NO940669L - Nye isosteriske peptider - Google Patents

Nye isosteriske peptider

Info

Publication number
NO940669L
NO940669L NO940669A NO940669A NO940669L NO 940669 L NO940669 L NO 940669L NO 940669 A NO940669 A NO 940669A NO 940669 A NO940669 A NO 940669A NO 940669 L NO940669 L NO 940669L
Authority
NO
Norway
Prior art keywords
novel
isosteric peptides
peptides
novel isosteric
compounds
Prior art date
Application number
NO940669A
Other languages
English (en)
Norwegian (no)
Other versions
NO940669D0 (no
Inventor
Butrus Atrash
David Michael Jones
Michael Szelke
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Publication of NO940669D0 publication Critical patent/NO940669D0/no
Publication of NO940669L publication Critical patent/NO940669L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
NO940669A 1991-08-28 1994-02-25 Nye isosteriske peptider NO940669L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9102462A SE9102462D0 (sv) 1991-08-28 1991-08-28 New isosteric peptides
PCT/SE1992/000584 WO1993005069A1 (en) 1991-08-28 1992-08-25 New isosteric peptides

Publications (2)

Publication Number Publication Date
NO940669D0 NO940669D0 (no) 1994-02-25
NO940669L true NO940669L (no) 1994-04-19

Family

ID=20383557

Family Applications (1)

Application Number Title Priority Date Filing Date
NO940669A NO940669L (no) 1991-08-28 1994-02-25 Nye isosteriske peptider

Country Status (27)

