IL108625A - 2-(4-bicyclichetero- arylmethylphenyl)- cyclohexane-1- carboxylic acid derivatives, their preparation and pharmaceutical compositions containing them - Google Patents

2-(4-bicyclichetero- arylmethylphenyl)- cyclohexane-1- carboxylic acid derivatives, their preparation and pharmaceutical compositions containing them

Info

Publication number
IL108625A
IL108625A IL108625A IL10862594A IL108625A IL 108625 A IL108625 A IL 108625A IL 108625 A IL108625 A IL 108625A IL 10862594 A IL10862594 A IL 10862594A IL 108625 A IL108625 A IL 108625A
Authority
IL
Israel
Prior art keywords
bicyclichetero
arylmethylphenyl
cyclohexane
preparation
carboxylic acid
Prior art date
Application number
IL108625A
Other languages
English (en)
Other versions
IL108625A0 (en
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of IL108625A0 publication Critical patent/IL108625A0/xx
Publication of IL108625A publication Critical patent/IL108625A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
IL108625A 1993-02-15 1994-02-11 2-(4-bicyclichetero- arylmethylphenyl)- cyclohexane-1- carboxylic acid derivatives, their preparation and pharmaceutical compositions containing them IL108625A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4304455A DE4304455A1 (de) 1993-02-15 1993-02-15 Heterocyclisch substituierte Phenyl-cyclohexan-carbonsäurederivate

Publications (2)

Publication Number Publication Date
IL108625A0 IL108625A0 (en) 1994-05-30
IL108625A true IL108625A (en) 1997-09-30

Family

ID=6480447

Family Applications (1)

Application Number Title Priority Date Filing Date
IL108625A IL108625A (en) 1993-02-15 1994-02-11 2-(4-bicyclichetero- arylmethylphenyl)- cyclohexane-1- carboxylic acid derivatives, their preparation and pharmaceutical compositions containing them

Country Status (25)

Country Link
US (1) US5395840A (fr)
EP (1) EP0611767B1 (fr)
JP (1) JPH06293741A (fr)
KR (1) KR940019708A (fr)
CN (1) CN1057085C (fr)
AT (1) ATE196141T1 (fr)
AU (1) AU672262B2 (fr)
CA (1) CA2115536C (fr)
CZ (1) CZ289096B6 (fr)
DE (2) DE4304455A1 (fr)
DK (1) DK0611767T3 (fr)
ES (1) ES2151908T3 (fr)
FI (1) FI106716B (fr)
GR (1) GR3034957T3 (fr)
IL (1) IL108625A (fr)
MY (1) MY131595A (fr)
NO (1) NO300810B1 (fr)
NZ (1) NZ250864A (fr)
PH (1) PH30172A (fr)
PL (1) PL177834B1 (fr)
PT (1) PT611767E (fr)
RU (1) RU2119480C1 (fr)
SK (1) SK15294A3 (fr)
UA (1) UA35574C2 (fr)
ZA (1) ZA94984B (fr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW300219B (fr) * 1991-09-14 1997-03-11 Hoechst Ag
HRP960015B1 (en) * 1995-02-01 2000-12-31 Bayer Ag Substituted indole derivatives
DE19503160A1 (de) * 1995-02-01 1996-08-08 Bayer Ag Verwendung von Phenylcyclohexylcarbonsäureamiden
DE19525028A1 (de) * 1995-07-10 1997-01-16 Bayer Ag Amide und Sulfonamide von heterocyclisch substituierten Benzylaminen
HRP980375A2 (en) 1997-07-03 1999-04-30 Argyrios Georgios Arvanitis Imidazopyrimidines and imidazopyridines for the treatment of neurological disorders
US6365589B1 (en) 1998-07-02 2002-04-02 Bristol-Myers Squibb Pharma Company Imidazo-pyridines, -pyridazines, and -triazines as corticotropin releasing factor antagonists
US6124463A (en) * 1998-07-02 2000-09-26 Dupont Pharmaceuticals Benzimidazoles as corticotropin release factor antagonists
PL347684A1 (en) * 1998-11-17 2002-04-22 Basf Ag 2-phenylbenzimidazoles and 2-phenylindoles, and production and use thereof
DE19924819A1 (de) * 1999-05-29 2000-11-30 Bayer Ag Substituierte Phenylcyclohexancarbonsäurebenzylamid (Adenosinaufnahmeinhibitoren)
DE19924818A1 (de) 1999-05-29 2000-11-30 Bayer Ag Substituierte Phenylcyclohexancarbonsäureamide
DE10044792A1 (de) 2000-09-11 2002-04-04 Bayer Ag Substituierte Phenylcyclohexancarbonsäureamide und ihre Verwendung
CN102746088B (zh) 2006-05-09 2014-09-17 三菱瓦斯化学株式会社 (反式-4-烷基环己基)苯的制备方法
WO2010148197A1 (fr) 2009-06-17 2010-12-23 Vertex Pharmaceuticals Incorporated Inhibiteurs de la réplication des virus de la grippe
CN103492381A (zh) 2010-12-16 2014-01-01 沃泰克斯药物股份有限公司 流感病毒复制的抑制剂
AU2012272898A1 (en) 2011-06-24 2013-04-11 Amgen Inc. TRPM8 antagonists and their use in treatments
US8710043B2 (en) 2011-06-24 2014-04-29 Amgen Inc. TRPM8 antagonists and their use in treatments
UA118010C2 (uk) 2011-08-01 2018-11-12 Вертекс Фармасьютікалз Інкорпорейтед Інгібітори реплікації вірусів грипу
EP3255049A1 (fr) 2012-06-29 2017-12-13 Pfizer Inc Nouvelles 7h-pyrrolo[2,3-d]pyrimidines substituées par un groupe amino en position 4, utilisées comme inhibiteurs de lrrk2
US8952009B2 (en) 2012-08-06 2015-02-10 Amgen Inc. Chroman derivatives as TRPM8 inhibitors
JP6615755B2 (ja) 2013-11-13 2019-12-04 バーテックス ファーマシューティカルズ インコーポレイテッド インフルエンザウイルスの複製の阻害剤
SG10201804021TA (en) 2013-11-13 2018-07-30 Vertex Pharma Methods of preparing inhibitors of influenza viruses replication
WO2015092592A1 (fr) 2013-12-17 2015-06-25 Pfizer Inc. Nouvelles 1h-pyrrolo[2,3- b]pyridines 3,4-disubstituées et 7h-pyrrolo[2,3-c]pyridazines 4,5-disubstituées en tant qu'inhibiteurs de la lrrk2
MA42422A (fr) 2015-05-13 2018-05-23 Vertex Pharma Inhibiteurs de la réplication des virus de la grippe
WO2016183116A1 (fr) 2015-05-13 2016-11-17 Vertex Pharmaceuticals Incorporated Procédés de préparation d'inhibiteurs de réplication des virus de la grippe
CN108137586B (zh) 2015-09-14 2021-04-13 辉瑞大药厂 作为LRRK2抑制剂的新颖咪唑并[4,5-c]喹啉和咪唑并[4,5-c][1,5]萘啶衍生物

