SK149394A3 - Uses of nucleic acid analogues in the inhibition on nucleic acid amplification - Google Patents

Uses of nucleic acid analogues in the inhibition on nucleic acid amplification Download PDF

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Publication number
SK149394A3
SK149394A3 SK1493-94A SK149394A SK149394A3 SK 149394 A3 SK149394 A3 SK 149394A3 SK 149394 A SK149394 A SK 149394A SK 149394 A3 SK149394 A3 SK 149394A3
Authority
SK
Slovakia
Prior art keywords
nucleic acid
amplification
template
primer
sequence
Prior art date
Application number
SK1493-94A
Other languages
English (en)
Slovak (sk)
Inventor
Ole Buchardt
Michael Egholm
Peter E Nielsen
Rolf H Berg
Original Assignee
Ole Buchardt
Michael Egholm
Nielsen Peter Eigil
Rolf H Berg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ole Buchardt, Michael Egholm, Nielsen Peter Eigil, Rolf H Berg filed Critical Ole Buchardt
Publication of SK149394A3 publication Critical patent/SK149394A3/sk

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/6848Nucleic acid amplification reactions characterised by the means for preventing contamination or increasing the specificity or sensitivity of an amplification reaction
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/686Polymerase chain reaction [PCR]

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
SK1493-94A 1992-06-05 1993-06-07 Uses of nucleic acid analogues in the inhibition on nucleic acid amplification SK149394A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929211979A GB9211979D0 (en) 1992-06-05 1992-06-05 Uses of nucleic acid analogues
PCT/EP1993/001435 WO1993025706A1 (fr) 1992-06-05 1993-06-07 Utilisations d'analogues d'acide nucleique pour inhiber les procedures d'amplification de l'acide nucleique

Publications (1)

Publication Number Publication Date
SK149394A3 true SK149394A3 (en) 1996-01-10

Family

ID=10716635

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1493-94A SK149394A3 (en) 1992-06-05 1993-06-07 Uses of nucleic acid analogues in the inhibition on nucleic acid amplification

Country Status (17)

Country Link
US (2) US5891625A (fr)
EP (1) EP0646181B1 (fr)
JP (1) JP3061064B2 (fr)
KR (2) KR0140836B1 (fr)
AT (1) ATE147441T1 (fr)
AU (1) AU674520B2 (fr)
CA (1) CA2136831C (fr)
CZ (1) CZ282786B6 (fr)
DE (1) DE69307317T2 (fr)
DK (1) DK0646181T3 (fr)
ES (1) ES2098752T3 (fr)
FI (1) FI110694B (fr)
GB (1) GB9211979D0 (fr)
HU (1) HU219371B (fr)
NO (1) NO317111B1 (fr)
SK (1) SK149394A3 (fr)
WO (1) WO1993025706A1 (fr)

