SK14672001A3 - Spôsob syntézy a kryštalizácie zlúčenín obsahujúcich piperazínový kruh - Google Patents

Spôsob syntézy a kryštalizácie zlúčenín obsahujúcich piperazínový kruh Download PDF

Info

Publication number
SK14672001A3
SK14672001A3 SK1467-2001A SK14672001A SK14672001A3 SK 14672001 A3 SK14672001 A3 SK 14672001A3 SK 14672001 A SK14672001 A SK 14672001A SK 14672001 A3 SK14672001 A3 SK 14672001A3
Authority
SK
Slovakia
Prior art keywords
mirtazapine
methyl
phenylpiperazine
cyanopyridyl
base
Prior art date
Application number
SK1467-2001A
Other languages
English (en)
Slovak (sk)
Inventor
Claude Singer
Anita Liberman
Nina Finkelstein
Original Assignee
Teva Pharmaceutical Industries Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharmaceutical Industries Ltd. filed Critical Teva Pharmaceutical Industries Ltd.
Publication of SK14672001A3 publication Critical patent/SK14672001A3/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
SK1467-2001A 1999-04-19 2000-04-18 Spôsob syntézy a kryštalizácie zlúčenín obsahujúcich piperazínový kruh SK14672001A3 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13004799P 1999-04-19 1999-04-19
PCT/US2000/010357 WO2000062782A1 (en) 1999-04-19 2000-04-18 Novel synthesis and crystallization of piperazine ring-containing compounds

Publications (1)

Publication Number Publication Date
SK14672001A3 true SK14672001A3 (sk) 2002-11-06

Family

ID=22442814

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1467-2001A SK14672001A3 (sk) 1999-04-19 2000-04-18 Spôsob syntézy a kryštalizácie zlúčenín obsahujúcich piperazínový kruh

Country Status (16)

Country Link
JP (1) JP2004500324A (sh)
KR (1) KR20020019902A (sh)
CN (4) CN1680374A (sh)
CA (1) CA2368815A1 (sh)
CZ (1) CZ20013658A3 (sh)
HK (1) HK1044116A1 (sh)
HR (1) HRP20010747A2 (sh)
HU (1) HUP0200839A3 (sh)
IL (1) IL146023A0 (sh)
PL (1) PL366289A1 (sh)
RU (1) RU2001128229A (sh)
SK (1) SK14672001A3 (sh)
TR (1) TR200103028T2 (sh)
WO (1) WO2000062782A1 (sh)
YU (1) YU74101A (sh)
ZA (1) ZA200108220B (sh)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6019900A (en) * 1999-11-24 2001-06-04 Sumika Fine Chemicals Co., Ltd. Anhydrous mirtazapine crystals and process for producing the same
AU6474200A (en) * 1999-12-13 2001-06-18 Sumika Fine Chemicals Co., Ltd. Process for the preparation of a pyridinemethanol compound
US6660730B2 (en) * 2000-11-27 2003-12-09 Sumika Fine Chemicals Co., Ltd. Anhydrous mirtazapine and process for preparing the same
UA83666C2 (ru) 2003-07-10 2008-08-11 Н.В. Органон Способ получения энантиомерно чистого миртазапина
ES2246161B1 (es) * 2004-07-22 2007-04-01 Medichem, S.A. Proceso mejorado para la fabricacion de mirtazapina.
JP4848704B2 (ja) * 2004-08-24 2011-12-28 住友化学株式会社 ２−（４−メチル−２−フェニルピペラジン−１−イル）−３−シアノピリジンの製造方法
JP5192707B2 (ja) 2007-03-22 2013-05-08 住友化学株式会社 ミルタザピンの製造方法
US7994314B2 (en) 2007-04-11 2011-08-09 N.V. Organon Method for the preparation of an enantiomerically pure benzazepine
AR066005A1 (es) 2007-04-11 2009-07-15 Organon Nv Un metodo para la preparacion de un enantiomero de una benzazepina tetraciclica
KR101485418B1 (ko) * 2013-05-29 2015-01-26 주식회사 메디켐코리아 고순도 미르타자핀의 제조방법
JP2017088564A (ja) * 2015-11-13 2017-05-25 株式会社トクヤマ ミルタザピンの製造方法
JP6571497B2 (ja) * 2015-11-13 2019-09-04 株式会社トクヤマ ミルタザピンの製造方法
CN108191873B (zh) * 2018-01-08 2021-09-24 山东省食品药品检验研究院 一种盐酸米安色林的纯化方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL189199C (nl) * 1975-04-05 1993-02-01 Akzo Nv Werkwijze ter bereiding van farmaceutische preparaten met werking op het centraal zenuwstelsel op basis van benz(aryl)azepinederivaten, de verkregen gevormde farmaceutische preparaten, alsmede werkwijze ter bereiding van de toe te passen benz(aryl)azepinederivaten.

