RS99503A - Pyrrolidine oxadiazole- and thiadiazole derivatives - Google Patents

Pyrrolidine oxadiazole- and thiadiazole derivatives

Info

Publication number
RS99503A
RS99503A YU99503A YUP99503A RS99503A RS 99503 A RS99503 A RS 99503A YU 99503 A YU99503 A YU 99503A YU P99503 A YUP99503 A YU P99503A RS 99503 A RS99503 A RS 99503A
Authority
RS
Serbia
Prior art keywords
pyrrolidine
derivatives
oxadiazole
present
dysmenorrhea
Prior art date
Application number
YU99503A
Other languages
English (en)
Inventor
Matthias Schwarz
Patrick Page
Vincent Pomel
Anna Quattropani
Russel J. Thomas
Original Assignee
Applied Research Systems Ars Holding N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems Ars Holding N.V. filed Critical Applied Research Systems Ars Holding N.V.
Publication of RS99503A publication Critical patent/RS99503A/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Ovaj pronalazak se odnosi na derivate pirolidin oksadijazola i tijadijazola za upotrebu kao farmaceutski aktivna jedinjenja, kao i farmaceutske formulacije sa sadržajem ovakvih derivata pirolidin oksadijazola. Pomenuti derivati pirolidina su korisni za lečenje i/ili prevenciju prevremenih trudova, prevremenog porođaja i dismenoreja. Pre svega, ovaj pronalazak se odnosi na derivate pirolidina koji ispoljavaju supstancijalnu modulatoru, a prevashodno antagonističku aktivnost za oksitocinske receptori. Još bolje, pomenuta jedinjenja su korisna za lečenje i/ili prevenciju of stanja bolesti posredovanih oksitocinom, uključujući prevremene trudove, prevremeni porođaj i dismenoreju. Ovaj present pronalazak je posebno povezan za nove derivate pirolidina kao i za metode njihove primene. B je jedna oksadijazol ili tijadijazol grupa.
YU99503A 2001-06-18 2002-06-14 Pyrrolidine oxadiazole- and thiadiazole derivatives RS99503A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01113632 2001-06-18
PCT/EP2002/006629 WO2002102799A2 (en) 2001-06-18 2002-06-14 Pyrrolidine oxadiazole- and thiadiazole oxime derivatives being oxytocin receptor antagonists

Publications (1)

Publication Number Publication Date
RS99503A true RS99503A (en) 2006-12-15

Family

ID=8177641

Family Applications (1)

Application Number Title Priority Date Filing Date
YU99503A RS99503A (en) 2001-06-18 2002-06-14 Pyrrolidine oxadiazole- and thiadiazole derivatives

Country Status (27)

