SI9300513B - Kvarterni bazični amidi, postopek za njihovo pripravo in farmacevtski sestavki, v katerih so prisotni - Google Patents

Kvarterni bazični amidi, postopek za njihovo pripravo in farmacevtski sestavki, v katerih so prisotni Download PDF

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Publication number
SI9300513B
SI9300513B SI9300513A SI9300513A SI9300513B SI 9300513 B SI9300513 B SI 9300513B SI 9300513 A SI9300513 A SI 9300513A SI 9300513 A SI9300513 A SI 9300513A SI 9300513 B SI9300513 B SI 9300513B
Authority
SI
Slovenia
Prior art keywords
carbon atoms
group
phenyl
alkyl
formula
Prior art date
Application number
SI9300513A
Other languages
English (en)
Slovenian (sl)
Other versions
SI9300513A (en
Inventor
Xavier Edmonds-Alt
Patrick Gueule
Vincenzo Proietto
Broeck Didier Van
Original Assignee
Sanofi-Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi-Synthelabo filed Critical Sanofi-Synthelabo
Publication of SI9300513A publication Critical patent/SI9300513A/sl
Publication of SI9300513B publication Critical patent/SI9300513B/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cephalosporin Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Indole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
SI9300513A 1992-09-30 1993-09-30 Kvarterni bazični amidi, postopek za njihovo pripravo in farmacevtski sestavki, v katerih so prisotni SI9300513B (sl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9212083A FR2696178B1 (fr) 1992-09-30 1992-09-30 Amides basiques quaternaires, procédé pour leur préparation et compositions pharmaceutiques en contenant.

Publications (2)

Publication Number Publication Date
SI9300513A SI9300513A (en) 1994-06-30
SI9300513B true SI9300513B (sl) 2002-02-28

Family

ID=9434374

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9300513A SI9300513B (sl) 1992-09-30 1993-09-30 Kvarterni bazični amidi, postopek za njihovo pripravo in farmacevtski sestavki, v katerih so prisotni

Country Status (27)

