FI940659A - Heterosyklisesti substituoituja fenyylisykloheksaanikarboksyylihappojohdannaisia - Google Patents

Heterosyklisesti substituoituja fenyylisykloheksaanikarboksyylihappojohdannaisia Download PDF

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Publication number
FI940659A
FI940659A FI940659A FI940659A FI940659A FI 940659 A FI940659 A FI 940659A FI 940659 A FI940659 A FI 940659A FI 940659 A FI940659 A FI 940659A FI 940659 A FI940659 A FI 940659A
Authority
FI
Finland
Prior art keywords
heterocyclic
acid derivatives
phenylcyclohexanecarboxylic acid
substituted
formula
Prior art date
Application number
FI940659A
Other languages
English (en)
Swedish (sv)
Other versions
FI940659A0 (fi
FI106716B (fi
Inventor
Ulrich Mueller
Juergen Dressel
Peter Fey
Rudolf H Hanko
Walter Huebsch
Thomas Kraemer
Matthias Mueller-Gliemann
Martin Beuck
Stanislav Kazda
Stefan Wohfeil
Andreas Knorr
Johannes-Peter Stasch
Siegfried Zaiss
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of FI940659A0 publication Critical patent/FI940659A0/fi
Publication of FI940659A publication Critical patent/FI940659A/fi
Application granted granted Critical
Publication of FI106716B publication Critical patent/FI106716B/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
FI940659A 1993-02-15 1994-02-11 Menetelmä uusien terapeuttisesti käyttökelpoisten imidatso[2,3-b]pyridiini- ja bentsimidatsolijohdannaisten valmistamiseksi FI106716B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4304455A DE4304455A1 (de) 1993-02-15 1993-02-15 Heterocyclisch substituierte Phenyl-cyclohexan-carbonsäurederivate
DE4304455 1993-02-15

Publications (3)

Publication Number Publication Date
FI940659A0 FI940659A0 (fi) 1994-02-11
FI940659A true FI940659A (fi) 1994-08-16
FI106716B FI106716B (fi) 2001-03-30

Family

ID=6480447

Family Applications (1)

Application Number Title Priority Date Filing Date
FI940659A FI106716B (fi) 1993-02-15 1994-02-11 Menetelmä uusien terapeuttisesti käyttökelpoisten imidatso[2,3-b]pyridiini- ja bentsimidatsolijohdannaisten valmistamiseksi

Country Status (25)

Country Link
US (1) US5395840A (fi)
EP (1) EP0611767B1 (fi)
JP (1) JPH06293741A (fi)
KR (1) KR940019708A (fi)
CN (1) CN1057085C (fi)
AT (1) ATE196141T1 (fi)
AU (1) AU672262B2 (fi)
CA (1) CA2115536C (fi)
CZ (1) CZ289096B6 (fi)
DE (2) DE4304455A1 (fi)
DK (1) DK0611767T3 (fi)
ES (1) ES2151908T3 (fi)
FI (1) FI106716B (fi)
GR (1) GR3034957T3 (fi)
IL (1) IL108625A (fi)
MY (1) MY131595A (fi)
NO (1) NO300810B1 (fi)
NZ (1) NZ250864A (fi)
PH (1) PH30172A (fi)
PL (1) PL177834B1 (fi)
PT (1) PT611767E (fi)
RU (1) RU2119480C1 (fi)
SK (1) SK15294A3 (fi)
UA (1) UA35574C2 (fi)
ZA (1) ZA94984B (fi)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW300219B (fi) * 1991-09-14 1997-03-11 Hoechst Ag
DE19503160A1 (de) * 1995-02-01 1996-08-08 Bayer Ag Verwendung von Phenylcyclohexylcarbonsäureamiden
HRP960015B1 (en) * 1995-02-01 2000-12-31 Bayer Ag Substituted indole derivatives
DE19525028A1 (de) * 1995-07-10 1997-01-16 Bayer Ag Amide und Sulfonamide von heterocyclisch substituierten Benzylaminen
CA2294117A1 (en) * 1997-07-03 1999-01-14 Dupont Pharmaceuticals Company Imidazopyrimidines and imidazopyridines for the treatment of neurological disorders
US6365589B1 (en) 1998-07-02 2002-04-02 Bristol-Myers Squibb Pharma Company Imidazo-pyridines, -pyridazines, and -triazines as corticotropin releasing factor antagonists
US6124463A (en) * 1998-07-02 2000-09-26 Dupont Pharmaceuticals Benzimidazoles as corticotropin release factor antagonists
ID28846A (id) * 1998-11-17 2001-07-05 Basf Ag 2-fenilbenzimidazol dan 2_fenilindol, pembuatan dan penggunaanya
DE19924818A1 (de) 1999-05-29 2000-11-30 Bayer Ag Substituierte Phenylcyclohexancarbonsäureamide
DE19924819A1 (de) * 1999-05-29 2000-11-30 Bayer Ag Substituierte Phenylcyclohexancarbonsäurebenzylamid (Adenosinaufnahmeinhibitoren)
DE10044792A1 (de) 2000-09-11 2002-04-04 Bayer Ag Substituierte Phenylcyclohexancarbonsäureamide und ihre Verwendung
EP2017252B1 (en) 2006-05-09 2012-12-19 Mitsubishi Gas Chemical Company, Inc. Preparation of 4-(4-alkylcyclohexyl)benzaldehyde
NZ619259A (en) 2009-06-17 2015-07-31 Vertex Pharma Inhibitors of influenza viruses replication
CN103492381A (zh) 2010-12-16 2014-01-01 沃泰克斯药物股份有限公司 流感病毒复制的抑制剂
MY157429A (en) 2011-06-24 2016-06-15 Amgen Inc Trpm8 antagonists and their use in treatments
CA2839703A1 (en) 2011-06-24 2012-12-27 Amgen Inc. Trpm8 antagonists and their use in treatments
UA118010C2 (uk) 2011-08-01 2018-11-12 Вертекс Фармасьютікалз Інкорпорейтед Інгібітори реплікації вірусів грипу
MD20140130A2 (ro) 2012-06-29 2015-04-30 Pfizer Inc. 4-(amino-substituite)-7H-pirolo[2,3-d]pirimidine noi ca inhibitori de LRRK2
US8952009B2 (en) 2012-08-06 2015-02-10 Amgen Inc. Chroman derivatives as TRPM8 inhibitors
CN105849100B (zh) 2013-11-13 2019-07-16 沃泰克斯药物股份有限公司 流感病毒复制抑制剂
CA2930297C (en) 2013-11-13 2022-04-05 Vertex Pharmaceuticals Incorporated Methods of preparing inhibitors of influenza viruses replication
JP6487921B2 (ja) 2013-12-17 2019-03-20 ファイザー・インク ＬＲＲＫ２阻害薬としての新規の３，４−二置換−１Ｈ−ピロロ［２，３−ｂ］ピリジンおよび４，５−二置換−７Ｈ−ピロロ［２，３−ｃ］ピリダジン
JP6704416B2 (ja) 2015-05-13 2020-06-03 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ インフルエンザウイルスの複製の阻害剤を調製する方法
JP6857617B2 (ja) 2015-05-13 2021-04-14 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ インフルエンザウイルスの複製の阻害剤
WO2017046675A1 (en) 2015-09-14 2017-03-23 Pfizer Inc. Novel imidazo [4,5-c] quinoline and imidazo [4,5-c][1,5] naphthyridine derivatives as lrrk2 inhibitors

