SK15552003A3 - Oxadiazolové a tiadiazolové deriváty pyrolidínu, spôsob ich výroby, farmaceutický prostriedok s ich obsahom a ich použitie - Google Patents

Oxadiazolové a tiadiazolové deriváty pyrolidínu, spôsob ich výroby, farmaceutický prostriedok s ich obsahom a ich použitie Download PDF

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Publication number
SK15552003A3
SK15552003A3 SK1555-2003A SK15552003A SK15552003A3 SK 15552003 A3 SK15552003 A3 SK 15552003A3 SK 15552003 A SK15552003 A SK 15552003A SK 15552003 A3 SK15552003 A3 SK 15552003A3
Authority
SK
Slovakia
Prior art keywords
biphenyl
oxadiazol
ylcarbonyl
pyrrolidinone
methyloxime
Prior art date
Application number
SK1555-2003A
Other languages
English (en)
Slovak (sk)
Inventor
Matthias Schwarz
Anna Quattropani
Patrick Page
Russell J. Thomas
Vincent Pomel
Original Assignee
Applied Research Systems Ars Holding N. V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems Ars Holding N. V. filed Critical Applied Research Systems Ars Holding N. V.
Publication of SK15552003A3 publication Critical patent/SK15552003A3/sk

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
SK1555-2003A 2001-06-18 2002-06-14 Oxadiazolové a tiadiazolové deriváty pyrolidínu, spôsob ich výroby, farmaceutický prostriedok s ich obsahom a ich použitie SK15552003A3 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01113632 2001-06-18
PCT/EP2002/006629 WO2002102799A2 (fr) 2001-06-18 2002-06-14 Derives de pyrrolidine oxadiazoles et thiadiazoles

Publications (1)

Publication Number Publication Date
SK15552003A3 true SK15552003A3 (sk) 2004-05-04

Family

ID=8177641

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1555-2003A SK15552003A3 (sk) 2001-06-18 2002-06-14 Oxadiazolové a tiadiazolové deriváty pyrolidínu, spôsob ich výroby, farmaceutický prostriedok s ich obsahom a ich použitie

Country Status (27)

Country Link
US (2) US7115639B2 (fr)
EP (1) EP1444225B1 (fr)
JP (1) JP4426284B2 (fr)
KR (1) KR20040030678A (fr)
CN (1) CN100564378C (fr)
AR (1) AR036108A1 (fr)
AU (1) AU2002319237B2 (fr)
BG (1) BG108424A (fr)
BR (1) BR0211030A (fr)
CA (1) CA2449578C (fr)
CZ (1) CZ20033475A3 (fr)
EA (1) EA006212B1 (fr)
EE (1) EE200400022A (fr)
ES (1) ES2397305T3 (fr)
HK (1) HK1074204A1 (fr)
HR (1) HRP20031017A2 (fr)
HU (1) HUP0400238A2 (fr)
IL (1) IL159219A0 (fr)
MX (1) MXPA03011441A (fr)
MY (1) MY128890A (fr)
NO (1) NO20035399L (fr)
PL (1) PL367275A1 (fr)
RS (1) RS99503A (fr)
SK (1) SK15552003A3 (fr)
UA (1) UA75145C2 (fr)
WO (1) WO2002102799A2 (fr)
ZA (1) ZA200309402B (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1444225B1 (fr) 2001-06-18 2012-10-10 Merck Serono SA Derives de pyrrolidine oxadiazoles et thiadiazoles utilisees en tant qu'antagonistes de l'oxytocine
JP4773335B2 (ja) * 2003-02-27 2011-09-14 メルク セローノ ソシエテ アノニム オキシトシンアンタゴニストとしてのピロリジン誘導体
DK1725526T3 (da) * 2004-02-26 2008-03-03 Serono Lab Fremgangsmåde til fremstilling af pyrrolidinoximer
KR101562549B1 (ko) 2005-05-10 2015-10-23 인사이트 홀딩스 코포레이션 인돌아민 2,3-디옥시게나제의 조절제 및 이의 사용방법
CA2634198C (fr) 2005-12-20 2014-06-03 Incyte Corporation N-hydroxyamidinoheterocycles en tant que modulateurs d'indoleamine 2,3-dioxygenase
WO2008036642A2 (fr) * 2006-09-19 2008-03-27 Incyte Corporation N-hydroxyamidinohétérocycles en tant que modulateurs d'indoléamine 2,3-dioxygénase
CL2007002650A1 (es) 2006-09-19 2008-02-08 Incyte Corp Compuestos derivados de heterociclo n-hidroxiamino; composicion farmaceutica, util para tratar cancer, infecciones virales y desordenes neurodegenerativos entre otras.
EA029781B1 (ru) 2008-07-08 2018-05-31 Инсайт Корпорейшн 1,2,5-оксадиазолы в качестве ингибиторов индоламин-2,3-диоксигеназы
EP2845850A1 (fr) 2013-09-10 2015-03-11 ObsEva S.A. Dérivés de pyrrolidine comme antagonistes des récepteurs V1a de vasopressine/oxytocine
SI3066085T1 (sl) 2013-11-08 2020-08-31 Incyte Holdings Corporation Postopek sinteze inhibitorja indolamina 2,3-dioksigenaze
EP2886107A1 (fr) 2013-12-17 2015-06-24 ObsEva S.A. Formules orales de dérivés de pyrrolydine
EA031353B1 (ru) 2014-07-02 2018-12-28 Обсева Са Кристаллический о-метилоксим (3z,5s)-5-(гидроксиметил)-1-[(2'-метил-1,1'-бифенил-4-ил)карбонил]пирролидин-3-он, полезный в способах лечения состояний, связанных с активностью ot-r

