SK11152001A3 - Indolové deriváty, spôsob ich prípravy, farmaceutická kompozícia s ich obsahom a ich použitie ako antagonistov mcp-1 - Google Patents
Indolové deriváty, spôsob ich prípravy, farmaceutická kompozícia s ich obsahom a ich použitie ako antagonistov mcp-1 Download PDFInfo
- Publication number
- SK11152001A3 SK11152001A3 SK1115-2001A SK11152001A SK11152001A3 SK 11152001 A3 SK11152001 A3 SK 11152001A3 SK 11152001 A SK11152001 A SK 11152001A SK 11152001 A3 SK11152001 A3 SK 11152001A3
- Authority
- SK
- Slovakia
- Prior art keywords
- compound
- group
- formula
- ethyl
- chlorophenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9902461.4A GB9902461D0 (en) | 1999-02-05 | 1999-02-05 | Chemical compounds |
| PCT/GB2000/000265 WO2000046196A1 (en) | 1999-02-05 | 2000-01-31 | Indole derivatives and their use as mcp-1 antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK11152001A3 true SK11152001A3 (sk) | 2001-12-03 |
Family
ID=10847084
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK1115-2001A SK11152001A3 (sk) | 1999-02-05 | 2000-01-31 | Indolové deriváty, spôsob ich prípravy, farmaceutická kompozícia s ich obsahom a ich použitie ako antagonistov mcp-1 |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US6737435B1 (xx) |
| EP (1) | EP1150952B1 (xx) |
| JP (1) | JP2002536359A (xx) |
| KR (1) | KR20010094755A (xx) |
| CN (1) | CN1339025A (xx) |
| AR (1) | AR022461A1 (xx) |
| AT (1) | ATE280757T1 (xx) |
| AU (1) | AU770856B2 (xx) |
| BR (1) | BR0007984A (xx) |
| CA (1) | CA2356898A1 (xx) |
| CZ (1) | CZ20012807A3 (xx) |
| DE (1) | DE60015296T2 (xx) |
| EE (1) | EE200100403A (xx) |
| GB (1) | GB9902461D0 (xx) |
| HU (1) | HUP0105079A3 (xx) |
| ID (1) | ID30401A (xx) |
| IL (1) | IL144611A0 (xx) |
| IS (1) | IS5980A (xx) |
| MY (1) | MY133209A (xx) |
| NO (1) | NO20013809L (xx) |
| NZ (1) | NZ512680A (xx) |
| PL (1) | PL350184A1 (xx) |
| RU (1) | RU2235090C2 (xx) |
| SK (1) | SK11152001A3 (xx) |
| TR (1) | TR200102233T2 (xx) |
| WO (1) | WO2000046196A1 (xx) |
| ZA (1) | ZA200105311B (xx) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9716657D0 (en) | 1997-08-07 | 1997-10-15 | Zeneca Ltd | Chemical compounds |
| GB9902461D0 (en) | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
| GB0000625D0 (en) * | 2000-01-13 | 2000-03-01 | Zeneca Ltd | Chemical compounds |
| GB0000626D0 (en) * | 2000-01-13 | 2000-03-01 | Zeneca Ltd | Chemical compounds |
| CN1505613A (zh) | 2000-10-10 | 2004-06-16 | ʷ��˿�������ȳ�ķ����˾ | 取代的吲哚、含这类吲哚的药物组合物及它们作为PPAR-γ结合剂的用途 |
| EP1343751A2 (en) | 2000-12-20 | 2003-09-17 | Bristol-Myers Squibb Company | Cyclic derivatives as modulators of chemokine receptor activity |
| CA2432908A1 (en) | 2000-12-20 | 2002-06-27 | Bristol-Myers Squibb Pharma Company | Diamines as modulators of chemokine receptor activity |
| KR101255356B1 (ko) | 2002-06-12 | 2013-04-17 | 케모센트릭스, 인크. | 염증 및 면역 질병의 치료를 위한 ｃｃｒ１ 길항물질로서사용하기 위한 1-아릴-4-치환된 피페라진 유도체 |
| US7589199B2 (en) | 2002-06-12 | 2009-09-15 | Chemocentryx, Inc. | Substituted piperazines |
| US7842693B2 (en) | 2002-06-12 | 2010-11-30 | Chemocentryx, Inc. | Substituted piperazines |
