NO178111C - Analogifremgangsmåte ved fremstilling av nye, terapeutisk aktive xantin-derivater - Google Patents

Analogifremgangsmåte ved fremstilling av nye, terapeutisk aktive xantin-derivater

Info

Publication number
NO178111C
NO178111C NO913236A NO913236A NO178111C NO 178111 C NO178111 C NO 178111C NO 913236 A NO913236 A NO 913236A NO 913236 A NO913236 A NO 913236A NO 178111 C NO178111 C NO 178111C
Authority
NO
Norway
Prior art keywords
treating
formamide
excess
compounds
making
Prior art date
Application number
NO913236A
Other languages
English (en)
Other versions
NO913236L (no
NO178111B (no
NO913236D0 (no
Inventor
Armando Vega Noverola
Jose Manuel Prieto Soto
Jacinto Moragues Mauri
Robert W Gristwood
Original Assignee
Almirall Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Almirall Lab filed Critical Almirall Lab
Publication of NO913236L publication Critical patent/NO913236L/no
Publication of NO913236D0 publication Critical patent/NO913236D0/no
Publication of NO178111B publication Critical patent/NO178111B/no
Publication of NO178111C publication Critical patent/NO178111C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Peptides Or Proteins (AREA)
NO913236A 1989-12-27 1991-08-19 Analogifremgangsmåte ved fremstilling av nye, terapeutisk aktive xantin-derivater NO178111C (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB898929208A GB8929208D0 (en) 1989-12-27 1989-12-27 New xanthine derivatives
PCT/GB1990/002027 WO1991009859A1 (en) 1989-12-27 1990-12-27 New xanthine derivatives

Publications (4)

Publication Number Publication Date
NO913236L NO913236L (no) 1991-08-19
NO913236D0 NO913236D0 (no) 1991-08-19
NO178111B NO178111B (no) 1995-10-16
NO178111C true NO178111C (no) 1996-01-24

Family

ID=10668520

Family Applications (1)

Application Number Title Priority Date Filing Date
NO913236A NO178111C (no) 1989-12-27 1991-08-19 Analogifremgangsmåte ved fremstilling av nye, terapeutisk aktive xantin-derivater

Country Status (30)

Country Link
US (1) US5223504A (no)
EP (1) EP0435811B1 (no)
JP (1) JPH089617B2 (no)
KR (1) KR970001528B1 (no)
CN (1) CN1029967C (no)
AT (1) ATE93860T1 (no)
AU (1) AU635104B2 (no)
BR (1) BR9007258A (no)
CA (1) CA2045478C (no)
CZ (1) CZ278328B6 (no)
DE (1) DE69003087T2 (no)
DK (1) DK0435811T3 (no)
EG (1) EG19436A (no)
ES (1) ES2058864T3 (no)
FI (1) FI96207C (no)
GB (1) GB8929208D0 (no)
HU (2) HU208825B (no)
IE (1) IE64065B1 (no)
IL (1) IL96708A (no)
MX (1) MX23884A (no)
MY (1) MY105303A (no)
NO (1) NO178111C (no)
NZ (1) NZ236517A (no)
PL (1) PL166152B1 (no)
PT (1) PT96332B (no)
RU (1) RU2073679C1 (no)
SK (1) SK278365B6 (no)
UA (1) UA32512C2 (no)
WO (1) WO1991009859A1 (no)
ZA (1) ZA9010240B (no)

