GB9902461D0 - Chemical compounds - Google Patents

Chemical compounds

Info

Publication number
GB9902461D0
GB9902461D0 GBGB9902461.4A GB9902461A GB9902461D0 GB 9902461 D0 GB9902461 D0 GB 9902461D0 GB 9902461 A GB9902461 A GB 9902461A GB 9902461 D0 GB9902461 D0 GB 9902461D0
Authority
GB
United Kingdom
Prior art keywords
chemical compounds
compounds
chemical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB9902461.4A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syngenta Ltd
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Priority to GBGB9902461.4A priority Critical patent/GB9902461D0/en
Publication of GB9902461D0 publication Critical patent/GB9902461D0/en
Priority to GB0001663A priority patent/GB0001663D0/en
Priority to EP20000901259 priority patent/EP1150952B1/en
Priority to BR0007984-7A priority patent/BR0007984A/pt
Priority to KR1020017009862A priority patent/KR20010094755A/ko
Priority to SK1115-2001A priority patent/SK11152001A3/sk
Priority to DE60015296T priority patent/DE60015296T2/de
Priority to JP2000597267A priority patent/JP2002536359A/ja
Priority to HU0105079A priority patent/HUP0105079A3/hu
Priority to EEP200100403A priority patent/EE200100403A/xx
Priority to PL00350184A priority patent/PL350184A1/xx
Priority to NZ512680A priority patent/NZ512680A/en
Priority to RU2001124567/04A priority patent/RU2235090C2/ru
Priority to ARP000100407A priority patent/AR022461A1/es
Priority to CN00803463A priority patent/CN1339025A/zh
Priority to AT00901259T priority patent/ATE280757T1/de
Priority to AU21213/00A priority patent/AU770856B2/en
Priority to TR2001/02233T priority patent/TR200102233T2/xx
Priority to IDW00200101667A priority patent/ID30401A/id
Priority to CA002356898A priority patent/CA2356898A1/en
Priority to PCT/GB2000/000265 priority patent/WO2000046196A1/en
Priority to US09/889,599 priority patent/US6737435B1/en
Priority to CZ20012807A priority patent/CZ20012807A3/cs
Priority to IL14461100A priority patent/IL144611A0/xx
Priority to MYPI20000404A priority patent/MY133209A/en
Priority to IS5980A priority patent/IS5980A/is
Priority to ZA200105311A priority patent/ZA200105311B/en
Priority to NO20013809A priority patent/NO20013809L/no
Ceased legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/30Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
GBGB9902461.4A 1999-02-05 1999-02-05 Chemical compounds Ceased GB9902461D0 (en)

Priority Applications (28)