| TW200508224A (en) | 2003-02-12 | 2005-03-01 | Bristol Myers Squibb Co | Cyclic derivatives as modulators of chemokine receptor activity |
| JP4736043B2 (ja) | 2003-03-14 | 2011-07-27 | 小野薬品工業株式会社 | 含窒素複素環誘導体およびそれらを有効成分とする薬剤 |
| WO2004092169A1 (ja) | 2003-04-18 | 2004-10-28 | Ono Pharmaceutical Co., Ltd. | スピロピペリジン化合物およびその医薬用途 |
| US7291615B2 (en) | 2003-05-01 | 2007-11-06 | Bristol-Myers Squibb Company | Cyclic derivatives as modulators of chemokine receptor activity |
| US7230133B2 (en) | 2003-05-01 | 2007-06-12 | Bristol-Myers Squibb Company | Malonamides and malonamide derivatives as modulators of chemokine receptor activity |
| US7732162B2 (en) | 2003-05-05 | 2010-06-08 | Probiodrug Ag | Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases |
| US7381738B2 (en) | 2004-02-19 | 2008-06-03 | Bristol-Myers Squibb Company | Substituted bicycloalkylamine derivatives as modulators of chemokine receptor activity |
| US7230022B2 (en) | 2004-02-19 | 2007-06-12 | Bristol-Myers Squibb Company | Substituted fused bicyclic amines as modulators of chemokine receptor activity |
| US7479496B2 (en) | 2004-02-19 | 2009-01-20 | Bristol-Myers Squibb Company | Substituted spiro azabicyclics as modulators of chemokine receptor activity |
| US7288563B2 (en) | 2004-02-19 | 2007-10-30 | Bristol-Myers Squibb Company | Substituted bicycloalkylamine derivatives as modulators of chemokine receptor activity |
| JP4845873B2 (ja) | 2004-03-03 | 2011-12-28 | ケモセントリックス インコーポレーティッド | 二環式および架橋した窒素複素環 |
| US7435831B2 (en) | 2004-03-03 | 2008-10-14 | Chemocentryx, Inc. | Bicyclic and bridged nitrogen heterocycles |
| US8481035B2 (en) | 2004-04-27 | 2013-07-09 | Northwestern University | Methods for treating chronic pelvic pain syndrome with antibodies that binds MCP-1 or MIP-1A |
| WO2006029173A2 (en) * | 2004-09-08 | 2006-03-16 | Boys Town National Research Hospital | Treatment of glomerular basement membrane disease involving matrix metalloproteinase-12 |
| TWI400232B (zh) | 2004-09-13 | 2013-07-01 | Ono Pharmaceutical Co | 含氮雜環衍生物及以該含氮雜環衍生物為有效成分之藥劑 |
| JPWO2006129679A1 (ja) | 2005-05-31 | 2009-01-08 | 小野薬品工業株式会社 | スピロピペリジン化合物およびその医薬用途 |
| FR2890071B1 (fr) | 2005-08-30 | 2007-11-09 | Fournier Sa Sa Lab | Nouveaux composes de l'indole |
| EP2657235A1 (en) | 2005-10-28 | 2013-10-30 | Ono Pharmaceutical Co., Ltd. | Compound containing basic group and use thereof |
| ES2407115T3 (es) | 2005-11-18 | 2013-06-11 | Ono Pharmaceutical Co., Ltd. | Compuesto que contiene un grupo básico y uso del mismo |
| CA2631128A1 (en) | 2005-12-09 | 2007-06-14 | F. Hoffmann-La Roche Ag | Tricyclic amide derivatives useful for treating obesity |
| JP5093096B2 (ja) * | 2006-03-02 | 2012-12-05 | アステラス製薬株式会社 | １７βＨＳＤｔｙｐｅ５阻害剤 |
| AU2007225836A1 (en) | 2006-03-10 | 2007-09-20 | Ono Pharmaceutical Co., Ltd. | Nitrogenated heterocyclic derivative, and pharmaceutical agent comprising the derivative as active ingredient |
| US8618122B2 (en) | 2006-05-16 | 2013-12-31 | Ono Pharmaceutical Co., Ltd. | Compound having acidic group which may be protected, and use thereof |
| DE102006033572A1 (de) | 2006-07-20 | 2008-01-24 | Bayer Cropscience Ag | N'-Cyano-N-halogenalkyl-imidamid Derivate |
| JP5245827B2 (ja) | 2006-07-31 | 2013-07-24 | 小野薬品工業株式会社 | スピロ結合した環状基を含有する化合物およびその用途 |
