SK1162003A3 - Method for injection moulding moulded bodies consisting of (meth)acrylate copolymers - Google Patents
Method for injection moulding moulded bodies consisting of (meth)acrylate copolymers Download PDFInfo
- Publication number
- SK1162003A3 SK1162003A3 SK116-2003A SK1162003A SK1162003A3 SK 1162003 A3 SK1162003 A3 SK 1162003A3 SK 1162003 A SK1162003 A SK 1162003A SK 1162003 A3 SK1162003 A3 SK 1162003A3
- Authority
- SK
- Slovakia
- Prior art keywords
- meth
- degassing
- injection
- molding
- temperature
- Prior art date
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- 229920001577 copolymer Polymers 0.000 title claims abstract description 40
- 238000001746 injection moulding Methods 0.000 title claims abstract description 20
- 238000000034 method Methods 0.000 title claims description 23
- 239000000203 mixture Substances 0.000 claims abstract description 44
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 28
- 239000004014 plasticizer Substances 0.000 claims abstract description 17
- 239000004480 active ingredient Substances 0.000 claims abstract description 13
- 239000000178 monomer Substances 0.000 claims abstract description 12
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims abstract description 10
- 238000009835 boiling Methods 0.000 claims abstract description 9
- 125000001453 quaternary ammonium group Chemical group 0.000 claims abstract description 9
- 239000000654 additive Substances 0.000 claims abstract description 7
- 238000002347 injection Methods 0.000 claims description 53
- 239000007924 injection Substances 0.000 claims description 53
- 238000007872 degassing Methods 0.000 claims description 33
- -1 ticarciline Chemical compound 0.000 claims description 33
- 239000013543 active substance Substances 0.000 claims description 16
- 238000002156 mixing Methods 0.000 claims description 13
- 238000000465 moulding Methods 0.000 claims description 13
- 239000002775 capsule Substances 0.000 claims description 12
- 238000002844 melting Methods 0.000 claims description 11
- 230000008018 melting Effects 0.000 claims description 11
- 239000002253 acid Substances 0.000 claims description 10
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- JZUFKLXOESDKRF-UHFFFAOYSA-N Chlorothiazide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC2=C1NCNS2(=O)=O JZUFKLXOESDKRF-UHFFFAOYSA-N 0.000 claims description 4
- 108010061435 Enalapril Proteins 0.000 claims description 4
- RYMZZMVNJRMUDD-UHFFFAOYSA-N SJ000286063 Natural products C12C(OC(=O)C(C)(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 RYMZZMVNJRMUDD-UHFFFAOYSA-N 0.000 claims description 4
- 229960003022 amoxicillin Drugs 0.000 claims description 4
- LSQZJLSUYDQPKJ-NJBDSQKTSA-N amoxicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=C(O)C=C1 LSQZJLSUYDQPKJ-NJBDSQKTSA-N 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- GBXSMTUPTTWBMN-XIRDDKMYSA-N enalapril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(O)=O)CC1=CC=CC=C1 GBXSMTUPTTWBMN-XIRDDKMYSA-N 0.000 claims description 4
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- LSQZJLSUYDQPKJ-UHFFFAOYSA-N p-Hydroxyampicillin Natural products O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)C(N)C1=CC=C(O)C=C1 LSQZJLSUYDQPKJ-UHFFFAOYSA-N 0.000 claims description 4
- RYMZZMVNJRMUDD-HGQWONQESA-N simvastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 RYMZZMVNJRMUDD-HGQWONQESA-N 0.000 claims description 4
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- RTHCYVBBDHJXIQ-MRXNPFEDSA-N (R)-fluoxetine Chemical compound O([C@H](CCNC)C=1C=CC=CC=1)C1=CC=C(C(F)(F)F)C=C1 RTHCYVBBDHJXIQ-MRXNPFEDSA-N 0.000 claims description 3
- SGTNSNPWRIOYBX-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile Chemical compound C1=C(OC)C(OC)=CC=C1CCN(C)CCCC(C#N)(C(C)C)C1=CC=C(OC)C(OC)=C1 SGTNSNPWRIOYBX-UHFFFAOYSA-N 0.000 claims description 3
- BSYNRYMUTXBXSQ-FOQJRBATSA-N 59096-14-9 Chemical compound CC(=O)OC1=CC=CC=C1[14C](O)=O BSYNRYMUTXBXSQ-FOQJRBATSA-N 0.000 claims description 3
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- 241001465754 Metazoa Species 0.000 claims description 3
- FNYLWPVRPXGIIP-UHFFFAOYSA-N Triamterene Chemical compound NC1=NC2=NC(N)=NC(N)=C2N=C1C1=CC=CC=C1 FNYLWPVRPXGIIP-UHFFFAOYSA-N 0.000 claims description 3
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- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 3
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- HTIQEAQVCYTUBX-UHFFFAOYSA-N amlodipine Chemical compound CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1Cl HTIQEAQVCYTUBX-UHFFFAOYSA-N 0.000 claims description 3
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- AHOUBRCZNHFOSL-YOEHRIQHSA-N (+)-Casbol Chemical compound C1=CC(F)=CC=C1[C@H]1[C@H](COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-YOEHRIQHSA-N 0.000 claims description 2
- BLXXJMDCKKHMKV-UHFFFAOYSA-N Nabumetone Chemical compound C1=C(CCC(C)=O)C=CC2=CC(OC)=CC=C21 BLXXJMDCKKHMKV-UHFFFAOYSA-N 0.000 claims description 2
- AHOUBRCZNHFOSL-UHFFFAOYSA-N Paroxetine hydrochloride Natural products C1=CC(F)=CC=C1C1C(COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-UHFFFAOYSA-N 0.000 claims description 2
- FAKRSMQSSFJEIM-RQJHMYQMSA-N captopril Chemical compound SC[C@@H](C)C(=O)N1CCC[C@H]1C(O)=O FAKRSMQSSFJEIM-RQJHMYQMSA-N 0.000 claims description 2
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- 229960001380 cimetidine Drugs 0.000 claims description 2