Also Published As

Publication number Publication date
HRP20010747A2 (en) 2002-12-31
ZA200108220B (en) 2006-02-26
HK1044116A1 (zh) 2002-10-11
YU74101A (sh) 2004-09-03
HUP0200839A2 (en) 2002-08-28
JP2004500324A (ja) 2004-01-08
IL146023A0 (en) 2002-07-25
WO2000062782A1 (en) 2000-10-26
CZ20013658A3 (cs) 2002-08-14
HUP0200839A3 (en) 2003-05-28
PL366289A1 (en) 2005-01-24
CN1356903A (zh) 2002-07-03
KR20020019902A (ko) 2002-03-13
RU2001128229A (ru) 2003-07-10
CN1680374A (zh) 2005-10-12
CA2368815A1 (en) 2000-10-26
CN1679586A (zh) 2005-10-12
CN1680365A (zh) 2005-10-12
TR200103028T2 (tr) 2002-01-21

Similar Documents

Publication Publication Date Title
EP0299470B1 (de) Imidazo[1,2-a]pyridine
IE882108L (en) Azithromycin dihydrate
SK14672001A3 (sk) Spôsob syntézy a kryštalizácie zlúčenín obsahujúcich piperazínový kruh
CN114315823B (zh) 盐酸小檗碱及其类似物的中间体及其制备方法
KR20150027986A (ko) 고순도 페메트렉세드 제조를 위한 향상된 중간체 제조 방법 및 이를 사용하여 고순도 페메트렉세드를 제조하는 방법
US6545149B2 (en) Synthesis and crystallization of piperazine ring-containing compounds
US20030069417A1 (en) Novel synthesis and crystallization of piperazine ring-containing compounds
US3201406A (en) Pyridylcoumarins
KR100656636B1 (ko) 6-메틸-2-(4-메틸-페닐)-이미다조[1,2-ａ]피리딘-3-(Ｎ,Ｎ-디메틸-아세트아미드) 및 중간체의 제조 방법
AU781221B2 (en) Novel synthesis and crystallization of piperazine ring-containing compounds
NO137999B (no) Analogifremgangsm}te ved fremstilling av terapeutisk aktive oxofurylestere av 6-(alfa-aminofenylacetamido)-penicillansyre
US4146713A (en) Method of preparing 3-morpholino-2-cyanoacrylamide
EP0216323A2 (en) Quinolonecarboxylic acid derivatives and their preparation
SK77893A3 (en) Process for preparing imidazopyridines
CN111233857B (zh) 一种连续化生产培西达替尼的合成方法
US4697013A (en) Condensed as-triazine derivatives
AU2005201117A1 (en) Novel synthesis and crystallization of piperazine ring-containing compounds
CA1189509A (en) Substituted 11-oxo-11h-pyrido [2,1-b] quinazolines
CN114560862A (zh) 一种吡咯并[1,2-a]喹喔啉-4(5h)-酮及其衍生物的合成方法
WO2023006986A1 (en) Method for preparing and purifying an agent suitable for treating anemia
GB2051799A (en) 2-(1-Naphthyl)piperidine derivative, its production and use as an anti-mycotic agent
KR820000099B1 (ko) 피리도[2, 1-b] 퀴나졸린 유도체의 제조방법
KR800000504B1 (ko) 2, 6-이치환된 2-페닐아미노-이미다졸리딘의 제조방법
US2517496A (en) Preparation of symmetrical monoaminodihydroxytoluene
KR20020068140A (ko) [(2-옥소-3-테트라히드로티에닐카바모일)-메틸티오]아세트산의 제조방법