Application Number Priority Date Filing Date Title
GBGB9902461.4A GB9902461D0 (en) 1999-02-05 1999-02-05 Chemical compounds
GB0001663A GB0001663D0 (en) 1999-02-05 2000-01-26 Chemical compounds
IL14461100A IL144611A0 (en) 1999-02-05 2000-01-31 Indole derivatives and their use as mcp-1 antagonists
RU2001124567/04A RU2235090C2 (ru) 1999-02-05 2000-01-31 Производные индола и их применение в качестве антагонистов мср-1
AT00901259T ATE280757T1 (de) 1999-02-05 2000-01-31 Indolderivate und ihre verwendung als mcp-1 rezeptor antagonisten
KR1020017009862A KR20010094755A (ko) 1999-02-05 2000-01-31 인돌 유도체 및 이의 mcp-1 길항물질로서의 용도
SK1115-2001A SK11152001A3 (sk) 1999-02-05 2000-01-31 Indolové deriváty, spôsob ich prípravy, farmaceutická kompozícia s ich obsahom a ich použitie ako antagonistov mcp-1
DE60015296T DE60015296T2 (de) 1999-02-05 2000-01-31 Indolderivate und ihre verwendung als mcp-1 rezeptor antagonisten
JP2000597267A JP2002536359A (ja) 1999-02-05 2000-01-31 インドール誘導体およびmcp−1拮抗物質としての該化合物の使用
HU0105079A HUP0105079A3 (en) 1999-02-05 2000-01-31 Indole derivatives and their use as mcp-1 antagonists, process for preparation of the compounds and medicaments containing them
EEP200100403A EE200100403A (et) 1999-02-05 2000-01-31 Indooli derivaadid ja nende kasutamine MCP-1 antagonistidena
PL00350184A PL350184A1 (en) 1999-02-05 2000-01-31 Indole derivatives and their use as mcp-1 antagonists
NZ512680A NZ512680A (en) 1999-02-05 2000-01-31 Indole derivatives useful as MCP-1 antagonists
EP20000901259 EP1150952B1 (en) 1999-02-05 2000-01-31 Indole derivatives and their use as mcp-1 receptor antagonists
ARP000100407A AR022461A1 (es) 1999-02-05 2000-01-31 Compuesto de 5-hidroxiindol sustituido; proceso para su preparacion y composicion farmaceutica que lo contiene
CN00803463A CN1339025A (zh) 1999-02-05 2000-01-31 吲哚衍生物及其作为mcp-1拮抗剂的用途
BR0007984-7A BR0007984A (pt) 1999-02-05 2000-01-31 Composto, processo para preparar um composto, e, composição farmacêutica
AU21213/00A AU770856B2 (en) 1999-02-05 2000-01-31 Indole derivatives and their use as MCP-1 antagonists
TR2001/02233T TR200102233T2 (tr) 1999-02-05 2000-01-31 İndol türevleri ve bunların MCP-1 antagonistleri olarak kullanımı.
IDW00200101667A ID30401A (id) 1999-02-05 2000-01-31 Turunan-turunan indol dan penggunaannya sebagai antagonis mcp-1
CA002356898A CA2356898A1 (en) 1999-02-05 2000-01-31 Indole derivatives and their use as mcp-1 antagonists
PCT/GB2000/000265 WO2000046196A1 (en) 1999-02-05 2000-01-31 Indole derivatives and their use as mcp-1 antagonists
US09/889,599 US6737435B1 (en) 1999-02-05 2000-01-31 Indole derivatives and their use as MCP-1 antagonist
CZ20012807A CZ20012807A3 (cs) 1999-02-05 2000-01-31 Indolové deriváty a jejich pouľití jako antagonistů MCP-1
MYPI20000404A MY133209A (en) 1999-02-05 2000-02-04 Chemical compounds
IS5980A IS5980A (is) 1999-02-05 2001-06-26 Indól afleiður og notkun þeirra sem MCP-1 mótlyf
ZA200105311A ZA200105311B (en) 1999-02-05 2001-06-27 Indole derivatives and their use as MCP-1 antagonists.
NO20013809A NO20013809L (no) 1999-02-05 2001-08-03 Indolderivater og anvendelse derav som MCP-1 antagonister

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9902461.4A GB9902461D0 (en) 1999-02-05 1999-02-05 Chemical compounds

Publications (1)

Publication Number Publication Date
GB9902461D0 true GB9902461D0 (en) 1999-03-24

Family

ID=10847084

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB9902461.4A Ceased GB9902461D0 (en) 1999-02-05 1999-02-05 Chemical compounds

Country Status (27)