- CCGSUNCLSOWKJO-UHFFFAOYSA-N cimetidine Chemical compound N#CNC(=N/C)\NCCSCC1=NC=N[C]1C CCGSUNCLSOWKJO-UHFFFAOYSA-N 0.000 claims description 2
- MFWNKCLOYSRHCJ-BTTYYORXSA-N granisetron Chemical compound C1=CC=C2C(C(=O)N[C@H]3C[C@H]4CCC[C@@H](C3)N4C)=NN(C)C2=C1 MFWNKCLOYSRHCJ-BTTYYORXSA-N 0.000 claims description 2
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- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 claims description 2
- PCZOHLXUXFIOCF-UHFFFAOYSA-N Monacolin X Natural products C12C(OC(=O)C(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 PCZOHLXUXFIOCF-UHFFFAOYSA-N 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 1
- PCZOHLXUXFIOCF-BXMDZJJMSA-N lovastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 PCZOHLXUXFIOCF-BXMDZJJMSA-N 0.000 claims 1
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- QLJODMDSTUBWDW-UHFFFAOYSA-N lovastatin hydroxy acid Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(C)C=C21 QLJODMDSTUBWDW-UHFFFAOYSA-N 0.000 claims 1
- VMXUWOKSQNHOCA-UKTHLTGXSA-N ranitidine Chemical compound [O-][N+](=O)\C=C(/NC)NCCSCC1=CC=C(CN(C)C)O1 VMXUWOKSQNHOCA-UKTHLTGXSA-N 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 abstract description 13
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 abstract description 12
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 abstract description 9
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- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
- B29C45/0001—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor characterised by the choice of material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
- B29C48/03—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor characterised by the shape of the extruded material at extrusion
- B29C48/09—Articles with cross-sections having partially or fully enclosed cavities, e.g. pipes or channels
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
- B29C48/25—Component parts, details or accessories; Auxiliary operations
- B29C48/36—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die
- B29C48/395—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die using screws surrounded by a cooperating barrel, e.g. single screw extruders
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
- B29C48/25—Component parts, details or accessories; Auxiliary operations
- B29C48/36—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die
- B29C48/395—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die using screws surrounded by a cooperating barrel, e.g. single screw extruders
- B29C48/40—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die using screws surrounded by a cooperating barrel, e.g. single screw extruders using two or more parallel screws or at least two parallel non-intermeshing screws, e.g. twin screw extruders
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
- B29C48/25—Component parts, details or accessories; Auxiliary operations
- B29C48/36—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die
- B29C48/50—Details of extruders
- B29C48/76—Venting, drying means; Degassing means
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
- B29C48/03—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor characterised by the shape of the extruded material at extrusion
- B29C48/06—Rod-shaped
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
- B29K2033/00—Use of polymers of unsaturated acids or derivatives thereof as moulding material
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
- B29K2105/00—Condition, form or state of moulded material or of the material to be shaped
- B29K2105/0005—Condition, form or state of moulded material or of the material to be shaped containing compounding ingredients
- B29K2105/0035—Medical or pharmaceutical agents
Landscapes
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Health & Medical Sciences (AREA)
- Manufacturing & Machinery (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Medicinal Preparation (AREA)
- Injection Moulding Of Plastics Or The Like (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Processing And Handling Of Plastics And Other Materials For Molding In General (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Manufacture Of Macromolecular Shaped Articles (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Moulds For Moulding Plastics Or The Like (AREA)
- Casting Or Compression Moulding Of Plastics Or The Like (AREA)
Description
Claims (9)
- PATENTOVÉ NÁROKY1. Spôsob výroby tvarovaných teliesok vstrekovaním s týmito stupňami postupu:a) roztavenie a zmiešanie (met)akrylátového kopolyméru, ktorý sa skladá z 85 až 98 % hmotn. radikálovo polymérizovaných Οχ- až C4-alkylesterov kyseliny akrylovej alebo ipetakrylovej a 15 až 2 % hmotn. (met) akrylátových monomérov s kvartérnou amóniovou skupinou v alkylovom zvyšku, s 10 až 25 % hmotn. zmäkčovadla a 10 až 50 % hmotn. antiadhézneho prostriedku β/alebo 0,1 až 3 % hmotn. odformovacieho prostriedku a poprípade ďalšími farmaceutický zvyčajnými prísadami alebo pomocnými látkami a/alebo jednou alebo viacerými farmaceutickými účinnými látkami,b) odplynenie zmesi pri teplote aspoň 120 °C, čím sa obsah nízkovrúcich zložiek s tlakom pár aspoň 190 kPa pri teplote 120 °C zníži na nanajvýš 0,5 % hmotn. ac) vstrekovanie odplynenej zmesi pri teplote 80 áž 160 °C do formy vstrekovacieho zariadenia a vybratie získaného tvarovaného telieska z formy.