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5138069A (en) * 1986-07-11 1992-08-11 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles
GB8911854D0 (en) * 1989-05-23 1989-07-12 Ici Plc Heterocyclic compounds
IE64514B1 (en) * 1989-05-23 1995-08-09 Zeneca Ltd Azaindenes
US5164407A (en) * 1989-07-03 1992-11-17 Merck & Co., Inc. Substituted imidazo-fused 5-membered ring heterocycles and their use as angiotensin ii antagonsists
ATE171177T1 (de) * 1990-06-08 1998-10-15 Hoechst Marion Roussel Inc Benzimidazol-derivate, verfahren und zwischenprodukte zu ihrer herstellung, ihre anwendung als arzneimittel und diese enthaltende pharmazeutische zusammensetzungen
RU1836357C (ru) * 1990-07-23 1993-08-23 Др.Карл Томэ ГмбХ Производные бензимидазола, их изомеры, смеси изомеров, гидраты или их физиологически переносимые соли, обладающие антагонистическими в отношении ангиотензина свойствами
EP0470543A1 (de) * 1990-08-10 1992-02-12 Dr. Karl Thomae GmbH Heterocyclische Imidazole, diese Verbindungen enthaltende Arzneimittel und Verfahren zur ihrer Herstellung
DE4031635A1 (de) * 1990-10-05 1992-04-09 Thomae Gmbh Dr K Substituierte 1-benzyl-benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE4224133A1 (de) * 1992-07-22 1994-01-27 Thomae Gmbh Dr K Benzimidazole, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
DE4200954A1 (de) * 1991-04-26 1992-10-29 Bayer Ag Heterocyclisch substituierte phenylessigsaeurederivate

Also Published As

Publication number Publication date
NO940506D0 (no) 1994-02-14
EP0611767A1 (de) 1994-08-24
EP0611767B1 (de) 2000-09-06
FI940659A0 (fi) 1994-02-11
PH30172A (en) 1997-01-21
NO940506L (fi) 1994-08-16
NZ250864A (en) 1995-03-28
PL177834B1 (pl) 2000-01-31
DE4304455A1 (de) 1994-08-18
IL108625A0 (en) 1994-05-30
ZA94984B (en) 1994-08-24
CZ32994A3 (en) 1994-08-17
IL108625A (en) 1997-09-30
AU5480794A (en) 1994-08-18
UA35574C2 (uk) 2001-04-16
DK0611767T3 (da) 2001-01-02
US5395840A (en) 1995-03-07
CA2115536A1 (en) 1994-08-16
CN1108257A (zh) 1995-09-13
ES2151908T3 (es) 2001-01-16
AU672262B2 (en) 1996-09-26
FI106716B (fi) 2001-03-30
PT611767E (pt) 2001-02-28
CA2115536C (en) 2004-11-02
KR940019708A (ko) 1994-09-14
MY131595A (en) 2007-08-30
DE59409509D1 (de) 2000-10-12
RU2119480C1 (ru) 1998-09-27
JPH06293741A (ja) 1994-10-21
NO300810B1 (no) 1997-07-28
SK15294A3 (en) 1994-12-07
CN1057085C (zh) 2000-10-04
PL302213A1 (en) 1994-08-22
CZ289096B6 (cs) 2001-11-14
ATE196141T1 (de) 2000-09-15
GR3034957T3 (en) 2001-02-28

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