SK146599A3 - Essentially pure or recombinant protein dtlr2-10, a fused protein, a bond substance, a nucleic acid, an expression vector, a host cell and process for their production - Google Patents
Essentially pure or recombinant protein dtlr2-10, a fused protein, a bond substance, a nucleic acid, an expression vector, a host cell and process for their production Download PDFInfo
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- SK146599A3 SK146599A3 SK1465-99A SK146599A SK146599A3 SK 146599 A3 SK146599 A3 SK 146599A3 SK 146599 A SK146599 A SK 146599A SK 146599 A3 SK146599 A3 SK 146599A3
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Toxicology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
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US4429397P | 1997-05-07 | 1997-05-07 | |
US7221298P | 1998-01-22 | 1998-01-22 | |
US7694798P | 1998-03-05 | 1998-03-05 | |
PCT/US1998/008979 WO1998050547A2 (en) | 1997-05-07 | 1998-05-07 | Human toll-like receptor proteins, related reagents and methods |
Publications (1)
Publication Number | Publication Date |
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SK146599A3 true SK146599A3 (en) | 2000-07-11 |
Family
ID=27366459
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SK1465-99A SK146599A3 (en) | 1997-05-07 | 1998-05-07 | Essentially pure or recombinant protein dtlr2-10, a fused protein, a bond substance, a nucleic acid, an expression vector, a host cell and process for their production |
Country Status (20)
Country | Link |
---|---|
EP (4) | EP1925666B1 (da) |
JP (4) | JP2002514083A (da) |
KR (1) | KR100388860B1 (da) |
CN (4) | CN1225555C (da) |
AT (3) | ATE443139T1 (da) |
AU (1) | AU740333B2 (da) |
CA (1) | CA2289912C (da) |
CY (1) | CY1109645T1 (da) |
DE (3) | DE69841514D1 (da) |
DK (2) | DK1798288T3 (da) |
ES (3) | ES2340210T3 (da) |
HK (3) | HK1022175A1 (da) |
ID (1) | ID28299A (da) |
IL (1) | IL132614A0 (da) |
NO (1) | NO995458L (da) |
NZ (1) | NZ338073A (da) |
PL (1) | PL336635A1 (da) |
PT (1) | PT1798288E (da) |
SK (1) | SK146599A3 (da) |
WO (1) | WO1998050547A2 (da) |
Families Citing this family (64)
Publication number | Priority date | Publication date | Assignee | Title |
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US8212004B2 (en) | 1999-03-02 | 2012-07-03 | Human Genome Sciences, Inc. | Neutrokine-alpha fusion proteins |
US6812327B1 (en) | 1996-10-25 | 2004-11-02 | Human Genome Sciences, Inc. | Neutrokine-alpha polypeptides |
US7696327B1 (en) | 1997-10-17 | 2010-04-13 | Genentech, Inc. | Antibodies to human Toll homologues |
US20030032090A1 (en) | 1997-05-07 | 2003-02-13 | Schering Corporation, A New Jersey Corporation | Human receptor proteins; related reagents and methods |
AU2003203679B2 (en) * | 1997-10-17 | 2007-04-05 | Genentech, Inc. | Human toll homologues |
PT1887014E (pt) * | 1997-10-17 | 2010-07-05 | Genentech Inc | Homëlogos de toll humana |
JP2000128900A (ja) * | 1998-10-26 | 2000-05-09 | Japan Science & Technology Corp | 新規トル様(Toll−like)レセプター及びその遺伝子 |
US6303321B1 (en) | 1999-02-11 | 2001-10-16 | North Shore-Long Island Jewish Research Institute | Methods for diagnosing sepsis |
US6740487B1 (en) | 1999-06-10 | 2004-05-25 | University Of Iowa Research Foundation | Variant TLR4 nucleic acid and uses thereof |
CA2389765A1 (en) * | 1999-11-02 | 2001-05-10 | Chiron Corporation | Cpg receptor (cpg-r) and methods relating thereto |
GB9927332D0 (en) * | 1999-11-18 | 2000-01-12 | Leiv Eiriksson Nyfotek As | Novel antibody and uses thereof |
GB0001704D0 (en) * | 2000-01-25 | 2000-03-15 | Glaxo Group Ltd | Protein |
US20030083244A1 (en) * | 2000-04-26 | 2003-05-01 | Vernet Corine A.M. | Novel proteins and nucleic acids encoding same |
EP1283849A2 (en) * | 2000-05-25 | 2003-02-19 | Schering Corporation | Human receptor proteins; related reagents and methods |
US7879328B2 (en) | 2000-06-16 | 2011-02-01 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to B lymphocyte stimulator |
WO2002002641A1 (en) | 2000-06-16 | 2002-01-10 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to blys |