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2722190B1 (fr) 1994-07-05 1996-10-04 Sanofi Sa Derives de 1-benzyl-1,3-dihydro-2h-benzimidazol-2-one, leur preparation, les compositions pharmaceutique en contenant
CA2210138A1 (fr) 1995-01-24 1996-08-01 Peter D. Williams Antagonistes tocolytiques des recepteurs de l'oxytocine
US5756497A (en) 1996-03-01 1998-05-26 Merck & Co., Inc. Tocolytic oxytocin receptor antagonists
FR2757157B1 (fr) 1996-12-13 1999-12-31 Sanofi Sa Derives d'indolin-2-one, procede pour leur preparation et compositions pharmaceutiques les contenant
EP1176959B1 (fr) * 1999-05-05 2006-03-08 Merck & Co., Inc. Prolines en tant qu'agents antimicrobiens
EP1268418B1 (fr) * 2000-03-27 2006-06-14 Applied Research Systems ARS Holding N.V. Derives de la pyrrolidine pharmaceutiquement actifs comme inhibiteurs de bax
US7211601B2 (en) * 2000-03-27 2007-05-01 Applied Research Systems Ars Holding N.V. Pharmaceutically active pyrrolidine derivatives
WO2002032864A1 (fr) * 2000-10-17 2002-04-25 Applied Research Systems Ars Holding N.V. Derives de sulfanilide actifs du point de vue pharmaceutique
ES2303854T3 (es) * 2001-03-20 2008-09-01 Laboratoires Serono Sa Derivados de ester de pirrolidina con actividad moduladora de oxitocina.
EP1444225B1 (fr) 2001-06-18 2012-10-10 Merck Serono SA Derives de pyrrolidine oxadiazoles et thiadiazoles utilisees en tant qu'antagonistes de l'oxytocine
DE60207755T2 (de) * 2001-12-20 2006-07-27 Applied Research Systems Ars Holding N.V. Triazole als oxytocin-antagonisten
UA78058C2 (en) * 2002-07-05 2007-02-15 Applied Research Systems Pyrrolidine derivative as oxitocin antagonists

Also Published As

Publication number Publication date
RS99503A (en) 2006-12-15
US7115639B2 (en) 2006-10-03
HUP0400238A2 (hu) 2004-07-28
AU2002319237B2 (en) 2008-01-03
HK1074204A1 (en) 2005-11-04
JP4426284B2 (ja) 2010-03-03
ES2397305T3 (es) 2013-03-06
BG108424A (en) 2005-03-31
EA006212B1 (ru) 2005-10-27
WO2002102799A2 (fr) 2002-12-27
MY128890A (en) 2007-02-28
UA75145C2 (en) 2006-03-15
IL159219A0 (en) 2004-06-01
BR0211030A (pt) 2004-06-22
EA200400049A1 (ru) 2004-08-26
PL367275A1 (en) 2005-02-21
HRP20031017A2 (en) 2004-04-30
US20040220238A1 (en) 2004-11-04
CZ20033475A3 (en) 2004-05-12
MXPA03011441A (es) 2004-07-01
CA2449578C (fr) 2011-12-13
CN100564378C (zh) 2009-12-02
EP1444225A2 (fr) 2004-08-11
NO20035399L (no) 2004-02-17
CN1639155A (zh) 2005-07-13
JP2004534804A (ja) 2004-11-18
NO20035399D0 (no) 2003-12-04
EE200400022A (et) 2004-04-15
US20060229343A1 (en) 2006-10-12
WO2002102799A3 (fr) 2003-04-03
CA2449578A1 (fr) 2002-12-27
ZA200309402B (en) 2004-12-03
AR036108A1 (es) 2004-08-11
EP1444225B1 (fr) 2012-10-10
KR20040030678A (ko) 2004-04-09

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