SK23394A3 - New isosteric peptides - Google Patents

New isosteric peptides Download PDF

Info

Publication number
SK23394A3
SK23394A3 SK233-94A SK23394A SK23394A3 SK 23394 A3 SK23394 A3 SK 23394A3 SK 23394 A SK23394 A SK 23394A SK 23394 A3 SK23394 A3 SK 23394A3
Authority
SK
Slovakia
Prior art keywords
arg
pro
dcha
group
phenyl
Prior art date
Application number
SK233-94A
Other languages
English (en)
Slovak (sk)
Inventor
Butrus Airash
David M Jones
Michael Szelke
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Publication of SK23394A3 publication Critical patent/SK23394A3/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SK233-94A 1991-08-28 1992-08-25 New isosteric peptides SK23394A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9102462A SE9102462D0 (sv) 1991-08-28 1991-08-28 New isosteric peptides
PCT/SE1992/000584 WO1993005069A1 (en) 1991-08-28 1992-08-25 New isosteric peptides

Publications (1)

Publication Number Publication Date
SK23394A3 true SK23394A3 (en) 1994-08-10

Family

ID=20383557

Family Applications (1)

Application Number Title Priority Date Filing Date
SK233-94A SK23394A3 (en) 1991-08-28 1992-08-25 New isosteric peptides

Country Status (27)

