SK15294A3 - Heterocyclic substituted derivatives of phenyl-cyclohexane carboxyle acid - Google Patents

Heterocyclic substituted derivatives of phenyl-cyclohexane carboxyle acid Download PDF

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Publication number
SK15294A3
SK15294A3 SK152-94A SK15294A SK15294A3 SK 15294 A3 SK15294 A3 SK 15294A3 SK 15294 A SK15294 A SK 15294A SK 15294 A3 SK15294 A3 SK 15294A3
Authority
SK
Slovakia
Prior art keywords
group
carbon atoms
straight
branched alkyl
hydrogen atom
Prior art date
Application number
SK152-94A
Other languages
English (en)
Slovak (sk)
Inventor
Ulrich E Muller
Jurgen Dressel
Peter Fey
Rudolf H Hanko
Walter Hubsch
Thomas Kramer
Matthias Muller-Gliemann
Martin Beuck
Stanislav Kazda
Stefan Wohlfeil
Andreas Knorr
Johannes-Peter Stasch
Siegfried Zaiss
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of SK15294A3 publication Critical patent/SK15294A3/sk

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SK152-94A 1993-02-15 1994-02-09 Heterocyclic substituted derivatives of phenyl-cyclohexane carboxyle acid SK15294A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4304455A DE4304455A1 (de) 1993-02-15 1993-02-15 Heterocyclisch substituierte Phenyl-cyclohexan-carbonsäurederivate

Publications (1)

Publication Number Publication Date
SK15294A3 true SK15294A3 (en) 1994-12-07

Family

ID=6480447

Family Applications (1)

Application Number Title Priority Date Filing Date
SK152-94A SK15294A3 (en) 1993-02-15 1994-02-09 Heterocyclic substituted derivatives of phenyl-cyclohexane carboxyle acid

Country Status (25)

Country Link
US (1) US5395840A (fr)
EP (1) EP0611767B1 (fr)
JP (1) JPH06293741A (fr)
KR (1) KR940019708A (fr)
CN (1) CN1057085C (fr)
AT (1) ATE196141T1 (fr)
AU (1) AU672262B2 (fr)
CA (1) CA2115536C (fr)
CZ (1) CZ289096B6 (fr)
DE (2) DE4304455A1 (fr)
DK (1) DK0611767T3 (fr)
ES (1) ES2151908T3 (fr)
FI (1) FI106716B (fr)
GR (1) GR3034957T3 (fr)
IL (1) IL108625A (fr)
MY (1) MY131595A (fr)
NO (1) NO300810B1 (fr)
NZ (1) NZ250864A (fr)
PH (1) PH30172A (fr)
PL (1) PL177834B1 (fr)
PT (1) PT611767E (fr)
RU (1) RU2119480C1 (fr)
SK (1) SK15294A3 (fr)
UA (1) UA35574C2 (fr)
ZA (1) ZA94984B (fr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW300219B (fr) * 1991-09-14 1997-03-11 Hoechst Ag
DE19503160A1 (de) * 1995-02-01 1996-08-08 Bayer Ag Verwendung von Phenylcyclohexylcarbonsäureamiden
HRP960015B1 (en) * 1995-02-01 2000-12-31 Bayer Ag Substituted indole derivatives
DE19525028A1 (de) * 1995-07-10 1997-01-16 Bayer Ag Amide und Sulfonamide von heterocyclisch substituierten Benzylaminen
US6143743A (en) 1997-07-03 2000-11-07 Dupont Pharmaceuticals Company Imidazopyrimidines and imidazopyridines for the treatment of neurological disorders
US6124463A (en) * 1998-07-02 2000-09-26 Dupont Pharmaceuticals Benzimidazoles as corticotropin release factor antagonists
US6365589B1 (en) 1998-07-02 2002-04-02 Bristol-Myers Squibb Pharma Company Imidazo-pyridines, -pyridazines, and -triazines as corticotropin releasing factor antagonists
SI1131301T1 (sl) * 1998-11-17 2006-02-28 Abbott Gmbh & Co Kg 2-fenilbenzimidazoli in 2-fenilindoli, njihova priprava in uporaba
DE19924818A1 (de) 1999-05-29 2000-11-30 Bayer Ag Substituierte Phenylcyclohexancarbonsäureamide
DE19924819A1 (de) * 1999-05-29 2000-11-30 Bayer Ag Substituierte Phenylcyclohexancarbonsäurebenzylamid (Adenosinaufnahmeinhibitoren)
DE10044792A1 (de) 2000-09-11 2002-04-04 Bayer Ag Substituierte Phenylcyclohexancarbonsäureamide und ihre Verwendung
CN102746088B (zh) * 2006-05-09 2014-09-17 三菱瓦斯化学株式会社 (反式-4-烷基环己基)苯的制备方法
CN104940202B (zh) 2009-06-17 2018-10-16 沃泰克斯药物股份有限公司 流感病毒复制抑制剂
CN103492381A (zh) 2010-12-16 2014-01-01 沃泰克斯药物股份有限公司 流感病毒复制的抑制剂
MX2013015058A (es) 2011-06-24 2014-01-20 Amgen Inc Antagonistas de melastatina 8 de potencial receptor transitorio y su uso en tratamientos.
CA2839699A1 (fr) 2011-06-24 2012-12-27 Amgen Inc. Antagonistes de trpm8 et leur utilisation dans des traitements
UA118010C2 (uk) 2011-08-01 2018-11-12 Вертекс Фармасьютікалз Інкорпорейтед Інгібітори реплікації вірусів грипу
JP6189948B2 (ja) 2012-06-29 2017-08-30 ファイザー・インク ＬＲＲＫ２阻害薬としての新規な４−（置換アミノ）−７Ｈ−ピロロ［２，３−ｄ］ピリミジン
US8952009B2 (en) 2012-08-06 2015-02-10 Amgen Inc. Chroman derivatives as TRPM8 inhibitors
PL3068782T3 (pl) 2013-11-13 2018-12-31 Vertex Pharmaceuticals Incorporated Sposoby wytwarzania inhibitorów replikacji wirusów grypy
NZ719729A (en) 2013-11-13 2022-04-29 Vertex Pharma Inhibitors of influenza viruses replication
US9695171B2 (en) 2013-12-17 2017-07-04 Pfizer Inc. 3,4-disubstituted-1 H-pyrrolo[2,3-b]pyridines and 4,5-disubstituted-7H-pyrrolo[2,3-c]pyridazines as LRRK2 inhibitors
MA42422A (fr) 2015-05-13 2018-05-23 Vertex Pharma Inhibiteurs de la réplication des virus de la grippe
JP6704416B2 (ja) 2015-05-13 2020-06-03 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ インフルエンザウイルスの複製の阻害剤を調製する方法
RU2722149C1 (ru) 2015-09-14 2020-05-27 Пфайзер Инк. Новые производные имидазо[4,5-c] хинолинов и имидазо[4,5-c][1,5] нафтиридинов в качестве ингибиторов LRRK2