Families Citing this family (140)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6020124A (en) * 1992-04-27 2000-02-01 Trustees Of Dartmouth College Detection of soluble gene sequences in biological fluids
US7825215B1 (en) 1993-04-26 2010-11-02 Peter E. Nielsen Substituted nucleic acid mimics
GB9311386D0 (en) * 1993-06-02 1993-07-21 Pna Diagnostics As Nucleic acid analogue assay procedures
EP0726965A1 (fr) * 1993-11-23 1996-08-21 Ciba Corning Diagnostics Corp. Utilisation d'oligomeres antisens dans un procede destine a limiter la contamination dans les reactions d'amplification de l'acide nucleique
GB2284209A (en) * 1993-11-25 1995-05-31 Ole Buchardt Nucleic acid analogue-induced transcription of RNA from a double-stranded DNA template
US6133444A (en) 1993-12-22 2000-10-17 Perseptive Biosystems, Inc. Synthons for the synthesis and deprotection of peptide nucleic acids under mild conditions
AU2369895A (en) * 1994-04-29 1995-11-29 Perseptive Biosystems, Inc. Activated esters of 1-phenylpyrazolin-5-one for labelling amine-functionalized molecules
US5629152A (en) * 1994-08-01 1997-05-13 Isis Pharmaceuticals, Inc. Trisubstituted β-lactams and oligo β-lactamamides
ZA956776B (en) * 1994-08-25 1996-03-20 Akzo Nobel Nv A process for making the product of a nucleic acid amplification reaction incapable of being a target for further amplification a diagnostic assay employing said process a kit and a container suitable for carrying out said process for assay
EP0799888B1 (fr) * 1994-12-09 2005-05-18 Wakunaga Seiyaku Kabushiki Kaisha Procede d'inhibition de l'hybridation non specifique dans une extension d'amorce
CA2214430A1 (fr) * 1995-03-04 1996-09-12 Boehringer Mannheim Gmbh Detection d'acides nucleiques specifique aux sequences
WO1996034983A1 (fr) 1995-05-05 1996-11-07 The Perkin-Elmer Corporation Procedes et reactifs pour combiner une amplification par reaction en chaine de la polymerase et une technique de sondage par hybridation
US6001645A (en) * 1995-06-07 1999-12-14 Promega Corporation Thermophilic DNA polymerases from thermotoga neapolitana
JP2001518054A (ja) * 1995-06-07 2001-10-09 パーセプティブ バイオシステムズ,インコーポレーテッド Pna−dnaキメラと、このキメラ合成用のpnaシントン
US6077664A (en) * 1995-06-07 2000-06-20 Promega Corporation Thermophilic DNA polymerases from Thermotoga neapolitana
CA2223050A1 (fr) * 1995-06-07 1996-12-19 Abbott Laboratories Procede de masquage de sonde servant a limiter le signal d'arriere-plan dans une reaction d'amplification
DE69637086T2 (de) 1995-10-12 2008-01-10 Lansdorp, Peter M., Vancouver Verfahren zum nachweis von mehrfachkopien einer wiederholungssequenz in einem nukleinsäuremolekül
AU7016096A (en) * 1995-10-20 1997-05-07 Trustees Of Boston University Nucleic acid clamps
US6143496A (en) 1997-04-17 2000-11-07 Cytonix Corporation Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly
US6617422B1 (en) 1997-05-23 2003-09-09 Peter Nielsen Peptide nucleic acid monomers and oligomers
CA2292893C (fr) * 1997-06-03 2012-01-17 Arch Development Corporation Compositions de chromosomes artificiels de plantes et procedes
US6900012B1 (en) * 1997-06-03 2005-05-31 The University Of Chicago Plant artificial chromosome compositions and methods
US7235716B2 (en) 1997-06-03 2007-06-26 Chromatin, Inc. Plant centromere compositions
US7119250B2 (en) * 1997-06-03 2006-10-10 The University Of Chicago Plant centromere compositions
US7193128B2 (en) * 1997-06-03 2007-03-20 Chromatin, Inc. Methods for generating or increasing revenues from crops
US7227057B2 (en) 1997-06-03 2007-06-05 Chromatin, Inc. Plant centromere compositions
US6485901B1 (en) 1997-10-27 2002-11-26 Boston Probes, Inc. Methods, kits and compositions pertaining to linear beacons