Country Link
US (1) US5424291A (zh)
EP (2) EP0605462B1 (zh)
JP (1) JP3353297B2 (zh)
CN (1) CN1069736A (zh)
AP (1) AP313A (zh)
AT (1) ATE212643T1 (zh)
AU (1) AU2499092A (zh)
BG (1) BG98583A (zh)
CA (1) CA2116527A1 (zh)
CZ (1) CZ38094A3 (zh)
DE (1) DE69232394T2 (zh)
DZ (1) DZ1613A1 (zh)
FI (1) FI940945A0 (zh)
HU (1) HUT66060A (zh)
IL (1) IL102840A0 (zh)
IS (1) IS3906A (zh)
MA (1) MA22632A1 (zh)
MX (1) MX9204767A (zh)
NO (1) NO940669L (zh)
NZ (1) NZ243675A (zh)
SE (1) SE9102462D0 (zh)
SI (1) SI9200193A (zh)
SK (1) SK23394A3 (zh)
TN (1) TNSN92076A1 (zh)
TW (1) TW221816B (zh)
WO (1) WO1993005069A1 (zh)
ZA (1) ZA925737B (zh)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ245039A (en) * 1991-11-12 1994-12-22 Lilly Co Eli N-phenylalanyl and n-phenylglycyl derivatives of the dipeptide of l-azetidine-2-carboxylic acid and l-arginine aldehyde; anti-blood clotting compositions
SE9103612D0 (sv) * 1991-12-04 1991-12-04 Astra Ab New peptide derivatives
JPH06329627A (ja) * 1993-05-03 1994-11-29 Bristol Myers Squibb Co グアニジニル−またはアミジニル−置換ヘテロ環トロンビンインヒビター
SE9301916D0 (sv) * 1993-06-03 1993-06-03 Ab Astra New peptides derivatives
US6984627B1 (en) 1993-06-03 2006-01-10 Astrazeneca Ab Peptide derivatives
US5783563A (en) * 1993-06-03 1998-07-21 Astra Aktiebolag Method for treatment or prophylaxis of venous thrombosis
US5705487A (en) * 1994-03-04 1998-01-06 Eli Lilly And Company Antithrombotic agents
US5726159A (en) * 1994-03-04 1998-03-10 Eli Lilly And Company Antithrombotic agents
US5602101A (en) * 1994-03-04 1997-02-11 Eli Lilly And Company Antithrombotic agents
US5484772A (en) * 1994-03-04 1996-01-16 Eli Lilly And Company Antithrombotic agents
US5885967A (en) * 1994-03-04 1999-03-23 Eli Lilly And Company Antithrombotic agents
US5488037A (en) * 1994-03-04 1996-01-30 Eli Lilly And Company Antithrombotic agents
ZA951617B (en) * 1994-03-04 1997-02-27 Lilly Co Eli Antithrombotic agents.
US5436229A (en) * 1994-03-04 1995-07-25 Eli Lilly And Company Bisulfite adducts of arginine aldehydes
CA2143533A1 (en) * 1994-03-04 1995-09-05 Kenneth D. Kurz Antithrombotic agents
US5439888A (en) * 1994-03-04 1995-08-08 Eli Lilly And Company Antithrombotic agents
US5707966A (en) * 1994-03-04 1998-01-13 Eli Lilly And Company Antithrombotic agents
ZA951618B (en) * 1994-03-04 1996-08-27 Lilly Co Eli Antithrombotic agents
DE4421052A1 (de) 1994-06-17 1995-12-21 Basf Ag Neue Thrombininhibitoren, ihre Herstellung und Verwendung
SE9404196D0 (sv) * 1994-12-02 1994-12-02 Astra Ab New antithrombotic formulation
NZ302649A (en) * 1995-02-17 2000-01-28 Basf Ag Dipeptide amidine derivatives, preparation and pharmaceutical compositions thereof
US5914319A (en) * 1995-02-27 1999-06-22 Eli Lilly And Company Antithrombotic agents
US5710130A (en) * 1995-02-27 1998-01-20 Eli Lilly And Company Antithrombotic agents
SA96170106A (ar) 1995-07-06 2005-12-03 أسترا أكتيبولاج مشتقات حامض أميني جديدة
TWI238827B (en) 1995-12-21 2005-09-01 Astrazeneca Ab Prodrugs of thrombin inhibitors
SE9602263D0 (sv) 1996-06-07 1996-06-07 Astra Ab New amino acid derivatives
US5840733A (en) * 1996-07-01 1998-11-24 Redcell, Canada, Inc. Methods and compositions for producing novel conjugates of thrombin inhibitors and endogenous carriers resulting in anti-thrombins with extended lifetimes
SE9602646D0 (sv) 1996-07-04 1996-07-04 Astra Ab Pharmaceutically-useful compounds
AR013084A1 (es) 1997-06-19 2000-12-13 Astrazeneca Ab Derivados de amidino utiles como inhibidores de la trombina, composicion farmaceutica, utilizacion de dichos compuestos para la preparacion demedicamentos y proceso para la preparacion de los compuestos mencionados
SE9704543D0 (sv) 1997-12-05 1997-12-05 Astra Ab New compounds
CA2317761A1 (en) 1998-01-26 1999-07-29 Basf Aktiengesellschaft Thrombin inhibitors
US6417161B1 (en) 1998-04-24 2002-07-09 3-Dimensional Pharmaceuticals, Inc. Amino acid amidinohydrazones, alkoxyguanidines and aminoguanidines as protease inhibitors
SE9802973D0 (sv) 1998-09-03 1998-09-03 Astra Ab Immediate release tablet
SE9804313D0 (sv) 1998-12-14 1998-12-14 Astra Ab New compounds
WO2000042059A1 (en) 1999-01-13 2000-07-20 Astrazeneca Ab New amidinobenzylamine derivatives and their use as thrombin inhibitors
AR023510A1 (es) 1999-04-21 2002-09-04 Astrazeneca Ab Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina.
AU1226001A (en) * 1999-11-09 2001-06-06 Alcon Universal Limited Phospholipids of hydroxyeicosatetraenoic acid-like derivatives
SE0001803D0 (sv) 2000-05-16 2000-05-16 Astrazeneca Ab New compounds i
US6433186B1 (en) 2000-08-16 2002-08-13 Astrazeneca Ab Amidino derivatives and their use as thormbin inhibitors
US7129233B2 (en) 2000-12-01 2006-10-31 Astrazeneca Ab Mandelic acid derivatives and their use as thrombin inhibitors
AR035216A1 (es) 2000-12-01 2004-05-05 Astrazeneca Ab Derivados de acido mandelico ,derivados farmaceuticamente aceptables, uso de estos derivados para la fabricacion de medicamentos, metodos de tratamiento ,procesos para la preparacion de estos derivados, y compuestos intermediarios
AR034517A1 (es) 2001-06-21 2004-02-25 Astrazeneca Ab Formulacion farmaceutica
SE0201661D0 (sv) 2002-05-31 2002-05-31 Astrazeneca Ab New salts
SE0201659D0 (sv) 2002-05-31 2002-05-31 Astrazeneca Ab Modified release pharmaceutical formulation
US7781424B2 (en) 2003-05-27 2010-08-24 Astrazeneca Ab Modified release pharmaceutical formulation
US7795205B2 (en) 2004-04-12 2010-09-14 Canyon Pharmaceuticals, Inc. Methods for effecting regression of tumor mass and size in a metastasized pancreatic tumor
TW200827336A (en) 2006-12-06 2008-07-01 Astrazeneca Ab New crystalline forms
PE20171335A1 (es) 2014-10-06 2017-09-13 Cortexyme Inc Inhibidores de gingipaina de lisina
JP6877424B2 (ja) 2015-11-09 2021-05-26 コーテクシーミー， インコーポレイテッド アルギニンジンジパインの阻害剤
US10590084B2 (en) 2016-03-09 2020-03-17 Blade Therapeutics, Inc. Cyclic keto-amide compounds as calpain modulators and methods of production and use thereof
WO2018009417A1 (en) 2016-07-05 2018-01-11 Blade Therapeutics, Inc. Calpain modulators and therapeutic uses thereof
BR112019004864A8 (pt) 2016-09-16 2023-03-07 Cortexyme Inc Inibidores cetona de lisina gingipain
KR20190063473A (ko) 2016-09-28 2019-06-07 블레이드 테라퓨틱스, 인크. 칼페인 조정자 및 그 치료학적 용도
MX2020010033A (es) * 2018-03-28 2020-10-14 Blade Therapeutics Inc Moduladores calpaina y usos terapeuticos de los mismos.
US20220204457A1 (en) * 2019-03-21 2022-06-30 Cortexyme, Inc. Arginine gingipain inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4318904A (en) * 1980-04-25 1982-03-09 Research Corporation Peptide affinity labels for thrombin and other trypsin-like proteases
GB8305985D0 (en) * 1983-03-04 1983-04-07 Szelke M Enzyme inhibition
DE3505555A1 (de) * 1985-02-18 1986-09-11 Behringwerke Ag, 3550 Marburg Neue oligopeptidylargininolderivate und deren homologe, verfahren zu deren herstellung, deren verwendung und diese enthaltende mittel
IL99527A (en) * 1990-09-28 1997-08-14 Lilly Co Eli Tripeptide antithrombotic agents

