU (1) RU2073679C1 (de)
SK (1) SK278365B6 (de)
UA (1) UA32512C2 (de)
WO (1) WO1991009859A1 (de)
ZA (1) ZA9010240B (de)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5521315A (en) * 1993-01-12 1996-05-28 Cell Therapeutics, Inc. Olefin substituted long chain compounds
GB9312853D0 (en) 1993-06-22 1993-08-04 Euro Celtique Sa Chemical compounds
US5922751A (en) 1994-06-24 1999-07-13 Euro-Celtique, S.A. Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same
US5591776A (en) 1994-06-24 1997-01-07 Euro-Celtique, S.A. Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV
US5661153A (en) * 1994-07-19 1997-08-26 Japan Energy Corporation 1-arylpyrimidine derivatives and pharmaceutical use thereof
EP0814809B1 (de) 1994-12-13 2003-08-13 Euroceltique S.A. Arylthioxanthine
AU4527996A (en) 1994-12-13 1996-07-03 Euro-Celtique S.A. Trisubstituted thioxanthines
US6025361A (en) * 1994-12-13 2000-02-15 Euro-Celtique, S.A. Trisubstituted thioxanthines
EP0825993A1 (de) * 1995-05-19 1998-03-04 Chiroscience Limited Xanthine und ihre therapeutische anwendung
US6166041A (en) 1995-10-11 2000-12-26 Euro-Celtique, S.A. 2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for the treatment of asthma
US6075016A (en) 1996-04-10 2000-06-13 Euro-Celtique S.A. 6,5-fused aromatic ring systems having enhanced phosphodiesterase IV inhibitory activity
US5864037A (en) * 1996-06-06 1999-01-26 Euro-Celtique, S.A. Methods for the synthesis of chemical compounds having PDE-IV inhibitory activity
US5874437A (en) * 1996-11-01 1999-02-23 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
US5958926A (en) 1996-11-01 1999-09-28 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
USRE37234E1 (en) * 1996-11-01 2001-06-19 Nitromed, Inc. Nitrosated and nitrosylated phosphodiestrase inhibitor compounds, compositions and their uses
EP0941086A4 (de) * 1996-11-01 2000-07-12 Nitromed Inc Nitrosierte und nitrosylierte phosphodiesterase hemmende verbindungen, zusammensetzungen und ihre verwendungen
US6331543B1 (en) 1996-11-01 2001-12-18 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use
GB9623859D0 (en) * 1996-11-15 1997-01-08 Chiroscience Ltd Novel compounds
US6472425B1 (en) 1997-10-31 2002-10-29 Nitromed, Inc. Methods for treating female sexual dysfunctions
IL132407A0 (en) * 1998-10-21 2001-03-19 Pfizer Prod Inc Method for treating congestive heart failure
JP2002543133A (ja) * 1999-05-04 2002-12-17 ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング ロフルミラストおよびｐｄｅ−３インヒビターを含有する共力薬の組合せ物
ATE447952T1 (de) 1999-08-21 2009-11-15 Nycomed Gmbh Synergistische kombination von pumafentrine und salmeterol
GB0005199D0 (en) * 2000-03-04 2000-04-26 Imp College Innovations Ltd Modulation of histone deacetylase
CA2402384A1 (en) 2000-03-16 2001-09-20 Inflazyme Pharmaceuticals Ltd. Benzylated pde4 inhibitors
CN1520313A (zh) * 2001-05-23 2004-08-11 ������ҩ��ʽ���� 一种加速骨折愈合的组合物
CN1537018A (zh) * 2001-05-23 2004-10-13 田边制药株式会社 一种用于软骨疾病再生治疗的组合物
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
MXPA05010373A (es) 2003-04-01 2005-12-05 Applied Research Systems Inhibidores de fosfodiesterasas en infertilidad.
EP2998314B1 (de) 2007-06-04 2020-01-22 Bausch Health Ireland Limited Für die behandlung von gastrointestinalen erkrankungen, entzündungen, krebs und anderen erkrankungen geeignete agonisten von guanylatcyclase
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
WO2009149279A2 (en) 2008-06-04 2009-12-10 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
WO2010009319A2 (en) 2008-07-16 2010-01-21 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
US9580471B2 (en) 2011-03-01 2017-02-28 Synergy Pharmaceuticals, Inc. Process of preparing guanylate cyclase C agonists
EP3718557A3 (de) 2013-02-25 2020-10-21 Bausch Health Ireland Limited Guanylat-cyclase-rezeptoragonist sp-333 zur verwendung in der darmreinigung
US9708367B2 (en) 2013-03-15 2017-07-18 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
AU2014235209B2 (en) 2013-03-15 2018-06-14 Bausch Health Ireland Limited Guanylate cyclase receptor agonists combined with other drugs
KR102272746B1 (ko) 2013-06-05 2021-07-08 보슈 헬스 아일랜드 리미티드 구아닐레이트 사이클라제 c의 초순수 작용제, 및 이의 제조 및 사용 방법
WO2015021358A2 (en) 2013-08-09 2015-02-12 Dominique Charmot Compounds and methods for inhibiting phosphate transport
EP3165224A1 (de) 2015-11-09 2017-05-10 Albert-Ludwigs-Universität Freiburg Verwendung von pde4 hemmern zur prophylaxe und/oder therapie von dyslipoproteinaemie und verwandten erkrankungen
WO2017089347A1 (en) 2015-11-25 2017-06-01 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods and pharmaceutical compositions for the treatment of braf inhibitor resistant melanomas
AR115689A1 (es) 2018-07-05 2021-02-17 Sumitomo Chemical Co Compuestos de uracilo y su utilización
CN114340631A (zh) 2019-05-21 2022-04-12 阿德利克斯股份有限公司 用于降低患者的血清磷酸盐的组合

