SK1192002A3 - Caspase inhibitors and uses thereof - Google Patents

Caspase inhibitors and uses thereof Download PDF

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Publication number
SK1192002A3
SK1192002A3 SK119-2002A SK1192002A SK1192002A3 SK 1192002 A3 SK1192002 A3 SK 1192002A3 SK 1192002 A SK1192002 A SK 1192002A SK 1192002 A3 SK1192002 A3 SK 1192002A3
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SK
Slovakia
Prior art keywords
group
optionally substituted
nmr
mhz
dmso
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Application number
SK119-2002A
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English (en)
Slovak (sk)
Inventor
Julian Golec
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Vertex Pharma
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Publication of SK1192002A3 publication Critical patent/SK1192002A3/sk

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    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Neurology (AREA)
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  • Oncology (AREA)
  • Diabetes (AREA)
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  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
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  • Hematology (AREA)
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  • Pulmonology (AREA)
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SK119-2002A 2000-05-23 2001-05-23 Caspase inhibitors and uses thereof SK1192002A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US20636200P 2000-05-23 2000-05-23
US21700600P 2000-07-10 2000-07-10
PCT/US2001/017075 WO2001090070A2 (en) 2000-05-23 2001-05-23 Caspase inhibitors and uses thereof

Publications (1)

Publication Number Publication Date
SK1192002A3 true SK1192002A3 (en) 2002-09-10

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Family Applications (1)

Application Number Title Priority Date Filing Date
SK119-2002A SK1192002A3 (en) 2000-05-23 2001-05-23 Caspase inhibitors and uses thereof

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US (1) US7053057B2 (es)
EP (1) EP1283827A2 (es)
JP (1) JP2003534325A (es)
KR (1) KR20020025959A (es)
AP (1) AP2002002407A0 (es)
AR (1) AR028619A1 (es)
AU (1) AU2001265008A1 (es)
CA (1) CA2380935A1 (es)
MX (1) MXPA02000823A (es)
NO (1) NO20020343L (es)
NZ (1) NZ516918A (es)
PE (1) PE20020058A1 (es)
PL (1) PL357713A1 (es)
SK (1) SK1192002A3 (es)
TR (1) TR200200767T1 (es)
WO (1) WO2001090070A2 (es)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
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DE60035037T2 (de) 1999-04-09 2008-01-31 Cytovia, Inc., San Diego Caspase inhibitoren und ihre verwendung
ATE266623T1 (de) 1999-08-06 2004-05-15 Vertex Pharma Caspase inhibitoren und deren verwendung
DE60040397D1 (de) 1999-08-27 2008-11-13 Cytovia Inc Substituierte alpha-hydroxy-säuren als caspase-hemmer und ihre verwendung
PE20011350A1 (es) 2000-05-19 2002-01-15 Vertex Pharma PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE)
WO2003024955A2 (en) 2001-09-18 2003-03-27 Sunesis Pharmaceuticals, Inc. Small molecule inhibitors of caspases
US7410956B2 (en) 2002-02-11 2008-08-12 Vertex Pharmaceuticals Incorporated Caspase inhibitor prodrugs
AU2003225088A1 (en) * 2002-04-19 2003-11-03 Vertex Pharmaceuticals Incorporated Regulation of tnf-alpha
US20060212020A1 (en) * 2002-10-10 2006-09-21 Lynne Rainen Sample collection system with caspase inhibitor
EP1626732B1 (en) * 2003-05-22 2013-04-03 CHIESI FARMACEUTICI S.p.A. Means for preventing and treating cellular death and their biological applications
AU2003902704A0 (en) * 2003-05-29 2003-06-19 Crc For Waste Management And Pollution Control Limited Of Unsw Process for producing a nanoscale zero-valent metal
RU2382780C2 (ru) 2004-02-27 2010-02-27 Вертекс Фармасьютикалз Инкорпорейтед Ингибиторы каспаз и их применение
WO2005090334A2 (en) 2004-03-12 2005-09-29 Vertex Pharmaceuticals Incorporated Processes and intermediates for the preparation of aspartic acetal caspase inhibitors
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