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| WO2008055945A1 (en) | 2006-11-09 | 2008-05-15 | Probiodrug Ag | 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases |
| EP2091948B1 (en) | 2006-11-30 | 2012-04-18 | Probiodrug AG | Novel inhibitors of glutaminyl cyclase |
| MX2009009234A (es) | 2007-03-01 | 2009-12-01 | Probiodrug Ag | Uso nuevo de inhibidores de ciclasa de glutaminilo. |
| EP2865670B1 (en) | 2007-04-18 | 2017-01-11 | Probiodrug AG | Thiourea derivatives as glutaminyl cyclase inhibitors |
| EP2250161B1 (en) * | 2008-01-18 | 2013-10-16 | Atopix Therapeutics Limited | Compounds having crth2 antagonist activity |
| JP5656848B2 (ja) * | 2008-10-16 | 2015-01-21 | ジャンセン ファーマシューティカルズ， インコーポレイテッド． | 代謝型グルタミン酸受容体モジュレーターとしてのインドールおよびベンゾモルホリンの誘導体 |
| WO2010129351A1 (en) | 2009-04-28 | 2010-11-11 | Schepens Eye Research Institute | Method to identify and treat age-related macular degeneration |
| ES2548913T3 (es) | 2009-09-11 | 2015-10-21 | Probiodrug Ag | Derivados heterocíclicos como inhibidores de glutaminil ciclasa |
| FR2950053B1 (fr) | 2009-09-11 | 2014-08-01 | Fournier Lab Sa | Utilisation de derives d'indole benzoique comme activateurs de nurr-1, pour le traitement de la maladie de parkinson |
| ES2586231T3 (es) | 2010-03-03 | 2016-10-13 | Probiodrug Ag | Inhibidores de glutaminil ciclasa |
| AU2011226074B2 (en) | 2010-03-10 | 2015-01-22 | Vivoryon Therapeutics N.V. | Heterocyclic inhibitors of glutaminyl cyclase (QC, EC 2.3.2.5) |
| EP2560953B1 (en) | 2010-04-21 | 2016-01-06 | Probiodrug AG | Inhibitors of glutaminyl cyclase |
| KR101350077B1 (ko) * | 2010-12-13 | 2014-01-14 | 한국화학연구원 | 신규한 3-인돌리논 유도체 및 이를 포함하는 조성물 |
| US8530670B2 (en) | 2011-03-16 | 2013-09-10 | Probiodrug Ag | Inhibitors |
| US20180206726A1 (en) | 2016-12-07 | 2018-07-26 | Progenity Inc. | Gastrointestinal tract detection methods, devices and systems |
| CA3045310A1 (en) | 2016-12-14 | 2018-06-21 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with a chemokine/chemokine receptor inhibitor |
| DK3461819T3 (da) | 2017-09-29 | 2020-08-10 | Probiodrug Ag | Inhibitorer af glutaminylcyklase |
| WO2020106754A1 (en) | 2018-11-19 | 2020-05-28 | Progenity, Inc. | Methods and devices for treating a disease with biotherapeutics |
| WO2021119482A1 (en) | 2019-12-13 | 2021-06-17 | Progenity, Inc. | Ingestible device for delivery of therapeutic agent to the gastrointestinal tract |
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| GB9716657D0 (en) | 1997-08-07 | 1997-10-15 | Zeneca Ltd | Chemical compounds |
| GB9716656D0 (en) | 1997-08-07 | 1997-10-15 | Zeneca Ltd | Chemical compounds |
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| GB9902453D0 (en) | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
| GB9902461D0 (en) | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
| GB9902459D0 (en) | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
| GB9902452D0 (en) | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
| GB9902455D0 (en) | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
| GB0000626D0 (en) | 2000-01-13 | 2000-03-01 | Zeneca Ltd | Chemical compounds |
