SK10842002A3 - Spôsob prípravy acetyl-amidiniofenylalanyl-cyklohexylglycyl- pyridinioalanínamidov a medziprodukty používané pri tomto spôsobe - Google Patents

Spôsob prípravy acetyl-amidiniofenylalanyl-cyklohexylglycyl- pyridinioalanínamidov a medziprodukty používané pri tomto spôsobe Download PDF

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Publication number
SK10842002A3
SK10842002A3 SK1084-2002A SK10842002A SK10842002A3 SK 10842002 A3 SK10842002 A3 SK 10842002A3 SK 10842002 A SK10842002 A SK 10842002A SK 10842002 A3 SK10842002 A3 SK 10842002A3
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SK
Slovakia
Prior art keywords
formula
compound
salt
acid
reaction
Prior art date
Application number
SK1084-2002A
Other languages
English (en)
Slovak (sk)
Inventor
Gerhard Breipohl
Wolfgang Holla
Heiner Jendralla
Gerhard Beck
Original Assignee
Aventis Pharma Deutschland Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Deutschland Gmbh filed Critical Aventis Pharma Deutschland Gmbh
Publication of SK10842002A3 publication Critical patent/SK10842002A3/sk

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Catalysts (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
SK1084-2002A 2000-01-28 2001-01-18 Spôsob prípravy acetyl-amidiniofenylalanyl-cyklohexylglycyl- pyridinioalanínamidov a medziprodukty používané pri tomto spôsobe SK10842002A3 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10003586 2000-01-28
PCT/EP2001/000523 WO2001055175A2 (en) 2000-01-28 2001-01-18 Process for the preparation of acetyl-amidiniophenylalanyl-cyclohexylglycyl-pyridinioalaninamides

Publications (1)

Publication Number Publication Date
SK10842002A3 true SK10842002A3 (sk) 2003-04-01

Family

ID=7628946

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1084-2002A SK10842002A3 (sk) 2000-01-28 2001-01-18 Spôsob prípravy acetyl-amidiniofenylalanyl-cyklohexylglycyl- pyridinioalanínamidov a medziprodukty používané pri tomto spôsobe

Country Status (30)