Country Link
US (2) US7115639B2 (sr)
EP (1) EP1444225B1 (sr)
JP (1) JP4426284B2 (sr)
KR (1) KR20040030678A (sr)
CN (1) CN100564378C (sr)
AR (1) AR036108A1 (sr)
AU (1) AU2002319237B2 (sr)
BG (1) BG108424A (sr)
BR (1) BR0211030A (sr)
CA (1) CA2449578C (sr)
CZ (1) CZ20033475A3 (sr)
EA (1) EA006212B1 (sr)
EE (1) EE200400022A (sr)
ES (1) ES2397305T3 (sr)
HK (1) HK1074204A1 (sr)
HR (1) HRP20031017A2 (sr)
HU (1) HUP0400238A2 (sr)
IL (1) IL159219A0 (sr)
MX (1) MXPA03011441A (sr)
MY (1) MY128890A (sr)
NO (1) NO20035399L (sr)
PL (1) PL367275A1 (sr)
RS (1) RS99503A (sr)
SK (1) SK15552003A3 (sr)
UA (1) UA75145C2 (sr)
WO (1) WO2002102799A2 (sr)
ZA (1) ZA200309402B (sr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL159219A0 (en) 2001-06-18 2004-06-01 Applied Research Systems Pyrrolidine oxadiazole derivatives, their preparation and pharmaceutical compositions containing them
ATE449067T1 (de) * 2003-02-27 2009-12-15 Merck Serono Sa Pyrrolidin-derivate als oxytocin antagonisten
BRPI0508059A (pt) * 2004-02-26 2007-07-17 Applied Research Systems método para preparação de pirrolidina oximas
DK2559690T3 (en) 2005-05-10 2016-04-25 Incyte Holdings Corp Modulators of indoleamine 2,3-dioxygenase and methods of use thereof
EP1971583B1 (en) 2005-12-20 2015-03-25 Incyte Corporation N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase
CL2007002650A1 (es) 2006-09-19 2008-02-08 Incyte Corp Compuestos derivados de heterociclo n-hidroxiamino; composicion farmaceutica, util para tratar cancer, infecciones virales y desordenes neurodegenerativos entre otras.
WO2008036642A2 (en) * 2006-09-19 2008-03-27 Incyte Corporation N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase
BRPI0915692B8 (pt) 2008-07-08 2021-05-25 Incyte Corp compostos derivados de 1,2,5-oxadiazóis, sua forma sólida, sua composição, bem como seus usos
EP2845850A1 (en) 2013-09-10 2015-03-11 ObsEva S.A. Pyrrolidine derivatives as oxytocin/vasopressin V1a receptors antagonists
SG10201803874PA (en) 2013-11-08 2018-07-30 Incyte Holdings Corp Process for the synthesis of an indoleamine 2,3-dioxygenase inhibitor
EP2886107A1 (en) 2013-12-17 2015-06-24 ObsEva S.A. Oral formulations of pyrrolydine derivatives
UA122210C2 (uk) 2014-07-02 2020-10-12 Обсева С.А. Кристалічний о-метилоксим (3z,5s)-5-(гідроксиметил)-1-[(2'-метил-1,1'-біфеніл-4-іл)карбоніл]піролідин-3-oну, корисний у способах лікування станів, пов'язаних з активністю ot-r

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2722190B1 (fr) * 1994-07-05 1996-10-04 Sanofi Sa Derives de 1-benzyl-1,3-dihydro-2h-benzimidazol-2-one, leur preparation, les compositions pharmaceutique en contenant
CA2210138A1 (en) 1995-01-24 1996-08-01 Peter D. Williams Tocolytic oxytocin receptor antagonists
US5756497A (en) 1996-03-01 1998-05-26 Merck & Co., Inc. Tocolytic oxytocin receptor antagonists
FR2757157B1 (fr) * 1996-12-13 1999-12-31 Sanofi Sa Derives d'indolin-2-one, procede pour leur preparation et compositions pharmaceutiques les contenant
JP2002543129A (ja) * 1999-05-05 2002-12-17 メルク エンド カムパニー インコーポレーテッド 抗微生物剤としての新規なプロリン類
DE60120940T2 (de) * 2000-03-27 2007-01-25 Applied Research Systems Ars Holding N.V. Pyrrolidin-derivate verwendbar als bax-inhibitoren
SI1268418T1 (sl) * 2000-03-27 2006-10-31 Applied Research Systems Farmacevtsko aktivni pirolidinski derivati kot bax-inhibitorji
CA2423933A1 (en) * 2000-10-17 2002-04-25 Applied Research Systems Ars Holding N.V. Pharmaceutically active sulfanilide derivatives
JP4350948B2 (ja) * 2001-03-20 2009-10-28 ラボラトワール セローノ ソシエテ アノニム オキシトシン調節活性を有するピロリジンエステル誘導体
IL159219A0 (en) 2001-06-18 2004-06-01 Applied Research Systems Pyrrolidine oxadiazole derivatives, their preparation and pharmaceutical compositions containing them
CA2469042A1 (en) * 2001-12-20 2003-07-03 Applied Research Systems Ars Holding N.V. Triazoles as oxytocin antagonists
UA78058C2 (en) * 2002-07-05 2007-02-15 Applied Research Systems Pyrrolidine derivative as oxitocin antagonists