Also Published As

Publication number Publication date
US5424291A (en) 1995-06-13
ATE212643T1 (de) 2002-02-15
AP9200418A0 (en) 1992-10-31
EP0530167A1 (en) 1993-03-03
EP0605462B1 (en) 2002-01-30
IS3906A (is) 1993-03-01
CA2116527A1 (en) 1993-03-18
NO940669L (no) 1994-04-19
MA22632A1 (fr) 1993-04-01
NO940669D0 (no) 1994-02-25
SI9200193A (en) 1993-06-30
SE9102462D0 (sv) 1991-08-28
BG98583A (bg) 1994-09-30
ZA925737B (en) 1993-03-01
DE69232394D1 (de) 2002-03-14
CN1069736A (zh) 1993-03-10
JP3353297B2 (ja) 2002-12-03
FI940945A (fi) 1994-02-28
CZ38094A3 (en) 1994-08-17
TW221816B (zh) 1994-03-21
HU9400589D0 (en) 1994-05-30
NZ243675A (en) 1994-06-27
AU2499092A (en) 1993-04-05
TNSN92076A1 (fr) 1993-06-08
FI940945A0 (fi) 1994-02-28
DZ1613A1 (fr) 2002-02-17
JPH06510059A (ja) 1994-11-10
MX9204767A (es) 1993-05-01
WO1993005069A1 (en) 1993-03-18
IL102840A0 (en) 1993-01-31
EP0605462A1 (en) 1994-07-13
AP313A (en) 1994-02-10
HUT66060A (en) 1994-09-28
DE69232394T2 (de) 2002-08-22

Similar Documents

Publication Publication Date Title
SK23394A3 (en) New isosteric peptides
US5055451A (en) Aryloxy and arylacyloxy methyl ketones as thiol protease inhibitors
US6162828A (en) Cysteine protease inhibitor
EP0183398B1 (en) Angiotensin converting enzyme inhibitors and their production and use as pharmaceuticals
SK63194A3 (en) Peptide derivatives
TW487708B (en) Acylguanidine derivatives and their use as serine protease inhibitors
AU691243B2 (en) Novel mercaptoacetylamido 1,3,4,5-tetrahydro-benzo(c)azepin-3-one disulfide derivatives useful as inhibitors of enkephalinase and ace
JPH02202898A (ja) ジペプチドの酵素‐阻害尿素誘導体
FR2518088A1 (fr) Nouveaux derives d'aminoacides, et leur application therapeutique
JPH11503455A (ja) トロンビン阻害剤
TW442452B (en) Serine protease inhibitors having an alkynylamino side chain
CZ277998A3 (cs) Inhibitory serinproteázy a farmaceutický prostředek
CA2005337A1 (en) Use of peptide isosteres as retroviral protease inhibitors
US5158936A (en) Aryloxy and arylacyloxy methyl ketones as thiol protease inhibitors
HU207508B (en) Process for producing renin-inhibiting glycolic acid derivatives and pharmaceutical compositions containing them
JPH05222005A (ja) ３（ｓ）−アミノ−４−シクロヘキシル−２（ｒ）−ヒドロキシ酪酸若しくは４−シクロヘキシル−（２ｒ，３ｓ）−ジヒドロキシ酪酸又は関連類似体を含む環状レニン阻害剤
CA2074967A1 (en) Hexapeptide
US9045524B2 (en) Selective caspase inhibitors and uses thereof
JPH02503799A (ja) メルカプト‐アシルアミノ酸抗高血圧剤
HU196609B (en) Process for producing new peptides and pharmaceutics comprising them
HU208427B (en) Process for producing renine-inhibiting amino-acid derivatives and pharmaceutical compositions containing them
EP0158947A2 (en) Amino thiol dipeptides
JPH09295996A (ja) システインプロテアーゼ阻害化合物
HUT51291A (en) Process for production of new derivatives of dipeptide with inhibitor effect
IE65539B1 (en) Trifluoromethyl mercaptan and mercaptoacyl derivatives and method of using same