HRP20031017A2 - Pyrrolidine oxasidiazole- and thiadiazole derivatives - Google Patents

Pyrrolidine oxasidiazole- and thiadiazole derivatives

Info

Publication number
HRP20031017A2
HRP20031017A2 HR20031017A HRP20031017A HRP20031017A2 HR P20031017 A2 HRP20031017 A2 HR P20031017A2 HR 20031017 A HR20031017 A HR 20031017A HR P20031017 A HRP20031017 A HR P20031017A HR P20031017 A2 HRP20031017 A2 HR P20031017A2
Authority
HR
Croatia
Prior art keywords
oxasidiazole
pyrrolidine
thiadiazole derivatives
thiadiazole
derivatives
Prior art date
Application number
HR20031017A
Other languages
English (en)
Inventor
Matthias Schwarz
Patrick Page
Vincent Pomel
Anna Quattropani
Russel J Thomas
Original Assignee
Applied Research Systems
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems filed Critical Applied Research Systems
Publication of HRP20031017A2 publication Critical patent/HRP20031017A2/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
HR20031017A 2001-06-18 2003-12-08 Pyrrolidine oxasidiazole- and thiadiazole derivatives HRP20031017A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01113632 2001-06-18
PCT/EP2002/006629 WO2002102799A2 (en) 2001-06-18 2002-06-14 Pyrrolidine oxadiazole- and thiadiazole oxime derivatives being oxytocin receptor antagonists

Publications (1)

Publication Number Publication Date
HRP20031017A2 true HRP20031017A2 (en) 2004-04-30

Family

ID=8177641

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20031017A HRP20031017A2 (en) 2001-06-18 2003-12-08 Pyrrolidine oxasidiazole- and thiadiazole derivatives

Country Status (27)

Country Link
US (2) US7115639B2 (sr)
EP (1) EP1444225B1 (sr)
JP (1) JP4426284B2 (sr)
KR (1) KR20040030678A (sr)
CN (1) CN100564378C (sr)
AR (1) AR036108A1 (sr)
AU (1) AU2002319237B2 (sr)
BG (1) BG108424A (sr)
BR (1) BR0211030A (sr)
CA (1) CA2449578C (sr)
CZ (1) CZ20033475A3 (sr)
EA (1) EA006212B1 (sr)
EE (1) EE200400022A (sr)
ES (1) ES2397305T3 (sr)
HK (1) HK1074204A1 (sr)
HR (1) HRP20031017A2 (sr)
HU (1) HUP0400238A2 (sr)
IL (1) IL159219A0 (sr)
MX (1) MXPA03011441A (sr)
MY (1) MY128890A (sr)
NO (1) NO20035399L (sr)
PL (1) PL367275A1 (sr)
RS (1) RS99503A (sr)
SK (1) SK15552003A3 (sr)
UA (1) UA75145C2 (sr)
WO (1) WO2002102799A2 (sr)
ZA (1) ZA200309402B (sr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL159219A0 (en) 2001-06-18 2004-06-01 Applied Research Systems Pyrrolidine oxadiazole derivatives, their preparation and pharmaceutical compositions containing them
ATE449067T1 (de) * 2003-02-27 2009-12-15 Merck Serono Sa Pyrrolidin-derivate als oxytocin antagonisten
BRPI0508059A (pt) * 2004-02-26 2007-07-17 Applied Research Systems método para preparação de pirrolidina oximas
DK2559690T3 (en) 2005-05-10 2016-04-25 Incyte Holdings Corp Modulators of indoleamine 2,3-dioxygenase and methods of use thereof
EP1971583B1 (en) 2005-12-20 2015-03-25 Incyte Corporation N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase
CL2007002650A1 (es) 2006-09-19 2008-02-08 Incyte Corp Compuestos derivados de heterociclo n-hidroxiamino; composicion farmaceutica, util para tratar cancer, infecciones virales y desordenes neurodegenerativos entre otras.
WO2008036642A2 (en) * 2006-09-19 2008-03-27 Incyte Corporation N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase
BRPI0915692B8 (pt) 2008-07-08 2021-05-25 Incyte Corp compostos derivados de 1,2,5-oxadiazóis, sua forma sólida, sua composição, bem como seus usos
EP2845850A1 (en) 2013-09-10 2015-03-11 ObsEva S.A. Pyrrolidine derivatives as oxytocin/vasopressin V1a receptors antagonists
SG10201803874PA (en) 2013-11-08 2018-07-30 Incyte Holdings Corp Process for the synthesis of an indoleamine 2,3-dioxygenase inhibitor
EP2886107A1 (en) 2013-12-17 2015-06-24 ObsEva S.A. Oral formulations of pyrrolydine derivatives
UA122210C2 (uk) 2014-07-02 2020-10-12 Обсева С.А. Кристалічний о-метилоксим (3z,5s)-5-(гідроксиметил)-1-[(2'-метил-1,1'-біфеніл-4-іл)карбоніл]піролідин-3-oну, корисний у способах лікування станів, пов'язаних з активністю ot-r