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5138069A (en) * 1986-07-11 1992-08-11 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles
GB8911854D0 (en) * 1989-05-23 1989-07-12 Ici Plc Heterocyclic compounds
IE64514B1 (en) * 1989-05-23 1995-08-09 Zeneca Ltd Azaindenes
US5164407A (en) * 1989-07-03 1992-11-17 Merck & Co., Inc. Substituted imidazo-fused 5-membered ring heterocycles and their use as angiotensin ii antagonsists
ATE171177T1 (de) * 1990-06-08 1998-10-15 Hoechst Marion Roussel Inc Benzimidazol-derivate, verfahren und zwischenprodukte zu ihrer herstellung, ihre anwendung als arzneimittel und diese enthaltende pharmazeutische zusammensetzungen
RU1836357C (ru) * 1990-07-23 1993-08-23 Др.Карл Томэ ГмбХ Производные бензимидазола, их изомеры, смеси изомеров, гидраты или их физиологически переносимые соли, обладающие антагонистическими в отношении ангиотензина свойствами
EP0470543A1 (fr) * 1990-08-10 1992-02-12 Dr. Karl Thomae GmbH Imidazoles hétérocycliques, médicaments contenant ces composés et procédés pour leur préparation
DE4031635A1 (de) * 1990-10-05 1992-04-09 Thomae Gmbh Dr K Substituierte 1-benzyl-benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE4224133A1 (de) * 1992-07-22 1994-01-27 Thomae Gmbh Dr K Benzimidazole, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
DE4200954A1 (de) * 1991-04-26 1992-10-29 Bayer Ag Heterocyclisch substituierte phenylessigsaeurederivate

Also Published As

Publication number Publication date
UA35574C2 (uk) 2001-04-16
DE59409509D1 (de) 2000-10-12
JPH06293741A (ja) 1994-10-21
IL108625A0 (en) 1994-05-30
DE4304455A1 (de) 1994-08-18
US5395840A (en) 1995-03-07
FI940659A (fi) 1994-08-16
PH30172A (en) 1997-01-21
NO300810B1 (no) 1997-07-28
PL177834B1 (pl) 2000-01-31
EP0611767B1 (fr) 2000-09-06
FI940659A0 (fi) 1994-02-11
ES2151908T3 (es) 2001-01-16
KR940019708A (ko) 1994-09-14
DK0611767T3 (da) 2001-01-02
CZ289096B6 (cs) 2001-11-14
ZA94984B (en) 1994-08-24
MY131595A (en) 2007-08-30
PT611767E (pt) 2001-02-28
FI106716B (fi) 2001-03-30
AU672262B2 (en) 1996-09-26
GR3034957T3 (en) 2001-02-28
IL108625A (en) 1997-09-30
RU2119480C1 (ru) 1998-09-27
AU5480794A (en) 1994-08-18
ATE196141T1 (de) 2000-09-15
CA2115536A1 (fr) 1994-08-16
NZ250864A (en) 1995-03-28
NO940506L (fr) 1994-08-16
CZ32994A3 (en) 1994-08-17
NO940506D0 (no) 1994-02-14
PL302213A1 (en) 1994-08-22
CN1108257A (zh) 1995-09-13
CN1057085C (zh) 2000-10-04
CA2115536C (fr) 2004-11-02
EP0611767A1 (fr) 1994-08-24

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