Country Link
US (2) US20010031858A1 (pt)
EP (1) EP1254159B9 (pt)
JP (1) JP4778181B2 (pt)
KR (1) KR100758141B1 (pt)
CN (1) CN1176104C (pt)
AR (1) AR027246A1 (pt)
AT (1) ATE325810T1 (pt)
AU (1) AU779722B2 (pt)
BR (1) BR0107804A (pt)
CA (1) CA2398497C (pt)
CZ (1) CZ20022583A3 (pt)
DE (1) DE60119491T2 (pt)
DK (1) DK1254159T3 (pt)
EE (1) EE200200410A (pt)
ES (1) ES2262632T3 (pt)
HK (1) HK1051866A1 (pt)
HR (1) HRP20020631A2 (pt)
HU (1) HUP0301986A2 (pt)
IL (2) IL150897A0 (pt)
MX (1) MXPA02006762A (pt)
NO (1) NO20023577L (pt)
NZ (1) NZ520427A (pt)
PL (1) PL356801A1 (pt)
PT (1) PT1254159E (pt)
RU (1) RU2250212C2 (pt)
SK (1) SK10842002A3 (pt)
TW (1) TWI236481B (pt)
WO (1) WO2001055175A2 (pt)
YU (1) YU51202A (pt)
ZA (1) ZA200205990B (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH695999A5 (de) 2002-02-28 2006-11-15 Wilex Ag Verfahren zur Herstellung von 3- Amidinophenylalanin-Derivaten.
EP1968999A2 (en) * 2005-12-07 2008-09-17 Technische Universität München Small peptidic and peptido-mimetic affinity ligands for factor viii and factor viii-like proteins
CN101774942B (zh) * 2010-01-27 2012-08-22 宁波武盛化学有限公司 制备n-乙酰基-dl-环己基甘氨酸的方法
WO2011133651A1 (en) * 2010-04-20 2011-10-27 Chiral Quest , Inc. An enantioselective process for cycloalkenyl b-substituted alanines
EP2646150A4 (en) * 2010-11-29 2014-10-08 Takasago Perfumery Co Ltd CATALYST FOR ASYMMETRIC HYDROGENATION AND METHOD FOR PRODUCING AN OPTICALLY ACTIVE CARBONYL COMPOUND THEREWITH
CN115068469B (zh) * 2022-07-08 2024-02-27 深圳市小分子新药创新中心有限公司 Tigit抑制剂及其应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2916711A1 (de) 1979-04-25 1980-11-06 Behringwerke Ag Blutgerinnungsfaktoren und verfahren zu ihrer herstellung
US4623717A (en) * 1980-03-05 1986-11-18 Miles Laboratories, Inc. Pasteurized therapeutically active protein compositions
US4440679A (en) * 1980-03-05 1984-04-03 Cutter Laboratories, Inc. Pasteurized therapeutically active protein compositions
US5849510A (en) 1994-04-26 1998-12-15 Selectide Corporation Factor Xa inhibitors
KR100380124B1 (ko) * 1994-04-26 2003-08-02 셀렉타이드 코포레이션 인자Xa억제제
WO1997022712A1 (en) * 1995-12-20 1997-06-26 Hoechst Marion Roussel, Inc. NOVEL PROCESS FOR PREPARING N-ACETYL(L)-4-CYANOPHENYLALANINE Ac-(L)-Phe(4-CN)-OH AND N-ACETYL-(L)-p-AMIDINOPHENYLALANINE-CYCLOHEXYLGLYCINE-β-(3-N-METHYLPYRIDINIUM)-ALANINE Ac-(L)-pAph-Chg-PalMe(3)-NH¿2?
DE19856443A1 (de) 1998-12-08 2000-06-21 Centeon Pharma Gmbh Stabilisiertes Antithrombin III-Präparat

Also Published As

Publication number Publication date
KR20030019306A (ko) 2003-03-06
EP1254159A2 (en) 2002-11-06
EP1254159B9 (en) 2006-06-28
DK1254159T3 (da) 2006-09-11
CN1176104C (zh) 2004-11-17
IL150897A0 (en) 2003-02-12
NO20023577D0 (no) 2002-07-26
EP1254159B1 (en) 2006-05-10
KR100758141B1 (ko) 2007-09-13
CA2398497C (en) 2011-04-26
HUP0301986A2 (hu) 2003-09-29
ATE325810T1 (de) 2006-06-15
ES2262632T3 (es) 2006-12-01
RU2002123046A (ru) 2004-01-10
US7084250B2 (en) 2006-08-01
HRP20020631A2 (en) 2004-12-31
DE60119491D1 (de) 2006-06-14
CZ20022583A3 (cs) 2002-10-16
PL356801A1 (en) 2004-07-12
US20040225109A1 (en) 2004-11-11
BR0107804A (pt) 2002-10-22
WO2001055175A3 (en) 2002-02-21
CN1396928A (zh) 2003-02-12
TWI236481B (en) 2005-07-21
AU779722B2 (en) 2005-02-10
MXPA02006762A (es) 2002-10-23
NO20023577L (no) 2002-08-28
JP4778181B2 (ja) 2011-09-21
AU4051601A (en) 2001-08-07
CA2398497A1 (en) 2001-08-02
HK1051866A1 (en) 2003-08-22
IL150897A (en) 2008-08-07
PT1254159E (pt) 2006-07-31
US20010031858A1 (en) 2001-10-18
AR027246A1 (es) 2003-03-19
NZ520427A (en) 2004-02-27
EE200200410A (et) 2003-12-15
RU2250212C2 (ru) 2005-04-20
DE60119491T2 (de) 2006-11-16
YU51202A (sh) 2005-11-28
ZA200205990B (en) 2003-04-30
JP2003523364A (ja) 2003-08-05
WO2001055175A2 (en) 2001-08-02

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