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2722190B1 (fr) * 1994-07-05 1996-10-04 Sanofi Sa Derives de 1-benzyl-1,3-dihydro-2h-benzimidazol-2-one, leur preparation, les compositions pharmaceutique en contenant
CA2210138A1 (en) 1995-01-24 1996-08-01 Peter D. Williams Tocolytic oxytocin receptor antagonists
US5756497A (en) 1996-03-01 1998-05-26 Merck & Co., Inc. Tocolytic oxytocin receptor antagonists
FR2757157B1 (fr) * 1996-12-13 1999-12-31 Sanofi Sa Derives d'indolin-2-one, procede pour leur preparation et compositions pharmaceutiques les contenant
JP2002543129A (ja) * 1999-05-05 2002-12-17 メルク エンド カムパニー インコーポレーテッド 抗微生物剤としての新規なプロリン類
DE60120940T2 (de) * 2000-03-27 2007-01-25 Applied Research Systems Ars Holding N.V. Pyrrolidin-derivate verwendbar als bax-inhibitoren
SI1268418T1 (sl) * 2000-03-27 2006-10-31 Applied Research Systems Farmacevtsko aktivni pirolidinski derivati kot bax-inhibitorji
CA2423933A1 (en) * 2000-10-17 2002-04-25 Applied Research Systems Ars Holding N.V. Pharmaceutically active sulfanilide derivatives
JP4350948B2 (ja) * 2001-03-20 2009-10-28 ラボラトワール セローノ ソシエテ アノニム オキシトシン調節活性を有するピロリジンエステル誘導体
IL159219A0 (en) 2001-06-18 2004-06-01 Applied Research Systems Pyrrolidine oxadiazole derivatives, their preparation and pharmaceutical compositions containing them
CA2469042A1 (en) * 2001-12-20 2003-07-03 Applied Research Systems Ars Holding N.V. Triazoles as oxytocin antagonists
UA78058C2 (en) * 2002-07-05 2007-02-15 Applied Research Systems Pyrrolidine derivative as oxitocin antagonists

Also Published As

Publication number Publication date
CA2449578C (en) 2011-12-13
ES2397305T3 (es) 2013-03-06
AU2002319237B2 (en) 2008-01-03
CN1639155A (zh) 2005-07-13
RS99503A (en) 2006-12-15
IL159219A0 (en) 2004-06-01
AR036108A1 (es) 2004-08-11
EP1444225B1 (en) 2012-10-10
HK1074204A1 (en) 2005-11-04
NO20035399L (no) 2004-02-17
CZ20033475A3 (en) 2004-05-12
CN100564378C (zh) 2009-12-02
PL367275A1 (en) 2005-02-21
MXPA03011441A (es) 2004-07-01
HUP0400238A2 (hu) 2004-07-28
JP4426284B2 (ja) 2010-03-03
EA200400049A1 (ru) 2004-08-26
US7115639B2 (en) 2006-10-03
MY128890A (en) 2007-02-28
US20040220238A1 (en) 2004-11-04
EE200400022A (et) 2004-04-15
JP2004534804A (ja) 2004-11-18
SK15552003A3 (sk) 2004-05-04
BG108424A (en) 2005-03-31
KR20040030678A (ko) 2004-04-09
UA75145C2 (en) 2006-03-15
EP1444225A2 (en) 2004-08-11
CA2449578A1 (en) 2002-12-27
EA006212B1 (ru) 2005-10-27
BR0211030A (pt) 2004-06-22
US20060229343A1 (en) 2006-10-12
WO2002102799A2 (en) 2002-12-27
WO2002102799A3 (en) 2003-04-03
ZA200309402B (en) 2004-12-03
NO20035399D0 (no) 2003-12-04

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Legal Events

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A1OB Publication of a patent application
ARAI Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application
OBST Application withdrawn