JPS5629585A - Preparation of dibenz b,f oxepin derivative - Google Patents
Preparation of dibenz b,f oxepin derivativeInfo
- Publication number
- JPS5629585A JPS5629585A JP10420879A JP10420879A JPS5629585A JP S5629585 A JPS5629585 A JP S5629585A JP 10420879 A JP10420879 A JP 10420879A JP 10420879 A JP10420879 A JP 10420879A JP S5629585 A JPS5629585 A JP S5629585A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- dibenz
- sulfur
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pyrane Compounds (AREA)
Abstract
PURPOSE: To obtain the titled compound having an antiinflammatory, analgesic and antipyretic actions, by reacting an ester derivative of 2-[4-(2'-acetylphenoxy) phenyl]propionic acid with sulfur and a secondary amine, and hydrolyzing and cyclizing the reaction product.
CONSTITUTION: A mixture of (A) a compound of formula II (R1 is 1W3C alkyl; R2 is 1W6C alkyl) with (B) sulfur in a molar amount of 1W3 times that of the compound of formula II and (C) a secondary amine, e.g. dimethylamine or morpholine, of the formula HNR3R4 (R3 and R4 are 1W3C alkyls or may form a heterocyclic ring with the adjacent N atom) is heated at 100W160°C to give a compound of formula IV, which is then hydrolyzed by the conventional method to form a dicarboxylic acid of formula V. The dicarboxylic acid thus obtained is isolated, purified and then cyclized in the presence of a condensing agent, e.g. polyphosphoric acid or hydrogen fluoride, to afford a dibenz[b,f]oxepin derivative of formula I.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10420879A JPS5629585A (en) | 1979-08-15 | 1979-08-15 | Preparation of dibenz b,f oxepin derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10420879A JPS5629585A (en) | 1979-08-15 | 1979-08-15 | Preparation of dibenz b,f oxepin derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5629585A true JPS5629585A (en) | 1981-03-24 |
JPS6330907B2 JPS6330907B2 (en) | 1988-06-21 |
Family
ID=14374544
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP10420879A Granted JPS5629585A (en) | 1979-08-15 | 1979-08-15 | Preparation of dibenz b,f oxepin derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5629585A (en) |
-
1979
- 1979-08-15 JP JP10420879A patent/JPS5629585A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
JPS6330907B2 (en) | 1988-06-21 |
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