CA2210138A1 - Antagonistes tocolytiques des recepteurs de l'oxytocine - Google Patents
Antagonistes tocolytiques des recepteurs de l'oxytocineInfo
- Publication number
- CA2210138A1 CA2210138A1 CA 2210138 CA2210138A CA2210138A1 CA 2210138 A1 CA2210138 A1 CA 2210138A1 CA 2210138 CA2210138 CA 2210138 CA 2210138 A CA2210138 A CA 2210138A CA 2210138 A1 CA2210138 A1 CA 2210138A1
- Authority
- CA
- Canada
- Prior art keywords
- alkyl
- compound
- hydrogen
- methyl
- piperidin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
L'invention concerne des composés de la formule (I) dans laquelle X est choisi entre CH¿2? et O, à condition que lorsque R?1¿ et R?3¿ représentent l'un et l'autre simultanément hydrogène, alors (a) R?8¿ représente alkyle C¿1-5? ou halogène, et R?2¿ représente alcoxy C¿1-5?, ou (b) R?4¿ représente (II); ainsi que leurs sels pharmaceutiquement acceptables. Ces composés sont utiles chez les mammifères en tant qu'antagonistes des récepteurs de l'oxytocine, dans le traitement du travail avant terme, de la dysménorrhée et de l'arrêt du travail avant l'accouchement par césarienne.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US37811395A | 1995-01-24 | 1995-01-24 | |
US378,113 | 1995-01-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2210138A1 true CA2210138A1 (fr) | 1996-08-01 |
Family
ID=23491770
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA 2210138 Abandoned CA2210138A1 (fr) | 1995-01-24 | 1996-01-19 | Antagonistes tocolytiques des recepteurs de l'oxytocine |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0805681A4 (fr) |
AU (1) | AU4763896A (fr) |
CA (1) | CA2210138A1 (fr) |
WO (1) | WO1996022775A1 (fr) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2310660A (en) * | 1996-03-01 | 1997-09-03 | Merck & Co Inc | Benzoxazinone oxytocin receptor antagonists |
GB2326410A (en) * | 1997-06-18 | 1998-12-23 | Merck & Co Inc | Tocolytic Oxytocin Receptor Antagonists |
US7211601B2 (en) | 2000-03-27 | 2007-05-01 | Applied Research Systems Ars Holding N.V. | Pharmaceutically active pyrrolidine derivatives |
WO2002032864A1 (fr) | 2000-10-17 | 2002-04-25 | Applied Research Systems Ars Holding N.V. | Derives de sulfanilide actifs du point de vue pharmaceutique |
ES2303854T3 (es) | 2001-03-20 | 2008-09-01 | Laboratoires Serono Sa | Derivados de ester de pirrolidina con actividad moduladora de oxitocina. |
US7326700B2 (en) | 2001-04-12 | 2008-02-05 | Wyeth | Cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists |
US6977254B2 (en) | 2001-04-12 | 2005-12-20 | Wyeth | Hydroxy cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists |
US7202239B2 (en) | 2001-04-12 | 2007-04-10 | Wyeth | Cyclohexylphenyl carboxamides tocolytic oxytocin receptor antagonists |
US7064120B2 (en) | 2001-04-12 | 2006-06-20 | Wyeth | Tricyclic pyridyl carboxamides and derivatives thereof tocolytic oxytocin receptor antagonists |
US6900200B2 (en) | 2001-04-12 | 2005-05-31 | Wyeth | Tricyclic hydroxy carboxamides and derivatives thereof tocolytic oxytocin receptor antagonists |
US7109193B2 (en) | 2001-04-12 | 2006-09-19 | Wyeth | Tricyclic diazepines tocolytic oxytocin receptor antagonists |
US7022699B2 (en) | 2001-04-12 | 2006-04-04 | Wyeth | Cyclohexenyl phenyl diazepines vasopressin and oxytocin receptor modulators |
EP1444225B1 (fr) | 2001-06-18 | 2012-10-10 | Merck Serono SA | Derives de pyrrolidine oxadiazoles et thiadiazoles utilisees en tant qu'antagonistes de l'oxytocine |
DE60207755T2 (de) | 2001-12-20 | 2006-07-27 | Applied Research Systems Ars Holding N.V. | Triazole als oxytocin-antagonisten |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3026534A1 (de) * | 1980-07-12 | 1982-03-18 | C.H. Boehringer Sohn, 6507 Ingelheim | 3,1-benzoxazin-2-one, ihre herstellung und verwendung |
TW199153B (fr) * | 1990-08-07 | 1993-02-01 | Dtsuka Seiyaku Kk | |
TW249201B (fr) * | 1992-07-02 | 1995-06-11 | Otsuka Pharma Co Ltd | |
ATE216580T1 (de) * | 1993-07-16 | 2002-05-15 | Merck & Co Inc | Benzoxazinon- und benzopyrimidinon- piperidinyl- verbindungen als tokolytische oxytocin-rezeptor- antagonisten |
WO1997025992A1 (fr) * | 1996-01-16 | 1997-07-24 | Merck & Co., Inc. | Antagonistes des recepteurs de l'oxytocine tocolytique |
-
1996
- 1996-01-19 CA CA 2210138 patent/CA2210138A1/fr not_active Abandoned
- 1996-01-19 AU AU47638/96A patent/AU4763896A/en not_active Abandoned
- 1996-01-19 EP EP96903618A patent/EP0805681A4/fr not_active Withdrawn
- 1996-01-19 WO PCT/US1996/000850 patent/WO1996022775A1/fr not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO1996022775A1 (fr) | 1996-08-01 |
AU4763896A (en) | 1996-08-14 |
EP0805681A4 (fr) | 1998-05-06 |
EP0805681A1 (fr) | 1997-11-12 |
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EP0533243B1 (fr) | Dérivés de spiroindanylcamphorsulfonyl substitués par un radical hydantoine ou succinimide comme antagonists d'oxytocine | |
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CA2151821A1 (fr) | Derives de substitution hydantoine et succinimide d'antagonistes de spiro-indanylcamphresulfonyle oxytocine | |
JP2004083511A (ja) | アクリルアミド誘導体 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Dead |