Country Link
US (1) US6737435B1 (xx)
EP (1) EP1150952B1 (xx)
JP (1) JP2002536359A (xx)
KR (1) KR20010094755A (xx)
CN (1) CN1339025A (xx)
AR (1) AR022461A1 (xx)
AT (1) ATE280757T1 (xx)
AU (1) AU770856B2 (xx)
BR (1) BR0007984A (xx)
CA (1) CA2356898A1 (xx)
CZ (1) CZ20012807A3 (xx)
DE (1) DE60015296T2 (xx)
EE (1) EE200100403A (xx)
GB (1) GB9902461D0 (xx)
HU (1) HUP0105079A3 (xx)
ID (1) ID30401A (xx)
IL (1) IL144611A0 (xx)
IS (1) IS5980A (xx)
MY (1) MY133209A (xx)
NO (1) NO20013809L (xx)
NZ (1) NZ512680A (xx)
PL (1) PL350184A1 (xx)
RU (1) RU2235090C2 (xx)
SK (1) SK11152001A3 (xx)
TR (1) TR200102233T2 (xx)
WO (1) WO2000046196A1 (xx)
ZA (1) ZA200105311B (xx)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9716657D0 (en) 1997-08-07 1997-10-15 Zeneca Ltd Chemical compounds
GB9902461D0 (en) 1999-02-05 1999-03-24 Zeneca Ltd Chemical compounds
GB0000625D0 (en) * 2000-01-13 2000-03-01 Zeneca Ltd Chemical compounds
GB0000626D0 (en) * 2000-01-13 2000-03-01 Zeneca Ltd Chemical compounds
CA2427499A1 (en) 2000-10-10 2002-04-18 Smithkline Beecham Corporation Substituted indoles, pharmaceutical compositions containing such indoles and their use as ppar-.gamma. binding agents
JP2004523534A (ja) 2000-12-20 2004-08-05 ブリストル−マイヤーズ スクイブ カンパニー ケモカイン受容体活性調節剤としての環状誘導体
JP2005506949A (ja) 2000-12-20 2005-03-10 ブリストル−マイヤーズ・スクイブ・ファーマ・カンパニー ケモカイン受容体の調節剤としてのジアミン
DE60328690D1 (de) 2002-06-12 2009-09-17 Chemocentryx Inc 1-aryl-4-substituierte piperazin-derivate zur verwendung als ccr1-antagonisten zur behandlung von entzündungen und immunerkrankungen
US7589199B2 (en) 2002-06-12 2009-09-15 Chemocentryx, Inc. Substituted piperazines
US7842693B2 (en) 2002-06-12 2010-11-30 Chemocentryx, Inc. Substituted piperazines
TW200508224A (en) 2003-02-12 2005-03-01 Bristol Myers Squibb Co Cyclic derivatives as modulators of chemokine receptor activity
WO2004080966A1 (ja) 2003-03-14 2004-09-23 Ono Pharmaceutical Co., Ltd. 含窒素複素環誘導体およびそれらを有効成分とする薬剤
EP1619193A4 (en) 2003-04-18 2010-08-11 Ono Pharmaceutical Co SPIROPIPERIDINE COMPOUND AND MEDICINAL USE THEREOF
US7291615B2 (en) 2003-05-01 2007-11-06 Bristol-Myers Squibb Company Cyclic derivatives as modulators of chemokine receptor activity
US7230133B2 (en) 2003-05-01 2007-06-12 Bristol-Myers Squibb Company Malonamides and malonamide derivatives as modulators of chemokine receptor activity
US7732162B2 (en) 2003-05-05 2010-06-08 Probiodrug Ag Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases
US7230022B2 (en) 2004-02-19 2007-06-12 Bristol-Myers Squibb Company Substituted fused bicyclic amines as modulators of chemokine receptor activity
US7381738B2 (en) 2004-02-19 2008-06-03 Bristol-Myers Squibb Company Substituted bicycloalkylamine derivatives as modulators of chemokine receptor activity
US7479496B2 (en) 2004-02-19 2009-01-20 Bristol-Myers Squibb Company Substituted spiro azabicyclics as modulators of chemokine receptor activity
US7288563B2 (en) 2004-02-19 2007-10-30 Bristol-Myers Squibb Company Substituted bicycloalkylamine derivatives as modulators of chemokine receptor activity
CA2558211C (en) 2004-03-03 2013-09-03 Chemocentryx, Inc. Bicyclic and bridged nitrogen heterocycles
US7435831B2 (en) 2004-03-03 2008-10-14 Chemocentryx, Inc. Bicyclic and bridged nitrogen heterocycles
US8481035B2 (en) 2004-04-27 2013-07-09 Northwestern University Methods for treating chronic pelvic pain syndrome with antibodies that binds MCP-1 or MIP-1A
JP2008512463A (ja) * 2004-09-08 2008-04-24 ボーイズ タウン ナショナル リサーチ ホスピタル マトリックスメタロプロテイナーゼ−12に関連する糸球体基底膜疾患の治療