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US5521315A (en) * 1993-01-12 1996-05-28 Cell Therapeutics, Inc. Olefin substituted long chain compounds
GB9312853D0 (en) 1993-06-22 1993-08-04 Euro Celtique Sa Chemical compounds
US5922751A (en) 1994-06-24 1999-07-13 Euro-Celtique, S.A. Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same
US5591776A (en) 1994-06-24 1997-01-07 Euro-Celtique, S.A. Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV
US5661153A (en) * 1994-07-19 1997-08-26 Japan Energy Corporation 1-arylpyrimidine derivatives and pharmaceutical use thereof
ATE247116T1 (de) 1994-12-13 2003-08-15 Euro Celtique Sa Arylthioxanthine
US6025361A (en) * 1994-12-13 2000-02-15 Euro-Celtique, S.A. Trisubstituted thioxanthines
CA2206804C (en) 1994-12-13 2002-03-19 Euro-Celtique, S.A. Trisubstituted thioxanthines
JPH11505241A (ja) * 1995-05-19 1999-05-18 カイロサイエンス・リミテッド キサンチン類およびこれらの治療的使用
US6166041A (en) 1995-10-11 2000-12-26 Euro-Celtique, S.A. 2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for the treatment of asthma
US6075016A (en) 1996-04-10 2000-06-13 Euro-Celtique S.A. 6,5-fused aromatic ring systems having enhanced phosphodiesterase IV inhibitory activity
US5864037A (en) 1996-06-06 1999-01-26 Euro-Celtique, S.A. Methods for the synthesis of chemical compounds having PDE-IV inhibitory activity
USRE37234E1 (en) * 1996-11-01 2001-06-19 Nitromed, Inc. Nitrosated and nitrosylated phosphodiestrase inhibitor compounds, compositions and their uses
US5958926A (en) 1996-11-01 1999-09-28 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
US6331543B1 (en) * 1996-11-01 2001-12-18 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use
AU722480B2 (en) * 1996-11-01 2000-08-03 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
US5874437A (en) * 1996-11-01 1999-02-23 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
GB9623859D0 (en) * 1996-11-15 1997-01-08 Chiroscience Ltd Novel compounds
US6472425B1 (en) 1997-10-31 2002-10-29 Nitromed, Inc. Methods for treating female sexual dysfunctions
IL132407A0 (en) * 1998-10-21 2001-03-19 Pfizer Prod Inc Method for treating congestive heart failure
CA2372850C (en) * 1999-05-04 2011-01-18 Ulrich Kilian Synergistic combination comprising roflumilast and a pde-3 inhibitor
KR100701904B1 (ko) 1999-08-21 2007-04-02 알타나 파마 아게 Ｐｄｅ 억제제 및 베타 2 아드레날린수용체 작동제의상승적 조합
GB0005199D0 (en) * 2000-03-04 2000-04-26 Imp College Innovations Ltd Modulation of histone deacetylase
CA2402384A1 (en) 2000-03-16 2001-09-20 Inflazyme Pharmaceuticals Ltd. Benzylated pde4 inhibitors
KR20040007596A (ko) * 2001-05-23 2004-01-24 다나베 세이야꾸 가부시키가이샤 골절 치료 촉진용 조성물
JP4510383B2 (ja) * 2001-05-23 2010-07-21 田辺三菱製薬株式会社 軟骨疾患修復治療用組成物
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
WO2004087211A2 (en) 2003-04-01 2004-10-14 Applied Research Systems Ars Holding N.V. Inhibitors of phosphodiesterases in infertility
JP5546451B2 (ja) 2007-06-04 2014-07-09 シナジー ファーマシューティカルズ インコーポレイテッド 胃腸の障害、炎症、癌および他の障害の処置に有用なグアニル酸シクラーゼのアゴニスト
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
AU2009256157B2 (en) 2008-06-04 2014-12-18 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
WO2010009319A2 (en) 2008-07-16 2010-01-21 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CN103764672A (zh) 2011-03-01 2014-04-30 辛纳吉制药公司 制备鸟苷酸环化酶c激动剂的方法
WO2014131024A2 (en) 2013-02-25 2014-08-28 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
CA2905435A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
WO2014151206A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
US10011637B2 (en) 2013-06-05 2018-07-03 Synergy Pharmaceuticals, Inc. Ultra-pure agonists of guanylate cyclase C, method of making and using same
US20160184387A1 (en) 2013-08-09 2016-06-30 Dominique Charmot Compounds and methods for inhibiting phosphate transport
EP3165224A1 (en) 2015-11-09 2017-05-10 Albert-Ludwigs-Universität Freiburg Use of pde4 inhibitors for the prophylaxis and/or therapy of dyslipoproteinaemia and related disorders
WO2017089347A1 (en) 2015-11-25 2017-06-01 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods and pharmaceutical compositions for the treatment of braf inhibitor resistant melanomas
AR115689A1 (es) 2018-07-05 2021-02-17 Sumitomo Chemical Co Compuestos de uracilo y su utilización
WO2020237096A1 (en) 2019-05-21 2020-11-26 Ardelyx, Inc. Combination for lowering serum phosphate in a patient

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1245969B (de) * 1967-08-03 VEB Arzneimittelwerk Dresden, Radebeul Verfahren zur Herstellung von Xanthinderivaten
CH629788A5 (de) * 1977-07-20 1982-05-14 Lonza Ag Verfahren zur herstellung von 5,6-diaminouracil.
SE416810C (sv) * 1977-10-14 1982-07-19 Draco Ab Forfarande for framstellning av xantinderivat med antiallergisk aktivitet
GB8826595D0 (en) * 1988-11-14 1988-12-21 Beecham Wuelfing Gmbh & Co Kg Active compounds

Also Published As

Publication number Publication date
MY105303A (en) 1994-09-30
HUT57766A (en) 1991-12-30
DK0435811T3 (da) 1993-11-01
CA2045478A1 (en) 1991-06-28
ATE93860T1 (de) 1993-09-15
WO1991009859A1 (en) 1991-07-11
NO913236L (no) 1991-08-19
FI914014A0 (fi) 1991-08-26
CN1029967C (zh) 1995-10-11
FI96207C (fi) 1996-05-27
MX23884A (es) 1993-09-01
US5223504A (en) 1993-06-29
NO178111B (no) 1995-10-16
SK278365B6 (en) 1997-01-08
HU208825B (en) 1994-01-28
PL166152B1 (en) 1995-04-28
JPH05500226A (ja) 1993-01-21
BR9007258A (pt) 1992-02-25
CZ278328B6 (en) 1993-11-17
IL96708A0 (en) 1991-09-16
IE64065B1 (en) 1995-07-12
FI96207B (fi) 1996-02-15
IL96708A (en) 1994-06-24
NZ236517A (en) 1992-09-25
EP0435811A1 (en) 1991-07-03
IE904634A1 (en) 1991-07-17
HU211573A9 (en) 1995-12-28
AU6976891A (en) 1991-07-24
UA32512C2 (uk) 2001-02-15
JPH089617B2 (ja) 1996-01-31
CN1052858A (zh) 1991-07-10
DE69003087D1 (de) 1993-10-07
PT96332A (pt) 1991-09-30
GB8929208D0 (en) 1990-02-28
RU2073679C1 (ru) 1997-02-20
NO913236D0 (no) 1991-08-19
AU635104B2 (en) 1993-03-11
KR970001528B1 (ko) 1997-02-11
EP0435811B1 (en) 1993-09-01
ES2058864T3 (es) 1994-11-01
ZA9010240B (en) 1991-10-30
KR920701207A (ko) 1992-08-11
EG19436A (en) 1995-02-28
DE69003087T2 (de) 1993-12-16
PT96332B (pt) 1998-06-30
CA2045478C (en) 1998-12-29

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