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1245969B (de) * 1967-08-03 VEB Arzneimittelwerk Dresden, Radebeul Verfahren zur Herstellung von Xanthinderivaten
CH629788A5 (de) * 1977-07-20 1982-05-14 Lonza Ag Verfahren zur herstellung von 5,6-diaminouracil.
SE416810C (sv) * 1977-10-14 1982-05-11 Draco Ab Forfarande for framstellning av xantinderivat med antiallergisk aktivitet
GB8826595D0 (en) * 1988-11-14 1988-12-21 Beecham Wuelfing Gmbh & Co Kg Active compounds

Also Published As

Publication number Publication date
PT96332A (pt) 1991-09-30
NO178111C (no) 1996-01-24
NO913236L (no) 1991-08-19
HUT57766A (en) 1991-12-30
DE69003087T2 (de) 1993-12-16
IE904634A1 (en) 1991-07-17
IL96708A (en) 1994-06-24
NZ236517A (en) 1992-09-25
FI914014A0 (fi) 1991-08-26
CN1052858A (zh) 1991-07-10
EP0435811B1 (de) 1993-09-01
ATE93860T1 (de) 1993-09-15
PT96332B (pt) 1998-06-30
SK278365B6 (en) 1997-01-08
KR970001528B1 (ko) 1997-02-11
NO178111B (no) 1995-10-16
HU211573A9 (en) 1995-12-28
CA2045478C (en) 1998-12-29
UA32512C2 (uk) 2001-02-15
AU6976891A (en) 1991-07-24
WO1991009859A1 (en) 1991-07-11
IL96708A0 (en) 1991-09-16
JPH089617B2 (ja) 1996-01-31
FI96207B (fi) 1996-02-15
PL166152B1 (en) 1995-04-28
JPH05500226A (ja) 1993-01-21
MX23884A (es) 1993-09-01
ES2058864T3 (es) 1994-11-01
AU635104B2 (en) 1993-03-11
MY105303A (en) 1994-09-30
RU2073679C1 (ru) 1997-02-20
BR9007258A (pt) 1992-02-25
GB8929208D0 (en) 1990-02-28
CN1029967C (zh) 1995-10-11
ZA9010240B (en) 1991-10-30
KR920701207A (ko) 1992-08-11
IE64065B1 (en) 1995-07-12
DK0435811T3 (da) 1993-11-01
US5223504A (en) 1993-06-29
FI96207C (fi) 1996-05-27
EG19436A (en) 1995-02-28
CA2045478A1 (en) 1991-06-28
CZ278328B6 (en) 1993-11-17
EP0435811A1 (de) 1991-07-03
HU208825B (en) 1994-01-28
NO913236D0 (no) 1991-08-19

Similar Documents

Publication Publication Date Title
DE69003087D1 (de) Xanthinderivate.
HU912676D0 (en) Sulfonamide derivatives
CA2079143A1 (en) Novel 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ace
TW377352B (en) Pyrido[2,3-d]pyrimidine derivatives and pharmaceutical compositions thereof
YU47555B (sh) Derivati tetrahidrobenzimidazola i postupak za njihovo dobijanje
IE45700L (en) PYRAZOLO (3,4-b) PYRIDINES
ES8700857A1 (es) Un procedimiento para la produccion de dihidropiridinas
ATE13425T1 (de) Piperidin-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
ES2057031T3 (es) Compuestos de nucleosido de 2'-metilidenpirimidina, su uso y metodo para su produccion.
ZA897590B (en) Aryloxy-,arylthio-,heteroaryloxy-,heteroarylthio-alkenylene derivatives of amines
HUT48201A (en) Herbicide comprising anilide derivatives and process for producing such compounds
MY104630A (en) 4(1h) ouinoline derivatives

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: ALMIRALL-PRODESFARMA, S.A., BARCELONA, ES

8339 Ceased/non-payment of the annual fee