NZ553696A (en) 2004-09-13 2010-02-26 Ono Pharmaceutical Co Nitrogenous heterocyclic derivative and medicine containing the same as an active ingredient
WO2006129679A1 (ja) 2005-05-31 2006-12-07 Ono Pharmaceutical Co., Ltd. スピロピペリジン化合物およびその医薬用途
FR2890071B1 (fr) 2005-08-30 2007-11-09 Fournier Sa Sa Lab Nouveaux composes de l'indole
PT1942108E (pt) 2005-10-28 2013-10-24 Ono Pharmaceutical Co Composto com um grupo básico e a sua utilização
ES2407115T3 (es) 2005-11-18 2013-06-11 Ono Pharmaceutical Co., Ltd. Compuesto que contiene un grupo básico y uso del mismo
ATE448230T1 (de) 2005-12-09 2009-11-15 Hoffmann La Roche Für die behandlung von obesitas geeignete tricyclische amidderivate
EP1990335A4 (en) * 2006-03-02 2009-11-11 Astellas Pharma Inc 17-BETA-HSD-type-5 INHIBITOR
AU2007225836A1 (en) 2006-03-10 2007-09-20 Ono Pharmaceutical Co., Ltd. Nitrogenated heterocyclic derivative, and pharmaceutical agent comprising the derivative as active ingredient
EP2042503B1 (en) 2006-05-16 2013-01-30 Ono Pharmaceutical Co., Ltd. Compound having acidic group which may be protected, and use thereof
DE102006033572A1 (de) 2006-07-20 2008-01-24 Bayer Cropscience Ag N'-Cyano-N-halogenalkyl-imidamid Derivate
WO2008016006A1 (en) 2006-07-31 2008-02-07 Ono Pharmaceutical Co., Ltd. Compound having cyclic group bound thereto through spiro binding and use thereof
US20080076120A1 (en) * 2006-09-14 2008-03-27 Millennium Pharmaceuticals, Inc. Methods for the identification, evaluation and treatment of patients having CC-Chemokine receptor 2 (CCR-2) mediated disorders
WO2008055945A1 (en) 2006-11-09 2008-05-15 Probiodrug Ag 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases
US9126987B2 (en) 2006-11-30 2015-09-08 Probiodrug Ag Inhibitors of glutaminyl cyclase
CN101668525A (zh) 2007-03-01 2010-03-10 前体生物药物股份公司 谷氨酰胺酰环化酶抑制剂的新用途
EP2142514B1 (en) 2007-04-18 2014-12-24 Probiodrug AG Thiourea derivatives as glutaminyl cyclase inhibitors
PT2250161E (pt) * 2008-01-18 2014-01-21 Atopix Therapeutics Ltd Compostos tendo atividade antagonista de crth2
JP5656848B2 (ja) * 2008-10-16 2015-01-21 ジャンセン ファーマシューティカルズ, インコーポレイテッド. 代謝型グルタミン酸受容体モジュレーターとしてのインドールおよびベンゾモルホリンの誘導体
WO2010129351A1 (en) 2009-04-28 2010-11-11 Schepens Eye Research Institute Method to identify and treat age-related macular degeneration
FR2950053B1 (fr) 2009-09-11 2014-08-01 Fournier Lab Sa Utilisation de derives d'indole benzoique comme activateurs de nurr-1, pour le traitement de la maladie de parkinson
SG178953A1 (en) 2009-09-11 2012-04-27 Probiodrug Ag Heterocylcic derivatives as inhibitors of glutaminyl cyclase
ES2586231T3 (es) 2010-03-03 2016-10-13 Probiodrug Ag Inhibidores de glutaminil ciclasa
DK2545047T3 (da) 2010-03-10 2014-07-28 Probiodrug Ag Heterocycliske inhibitorer af glutaminylcyclase (QC, EC 2.3.2.5)
WO2011131748A2 (en) 2010-04-21 2011-10-27 Probiodrug Ag Novel inhibitors
KR101350077B1 (ko) * 2010-12-13 2014-01-14 한국화학연구원 신규한 3-인돌리논 유도체 및 이를 포함하는 조성물
ES2570167T3 (es) 2011-03-16 2016-05-17 Probiodrug Ag Derivados de benzimidazol como inhibidores de glutaminil ciclasa
EP4252629A3 (en) 2016-12-07 2023-12-27 Biora Therapeutics, Inc. Gastrointestinal tract detection methods, devices and systems
EP3554541B1 (en) 2016-12-14 2023-06-07 Biora Therapeutics, Inc. Treatment of a disease of the gastrointestinal tract with a chemokine/chemokine receptor inhibitor
PL3461819T3 (pl) 2017-09-29 2020-11-30 Probiodrug Ag Inhibitory cyklazy glutaminylowej
KR20210095165A (ko) 2018-11-19 2021-07-30 프로제너티, 인크. 바이오의약품으로 질환을 치료하기 위한 방법 및 디바이스
CN115666704A (zh) 2019-12-13 2023-01-31 比奥拉治疗股份有限公司 用于将治疗剂递送至胃肠道的可摄取装置