Country Link
EP (1) EP0591040B1 (ja)
JP (2) JP2857041B2 (ja)
KR (1) KR100279084B1 (ja)
CN (1) CN1036652C (ja)
AT (1) ATE176469T1 (ja)
AU (1) AU674875B2 (ja)
BR (1) BR9303982A (ja)
CA (1) CA2107432C (ja)
CZ (1) CZ287272B6 (ja)
DE (1) DE69323375T2 (ja)
DK (1) DK0591040T3 (ja)
ES (1) ES2130238T3 (ja)
FI (1) FI114474B (ja)
FR (1) FR2696178B1 (ja)
GR (1) GR3030000T3 (ja)
HU (2) HU215848B (ja)
IL (1) IL107158A0 (ja)
MX (1) MX9306024A (ja)
MY (1) MY108881A (ja)
NO (1) NO304888B1 (ja)
NZ (1) NZ248821A (ja)
OA (1) OA09869A (ja)
RU (1) RU2120436C1 (ja)
SG (1) SG47807A1 (ja)
SI (1) SI9300513B (ja)
TW (1) TW242625B (ja)
ZA (1) ZA937276B (ja)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5583134A (en) * 1992-09-30 1996-12-10 Sanofi 1-azoniabicyclo[2.2.2] octanes and pharmaceutical compositions in which they are present
FR2717804B1 (fr) * 1994-03-25 1996-06-21 Sanofi Sa Sels de composés hétéroaromatiques azotés substitués, procédé pour leur préparation et compositions pharmaceutiques en contenant.
FR2717802B1 (fr) * 1994-03-25 1996-06-21 Sanofi Sa Nouveaux composés aromatiques, procédé pour leur préparation et compositions pharmaceutiques en contenant.
PE27997A1 (es) 1994-04-29 1997-09-20 Lilly Co Eli Antagonistas de receptores de taquicininas
CN1067067C (zh) 1994-07-12 2001-06-13 伊莱利利公司 杂环速激肽受体拮抗物
FR2725900B1 (fr) * 1994-10-21 1997-07-18 Sanofi Sa Utilisation d'antagonistes des recepteurs nk1 pour la preparation de medicaments a action cardioregulatrice
GB9421709D0 (en) * 1994-10-27 1994-12-14 Zeneca Ltd Therapeutic compounds
US6008223A (en) * 1994-10-27 1999-12-28 Zeneca Limited Therapeutic compounds
CA2162786A1 (en) * 1994-11-22 1996-05-23 Philip Arthur Hipskind Heterocyclic tachykinin receptor antagonists
FR2751654B1 (fr) * 1996-07-26 1998-10-23 Sanofi Sa Composes heterocycliques substitues, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2729951B1 (fr) * 1995-01-30 1997-04-18 Sanofi Sa Nouveaux composes heterocycliques, procede pour leur preparation et compositions pharmaceutiques en contenant
FR2729954B1 (fr) * 1995-01-30 1997-08-01 Sanofi Sa Composes heterocycliques substitues, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2729952B1 (fr) * 1995-01-30 1997-04-18 Sanofi Sa Composes heterocycliques substitues, procede pour leur preparation et compositions pharmaceutiques les contenant
US5654316A (en) * 1995-06-06 1997-08-05 Schering Corporation Piperidine derivatives as neurokinin antagonists
DE69626123T2 (de) * 1995-06-06 2003-10-09 Schering Corp Substituierte benzokondensierte heterocyclen als neurokinin antagonisten
FR2745811B1 (fr) * 1996-03-07 1998-05-22 Sanofi Sa Glutarimide disubstitue procede pour sa preparation, et son utilisation
CA2255910A1 (en) * 1996-05-24 1997-11-27 Mitchell Irvin Steinberg Methods of treating hypertension
US5691362A (en) * 1996-06-05 1997-11-25 Schering-Plough Corporation Substituted benzene-fused hetero- and carbocyclics as nuerokinin antagonists
GB9617730D0 (en) * 1996-08-23 1996-10-02 Pfizer Ltd Quarternary ammonium compounds
FR2759584B1 (fr) * 1997-02-17 1999-06-11 Sanofi Sa Composition pharmaceutique pour l'administration orale de composes heterocycliques sous forme ammonium quaternaire
FR2759585B1 (fr) * 1997-02-17 1999-06-11 Sanofi Sa Formulations pharmaceutiques presentees sous forme seche pour l'administration orale d'un compose ammonium quaternaire cyclique
CA2287487A1 (en) * 1997-04-24 1998-10-29 Merck Sharp & Dohme Limited Use of nk-1 receptor antagonists for treating eating disorders
GB9712882D0 (en) * 1997-06-18 1997-08-20 Pfizer Ltd Quaternary ammonium compounds
CA2298777A1 (en) * 1997-08-04 1999-02-18 Merck Sharp & Dohme Limited Use of nk-1 receptor antagonists for treating mania
GB9716457D0 (en) * 1997-08-04 1997-10-08 Merck Sharp & Dohme Therapeutic agents
GB9716463D0 (en) * 1997-08-04 1997-10-08 Merck Sharp & Dohme Therapeutic agents
CA2298779A1 (en) * 1997-08-04 1999-02-18 Merck Sharp & Dohme Limited Use of nk-1 receptor antagonists for treating aggressive behaviour disorders
GB9816897D0 (en) * 1998-08-04 1998-09-30 Merck Sharp & Dohme Therapeutic use
GB9927125D0 (en) 1999-11-16 2000-01-12 Univ Reading The Placental human neurokinin B precursor
CN1942441A (zh) * 2004-02-25 2007-04-04 三共株式会社 磺酰氧基衍生物
CN104922117A (zh) 2005-03-22 2015-09-23 阿泽范药品公司 用于治疗月经前病症的β-内酰氨基链烷酸
KR101523776B1 (ko) 2005-07-19 2015-05-28 아제반 파마슈티칼스, 인코퍼레이티드 베타-락타민 페닐알라닌, 시스테인 그리고 세린 바소프레신길항물질
BRPI0807972A2 (pt) 2007-01-24 2014-06-10 Glaxo Group Ltd Composições farmacêuticas compreendendo 3,5-diamino-6-(2,3-diclofenil)-l,2,4-triazina ou r(-)-2,4-diamino-5-(2,3-diclorofenil)-6-fluorometilpirim idina e uma nk1
UA105182C2 (ru) 2008-07-03 2014-04-25 Ньюрексон, Інк. Бензоксазины, бензотиазины и родственные соединения, которые имеют ингибирующую nos активность
US9376424B2 (en) 2010-07-01 2016-06-28 Azevan Pharmaceuticals, Inc. Methods for treating post traumatic stress disorder
FI3122743T3 (fi) 2014-03-28 2023-03-02 Azevan Pharmaceuticals Inc Koostumuksia ja menetelmiä hermostoa rappeuttavien sairauksien hoitamiseksi
CA3047023C (en) * 2016-12-14 2022-05-31 Beijing Showby Pharmaceutical Co., Ltd. Class of bifunctional compounds with quaternary ammonium salt structure
JP2020534274A (ja) 2017-09-15 2020-11-26 アゼヴァン ファーマシューティカルズ，インコーポレイテッド 脳損傷を治療するための組成物及び方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI97540C (fi) * 1989-11-06 1997-01-10 Sanofi Sa Menetelmä terapeuttisesti käyttökelpoisten, aromaattisesti substituoitujen piperidiini- ja piperatsiinijohdannaisten valmistamiseksi
FR2666185B1 (fr) * 1990-08-21 1992-12-04 Sgs Thomson Microelectronics Convertisseur analogique/numerique a interpolation.
IL99320A (en) * 1990-09-05 1995-07-31 Sanofi Sa Arylalkylamines, their preparation and pharmaceutical preparations containing them