WO1999034014A2 (fr) * 1997-12-23 1999-07-08 Roche Diagnostics Gmbh Technique de determination d'un acide nucleique
JP2002521070A (ja) 1998-07-31 2002-07-16 ジェン−プローブ・インコーポレーテッド 可逆的阻害プローブ
US7981599B1 (en) 1998-07-31 2011-07-19 Boston Probes, Inc. Non-nucleic acid probes, probe sets, methods and kits pertaining to the detection of individual human chromosomes X, Y, 1, 2, 3, 4, 6, 7, 8, 9, 10, 11, 12, 16, 17, 18 and 20 as 13/21 as a pair
US6165337A (en) * 1998-12-23 2000-12-26 Shelton Scientific Manufacturing, Inc. Semi-dry electrophoresis apparatus and method
US7989202B1 (en) 1999-03-18 2011-08-02 The University Of Chicago Plant centromere compositions
EP1226281A2 (fr) * 1999-11-02 2002-07-31 Curagen Corporation Methode et compositions d'inhibition selective de l'amplification de sequences dans une population de molecules d'acides nucleiques
EP1255860A2 (fr) 1999-12-29 2002-11-13 Mergen Ltd. Procedes d'amplification et de detection de plusieurs polynucleotides sur un support en phase solide
US20020015951A1 (en) * 2000-01-06 2002-02-07 Bader Joel S. Method of analyzing a nucleic acid
US20040014644A1 (en) * 2000-03-14 2004-01-22 Vladimir Efimov Oligonucleotide analogues and methods of use for modulating gene expression
EP1263773A4 (fr) 2000-03-14 2005-08-31 Active Motif Analogues d'oligonucleotides, procedes de synthese et procedes de mise en oeuvre
US6962906B2 (en) * 2000-03-14 2005-11-08 Active Motif Oligonucleotide analogues, methods of synthesis and methods of use
US6376191B1 (en) 2000-03-22 2002-04-23 Mergen, Ltd. Microarray-based analysis of polynucleotide sequence variations
AU2001256976A1 (en) * 2000-04-03 2001-10-15 Cytyc Corporation Detection and typing of human papillomavirus using pna probes
US6936443B2 (en) * 2000-04-03 2005-08-30 Cytyc Corporation Detection and typing of human papillomavirus using PNA probes
GB0021286D0 (en) * 2000-08-30 2000-10-18 Gemini Genomics Ab Identification of drug metabolic capacity
DE60138916D1 (de) 2000-09-26 2009-07-16 Boston Probes Inc Sonden, sondensätzen,verfahren und kits zur nachweis, identifizierung und/oder die zählung von bakterien
EP1356113B1 (fr) * 2000-12-15 2012-07-18 Life Technologies Corporation Methodes destinees a determiner la presence d'organismes
JP4408628B2 (ja) * 2001-03-09 2010-02-03 ボストン プローブス,インコーポレイテッド 組み合わせオリゴマーならびにそれらの調製のためのライブラリーに適する、方法、キット、および組成物
WO2003027328A2 (fr) * 2001-09-24 2003-04-03 Boston Probes, Inc. Procedes, kits et compositions utilises dans la suppression d'une sonde detectable se liant a des sequences de repetition reparties de maniere aleatoire de l'acide nucleique genomique
EP1487858A4 (fr) * 2002-03-21 2006-01-04 Boston Probes Inc Oligomeres pna, ensembles d'oligomeres, procedes et trousses relatifs a la detection de bacillus anthracis
US20030211509A1 (en) * 2002-03-26 2003-11-13 Wiley Steven R. TNF-delta ligand and uses thereof
US7052840B2 (en) * 2002-04-03 2006-05-30 Capitol Genomix, Inc. Reversible association of nucleic acid with a carboxylated substrate
US20030211483A1 (en) * 2002-05-09 2003-11-13 Schroeder Benjamin G. Methods for the enrichment of low-abundance polynucleotides
WO2003100076A2 (fr) * 2002-05-17 2003-12-04 Applera Corporation Sondes de peptides pna, ensemble de sondes, procede et necessaires se rapportant a la determination des listeria
US20030220844A1 (en) * 2002-05-24 2003-11-27 Marnellos Georgios E. Method and system for purchasing genetic data
EP1558759A4 (fr) * 2002-07-01 2007-06-06 Univ State Cleveland Methode detection de polynucleotides ayant mute dans une vaste population de polynucleotides du type sauvage