- 2. Spôsob podlá nároku 1, vyznačuj úci sa tým, že stupeň odplynenia b) sa uskutočňuje extruzívnym sušením v. extrudéri s odplyňovacou zónou alebo odplynením vo vstrekovacom zariadení s predradeným odplyňovacím otvorom.
- 3. Vstrekovaním odliate tvarované teliesko vyrobitelné spôsobom pódia nároku 1 alebo 2.
- 4. Tvarované teliesko podľa nároku 3, vyznaču j úce sa t ý m , že má rázovú húževnatosť podľa ISO 179 aspoň 1,5 KJ/m2.
- 5. Tvarované teliesko podľa nároku 3 alebo ^vyznačujúce sa 't ý m , že priamo obsahuje jednu alebo viac farmaceutických účinných látok alebo sú tieto v tvarovanom teliesku uzavreté.
- 6. Tvarované teliesko podľa nároku 5, vyznačujúce sa tým, že sa jedná o kapsulu, v ktorej je uzavretá jedna alebo viac farmaceutických účinných látok.
- 7. Tvarované teliesko podľa jedného alebo viacerých nárokov 3 až 6, vyznačujúce sa tým, že toto tvarované teliesko je súčasťou väčšej liekovej formy alebo je v nej obsiahnuté.
- 8. Tvarované teliesko podľa jedného alebo viacerých nárokov 3 až 7,vyznačujúce sa tým, že jedna alebo viac farmaceutických účinných látok, ktoré sú priamo obsiahnuté alebo uzavreté v tvarovanom teliesku, sa môžu retardujúcim spôsobom uvoľňovať vo zvieracom alebo ľudskom gastrointestinálnom trakte.
- 9. Tvarované teliesko podľa jedného alebo viacerých nárokov 3 až 8, vyznačujúce sa tým, že farmaceutickou účinnou látkou priamo obsiahnutou alebo uzavretou v tvarovanom teliesku je kyselina acetylsalicylová, rantidin, simvastatín, enalapril, fluoxetin, amlodipin, amoxicilín, sertalin, nifidipín, ciprofloxacín, acyklovir, lovastatin, epoetin, paroxetin, captopril, nabumetón, granisetrón, cimetidin, tikarcilin, triamteren, hydrochlórtiazid, verapamil, paracetamol, deriváty morfinu, topotekan alebo farmaceutický používané soli.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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DE10127134A DE10127134A1 (de) | 2001-06-05 | 2001-06-05 | verfahren zur Herstellung von Formkörpern aus (Meth)acrylat-Copolymeren mittels Spritzguß |
PCT/EP2002/005041 WO2002098625A1 (de) | 2001-06-05 | 2002-05-08 | Verfahren zum spritzgiessen von formkörpern aus (meth)acrylat-copolymeren |
Publications (2)
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SK1162003A3 true SK1162003A3 (en) | 2004-01-08 |
SK287705B6 SK287705B6 (en) | 2011-07-06 |
Family
ID=7687172
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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SK116-2003A SK287705B6 (en) | 2001-06-05 | 2002-05-08 | Process for producing mouldings and moulding |
Country Status (19)
Country | Link |
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US (2) | US20040104501A1 (sk) |
EP (1) | EP1392485B1 (sk) |
JP (1) | JP4713830B2 (sk) |
KR (1) | KR100854256B1 (sk) |
AT (1) | ATE323579T1 (sk) |
BG (1) | BG66251B1 (sk) |
BR (1) | BR0205512A (sk) |
CA (1) | CA2418316C (sk) |
CY (1) | CY1105141T1 (sk) |
DE (2) | DE10127134A1 (sk) |
DK (1) | DK1392485T3 (sk) |
ES (1) | ES2262814T3 (sk) |
HU (1) | HU225242B1 (sk) |
IL (1) | IL153650A0 (sk) |
MX (1) | MXPA03001061A (sk) |
PL (1) | PL202610B1 (sk) |
