SK140699A3 - Amidine derivatives, preparation method thereof, compositions containing them and their use for the treatment - Google Patents

Amidine derivatives, preparation method thereof, compositions containing them and their use for the treatment Download PDF

Info

Publication number
SK140699A3
SK140699A3 SK1406-99A SK140699A SK140699A3 SK 140699 A3 SK140699 A3 SK 140699A3 SK 140699 A SK140699 A SK 140699A SK 140699 A3 SK140699 A3 SK 140699A3
Authority
SK
Slovakia
Prior art keywords
formula
compound
pharmaceutically acceptable
condition
disease
Prior art date
Application number
SK1406-99A
Other languages
English (en)
Slovak (sk)
Inventor
James Macdonald
James Matz
William Shakespeare
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Publication of SK140699A3 publication Critical patent/SK140699A3/sk

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
SK1406-99A 1997-05-05 1998-04-28 Amidine derivatives, preparation method thereof, compositions containing them and their use for the treatment SK140699A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9701682A SE9701682D0 (sv) 1997-05-05 1997-05-05 Compounds
PCT/SE1998/000792 WO1998050380A1 (fr) 1997-05-05 1998-04-28 Composes

Publications (1)

Publication Number Publication Date
SK140699A3 true SK140699A3 (en) 2000-06-12

Family

ID=20406836

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1406-99A SK140699A3 (en) 1997-05-05 1998-04-28 Amidine derivatives, preparation method thereof, compositions containing them and their use for the treatment

Country Status (28)

Country Link
US (1) US6166030A (fr)
EP (1) EP0983266B1 (fr)
JP (1) JP2001523263A (fr)
KR (1) KR20010012227A (fr)
CN (1) CN1255130A (fr)
AR (1) AR012602A1 (fr)
AT (1) ATE210661T1 (fr)
AU (1) AU734394B2 (fr)
BR (1) BR9808725A (fr)
CA (1) CA2287999A1 (fr)
DE (1) DE69802923T2 (fr)
DK (1) DK0983266T3 (fr)
EE (1) EE9900475A (fr)
ES (1) ES2168757T3 (fr)
HU (1) HUP0003766A3 (fr)
ID (1) ID23156A (fr)
IL (1) IL132677A0 (fr)
IS (1) IS5237A (fr)
MX (1) MXPA99009874A (fr)
NO (1) NO995404L (fr)
NZ (1) NZ500676A (fr)
PL (1) PL336854A1 (fr)
PT (1) PT983266E (fr)
SE (1) SE9701682D0 (fr)
SK (1) SK140699A3 (fr)
TR (1) TR199902719T2 (fr)
WO (1) WO1998050380A1 (fr)
ZA (1) ZA983740B (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001024826A2 (fr) * 1999-10-06 2001-04-12 The Brigham And Women's Hospital, Inc. Composes et procedes de modulation des effets non transcriptionnels des hormones steroides
US6683108B1 (en) * 2000-03-30 2004-01-27 Curis, Inc. Agonists of hedgehog signaling pathways and uses related thereto
US7115653B2 (en) * 2000-03-30 2006-10-03 Curis, Inc. Small organic molecule regulators of cell proliferation
US8852937B2 (en) * 2000-03-30 2014-10-07 Curis, Inc. Small organic molecule regulators of cell proliferation
US20030045449A1 (en) * 2001-08-15 2003-03-06 Pfizer, Inc. Pharmaceutical combinations for the treatment of neurodegenerative diseases
PT1883451E (pt) 2005-04-13 2011-03-02 Neuraxon Inc Compostos de indolo substituídos com actividade inibitória da sintetase de óxido nítrico (nos)
CL2008000838A1 (es) * 2007-03-23 2008-10-10 Neuraxon Inc Compuestos derivados de quinolina y tetrahidroquinolina, con actividad inhibidora nos; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar un dolor de cabeza tal como migrana, dolor cronico, desordenes del sistema nervios
WO2009062319A1 (fr) 2007-11-16 2009-05-22 Neuraxon, Inc. Composés d'indole et procédés de traitement de la douleur viscérale