WO2004022578A2 (fr) * 2002-09-08 2004-03-18 Applera Corporation Procedes, compositions et banques se rapportant a la synthese de dimere et d'oligomere d'anp
DE10253966B4 (de) * 2002-11-19 2005-03-24 Clondiag Chip Technologies Gmbh Microarray-basiertes Verfahren zur Amplifikation und Detektion von Nukleinsäuren in einem kontinuierlichen Prozess
US20040259132A1 (en) * 2002-11-22 2004-12-23 Henrik Stender Peptide nucleic acid probes for analysis of pseudomonas (sensu stricto)
EP2112229A3 (fr) 2002-11-25 2009-12-02 Sequenom, Inc. Procédés d'identification du risque du cancer du sein et traitements associés
WO2004106555A2 (fr) 2003-05-22 2004-12-09 Dow Agrosciences Llc Procedes de criblage a haut debit d'adn pour deletion et autres mutations
US20050221310A1 (en) * 2003-06-06 2005-10-06 Gene Ogic, Inc. Methods for enhancing gene expression analysis
WO2005003370A2 (fr) * 2003-06-06 2005-01-13 Gene Logic, Inc. Procedes ameliorant l'analyse de l'expression genique
CA2533119A1 (fr) * 2003-07-24 2005-02-03 Qiagen Gmbh Procede de transcription et/ou d'amplification inversee d'acides nucleiques
US20050123975A1 (en) * 2003-11-19 2005-06-09 Applera Corporation Methods for determining the degradation state or concentration of nucleic acids
MXPA06009225A (es) * 2004-02-23 2007-03-08 Chromatin Inc Plantas modificadas con mini-cromosomas.
CA2502549C (fr) 2004-04-23 2016-02-16 Becton, Dickinson And Company Utilisation d'un dispositif de controle de l'extraction au cours d'un procede d'extraction d'acides nucleiques
WO2005111235A2 (fr) * 2004-05-04 2005-11-24 Dak Denmark A/S Procedes de detection d'aberrations chromosomiques
US20080199480A1 (en) * 2004-07-22 2008-08-21 Sequenom, Inc. Methods for Identifying Risk of Type II Diabetes and Treatments Thereof
US20060223084A1 (en) * 2004-12-06 2006-10-05 Bioveris Corporation Methods and compositions for detecting Bacillus anthracis
WO2006081426A2 (fr) * 2005-01-28 2006-08-03 Applera Corporation Compositions et methodes pour completer une reaction de sequencage a un emplacement specifique d'un modele d'adn cible
US20060257902A1 (en) * 2005-03-25 2006-11-16 Ambion, Inc. Methods and compositions for depleting abundant RNA transcripts
WO2006130872A2 (fr) 2005-06-02 2006-12-07 Advandx, Inc. Sondes d'acides nucleiques peptidiques destinees a l'analyse de micro-organismes
US9017992B2 (en) 2005-07-01 2015-04-28 Dako Denmark A/S In situ hybridization detection method
US8222028B2 (en) * 2005-09-08 2012-07-17 Chromatin, Inc. Plants modified with mini-chromosomes
DE102005048503B4 (de) * 2005-10-07 2012-10-18 InViTek Gesellschaft für Biotechnik & Biodesign mbH Verfahren zur Steuerung der abschnittsweisen enzymatischen Nukleinsäurevervielfältigung über inkomplette Komplementärstränge
EP2479291A1 (fr) * 2005-10-27 2012-07-25 Life Technologies Corporation Amplification d'acides nucléiques au moyen d'amorces non aléatoires
DE602006018352D1 (de) 2005-12-06 2010-12-30 Ambion Inc Rückübertragungs-primer und verfahren zu deren entwurf
CA2651510C (fr) * 2006-05-12 2016-08-09 Cepheid Detection de la jonction de recombinaison d'adn
US8679741B2 (en) * 2006-05-31 2014-03-25 Sequenom, Inc. Methods and compositions for the extraction and amplification of nucleic acid from a sample
CA2654165A1 (fr) 2006-06-05 2007-12-13 Cancer Care Ontario Evaluation de risque pour cancer colorectal
US8119352B2 (en) * 2006-06-20 2012-02-21 Cepheld Multi-stage amplification reactions by control of sequence replication times
WO2008070525A1 (fr) 2006-12-04 2008-06-12 Luminex Corporation Acides nucléiques peptidiques oxocarbonamide et leurs procédés d'utilisation
US7902345B2 (en) 2006-12-05 2011-03-08 Sequenom, Inc. Detection and quantification of biomolecules using mass spectrometry