Family Cites Families (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3196162A (en) * 1961-03-13 1965-07-20 Merck & Co Inc Indolyl aliphatic acids
US3557142A (en) 1968-02-20 1971-01-19 Sterling Drug Inc 4,5,6,7-tetrahydro-indole-lower-alkanoic acids and esters
US3776923A (en) 1970-01-06 1973-12-04 American Cyanamid Co 2-nitro-4-oxo-4,5,6,7-tetrahydroindole
US3997557A (en) 1974-04-23 1976-12-14 American Hoechst Corporation Substituted N-aminoalkylpyrroles
US4496742A (en) 1981-10-13 1985-01-29 The Upjohn Company Analogs of 5,6-dihydro PGI2
FR2537974A1 (fr) 1982-12-16 1984-06-22 Adir Nouveaux derives de thieno (2,3-b) pyrrole, leur procede de preparation et les compositions pharmaceutiques les renfermant
US4529724A (en) 1983-10-11 1985-07-16 Mcneilab, Inc. 6H-indolo[2,1-c][1,4]benzodiazepines and 12-oxo derivatives useful as antihypertensives
FR2565981B1 (fr) 1984-06-15 1986-09-19 Adir Nouveaux derives de thieno (2,3-b) pyrrole, leur procede de preparation et les compositions pharmaceutiques les renfermant
CA1241660A (en) * 1984-06-25 1988-09-06 Yvan Guindon Indole-2-alkanoic acids
WO1986000896A1 (en) 1984-07-30 1986-02-13 Schering Corporation NOVEL PROCESS FOR THE PREPARATION OF CIS, ENDOOCTAHYDROCYCLOPENTA ADb BDPYRROLE-2-CARBOXYLATE
US4675332A (en) 1984-12-10 1987-06-23 Warner-Lambert Company Acidic tetrazolyl substituted indole compounds and their use as antiallergy agents
EP0189690B1 (en) 1984-12-12 1989-03-01 Merck & Co. Inc. Substituted aromatic sulfonamides, their preparation and ophthalmic compositions containing them
US4721725A (en) 1986-01-27 1988-01-26 E. R. Squibb & Sons, Inc. Aryl-cycloalkyl[b]pyrrole derivatives
IL84796A (en) 1986-12-17 1992-03-29 Merck Frosst Canada Inc Substituted n-benzyl-indoles and pharmaceutical compositions containing them
US4751231A (en) 1987-09-16 1988-06-14 Merck & Co., Inc. Substituted thieno[2,3-b]pyrrole-5-sulfonamides as antiglaucoma agents
DE3907388A1 (de) 1989-03-08 1990-09-13 Kali Chemie Pharma Gmbh Verfahren zur herstellung von indolcarbonsaeurederivaten
NZ234883A (en) 1989-08-22 1995-01-27 Merck Frosst Canada Inc Quinolin-2-ylmethoxy indole derivatives, preparation and pharmaceutical compositions thereof
US5272145A (en) 1989-08-22 1993-12-21 Merck Frosst Canada, Inc. (Quinolin-2-ylmethoxy)indoles as inhibitors of the biosynthesis of leukotrienes
DD298913A5 (de) 1989-11-17 1992-03-19 Arzneimittelwerk Dresden Gmbh,De Verfahren zur herstellung von n-substituierten 3-aminopyrrolen
DE3943225A1 (de) 1989-12-23 1991-06-27 Schering Ag Neue ss-carboline, verfahren zu deren herstellung und deren verwendung in arzneimitteln
US5081145A (en) 1990-02-01 1992-01-14 Merck Frosst Canada, Inc. Indole-2-alkanoic acids compositions of and anti allergic use thereof
US5260322A (en) 1990-10-08 1993-11-09 Merck & Co., Inc. Angiotension II antagonists in the treatment of hyperuricemia
CA2079374C (en) 1991-09-30 2003-08-05 Merck Frosst Canada Incorporated (bicyclic-azaarylmethoxy)indoles as inhibitors of leukotriene biosynthesis
US5290798A (en) 1991-09-30 1994-03-01 Merck Frosst Canada, Inc. (hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis
US5389650A (en) 1991-09-30 1995-02-14 Merck Frosst Canada, Inc. (Azaarylmethoxy)indoles as inhibitors of leukotriene biosynthesis
US5190968A (en) 1991-09-30 1993-03-02 Merck Frosst Canada, Inc. (Polycyclic-arylmethoxy) indoles as inhibitors of leukotriene biosynthesis
US5273980A (en) 1991-09-30 1993-12-28 Merck Frosst Canada Inc. Bicyclic-azaarylmethoxy) indoles as inhibitors of leukotriene biosynthesis
US5308850A (en) 1991-09-30 1994-05-03 Merck Frosst Canada, Inc. (Bicyclic-hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis
US5318985A (en) * 1991-12-20 1994-06-07 Merrell Dow Pharmaceuticals Inc. Potentiation of NMDA antagonists