| GB0000625D0 (en) | 2000-01-13 | 2000-03-01 | Zeneca Ltd | Chemical compounds |
-
1999
- 1999-02-05 GB GBGB9902461.4A patent/GB9902461D0/en not_active Ceased
-
2000
- 2000-01-31 EP EP20000901259 patent/EP1150952B1/en not_active Expired - Lifetime
- 2000-01-31 HU HU0105079A patent/HUP0105079A3/hu unknown
- 2000-01-31 SK SK1115-2001A patent/SK11152001A3/sk unknown
- 2000-01-31 ID IDW00200101667A patent/ID30401A/id unknown
- 2000-01-31 AT AT00901259T patent/ATE280757T1/de not_active IP Right Cessation
- 2000-01-31 KR KR1020017009862A patent/KR20010094755A/ko not_active Application Discontinuation
- 2000-01-31 EE EEP200100403A patent/EE200100403A/xx unknown
- 2000-01-31 JP JP2000597267A patent/JP2002536359A/ja active Pending
- 2000-01-31 CZ CZ20012807A patent/CZ20012807A3/cs unknown
- 2000-01-31 RU RU2001124567/04A patent/RU2235090C2/ru not_active IP Right Cessation
- 2000-01-31 CA CA002356898A patent/CA2356898A1/en not_active Abandoned
- 2000-01-31 IL IL14461100A patent/IL144611A0/xx unknown
- 2000-01-31 TR TR2001/02233T patent/TR200102233T2/xx unknown
- 2000-01-31 DE DE60015296T patent/DE60015296T2/de not_active Expired - Lifetime
- 2000-01-31 CN CN00803463A patent/CN1339025A/zh active Pending
- 2000-01-31 WO PCT/GB2000/000265 patent/WO2000046196A1/en not_active Application Discontinuation
- 2000-01-31 NZ NZ512680A patent/NZ512680A/en unknown
- 2000-01-31 US US09/889,599 patent/US6737435B1/en not_active Expired - Fee Related
- 2000-01-31 AU AU21213/00A patent/AU770856B2/en not_active Ceased
- 2000-01-31 AR ARP000100407A patent/AR022461A1/es not_active Application Discontinuation
- 2000-01-31 BR BR0007984-7A patent/BR0007984A/pt not_active IP Right Cessation
- 2000-01-31 PL PL00350184A patent/PL350184A1/xx not_active Application Discontinuation
- 2000-02-04 MY MYPI20000404A patent/MY133209A/en unknown
-
2001
- 2001-06-26 IS IS5980A patent/IS5980A/is unknown
- 2001-06-27 ZA ZA200105311A patent/ZA200105311B/en unknown
- 2001-08-03 NO NO20013809A patent/NO20013809L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| BR0007984A (pt) | 2001-11-06 |
| KR20010094755A (ko) | 2001-11-01 |
| CA2356898A1 (en) | 2000-08-10 |
| TR200102233T2 (tr) | 2001-12-21 |
| NZ512680A (en) | 2003-11-28 |
| HUP0105079A2 (hu) | 2002-04-29 |
| DE60015296D1 (de) | 2004-12-02 |
| US6737435B1 (en) | 2004-05-18 |
| MY133209A (en) | 2007-10-31 |
| ATE280757T1 (de) | 2004-11-15 |
| EP1150952B1 (en) | 2004-10-27 |
| ID30401A (id) | 2001-11-29 |
| CN1339025A (zh) | 2002-03-06 |
| RU2001124567A (ru) | 2004-01-10 |
| DE60015296T2 (de) | 2006-02-02 |
| NO20013809L (no) | 2001-10-02 |
| EP1150952A1 (en) | 2001-11-07 |
| GB9902461D0 (en) | 1999-03-24 |
| IL144611A0 (en) | 2002-05-23 |
| ZA200105311B (en) | 2002-09-27 |
| EE200100403A (et) | 2002-10-15 |
| WO2000046196A1 (en) | 2000-08-10 |
| HUP0105079A3 (en) | 2002-11-28 |
| IS5980A (is) | 2001-06-26 |
| JP2002536359A (ja) | 2002-10-29 |
| AR022461A1 (es) | 2002-09-04 |
| CZ20012807A3 (cs) | 2001-10-17 |
| AU2121300A (en) | 2000-08-25 |
| RU2235090C2 (ru) | 2004-08-27 |
| PL350184A1 (en) | 2002-11-18 |
| AU770856B2 (en) | 2004-03-04 |
| NO20013809D0 (no) | 2001-08-03 |
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