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9407515A (pt) * 1993-08-12 1997-01-07 Astra Ab Composto formulação farmaceutica uso do composto processos para o tratamento de desordens neurodegenerativas ou de enxaqueca ou para a prevenção e a reversão da tolerância aos opiatos e diazepinas ou para o tratamento do vicio das drogas e para a preparação do composto
AU7705694A (en) * 1993-10-04 1995-05-01 Glaxo Wellcome House Substituted urea and isothiourea derivatives as no synthase inhibitors
EP0724570B1 (fr) * 1993-10-21 1999-03-03 G.D. Searle & Co. Derives amidino utiles en tant qu'inhibiteurs de la synthase de l'oxyde nitrique
EP0759027B1 (fr) * 1994-05-07 1999-08-04 Astra Aktiebolag Derives amidine bicycliques comme inhibiteurs de la synthetase de l'oxyde nitrique
BR9509297A (pt) * 1995-08-10 1998-07-07 Astra Ab Composto composição farmacêutica utilização de um composto e processos de tratamento ou prolifaxia de uma doença ou condição na qual a síntese ou suprasintese da sintetase de óxido nitrico forma uma parte contribuinte e desordens neurodegenerativas ou de enxaqueca ou de prevenção e reversão da tolerância a opiatos e diazepinas ou de tratamento do vicio em tóxicos e de preparação de um composto

Also Published As

Publication number Publication date
WO1998050380A1 (fr) 1998-11-12
JP2001523263A (ja) 2001-11-20
NO995404L (no) 2000-01-05
MXPA99009874A (es) 2004-09-30
BR9808725A (pt) 2000-07-11
IS5237A (is) 1999-11-01
CA2287999A1 (fr) 1998-11-12
DE69802923T2 (de) 2002-07-04
EP0983266B1 (fr) 2001-12-12
CN1255130A (zh) 2000-05-31
US6166030A (en) 2000-12-26
AU734394B2 (en) 2001-06-14
DE69802923D1 (de) 2002-01-24
NZ500676A (en) 2001-05-25
ID23156A (id) 2000-03-23
AU7460098A (en) 1998-11-27
TR199902719T2 (xx) 2000-02-21
PL336854A1 (en) 2000-07-17
ZA983740B (en) 1999-02-19
HUP0003766A3 (en) 2001-09-28
KR20010012227A (ko) 2001-02-15
AR012602A1 (es) 2000-11-08
PT983266E (pt) 2002-05-31
IL132677A0 (en) 2001-03-19
SE9701682D0 (sv) 1997-05-05
NO995404D0 (no) 1999-11-04
ES2168757T3 (es) 2002-06-16
EE9900475A (et) 2000-06-15
EP0983266A1 (fr) 2000-03-08
DK0983266T3 (da) 2002-03-11
ATE210661T1 (de) 2001-12-15
HUP0003766A2 (en) 2001-03-28

Similar Documents

Publication Publication Date Title
PL180081B1 (pl) Nowe pochodne amidyny i sposób ich wytwarzania PL PL PL PL PL PL PL
EP0782567B1 (fr) Derives d'isothiouree en tant qu'inhibiteurs de no synthase
RU2157802C2 (ru) Бициклические производные изотиомочевины, способ их получения и фармацевтическая композиция на их основе
SK140699A3 (en) Amidine derivatives, preparation method thereof, compositions containing them and their use for the treatment
JPH10500138A (ja) 酸化窒素合成酵素阻害剤としての2環アミジン誘導体
US6489322B1 (en) Amidine derivatives as inhibitors of nitric oxide synthase
SK281442B6 (sk) Bicyklické amidínové deriváty, spôsob ich prípravy, farmaceutické kompozície s ich obsahom a ich použitie
AU701329B2 (en) Amidine and isothiourea derivatives as inhibitors of nitric oxide synthase
WO1994022861A1 (fr) PYRIDO[2,3-b][1,4]BENZODIAZEPINONES EN TANT QUE LIGAND DE RECEPTEUR M2 POUR LE TRAITEMENT DE TROUBLES NEUROLOGIQUES
JP6880325B2 (ja) 新規なn−[(ピリミジニルアミノ)プロパニル]−、n−[(ピリジルアミノ)プロパニル]−およびn−[(ピラジニルアミノ)プロパニル]アリールカルボキサミド
US5929085A (en) Amidine and isothiourea derivatives, compositions containing them and their use as inhibitors of nitric oxide synthase
CZ388999A3 (cs) Sloučeniny
MXPA00001586A (es) Proceso para la creacion de un plano optico que genera una vision en tercera dimension.
CZ388899A3 (cs) Amidinové deriváty jako inhibitory syntasy oxidu dusnatého
US6140322A (en) Amidine and isothiourea derivatives as inhibitors of nitric oxide synthase
RU2155761C2 (ru) Бициклические производные амидина, способ их получения, фармацевтическая композиция и способ ингибирования синтетазы окиси азота
HUT77376A (hu) Biciklusos amidinszármazékok, eljárás előállításukra, a vegyületeket tartalmazó gyógyszerkészítmények és alkalmazásuk