Also Published As

Publication number Publication date
CA2449578C (en) 2011-12-13
ES2397305T3 (es) 2013-03-06
AU2002319237B2 (en) 2008-01-03
CN1639155A (zh) 2005-07-13
IL159219A0 (en) 2004-06-01
AR036108A1 (es) 2004-08-11
EP1444225B1 (en) 2012-10-10
HK1074204A1 (en) 2005-11-04
NO20035399L (no) 2004-02-17
CZ20033475A3 (en) 2004-05-12
CN100564378C (zh) 2009-12-02
PL367275A1 (en) 2005-02-21
MXPA03011441A (es) 2004-07-01
HUP0400238A2 (hu) 2004-07-28
JP4426284B2 (ja) 2010-03-03
EA200400049A1 (ru) 2004-08-26
US7115639B2 (en) 2006-10-03
MY128890A (en) 2007-02-28
US20040220238A1 (en) 2004-11-04
EE200400022A (et) 2004-04-15
HRP20031017A2 (en) 2004-04-30
JP2004534804A (ja) 2004-11-18
SK15552003A3 (sk) 2004-05-04
BG108424A (en) 2005-03-31
KR20040030678A (ko) 2004-04-09
UA75145C2 (en) 2006-03-15
EP1444225A2 (en) 2004-08-11
CA2449578A1 (en) 2002-12-27
EA006212B1 (ru) 2005-10-27
BR0211030A (pt) 2004-06-22
US20060229343A1 (en) 2006-10-12
WO2002102799A2 (en) 2002-12-27
WO2002102799A3 (en) 2003-04-03
ZA200309402B (en) 2004-12-03
NO20035399D0 (no) 2003-12-04

Similar Documents

Publication Publication Date Title
IL155333A0 (en) Sulfanilide derivatives for use in medicine, certain such new derivatives and their preparation
TW200745111A (en) New compounds
MY144992A (en) Substituted 1,2,3,4-tetrahydroisoquinoline derivatives.
HUP0104718A2 (hu) Mikronizált eplerenon kompozíciók és eljárás az előállításukra
MXPA02007942A (es) Derivados de pirrolopirimidinona, procesos de preparacion y uso.
TW200606164A (en) New compounds
RS99503A (en) Pyrrolidine oxadiazole- and thiadiazole derivatives
TW200633978A (en) 2,3,4,9-tetrahydro-1H-carbazole derivatives as crth2 receptor antagonists
WO2003048164A3 (en) Adenosine a2a receptor antagonists
WO2002088100A3 (de) Deuterierte 3-piperidinopropiophenone sowie diese verbindungen enthaltende arzneimittel
TW200800984A (en) New compounds
DE60008399D1 (de) Carbonsäuren und acylsulfonamide, solche verbindungen enthaltende zubereitungen und behandlungsmethoden
SE0104331D0 (sv) Novel compounds
HUP0400553A2 (hu) Gyógyászati készítmények
EA200201026A1 (ru) Фармацевтически активные производные пирролидина
SE0102440D0 (sv) New compound
SI1458381T1 (sl) Triazoli kot oksitocinski antagonisti
HUP0300863A2 (hu) N-(3,5-diklór-2-metoxi-fenil)-4-metoxi-3-(1-piperazinil)-benzolszulfonamid, eljárás elżállítására és a vegyületet tartalmazó gyógyszerkészítmény
GB0228552D0 (en) Chemical compounds
EP1613328B8 (en) Use of carbamazepine derivatives for the treatment of agitation in dementia patients
AP9801417A0 (en) Piperidine acetic acid derivatives and their use in the treatment of thrombotic disorders.
WO2002092565A3 (en) 3-aminoalkyl-2-aryl-indole derivatives and their use as gnrh antagonists
Li et al. Studies on the structure–activity relationship of 1, 3, 3, 4-tetra-substituted pyrrolidine embodied CCR5 receptor antagonists. Part 2: Discovery of highly potent anti-HIV agents
EE200200660A (et) Akrüloüüldistamütsiini derivaati sisaldav farmatseutiline kompositsioon, derivaadi kasutamine tuumorivastase ravimi valmistamiseks ning kombineeritudravimpreparaat
EA200400691A1 (ru) Получение чистых стереоизомеров трицикло[5,2,1,02,6]дец-9-ил-ксантогената и содержащие их лекарственные средства