Country Link
US (1) US5424291A (zh)
EP (2) EP0530167A1 (zh)
JP (1) JP3353297B2 (zh)
CN (1) CN1069736A (zh)
AP (1) AP313A (zh)
AT (1) ATE212643T1 (zh)
AU (1) AU2499092A (zh)
BG (1) BG98583A (zh)
CA (1) CA2116527A1 (zh)
CZ (1) CZ38094A3 (zh)
DE (1) DE69232394T2 (zh)
DZ (1) DZ1613A1 (zh)
FI (1) FI940945A (zh)
HU (1) HUT66060A (zh)
IL (1) IL102840A0 (zh)
IS (1) IS3906A (zh)
MA (1) MA22632A1 (zh)
MX (1) MX9204767A (zh)
NO (1) NO940669L (zh)
NZ (1) NZ243675A (zh)
SE (1) SE9102462D0 (zh)
SI (1) SI9200193A (zh)
SK (1) SK23394A3 (zh)
TN (1) TNSN92076A1 (zh)
TW (1) TW221816B (zh)
WO (1) WO1993005069A1 (zh)
ZA (1) ZA925737B (zh)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ333492A3 (en) * 1991-11-12 1993-09-15 Lilly Co Eli Dipeptide of l-azetidine-2-carboxylic acids and l-argininaldehyde, process of its preparation and pharmaceutical preparation in which said dipeptide is comprised
SE9103612D0 (sv) * 1991-12-04 1991-12-04 Astra Ab New peptide derivatives
JPH06329627A (ja) * 1993-05-03 1994-11-29 Bristol Myers Squibb Co グアニジニル−またはアミジニル−置換ヘテロ環トロンビンインヒビター
US6984627B1 (en) 1993-06-03 2006-01-10 Astrazeneca Ab Peptide derivatives
US5783563A (en) * 1993-06-03 1998-07-21 Astra Aktiebolag Method for treatment or prophylaxis of venous thrombosis
SE9301916D0 (sv) * 1993-06-03 1993-06-03 Ab Astra New peptides derivatives
US5705487A (en) * 1994-03-04 1998-01-06 Eli Lilly And Company Antithrombotic agents
US5488037A (en) * 1994-03-04 1996-01-30 Eli Lilly And Company Antithrombotic agents
IL112795A (en) * 1994-03-04 2001-01-28 Astrazeneca Ab Derivatives of peptides as antithrombotic drugs, their preparation, and pharmaceutical preparations containing them
US5602101A (en) * 1994-03-04 1997-02-11 Eli Lilly And Company Antithrombotic agents
US5484772A (en) * 1994-03-04 1996-01-16 Eli Lilly And Company Antithrombotic agents
US5885967A (en) * 1994-03-04 1999-03-23 Eli Lilly And Company Antithrombotic agents
US5726159A (en) * 1994-03-04 1998-03-10 Eli Lilly And Company Antithrombotic agents
US5439888A (en) * 1994-03-04 1995-08-08 Eli Lilly And Company Antithrombotic agents
CA2143533A1 (en) * 1994-03-04 1995-09-05 Kenneth D. Kurz Antithrombotic agents
US5707966A (en) * 1994-03-04 1998-01-13 Eli Lilly And Company Antithrombotic agents
ZA951618B (en) * 1994-03-04 1996-08-27 Lilly Co Eli Antithrombotic agents
US5436229A (en) * 1994-03-04 1995-07-25 Eli Lilly And Company Bisulfite adducts of arginine aldehydes
DE4421052A1 (de) 1994-06-17 1995-12-21 Basf Ag Neue Thrombininhibitoren, ihre Herstellung und Verwendung
SE9404196D0 (sv) * 1994-12-02 1994-12-02 Astra Ab New antithrombotic formulation
JPH11500120A (ja) * 1995-02-17 1999-01-06 ビーエーエスエフ アクチェンゲゼルシャフト 新規なトロンビンインヒビター
US5710130A (en) * 1995-02-27 1998-01-20 Eli Lilly And Company Antithrombotic agents
US5914319A (en) * 1995-02-27 1999-06-22 Eli Lilly And Company Antithrombotic agents
SA96170106A (ar) 1995-07-06 2005-12-03 أسترا أكتيبولاج مشتقات حامض أميني جديدة
TWI238827B (en) 1995-12-21 2005-09-01 Astrazeneca Ab Prodrugs of thrombin inhibitors
SE9602263D0 (sv) 1996-06-07 1996-06-07 Astra Ab New amino acid derivatives
US5840733A (en) * 1996-07-01 1998-11-24 Redcell, Canada, Inc. Methods and compositions for producing novel conjugates of thrombin inhibitors and endogenous carriers resulting in anti-thrombins with extended lifetimes
SE9602646D0 (sv) 1996-07-04 1996-07-04 Astra Ab Pharmaceutically-useful compounds
AR013084A1 (es) 1997-06-19 2000-12-13 Astrazeneca Ab Derivados de amidino utiles como inhibidores de la trombina, composicion farmaceutica, utilizacion de dichos compuestos para la preparacion demedicamentos y proceso para la preparacion de los compuestos mencionados
SE9704543D0 (sv) 1997-12-05 1997-12-05 Astra Ab New compounds
WO1999037668A1 (de) 1998-01-26 1999-07-29 Basf Aktiengesellschaft Thrombininhibitoren
US6417161B1 (en) 1998-04-24 2002-07-09 3-Dimensional Pharmaceuticals, Inc. Amino acid amidinohydrazones, alkoxyguanidines and aminoguanidines as protease inhibitors
SE9802973D0 (sv) 1998-09-03 1998-09-03 Astra Ab Immediate release tablet
SE9804313D0 (sv) 1998-12-14 1998-12-14 Astra Ab New compounds
DE60037183T2 (de) 1999-01-13 2008-10-09 Astrazeneca Ab Neue amidinbenzylamin-derivate und ihre verwendung als thrombin-inhibitoren
AR023510A1 (es) 1999-04-21 2002-09-04 Astrazeneca Ab Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina.
US6353032B1 (en) * 1999-11-09 2002-03-05 Alcon Universal Ltd. Phospholipids of hydroxyeicosatetraenoic acid-like derivatives and methods of use
SE0001803D0 (sv) 2000-05-16 2000-05-16 Astrazeneca Ab New compounds i
US6433186B1 (en) 2000-08-16 2002-08-13 Astrazeneca Ab Amidino derivatives and their use as thormbin inhibitors
US7129233B2 (en) 2000-12-01 2006-10-31 Astrazeneca Ab Mandelic acid derivatives and their use as thrombin inhibitors
AR035216A1 (es) 2000-12-01 2004-05-05 Astrazeneca Ab Derivados de acido mandelico ,derivados farmaceuticamente aceptables, uso de estos derivados para la fabricacion de medicamentos, metodos de tratamiento ,procesos para la preparacion de estos derivados, y compuestos intermediarios
AR034517A1 (es) 2001-06-21 2004-02-25 Astrazeneca Ab Formulacion farmaceutica
SE0201661D0 (sv) 2002-05-31 2002-05-31 Astrazeneca Ab New salts
SE0201659D0 (sv) 2002-05-31 2002-05-31 Astrazeneca Ab Modified release pharmaceutical formulation
US7781424B2 (en) 2003-05-27 2010-08-24 Astrazeneca Ab Modified release pharmaceutical formulation
US7795205B2 (en) 2004-04-12 2010-09-14 Canyon Pharmaceuticals, Inc. Methods for effecting regression of tumor mass and size in a metastasized pancreatic tumor
TW200827336A (en) 2006-12-06 2008-07-01 Astrazeneca Ab New crystalline forms
RU2728785C2 (ru) 2014-10-06 2020-07-31 Кортексим, Инк. Ингибиторы лизинспецифичного гингипаина
JP6877424B2 (ja) 2015-11-09 2021-05-26 コーテクシーミー， インコーポレイテッド アルギニンジンジパインの阻害剤
WO2017156071A1 (en) 2016-03-09 2017-09-14 Blade Therapeutics, Inc. Cyclic keto-amide compounds as calpain modulators and methods of production and use thereof
WO2018009417A1 (en) 2016-07-05 2018-01-11 Blade Therapeutics, Inc. Calpain modulators and therapeutic uses thereof
TWI787202B (zh) 2016-09-16 2022-12-21 美商昆斯治療公司 離胺酸牙齦蛋白酶（gingipain）之酮抑制劑
KR20190063473A (ko) 2016-09-28 2019-06-07 블레이드 테라퓨틱스, 인크. 칼페인 조정자 및 그 치료학적 용도
WO2019190885A1 (en) * 2018-03-28 2019-10-03 Blade Therapeutics, Inc. Calpain modulators and therapeutic uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4318904A (en) * 1980-04-25 1982-03-09 Research Corporation Peptide affinity labels for thrombin and other trypsin-like proteases
GB8305985D0 (en) * 1983-03-04 1983-04-07 Szelke M Enzyme inhibition
DE3505555A1 (de) * 1985-02-18 1986-09-11 Behringwerke Ag, 3550 Marburg Neue oligopeptidylargininolderivate und deren homologe, verfahren zu deren herstellung, deren verwendung und diese enthaltende mittel
IL99527A (en) * 1990-09-28 1997-08-14 Lilly Co Eli Tripeptide antithrombotic agents

