CA2210138A1 - Antagonistes tocolytiques des recepteurs de l'oxytocine - Google Patents

Antagonistes tocolytiques des recepteurs de l'oxytocine

Info

Publication number
CA2210138A1
CA2210138A1 CA 2210138 CA2210138A CA2210138A1 CA 2210138 A1 CA2210138 A1 CA 2210138A1 CA 2210138 CA2210138 CA 2210138 CA 2210138 A CA2210138 A CA 2210138A CA 2210138 A1 CA2210138 A1 CA 2210138A1
Authority
CA
Canada
Prior art keywords
alkyl
compound
hydrogen
methyl
piperidin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA 2210138
Other languages
English (en)
Inventor
Peter D. Williams
Roger M. Freidinger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2210138A1 publication Critical patent/CA2210138A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des composés de la formule (I) dans laquelle X est choisi entre CH¿2? et O, à condition que lorsque R?1¿ et R?3¿ représentent l'un et l'autre simultanément hydrogène, alors (a) R?8¿ représente alkyle C¿1-5? ou halogène, et R?2¿ représente alcoxy C¿1-5?, ou (b) R?4¿ représente (II); ainsi que leurs sels pharmaceutiquement acceptables. Ces composés sont utiles chez les mammifères en tant qu'antagonistes des récepteurs de l'oxytocine, dans le traitement du travail avant terme, de la dysménorrhée et de l'arrêt du travail avant l'accouchement par césarienne.
CA 2210138 1995-01-24 1996-01-19 Antagonistes tocolytiques des recepteurs de l'oxytocine Abandoned CA2210138A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37811395A 1995-01-24 1995-01-24
US378,113 1995-01-24

Publications (1)

Publication Number Publication Date
CA2210138A1 true CA2210138A1 (fr) 1996-08-01

Family

ID=23491770

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2210138 Abandoned CA2210138A1 (fr) 1995-01-24 1996-01-19 Antagonistes tocolytiques des recepteurs de l'oxytocine

Country Status (4)

Country Link
EP (1) EP0805681A4 (fr)
AU (1) AU4763896A (fr)
CA (1) CA2210138A1 (fr)
WO (1) WO1996022775A1 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2310660A (en) * 1996-03-01 1997-09-03 Merck & Co Inc Benzoxazinone oxytocin receptor antagonists
GB2326410A (en) * 1997-06-18 1998-12-23 Merck & Co Inc Tocolytic Oxytocin Receptor Antagonists
US7211601B2 (en) 2000-03-27 2007-05-01 Applied Research Systems Ars Holding N.V. Pharmaceutically active pyrrolidine derivatives
WO2002032864A1 (fr) 2000-10-17 2002-04-25 Applied Research Systems Ars Holding N.V. Derives de sulfanilide actifs du point de vue pharmaceutique
ES2303854T3 (es) 2001-03-20 2008-09-01 Laboratoires Serono Sa Derivados de ester de pirrolidina con actividad moduladora de oxitocina.
US7326700B2 (en) 2001-04-12 2008-02-05 Wyeth Cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists
US6977254B2 (en) 2001-04-12 2005-12-20 Wyeth Hydroxy cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists
US7202239B2 (en) 2001-04-12 2007-04-10 Wyeth Cyclohexylphenyl carboxamides tocolytic oxytocin receptor antagonists
US7064120B2 (en) 2001-04-12 2006-06-20 Wyeth Tricyclic pyridyl carboxamides and derivatives thereof tocolytic oxytocin receptor antagonists
US6900200B2 (en) 2001-04-12 2005-05-31 Wyeth Tricyclic hydroxy carboxamides and derivatives thereof tocolytic oxytocin receptor antagonists
US7109193B2 (en) 2001-04-12 2006-09-19 Wyeth Tricyclic diazepines tocolytic oxytocin receptor antagonists
US7022699B2 (en) 2001-04-12 2006-04-04 Wyeth Cyclohexenyl phenyl diazepines vasopressin and oxytocin receptor modulators
EP1444225B1 (fr) 2001-06-18 2012-10-10 Merck Serono SA Derives de pyrrolidine oxadiazoles et thiadiazoles utilisees en tant qu'antagonistes de l'oxytocine
DE60207755T2 (de) 2001-12-20 2006-07-27 Applied Research Systems Ars Holding N.V. Triazole als oxytocin-antagonisten

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3026534A1 (de) * 1980-07-12 1982-03-18 C.H. Boehringer Sohn, 6507 Ingelheim 3,1-benzoxazin-2-one, ihre herstellung und verwendung
TW199153B (fr) * 1990-08-07 1993-02-01 Dtsuka Seiyaku Kk
TW249201B (fr) * 1992-07-02 1995-06-11 Otsuka Pharma Co Ltd
ATE216580T1 (de) * 1993-07-16 2002-05-15 Merck & Co Inc Benzoxazinon- und benzopyrimidinon- piperidinyl- verbindungen als tokolytische oxytocin-rezeptor- antagonisten
WO1997025992A1 (fr) * 1996-01-16 1997-07-24 Merck & Co., Inc. Antagonistes des recepteurs de l'oxytocine tocolytique

Also Published As

Publication number Publication date
WO1996022775A1 (fr) 1996-08-01
AU4763896A (en) 1996-08-14
EP0805681A4 (fr) 1998-05-06
EP0805681A1 (fr) 1997-11-12

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Legal Events

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