US7955802B2 (en) 2006-12-13 2011-06-07 Luminex Corporation Systems and methods for multiplex analysis of PCR in real time
WO2008083259A1 (fr) * 2006-12-29 2008-07-10 Applera Corporation Systèmes et procédés de détection d'acides nucléiques
EP2118310B1 (fr) * 2006-12-29 2013-03-06 Applied Biosystems, LLC Systemes et procedes pour la detection d'acide nucleique
US8173370B2 (en) * 2007-02-08 2012-05-08 Sequenom, Inc. Nucleic acid-based tests for RHD typing, gender determination and nucleic acid quantification
GB0703996D0 (en) * 2007-03-01 2007-04-11 Oxitec Ltd Nucleic acid detection
GB0703997D0 (en) 2007-03-01 2007-04-11 Oxitec Ltd Methods for detecting nucleic sequences
WO2008106785A1 (fr) 2007-03-05 2008-09-12 Cancer Care Ontario Évaluation du risque de cancer colorectal
US8614089B2 (en) * 2007-03-15 2013-12-24 Chromatin, Inc. Centromere sequences and minichromosomes
AU2008230813B2 (en) 2007-03-26 2014-01-30 Sequenom, Inc. Restriction endonuclease enhanced polymorphic sequence detection
EP2167537A2 (fr) 2007-07-03 2010-03-31 Dako Denmark A/S Procedes compiles pour analyser et trier des echantillons
WO2009032781A2 (fr) 2007-08-29 2009-03-12 Sequenom, Inc. Méthodes et compositions s'appliquant à une amplification en chaîne par polymèrase universelle spécifique de la taille
EP2245049B1 (fr) 2008-01-10 2015-05-20 Research Development Foundation Vaccins et diagnostics pour les ehrlichioses
US8709726B2 (en) 2008-03-11 2014-04-29 Sequenom, Inc. Nucleic acid-based tests for prenatal gender determination
EP2276858A4 (fr) 2008-03-26 2011-10-05 Sequenom Inc Détection de séquence polymorphique amplifiée par endonucléase de restriction
ES2668555T3 (es) 2008-05-27 2018-05-18 Dako Denmark A/S Composiciones y métodos para la detección de aberraciones cromosómicas con tampones de hibridación novedosos
US8476013B2 (en) * 2008-09-16 2013-07-02 Sequenom, Inc. Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
US8962247B2 (en) * 2008-09-16 2015-02-24 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses
CN102272157B (zh) 2008-11-07 2015-11-25 研究发展基金会 用于抑制cripto/grp78复合物形成和信号的组合物和方法
WO2010077324A2 (fr) 2008-12-17 2010-07-08 Life Technologies Corporation Procédés, compositions et nécessaires de détection de variantes alléliques
EP3722810A3 (fr) 2009-02-11 2021-01-13 Caris MPI, Inc. Profilage moléculaire de tumeurs
WO2010097655A1 (fr) 2009-02-26 2010-09-02 Dako Denmark A/S Compositions et procédés pour des applications d'hybridation d'arn
US20100279295A1 (en) * 2009-03-18 2010-11-04 Sequenom, Inc. Use of thermostable endonucleases for generating reporter molecules
US20110045080A1 (en) * 2009-03-24 2011-02-24 William Marsh Rice University Single-Walled Carbon Nanotube/Bioactive Substance Complexes and Methods Related Thereto
CN102428190B (zh) 2009-03-27 2014-02-26 生命技术公司 用于检测等位基因变体的方法、组合物和试剂盒
WO2010115016A2 (fr) 2009-04-03 2010-10-07 Sequenom, Inc. Compositions constituées d'une préparation d'acides nucléiques et procédés associés
EP2449104B1 (fr) 2009-06-29 2014-06-04 Luminex Corporation Amorces chimériques avec conformations en épingle à cheveux et procédés d'utilisation de celles-ci
CA2767724A1 (fr) 2009-07-23 2011-01-27 Chromatin, Inc. Sequences de centromere et mini-chromosomes de sorgho
US20160186266A1 (en) 2009-10-27 2016-06-30 Carislife Sciences, Inc. Molecular profiling for personalized medicine
CA2781907C (fr) 2009-12-02 2019-07-16 Dako Denmark A/S Compositions et procedes pour realiser des hybridations sans denaturation
US9404160B2 (en) 2009-12-22 2016-08-02 Becton, Dickinson And Company Methods for the detection of microorganisms