AU3488693A (en) 1992-02-13 1993-09-03 Merck Frosst Canada Inc. (Azaaromaticalkoxy)indoles as inhibitors of leukotriene biosynthesis
ATE197051T1 (de) 1992-04-03 2000-11-15 Upjohn Co Pharmazeutisch wirksame bicyclisch heterocyclische amine
US5334719A (en) 1992-06-17 1994-08-02 Merck Frosst Canada, Inc. Bicyclic(azaaromatic)indoles as inhibitors of leukotriene bisynthesis
US5288743A (en) 1992-11-20 1994-02-22 Abbott Laboratories Indole carboxylate derivatives which inhibit leukotriene biosynthesis
ZA939516B (en) 1992-12-22 1994-06-06 Smithkline Beecham Corp Endothelin receptor antagonists
EP0639573A1 (de) 1993-08-03 1995-02-22 Hoechst Aktiengesellschaft Benzokondensierte 5-Ringheterocyclen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, ihre Verwendung als Diagnostikum, sowie sie enthaltendes Medikament
US5852046A (en) 1993-08-03 1998-12-22 Hoechst Aktiengesellschaft Benzo-fused heterocyclic compounds having a 5-membered ring processes for their preparation their use as medicaments their use as diagnostic agents and medicaments containing them
US5399699A (en) 1994-01-24 1995-03-21 Abbott Laboratories Indole iminooxy derivatives which inhibit leukotriene biosynthesis
CA2196046A1 (en) 1994-07-27 1996-02-08 Nigel Birdsall Heterocyclic compounds, useful as allosteric effectors at muscarinic receptors
US5482960A (en) * 1994-11-14 1996-01-09 Warner-Lambert Company Nonpeptide endothelin antagonists
US5684032A (en) 1994-12-13 1997-11-04 Smithkline Beecham Corporation Compounds
AU4514496A (en) * 1994-12-13 1996-07-03 Smithkline Beecham Corporation Novel compounds
EA199900808A1 (ru) 1995-04-04 2000-06-26 Тексаз Байотекнолоджи Корпорейшн Бифенилсульфонамиды и их производные, модулирующие активность эндотелина
IT1282797B1 (it) 1995-04-21 1998-03-31 Colla Paolo Pirril-(indolil)-aril-sulfoni e relativo processo di produzione ed impiego nella terapia delle infezioni da virus dell'aids
US5604253A (en) * 1995-05-22 1997-02-18 Merck Frosst Canada, Inc. N-benzylindol-3-yl propanoic acid derivatives as cyclooxygenase inhibitors
US5639780A (en) 1995-05-22 1997-06-17 Merck Frosst Canada, Inc. N-benzyl indol-3-yl butanoic acid derivatives as cyclooxygenase inhibitors
WO1997012613A1 (en) 1995-10-05 1997-04-10 Warner-Lambert Company Method for treating and preventing inflammation and atherosclerosis
DK0954305T3 (da) 1996-02-26 2003-08-25 Advanced Res & Tech Inst Anvendelse af carbonanhydraseinhibitorer til behandling af maculaødem
WO1997035572A1 (en) 1996-03-28 1997-10-02 Smithkline Beecham Corporation Carboxylic acid indole inhibitors of chemokines
EP0822185A1 (en) 1996-07-31 1998-02-04 Pfizer Inc. B-3-adrenergic agonists as antidiabetic and antiobesity agents
EP0927167A1 (en) 1996-08-14 1999-07-07 Warner-Lambert Company 2-phenyl benzimidazole derivatives as mcp-1 antagonists
GB9716656D0 (en) 1997-08-07 1997-10-15 Zeneca Ltd Chemical compounds
GB9716657D0 (en) 1997-08-07 1997-10-15 Zeneca Ltd Chemical compounds
RU2225397C2 (ru) * 1997-12-24 2004-03-10 Авентис Фарма Дойчланд Гмбх Производные индола как ингибиторы фактора Ха
GB9803228D0 (en) 1998-02-17 1998-04-08 Zeneca Ltd Chemical compounds
GB9803226D0 (en) 1998-02-17 1998-04-08 Zeneca Ltd Chemical compounds
GB9902461D0 (en) 1999-02-05 1999-03-24 Zeneca Ltd Chemical compounds
GB9902459D0 (en) 1999-02-05 1999-03-24 Zeneca Ltd Chemical compounds
GB9902455D0 (en) 1999-02-05 1999-03-24 Zeneca Ltd Chemical compounds
GB9902452D0 (en) 1999-02-05 1999-03-24 Zeneca Ltd Chemical compounds
GB9902453D0 (en) 1999-02-05 1999-03-24 Zeneca Ltd Chemical compounds
GB0000625D0 (en) 2000-01-13 2000-03-01 Zeneca Ltd Chemical compounds
GB0000626D0 (en) 2000-01-13 2000-03-01 Zeneca Ltd Chemical compounds