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5138069A (en) * 1986-07-11 1992-08-11 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles
IE64514B1 (en) * 1989-05-23 1995-08-09 Zeneca Ltd Azaindenes
GB8911854D0 (en) * 1989-05-23 1989-07-12 Ici Plc Heterocyclic compounds
US5164407A (en) * 1989-07-03 1992-11-17 Merck & Co., Inc. Substituted imidazo-fused 5-membered ring heterocycles and their use as angiotensin ii antagonsists
AU7820091A (en) * 1990-06-08 1991-12-12 Roussel-Uclaf New benzimidazole derivatives, their preparation process, the new intermediates obtained, their use as medicaments and the pharmaceutical compositions containing them
RU1836357C (ru) * 1990-07-23 1993-08-23 Др.Карл Томэ ГмбХ Производные бензимидазола, их изомеры, смеси изомеров, гидраты или их физиологически переносимые соли, обладающие антагонистическими в отношении ангиотензина свойствами
EP0470543A1 (fr) * 1990-08-10 1992-02-12 Dr. Karl Thomae GmbH Imidazoles hétérocycliques, médicaments contenant ces composés et procédés pour leur préparation
DE4031635A1 (de) * 1990-10-05 1992-04-09 Thomae Gmbh Dr K Substituierte 1-benzyl-benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE4224133A1 (de) * 1992-07-22 1994-01-27 Thomae Gmbh Dr K Benzimidazole, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
DE4200954A1 (de) * 1991-04-26 1992-10-29 Bayer Ag Heterocyclisch substituierte phenylessigsaeurederivate

Also Published As

Publication number Publication date
EP0611767B1 (fr) 2000-09-06
FI940659A0 (fi) 1994-02-11
FI940659A (fi) 1994-08-16
JPH06293741A (ja) 1994-10-21
NZ250864A (en) 1995-03-28
CN1108257A (zh) 1995-09-13
ZA94984B (en) 1994-08-24
KR940019708A (ko) 1994-09-14
NO940506L (fr) 1994-08-16
PT611767E (pt) 2001-02-28
DK0611767T3 (da) 2001-01-02
AU5480794A (en) 1994-08-18
CA2115536A1 (fr) 1994-08-16
DE4304455A1 (de) 1994-08-18
SK15294A3 (en) 1994-12-07
MY131595A (en) 2007-08-30
NO300810B1 (no) 1997-07-28
PL177834B1 (pl) 2000-01-31
PL302213A1 (en) 1994-08-22
UA35574C2 (uk) 2001-04-16
RU2119480C1 (ru) 1998-09-27
IL108625A0 (en) 1994-05-30
FI106716B (fi) 2001-03-30
ATE196141T1 (de) 2000-09-15
CA2115536C (fr) 2004-11-02
CZ289096B6 (cs) 2001-11-14
AU672262B2 (en) 1996-09-26
US5395840A (en) 1995-03-07
PH30172A (en) 1997-01-21
ES2151908T3 (es) 2001-01-16
CN1057085C (zh) 2000-10-04
NO940506D0 (no) 1994-02-14
EP0611767A1 (fr) 1994-08-24
GR3034957T3 (en) 2001-02-28
DE59409509D1 (de) 2000-10-12
CZ32994A3 (en) 1994-08-17

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
RH1 Patent not in force