JP2002034565A (ja) * | 2000-07-19 | 2002-02-05 | Japan Science & Technology Corp | 細菌dnaを特異的に認識する受容体タンパク質 |
AU2001288301A1 (en) | 2000-08-18 | 2002-03-04 | Human Genome Sciences, Inc. | Binding polypeptides and methods based thereon |
EP1674477B1 (en) * | 2000-08-18 | 2009-12-09 | Dyax Corp. | Binding polypeptides for B lymphocyte stimulator protein (BLYS) |
DK1366077T3 (da) | 2000-09-15 | 2011-09-12 | Coley Pharm Gmbh | Fremgangsmåde til screening i store mængder af CpG-baserede immunoagonister/-antagonister |
US7304034B2 (en) | 2001-05-15 | 2007-12-04 | The Feinstein Institute For Medical Research | Use of HMGB fragments as anti-inflammatory agents |
US7220723B2 (en) | 2001-05-15 | 2007-05-22 | The Feinstein Institute For Medical Research | Inhibitors of the interaction between HMGB polypeptides and toll-like receptor 2 as anti-inflammatory agents |
CN1633598A (zh) * | 2001-10-05 | 2005-06-29 | 科勒制药股份公司 | Toll样受体3信号传导的激动剂和拮抗剂 |
JP2005513021A (ja) * | 2001-11-16 | 2005-05-12 | スリーエム イノベイティブ プロパティズ カンパニー | Irm化合物およびトール様受容体経路に関する方法および組成物 |
GB0127618D0 (en) * | 2001-11-17 | 2002-01-09 | Univ Nottingham | "Composition and method for treatment of wounds" |
JP2004016021A (ja) | 2002-06-12 | 2004-01-22 | Japan Science & Technology Corp | 抗体および阻害剤並びにそれを用いた形質転換方法および形質転換キット |
WO2004053452A2 (en) * | 2002-12-11 | 2004-06-24 | 3M Innovative Properties Company | Assays relating to toll-like receptor activity |
WO2004094671A2 (en) * | 2003-04-22 | 2004-11-04 | Coley Pharmaceutical Gmbh | Methods and products for identification and assessment of tlr ligands |
US7696169B2 (en) | 2003-06-06 | 2010-04-13 | The Feinstein Institute For Medical Research | Inhibitors of the interaction between HMGB polypeptides and toll-like receptor 2 as anti-inflammatory agents |
JP4792392B2 (ja) | 2003-09-11 | 2011-10-12 | コーナーストーン セラピューティクス インコーポレイテッド | Hmgb1に対するモノクローナル抗体 |
US8871782B2 (en) | 2003-10-03 | 2014-10-28 | 3M Innovative Properties Company | Alkoxy substituted imidazoquinolines |
TW200516153A (en) * | 2003-10-03 | 2005-05-16 | Hitachi Chemical Co Ltd | Human toll-like receptor 3 gene polymorphism as marker for inherited factor of allergic disease and utilization of the same |
TW200514850A (en) * | 2003-10-03 | 2005-05-01 | Hitachi Chemical Co Ltd | Method of evaluating risk for viral infection |
WO2005039504A2 (en) | 2003-10-24 | 2005-05-06 | Eisai Co., Ltd. | Compounds and methods for treating toll-like receptor 2-related diseases and conditions |
AU2004293078B2 (en) | 2003-11-25 | 2012-01-19 | 3M Innovative Properties Company | Substituted imidazo ring systems and methods |
JP2008022701A (ja) * | 2004-09-24 | 2008-02-07 | Japan Science & Technology Agency | 可溶型Toll様受容体4タンパク質 |
WO2006054129A1 (en) | 2004-11-19 | 2006-05-26 | Institut Gustave Roussy | Improved treatment of cancer by double-stranded rna |
AR051836A1 (es) | 2004-11-30 | 2007-02-14 | Centocor Inc | Antagonistas de receptor 3 simil toll metodos y usos |
AU2006210392A1 (en) | 2005-02-04 | 2006-08-10 | Coley Pharmaceutical Group, Inc. | Aqueous gel formulations containing immune response modifiers |
US7498409B2 (en) | 2005-03-24 | 2009-03-03 | Schering Corporation | Screening assay for TLR7, TLR8 and TLR9 agonists and antagonists |
US7700728B2 (en) | 2005-03-24 | 2010-04-20 | Schering Corporation | Use of chimeric receptors in a screening assay for identifying agonists and antagonists of cell receptors |
US9168286B2 (en) | 2005-10-13 | 2015-10-27 | Human Genome Sciences, Inc. | Methods and compositions for use in treatment of patients with autoantibody positive disease |
JP5199878B2 (ja) | 2005-10-27 | 2013-05-15 | セントカー・インコーポレーテツド | Toll様受容体3モジュレーター、方法および用途 |
EP1991264B1 (en) | 2006-03-07 | 2015-01-07 | Vaxinnate Corporation | Compositions that include hemagglutinin, methods of making and methods of use thereof |
US8211649B2 (en) | 2006-03-31 | 2012-07-03 | Human Genome Sciences, Inc. | Methods of diagnosing and prognosing hodgkin's lymphoma |
CN101134046B (zh) * | 2006-09-01 | 2011-10-05 | 中国医学科学院药物研究所 | Tlr4和tlr9激动剂复方在抑制肿瘤转移中的应用 |