Also Published As

Publication number Publication date
BG98583A (bg) 1994-09-30
TNSN92076A1 (fr) 1993-06-08
HU9400589D0 (en) 1994-05-30
DZ1613A1 (fr) 2002-02-17
WO1993005069A1 (en) 1993-03-18
CZ38094A3 (en) 1994-08-17
NZ243675A (en) 1994-06-27
AP313A (en) 1994-02-10
FI940945A0 (fi) 1994-02-28
IL102840A0 (en) 1993-01-31
IS3906A (is) 1993-03-01
DE69232394D1 (de) 2002-03-14
CA2116527A1 (en) 1993-03-18
JPH06510059A (ja) 1994-11-10
SE9102462D0 (sv) 1991-08-28
SK23394A3 (en) 1994-08-10
MX9204767A (es) 1993-05-01
EP0605462A1 (en) 1994-07-13
EP0605462B1 (en) 2002-01-30
ZA925737B (en) 1993-03-01
AU2499092A (en) 1993-04-05
FI940945A (fi) 1994-02-28
SI9200193A (en) 1993-06-30
US5424291A (en) 1995-06-13
MA22632A1 (fr) 1993-04-01
TW221816B (zh) 1994-03-21
DE69232394T2 (de) 2002-08-22
ATE212643T1 (de) 2002-02-15
HUT66060A (en) 1994-09-28
EP0530167A1 (en) 1993-03-03
AP9200418A0 (en) 1992-10-31
NO940669D0 (no) 1994-02-25
JP3353297B2 (ja) 2002-12-03
CN1069736A (zh) 1993-03-10