US9926593B2 (en) 2009-12-22 2018-03-27 Sequenom, Inc. Processes and kits for identifying aneuploidy
CN102741429A (zh) * 2010-02-25 2012-10-17 松下电器产业株式会社 对双链dna中的目标序列进行扩增的方法
EP2663651B1 (fr) 2011-01-14 2018-06-20 Genefirst Limited Procédés, compositions et trousses pour la détermination de la présence/l'absence d'une séquence variante d'acide nucléique
CA2834218C (fr) 2011-04-29 2021-02-16 Sequenom, Inc. Quantification d'une minorite d'especes d'acide nucleique utilisant des oligonucleotides inhibiteurs
EP2761028A1 (fr) 2011-09-30 2014-08-06 Dako Denmark A/S Compositions d'hybridation et procédés utilisant du formamide
EP3252173A1 (fr) 2011-10-21 2017-12-06 Dako Denmark A/S Compositions et procédés d'hybridation
US20140377762A1 (en) 2011-12-19 2014-12-25 360 Genomics Ltd. Method for enriching and detection of variant target nucleic acids
US9605313B2 (en) 2012-03-02 2017-03-28 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US9920361B2 (en) 2012-05-21 2018-03-20 Sequenom, Inc. Methods and compositions for analyzing nucleic acid
EP2872648B1 (fr) 2012-07-13 2019-09-04 Sequenom, Inc. Procédés et compositions pour l'enrichissement basé sur la méthylation d'un échantillon maternel en acide nucléique foetal, utiles pour les diagnostics prénatals non invasifs
WO2014033314A1 (fr) 2012-09-03 2014-03-06 Uab Bioseka Oligonucléotides antisens ciblant des glucosyltransférases bactériennes
EP2929050A1 (fr) 2012-12-10 2015-10-14 AdvanDx, Inc. Utilisation de sondes pour l'identification par spectrométrie de masse de micro-organismes ou de cellules et de pathologies associées présentant un intérêt
US9896728B2 (en) 2013-01-29 2018-02-20 Arcticrx Ltd. Method for determining a therapeutic approach for the treatment of age-related macular degeneration (AMD)
EP3597774A1 (fr) 2013-03-13 2020-01-22 Sequenom, Inc. Amorces pour analyse de la méthylation de l'adn
EP2970976A4 (fr) 2013-03-15 2016-11-02 Techulon Inc Molécules antisens pour le traitement de l'infection à staphylococcus aureus
SG10201710369RA (en) 2013-03-15 2018-01-30 Techulon Inc Antisense molecules for treatment of staphylococcus aureus infection
LT6214B (lt) 2013-10-07 2015-08-25 Uab "Bioseka" Priešprasminiai oligonukleotidai aterosklerozės ir kardiovaskulinių infekcijų prevencijai
JP6640079B2 (ja) 2013-10-16 2020-02-05 ザ・ユニバーシティ・オブ・ブリティッシュ・コロンビア 小容積の粒子を調製するためのデバイス及び方法
EP3065706A4 (fr) 2013-11-08 2017-11-29 Baylor Research Institute La localisation nucléaire de glp-1 stimule la régénération myocardique et entraîne la régression d'une insuffisance cardiaque
EP3117011B1 (fr) 2014-03-13 2020-05-06 Sequenom, Inc. Méthodes et procédés d'évaluation non invasive de variations génétiques
WO2016134293A1 (fr) 2015-02-20 2016-08-25 Baylor College Of Medicine Inactivation de p63 pour le traitement de l'insuffisance cardiaque
CN108291227A (zh) 2015-10-14 2018-07-17 拜奥-帕斯控股股份有限公司 用于脂质体制剂的对乙氧基核酸
AU2016385135B2 (en) 2016-01-06 2022-02-17 The University Of British Columbia Bifurcating mixers and methods of their use and manufacture
US20190177391A1 (en) 2016-03-31 2019-06-13 Baylor Research Institute Angiopoietin-like protein 8 (angptl8)
CN109563506A (zh) 2016-05-06 2019-04-02 威廉马歇莱思大学 使用随机捕获探针文库的化学计量核酸纯化
EP3512525B1 (fr) 2016-09-16 2022-07-27 Bio-Path Holdings, Inc. Phytothérapie avec des oligonucléotides antisens liposomaux
EP3519578B1 (fr) 2016-10-03 2021-12-22 Precision Nanosystems Inc Compositions pour la transfection de types de cellules résistantes
EP3888021B1 (fr) 2018-11-30 2024-02-21 Caris MPI, Inc. Profilage moléculaire de nouvelle génération
WO2021112918A1 (fr) 2019-12-02 2021-06-10 Caris Mpi, Inc. Prédicteur de réponse au platine dans une approche pan-cancer