Also Published As

Publication number Publication date
ZA937276B (en) 1994-04-25
CZ203593A3 (en) 1994-04-13
HU9302770D0 (en) 1993-12-28
NO933481L (no) 1994-04-05
BR9303982A (pt) 1994-10-25
NO304888B1 (no) 1999-03-01
GR3030000T3 (en) 1999-07-30
DK0591040T3 (da) 1999-09-20
CN1036652C (zh) 1997-12-10
FI934273A0 (fi) 1993-09-29
DE69323375D1 (de) 1999-03-18
FI934273A (fi) 1994-03-31
OA09869A (fr) 1994-08-15
HU215848B (hu) 1999-04-28
AU674875B2 (en) 1997-01-16
IL107158A0 (en) 1993-12-28
CN1088582A (zh) 1994-06-29
RU2120436C1 (ru) 1998-10-20
ATE176469T1 (de) 1999-02-15
NZ248821A (en) 1995-10-26
FI114474B (fi) 2004-10-29
MY108881A (en) 1996-11-30
DE69323375T2 (de) 1999-06-24
JP3243212B2 (ja) 2002-01-07
CZ287272B6 (en) 2000-10-11
FR2696178B1 (fr) 1994-12-30
NO933481D0 (no) 1993-09-29
EP0591040A1 (fr) 1994-04-06
CA2107432A1 (en) 1994-03-31
JPH10175976A (ja) 1998-06-30
HU211889A9 (en) 1995-12-28
SI9300513A (en) 1994-06-30
MX9306024A (es) 1994-03-31
TW242625B (ja) 1995-03-11
JPH06211850A (ja) 1994-08-02
SG47807A1 (en) 1998-04-17
KR940007026A (ko) 1994-04-26
JP2857041B2 (ja) 1999-02-10
CA2107432C (en) 2000-04-04
AU4870893A (en) 1994-04-14
EP0591040B1 (fr) 1999-02-03
FR2696178A1 (fr) 1994-04-01
ES2130238T3 (es) 1999-07-01
HUT65759A (en) 1994-07-28
KR100279084B1 (ko) 2001-01-15

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Legal Events

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IF Valid on the event date
SP73 Change of data on owner

Owner name: SANOFI-AVENTIS; FR

Effective date: 20050325

KO00 Lapse of patent

Effective date: 20100531