Also Published As

Publication number Publication date
EP1150952A1 (en) 2001-11-07
AR022461A1 (es) 2002-09-04
HUP0105079A2 (hu) 2002-04-29
CN1339025A (zh) 2002-03-06
AU2121300A (en) 2000-08-25
CZ20012807A3 (cs) 2001-10-17
NO20013809D0 (no) 2001-08-03
EE200100403A (et) 2002-10-15
PL350184A1 (en) 2002-11-18
RU2001124567A (ru) 2004-01-10
IS5980A (is) 2001-06-26
HUP0105079A3 (en) 2002-11-28
ID30401A (id) 2001-11-29
NO20013809L (no) 2001-10-02
EP1150952B1 (en) 2004-10-27
CA2356898A1 (en) 2000-08-10
US6737435B1 (en) 2004-05-18
TR200102233T2 (tr) 2001-12-21
AU770856B2 (en) 2004-03-04
NZ512680A (en) 2003-11-28
BR0007984A (pt) 2001-11-06
RU2235090C2 (ru) 2004-08-27
ZA200105311B (en) 2002-09-27
ATE280757T1 (de) 2004-11-15
DE60015296D1 (de) 2004-12-02
JP2002536359A (ja) 2002-10-29
DE60015296T2 (de) 2006-02-02
IL144611A0 (en) 2002-05-23
KR20010094755A (ko) 2001-11-01
WO2000046196A1 (en) 2000-08-10
SK11152001A3 (sk) 2001-12-03
MY133209A (en) 2007-10-31

Similar Documents

Publication Publication Date Title
GB9907658D0 (en) Chemical compounds
GB9902461D0 (en) Chemical compounds
GB9909409D0 (en) Chemical compounds
GB9903861D0 (en) Chemical compounds
GB9910104D0 (en) Chemical compounds
GB9910110D0 (en) Chemical compounds
GB9914025D0 (en) Chemical compounds
GB9900078D0 (en) Chemical compounds
GB9914015D0 (en) Chemical compounds
GB9910394D0 (en) Chemical compounds
GB9914024D0 (en) Chemical compounds
GB9910419D0 (en) Chemical compounds
GB9914022D0 (en) Chemical compounds
GB9908355D0 (en) Chemical compounds
GB9909062D0 (en) Chemical compounds
GB9903859D0 (en) Chemical compounds
GB9905463D0 (en) Chemical compounds
GB9906564D0 (en) Chemical compounds
GB9906565D0 (en) Chemical compounds
GB9907653D0 (en) Chemical compounds
GB9907656D0 (en) Chemical compounds
GB9907657D0 (en) Chemical compounds
GB9905078D0 (en) Chemical compounds
GB9905077D0 (en) Chemical compounds
GB9905076D0 (en) Chemical compounds

Legal Events

Date Code Title Description
AT Applications terminated before publication under section 16(1)