EP2155889A4 (en) * | 2007-05-25 | 2010-06-16 | Centocor Ortho Biotech Inc | TOLL RECEPTOR 3 MODULATORS AND USES THEREOF |
US20110076296A1 (en) | 2008-04-25 | 2011-03-31 | Innate Pharma S.A. | TLR3 Agonist Compositions |
EP2116602A1 (en) | 2008-05-07 | 2009-11-11 | Institut Gustave Roussy | Combination products for treating cancer |
US8273541B2 (en) | 2008-09-17 | 2012-09-25 | Innate Pharma | Compositions and methods for detecting TLR3 |
WO2010033294A1 (en) | 2008-09-22 | 2010-03-25 | Cedars-Sinai Medical Center | Short-form human md-2 as a negative regulator of toll-like receptor 4 signaling |
US9512196B2 (en) | 2008-09-22 | 2016-12-06 | Cedars-Sinai Medical Center | Short-form human MD-2 as a negative regulator of toll-like receptor 4 signaling |
ES2543095T3 (es) | 2009-07-10 | 2015-08-14 | Innate Pharma | Agentes de unión a TLR3 |
JP5830744B2 (ja) * | 2009-08-19 | 2015-12-09 | 国立大学法人東京工業大学 | 乳酸菌の付着性を誘導するペプチド及びその用途 |
US9890202B2 (en) | 2010-07-19 | 2018-02-13 | Yeda Research And Development Co. Ltd. | Peptides based on the transmembrane domain of a toll-like receptor (TLR) for treatment of TLR-mediated diseases |
WO2012088272A1 (en) | 2010-12-21 | 2012-06-28 | Duke University | Methods and compositions combining immunotherapy with monocyte activation |
CA2824313A1 (en) | 2011-01-12 | 2012-07-19 | Innate Pharma | Tlr3 binding agents |
AU2012262021B2 (en) | 2011-06-01 | 2016-07-28 | Janus Biotherapeutics, Inc. | Novel immune system modulators |
BR112013030894A2 (pt) | 2011-06-01 | 2016-08-16 | Janus Biotherapeutics Inc | moduladores do sistema imune |
WO2013052550A2 (en) | 2011-10-04 | 2013-04-11 | Janus Biotherapeutics, Inc. | Novel imidazole quinoline-based immune system modulators |
EP2766384B1 (en) * | 2011-10-10 | 2016-11-23 | Yeda Research and Development Co. Ltd. | Toll-like receptor 4 (tlr-4) agonist peptides for modulating tlr-4 mediated immune response |
WO2013178736A1 (en) | 2012-05-31 | 2013-12-05 | Innate Pharma | Tlr3 binding agents |
US10017739B2 (en) | 2012-09-06 | 2018-07-10 | Duke University | Methods of expanding and assessing B cells and using expanded B cells to treat disease |
CN113502299B (zh) * | 2021-07-20 | 2023-03-14 | 中国农业大学 | 一种抗金黄色葡萄球菌遗传修饰山羊生产方法 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2046920B1 (da) | 1969-06-19 | 1974-05-03 | Citizen Watch Co Ltd | |
US3940475A (en) | 1970-06-11 | 1976-02-24 | Biological Developments, Inc. | Radioimmune method of assaying quantitatively for a hapten |
NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
US3817837A (en) | 1971-05-14 | 1974-06-18 | Syva Corp | Enzyme amplification assay |
US3939350A (en) | 1974-04-29 | 1976-02-17 | Board Of Trustees Of The Leland Stanford Junior University | Fluorescent immunoassay employing total reflection for activation |
US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
US4275149A (en) | 1978-11-24 | 1981-06-23 | Syva Company | Macromolecular environment control in specific receptor assays |
US4277437A (en) | 1978-04-05 | 1981-07-07 | Syva Company | Kit for carrying out chemically induced fluorescence immunoassay |
US4366241A (en) | 1980-08-07 | 1982-12-28 | Syva Company | Concentrating zone method in heterogeneous immunoassays |
US4659678A (en) | 1982-09-29 | 1987-04-21 | Serono Diagnostics Limited | Immunoassay of antigens |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US4859609A (en) | 1986-04-30 | 1989-08-22 | Genentech, Inc. | Novel receptors for efficient determination of ligands and their antagonists or agonists |
US5789192A (en) | 1992-12-10 | 1998-08-04 | Schering Corporation | Mammalian receptors for interleukin-10 (IL-10) |
WO1998002557A2 (en) * | 1996-07-12 | 1998-01-22 | Schering Corporation | MAMMALIAN TNF-α CONVERTASES |
EP1000146B1 (en) * | 1997-08-01 | 2006-08-30 | Serono Genetics Institute S.A. | 5'ESTs FOR NON TISSUE SPECIFIC SECRETED PROTEINS |
PT1887014E (pt) * | 1997-10-17 | 2010-07-05 | Genentech Inc | Homëlogos de toll humana |
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