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683195A (en) * 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4988617A (en) * 1988-03-25 1991-01-29 California Institute Of Technology Method of detecting a nucleotide change in nucleic acids
ES2141088T3 (es) * 1990-02-16 2000-03-16 Hoffmann La Roche Mejoras en la especificidad y conveniencia de la reaccion en cadena de la polimerasa.
AU8920191A (en) * 1990-10-31 1992-05-26 George D. Cimino Methods and compositions for minimizing inhibition of nucleic acid amplification
DK51092D0 (da) * 1991-05-24 1992-04-15 Ole Buchardt Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf

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US5972610A (en) 1999-10-26
CZ295194A3 (en) 1995-09-13
GB9211979D0 (en) 1992-07-15
EP0646181A1 (fr) 1995-04-05
CZ282786B6 (cs) 1997-10-15
KR0140836B1 (ko) 1998-06-15
DE69307317D1 (de) 1997-02-20
FI945725A (fi) 1994-12-05
CA2136831C (fr) 2002-11-05
NO944655L (no) 1995-02-03
HUT71931A (en) 1996-02-28
WO1993025706A1 (fr) 1993-12-23
JP3061064B2 (ja) 2000-07-10
HU219371B (en) 2001-03-28
ES2098752T3 (es) 1997-05-01
ATE147441T1 (de) 1997-01-15
FI945725A0 (fi) 1994-12-05
JPH08501681A (ja) 1996-02-27
AU674520B2 (en) 1997-01-02
US5891625A (en) 1999-04-06
DK0646181T3 (da) 1997-10-13
KR950702252A (ko) 1995-06-19
DE69307317T2 (de) 1997-05-22
NO944655D0 (no) 1994-12-02
AU4323593A (en) 1994-01-04
EP0646181B1 (fr) 1997-01-08
NO317111B1 (no) 2004-08-16
FI110694B (fi) 2003-03-14
CA2136831A1 (fr) 1993-12-23
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