PT (1) | PT1392485E (sk) |
SK (1) | SK287705B6 (sk) |
WO (1) | WO2002098625A1 (sk) |
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JP2004517157A (ja) * | 2001-01-29 | 2004-06-10 | レーム ゲゼルシヤフト ミツト ベシユレンクテル ハフツング ウント コンパニー コマンディートゲゼルシャフト | 薬学的適用のための貯蔵安定性接着および結合剤 |
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MXPA04010956A (es) * | 2003-01-30 | 2005-01-25 | Roehm Gmbh | Forma de dosis farmaceutica y metodo para la produccion de la misma. |
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-
2001
- 2001-06-05 DE DE10127134A patent/DE10127134A1/de not_active Withdrawn
-
2002
- 2002-05-08 HU HU0300757A patent/HU225242B1/hu not_active IP Right Cessation
- 2002-05-08 EP EP02742964A patent/EP1392485B1/de not_active Expired - Lifetime
- 2002-05-08 KR KR1020037001616A patent/KR100854256B1/ko not_active IP Right Cessation
- 2002-05-08 CA CA2418316A patent/CA2418316C/en not_active Expired - Fee Related
- 2002-05-08 BR BR0205512-0A patent/BR0205512A/pt not_active Application Discontinuation
- 2002-05-08 ES ES02742964T patent/ES2262814T3/es not_active Expired - Lifetime
- 2002-05-08 MX MXPA03001061A patent/MXPA03001061A/es active IP Right Grant
- 2002-05-08 PL PL358720A patent/PL202610B1/pl not_active IP Right Cessation
- 2002-05-08 SK SK116-2003A patent/SK287705B6/sk not_active IP Right Cessation
- 2002-05-08 PT PT02742964T patent/PT1392485E/pt unknown
- 2002-05-08 DK DK02742964T patent/DK1392485T3/da active
- 2002-05-08 DE DE50206478T patent/DE50206478D1/de not_active Expired - Lifetime
- 2002-05-08 WO PCT/EP2002/005041 patent/WO2002098625A1/de active IP Right Grant
- 2002-05-08 JP JP2003501646A patent/JP4713830B2/ja not_active Expired - Fee Related
- 2002-05-08 IL IL15365002A patent/IL153650A0/xx not_active IP Right Cessation
- 2002-05-08 AT AT02742964T patent/ATE323579T1/de active
- 2002-05-08 US US10/333,930 patent/US20040104501A1/en not_active Abandoned
-
2003
- 2003-01-31 BG BG107512A patent/BG66251B1/bg unknown
-
2006
- 2006-07-18 CY CY20061100999T patent/CY1105141T1/el unknown
-
2010
- 2010-06-03 US US12/793,549 patent/US20100239666A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
KR20030022359A (ko) | 2003-03-15 |
DK1392485T3 (da) | 2006-08-21 |
KR100854256B1 (ko) | 2008-08-26 |
PL202610B1 (pl) | 2009-07-31 |
CA2418316C (en) | 2010-10-26 |
DE50206478D1 (de) | 2006-05-24 |
BG66251B1 (bg) | 2012-09-28 |
EP1392485A1 (de) | 2004-03-03 |
IL153650A0 (en) | 2003-07-06 |
BG107512A (bg) | 2003-07-31 |
JP2004519370A (ja) | 2004-07-02 |
ATE323579T1 (de) | 2006-05-15 |
BR0205512A (pt) | 2003-06-24 |
SK287705B6 (en) | 2011-07-06 |
WO2002098625A1 (de) | 2002-12-12 |
CY1105141T1 (el) | 2009-11-04 |
DE10127134A1 (de) | 2002-12-12 |
US20040104501A1 (en) | 2004-06-03 |
US20100239666A1 (en) | 2010-09-23 |
HU225242B1 (en) | 2006-08-28 |
HUP0300757A3 (en) | 2005-10-28 |
CA2418316A1 (en) | 2003-02-03 |
JP4713830B2 (ja) | 2011-06-29 |
ES2262814T3 (es) | 2006-12-01 |
HUP0300757A2 (hu) | 2004-06-28 |
PT1392485E (pt) | 2006-08-31 |
PL358720A1 (en) | 2004-08-09 |
MXPA03001061A (es) | 2003-06-30 |
EP1392485B1 (de) | 2006-04-19 |
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