Similar Documents

Publication Publication Date Title
NO940669L (no) Nye isosteriske peptider
MX9700763A (es) Procedimiento para la preparacion de benzoxazoles y derivados de piridinas utiles en el tratamiento de la diabetes del tipo ii, los benzoxazoles y derivados de piridina obtenidos, composiciones de los mismos y su uso.
NO20003514L (no) Hypolipidemiske benzothiazepin-forbindelser
NO972538L (no) Nye sulfonamider
IL71324A (en) N-phenyl-n'-cycloalkylalkanoyl-piperazines,their production and pharmaceutical compositions containing them
MY107740A (en) Saccharin derivatives useful as proteolytic enzyme inhibitors and compositions and method of use thereof
EP0613883A4 (en) HYDROXAMIC ACID DERIVATIVE.
AR004961A1 (es) Modificacion cristalina v del clorhidrato de(r)-(-)-2-{n-[4-(1,1-dioxido-3- oxo-2,3-dihidro-benzisotiazol-2-il)-butil]-aminometil)cromano, unprocedimiento para su preparacion, medicamentos que lo contienen, el uso de dicho clorhidrato para la preparacion de medicamentos, una composicion para el
KR890700125A (ko) 신규 벤즈이미다졸 유도체, 그 제조방법 및 이 화합물을 함유하는 제약 조성물
EP0214659A3 (en) Peptide derivatives, process for the production thereof and pharmaceutical compositions containing same
DE69034226D1 (de) Herstellungsverfahren von Huperzine A und deren Analogen und Verbindungen nützlich dazu
GB9211172D0 (en) Compounds
MY129946A (en) Compound with gastric acid inhibitory effect and process for its preparation.
DK0672043T3 (da) Hidtil ukendte 4-(3-benzofuranyl)-piperidinyl- og 4-(3-benzothienyl)-piperidinyl-derivater og farmaceutiske præparater indeholdende dem
DK336387D0 (da) 4-(aroylamino)-piperidinbutanamidderivater
DK423289A (da) Sulfonamider med tetrazolylrest, fremgangsmaade til deres fremstilling samt laegemiddel
NO974651L (no) Biologisk aktive ureidoderivater som er nyttige i behandlingen av multippel sklerose
ATE170848T1 (de) Oxazolidin verbindungen und ihre verwendung als arzneimittel
EP0382854A4 (en) Indoleacetic acid derivatives, process for their preparation, and medicines containing same as active ingredients
ATE122352T1 (de) 3-(3-ethyl-1,2,4-oxadiazol-5-yl)-1- azabicycloheptan, verfahren zu seiner herstellung und dieses enthaltende pharmazeutische zubereitungen.
ATE72433T1 (de) Aether und thioaether mit heilender wirkung, deren herstellung und diese enthaltende pharmazeutische zusammenstellungen.
RU94018704A (ru) Новые изостерические пептиды, способ их получения, фармацевтическая композиция на их основе и их применение
DK598184D0 (da) 3-aryl-1,2-benzisoxazolsulfonyl- og -sulfinylalkansyrer og farmaceutisk acceptable salte deraf, deres fremstilling og anvendelse som laegemidler
SE9304065D0 (sv) New compound
JPS5598164A (en) Guanidinobenzoic acid derivative and its acid appition salt